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Other title: Testimony on House Bill 2269 Other title: House Bill 2269 Other title: HB 2269
No full text"February 18, 2019."
Testimony before the Kansas Legislature, House Corrections and Juvenile Justice Committee, presented by Roger Werholtz, Secretary, Kansas Department of Corrections.Testimony in opposition to HB 2269. "HB 2269 would compromise two of the department's most effective incentives related to reducing the prison population and reducing recidivism, based on completion of evidence-based programing. HB 2269 would amend K.S.A. 21-6821 which governs program credit for adult inmate participation in certified rehabilitation programs and K.S.A. 38-2398 which governs program credits for juvenile offenders by repealing the immunity afforded to the department and its employees for good time and program credit calculations.
Union Pacific (UP) 2269
No full textA photograph print showing Union Pacific (UP) 2269, 2-8-2, Topeka, KS
Holocene Mg/Ca, alkenones, and light stable isotope measurements on the outer North Iceland shelf, sediment core MD99-2269
No full textWe present new Holocene century to millennial-scale proxies for the well-dated piston core MD99-2269 from Húnaflóadjúp on the North Iceland Shelf. The core is located in 365 mwd and lies close to the fluctuating boundary between Atlantic and Arctic/Polar waters. The proxies are: alkenone-based SST°C, and Mg/Ca SST°C estimates and stable d13C and d18O values on planktonic and benthic foraminifera. The data were converted to 60 yr equi-spaced time-series. Significant trends in the data were extracted using Singular Spectrum Analysis and these accounted for between 50% and 70% of the variance. A comparison between these data with previously published climate proxies from MD99-2269 was carried out on a data set which consisted of 14-variable data set covering the interval 400-9200 cal yr BP at 100 yr time steps. This analysis indicated that the 1st two PC axes accounted for 57% of the variability with high loadings clustering primarily into "nutrient" and "temperature" proxies. Clustering on the 100 yr time-series indicated major changes in environment at ~6350 and ~3450 cal yr BP, which define early, mid- and late Holocene climatic intervals. We argue that a pervasive freshwater cap during the early Holocene resulted in warm SST°s, a stratified water column, and a depleted nutrient supply. The loss of the freshwater layer in the mid-Holocene resulted in high carbonate production, and the late Holocene/neoglacial interval was marked by significantly more variable sea surface conditions
Mandurama photograph collection [2269] [picture] /
No full textAlso available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an8526486-2269
Effects of LDD-2269 on the Senescence of Glioblastoma Cells
No full textBackground and Objective: Cellular senescence manifests as cell cycle arrest accompanied by phenotypic changes such as deregulated metabolism and specialized secretory activity. Senotherapeutics, which exploits cellular senescence for therapeutic purposes, is evolving with the advent of pharmacological interventions such as senolytics and senostatics. LDD-2269 is a benzylidene hydrazine derivative with lysine (K)-specific demethylase 4A activity and its effect on cellular senescence was examined in this study. Materials and Methods: Cellular senescence was measured using senescence-associated beta-galactosidase assay. Western blot and quantitative RT-PCR were employed for the measurement of p21 and IL-8 expression. Results: Treatment with LDD-2269 induced senescence in U87MG glioblastoma cells and primary rat astrocytes. LDD-2269 upregulated the gene expression of p21 and IL-8, which is consistent with the senescent phenotype induction. LDD-2269 also augmented growth inhibition by temozolomide. Conclusion: The results indicate that LDD-2269 can be utilized in cancer senotherapeutics. The combination of LDD-2269 with other senolytics is a promising senotherapeutic strategy in cancer treatment.TRUEsciescopu
Block Card 2269 Hayden Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | 2269 Hayden Street (Toledo, Ohio) | dwelling | Earlwood Heights Addition (Toledo, Ohio) | East Toledo (Toledo, Ohio
Block Card 2269 Timberlawn Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 2269 Timberlawn Drive (Toledo, Ohio) | Dwelling | Country Club Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
(Table 2) Radiocarbon and paleomagnetic secular variation tie points for sediment cores MD99-2269 and MD99-2322
No full text(Table 2) Radiocarbon and paleomagnetic secular variation tie points for sediment cores MD99-2269 and MD99-232
2269. S. Hugonis, Lincolnensis episcopi, vita
No full text2269. S. Hugonis, Lincolnensis episcopi, vita. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. p. 16
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