1,736,092 research outputs found
Other title: Testimony on House Bill 2337 Other title: House Bill 2337 Other title: HB 2337
No full text"March 13, 2019."
Testimony before the Kansas Legislature, House Corrections and Juvenile Justice Committee, presented by Roger Werholtz, Secretary, Kansas Department of Corrections.Testimony in support of HB 2337. "HB 2337 amends the composition of Community Corrections Advisory Boards and the award of community corrections grant funding. HB 2337 is the result of a cooperative effort between the department and the Community Corrections directors.
2337 Auburn Avenue, Toledo, Ohio, 1987
No full textTerms associated with the photograph are: historic buildings | dwelling | 2337 Auburn Avenue (Toledo, Ohio) | Cone Street (Toledo, Ohio) | duplex | Italianate Style | gable | porch | bay windows | bric
Block Card 2337 Bodette Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Modern Colonial Style | 2337 bodette Avenue (Toledo, Ohio) | Dwelling | Gilmour Place Addition (Toledo, Ohio) | Greenwood Park area (Toledo, Ohio
Block Card 2337 Charlotte Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 2337 Charlotte Street (Toledo, Ohio) | Dwelling | Elizabeth Park Addition (Toledo, Ohio) | Greenwood Park area (Toledo, Ohio
Block Card 2337 Auburn Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Modern Colonial Style | 2337 Auburn Avenue (Toledo, Ohio) | duplex | Auburndale Amended Plat Extension (Toledo, Ohio) | Auburndale Area (Toledo, Ohio
The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent
No full textAbstract The Toll-like receptor 8 (TLR8) agonist VTX-2337 (motolimod) is an anti-cancer immunotherapeutic agent that is believed to augment natural killer (NK) and dendritic cell (DC) activity. The goal of this work is to examine the role of TLR8 expression/activity in head and neck squamous cell carcinoma (HNSCC) to facilitate the prediction of responders to VTX-2337-based therapy. The prognostic role of TLR8 expression in HNSCC patients was assessed by TCGA and tissue microarray analyses. The anti-tumor effect of VTX-2337 was determined in SCCVII/C3H, mEERL/C57Bl/6 and TUBO-human EGFR/BALB/c syngeneic mouse models. The effect of combined VTX-2337 and cetuximab treatment on tumor growth, survival and immune cell recruitment was assessed. TLR8 expression was associated with CD8+ T cell infiltration and favorable survival outcomes. VTX-2337 delayed tumor growth in all 3 syngeneic mouse models and significantly increased the survival of cetuximab-treated mice. The anti-tumor effects of VTX-2337+ cetuximab were accompanied by increased splenic lymphoid DCs and IFNγ+ CD4+ and tumor-specific CD8+ T cells. Depletion of CD4+ T cells, CD8+ T cells and NK cells were all able to abolish the anti-tumor effect of VTX-2337+ cetuximab. Altogether, VTX-2337 remains promising as an adjuvant for cetuximab-based therapy however patients with high TLR8 expression may be more likely to derive benefit from this drug combination compared to patients with low TLR8 expression
Block Card 2337 Charlotte Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Bungalow Style | 2337 Charlotte Street (Toledo, Ohio) | Dwelling | Elizabeth Park Addition (Toledo, Ohio) | Greenwood Park area (Toledo, Ohio
VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC
No full textAbstract
Purpose: We aim to characterize VTX-2337, a novel Toll-like receptor (TLR) 8 agonist in clinical development, and investigate its potential to improve monoclonal antibody–based immunotherapy that includes the activation of natural killer (NK) cells.
Experimental Design: HEK-TLR transfectants were used to compare the selectivity and potency of VTX-2337, imiquimod, CpG ODN2006, and CL075. The ability of VTX-2337 to induce cytokine and chemokine production from human peripheral blood mononuclear cells (PBMC) and activation of specific immune cell subsets was examined. The potential for VTX-2337 to activate NK cell activity through direct and indirect mechanisms was also investigated. Finally, we tested the potential for VTX-2337 to augment antibody-dependent cell-mediated cytotoxicity (ADCC), especially in individuals with low-affinity FcγR3A single-nucleotide polymorphism (SNP).
Results: VTX-2337 selectively activates TLR8 with an EC50 of about 100 nmol/L and stimulates production of TNFα and interleukin (IL)-12 from monocytes and myeloid dendritic cells (mDC). VTX-2337 stimulates IFNγ production from NK cells and increases the cytotoxicity of NK cells against K562 and ADCC by rituximab and trastuzumab. Effects of VTX-2337 on NK cells were, in part, from direct activation as increased IFNγ production and cytotoxic activity were seen with purified NK cells. Finally, VTX-2337 augments ADCC by rituximab in PBMCs with different FcγR3A genotypes (V/V, V/F, and F/F at position 158).
Conclusions: VTX-2337 is a novel small-molecule TLR8 agonist that activates monocytes, DCs, and NK cells. Through the activation of NK cells, it has the potential to augment the effectiveness of monoclonal antibody treatments where a polymorphism in FcγR3A limits clinical efficacy. Clin Cancer Res; 18(2); 499–509. ©2011 AACR.</jats:p
Block Card 2337 Dellwood Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | 2337 Dellwood Drive (Toledo, Ohio) | Dwelling | Douglas Meadows Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
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