1,740,159 research outputs found
Highly Enantioselective Rhodium-Catalyzed Transfer Hydrogenation of Tetrasubstituted Olefins: Application toward the Synthesis of GPR40 Agonist MK-2305
No full textA highly efficient enantioselective
synthesis for the potent G-protein-coupled
receptor 40 agonist MK-2305 was developed. The key tetrasubstituted
olefin was prepared via a stereoselective Mukaiyama aldol reaction/elimination
sequence. The highly enantioselective rhodium-catalyzed transfer hydrogenation
of the tetrasubstituted olefin afforded the target compound MK-2305
in excellent optical and chemical purity. The key asymmetric transfer
hydrogenation proceeds in excellent yields and enantioselectivities
for a variety of substrates. The superior reactivity of the tethered
catalysts was revealed by NMR studies
Highly Enantioselective Rhodium-Catalyzed Transfer Hydrogenation of Tetrasubstituted Olefins: Application toward the Synthesis of GPR40 Agonist MK-2305
No full textA highly efficient enantioselective
synthesis for the potent G-protein-coupled
receptor 40 agonist MK-2305 was developed. The key tetrasubstituted
olefin was prepared via a stereoselective Mukaiyama aldol reaction/elimination
sequence. The highly enantioselective rhodium-catalyzed transfer hydrogenation
of the tetrasubstituted olefin afforded the target compound MK-2305
in excellent optical and chemical purity. The key asymmetric transfer
hydrogenation proceeds in excellent yields and enantioselectivities
for a variety of substrates. The superior reactivity of the tethered
catalysts was revealed by NMR studies
Chesapeake & Ohio (C&O) 2305
No full textA photograph print showing Chesapeake & Ohio (C&O) 2305, 2-8-2 (class K-3-a), Stephens, KY
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