1,732,129 research outputs found
Physics from Time Variability of the VHE Blazar PKS 2155-304
Get PDFBlazars are the principal extragalactic sources of very high energy gamma-ray emission in the Universe. These objects constitute a sub-class of Active Galactic Nuclei whose
emission is dominated by Doppler boosted non-thermal radiation from plasma outflowing at relativistic speeds from the central engine. This plasma outflow happens in the
form of large-scale collimated structures called jets, which can extend for Mpc in length and transport energy from the central engine of the galaxy to the larger scale intergalac-
tic medium. Over thirty such sources have been discovered to date by ground-based gamma-ray telescopes such as H.E.S.S., and PKS 2155-304 is the prototypical southern-hemisphere representative of this population of objects.
In this thesis I have studied in detail some aspects of the temporal variability of the jet emission from PKS 2155-304, combining coordinated observations across the electromagnetic spectrum, from optical polarimetric measurements to X-ray and ground-based gamma-ray data. The temporal properties of the dataset allowed us to derive important physical information about the structure and emission mechanisms of the source and put constraints to the location of the sites of VHE emission and particle acceleration within the jet. We have also derived a sensitive statistical measure, called Kolmogorov distance,
which we applied to the large outburst observed from PKS 2155-304 in July 2006, to derive the most stringent constraints to date on limits for the violation of Lorentz invariance induced by quantum-gravity effects from AGN measurements
The sensitivity of the Durham mk6 ground-based atmospheric cherenkov telescope to very high energy gamma-ray sources
Get PDFThe subject of this thesis is a determination of the sensitivity of the Durham Mk6 ground based Imaging Atmospheric Cherenkov Telescope (lACT), an instrument which uses the imaging atmospheric Cherenkov technique to detect Very High Energy (VHE) gamma-rays. The first three chapters are introductory: Chapter 1 describes the basics of Very High Energy (VHE) gamma ray astronomy. Chapter 2 describes the properties of Extensive Ak Showers (EAS). Chapter 3 describes the detection of these EAS on the ground by lACTs, Chapter 4 details the Durham Mk6 lACT and includes a description of the Cherenkov imaging technique for background discrimination. Chapter 5 describes the MOCCA and SOLMK simulation codes. Chapter 6 contains a description of the details of the simulations produced for this diesis. This chapter continues to its logical conclusion and presents a revised VHE gamma-ray flux of 2.5 ± 0.7(_stat) [+0.5 or -1.6](_syst x lO(_7) photons m(^-2) s(^-1) for a sub set of a previously published data set which gave a 6.8σ detection of the close X-ray selected BL Lac PKS 2155-304. Chapter 7 discusses the importance of PKS 2155- 304 and presents 3σ flux limits for another seven Southern hemisphere AGN observed between 1996 and 1999 using the Durham Mk6 IACT. Finally there is a short discussion on the future of VHE gamma-ray astronomy
Hypoglycemia in Laparoscopic Colectomy with Remifentanil Use and Preoperative Intravenous Glucose Infusion: a prospective, randomized, single-blind, controlled trial
Get PDF東京女子医科大学博士(医学)博士(医学) 乙第2948号(主論文の要旨、要約、審査結果の要旨、本文)，著者名:Rie KANAMORI・Rika AIHARA・Nobutada MORIOKA・Makoto OZAKI，タイトル:Hypoglycemia in laparoscopic colectomy with remifentanil use and preoperative intravenous glucose infusion: A prospective, randomized, single-blind, controlled trial，掲載誌:Journal of Anesthesia & Clinical Research(2155-6148)，巻・頁・年:7巻 p.608(2016)，著作権関連情報:© 2016 Kanamori R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.，DOI:10.4172/2155-6148.1000608doctoral thesi
Recommended from our members
Abstract 2155: BRCAness in HGSC cancer initiation
No full textAbstract Introduction: The luteal phase of BRCA mutation carrier tissues has distinct profiles of differentially expressed genes compared to wild-type fimbria. High Grade Serous Ovarian Carcinoma (HGSOC) is one of the most lethal gynecological diseases and presents at late tumor stage. Studies focusing on the early events of the disease have implicated the fimbriated end of the fallopian tube as the high-risk zone for cancer development. In this study, we aim to identify BRCA transcriptomic signatures in the fimbria of patients with a BRCA mutation and compare the luteal and follicular phases to capture the effect of the extrinsic milieu in response to stressors. Experimental Procedures: Laser capture microdissection (LCM) was performed on 68 formalin fixed paraffin embedded (FFPE) fallopian tube samples based on BRCA mutation status and ovulatory cycle: Normal-Follicular, Normal-Luteal, BRCA-Follicular, BRCA-Luteal. Nine HGSC samples were derived from patients with a mutation in BRCA1. Six-Twelve, 10um FFPE sections were cut and stained with hematoxylin prior to LCM. RNA was extracted using the Roche High Pure FFPE Micro Kit and samples and were processed using Illumina Tru-Seq Stranded Total RNA Kit with RiboGold ready and sequenced on the Illumina Hi-seq 2000 V3. Bioinformatic analysis performed on multiple comparisons highlighted differentially expressed genes. Gene Set Enrichment Analysis (GSEA) performed on subgroups highlighted pathways of interest for each comparison. Genes highly expressed or strongly suppressed were shortlisted for further analysis. Western blot analysis performed on wildtype patients (WT), BRCA1 mutation and BRCA2 mutation showed protein expression of selected genes. Results: The fimbriae compared to ampullae have more stem-like features, have up-regulated antioxidant/xenobiotic genes, and have more inflammatory cells intercalated within the epithelia. The fimbria of FTE-BRCA have distinctly up-regulated genes involved in DDR (DNA damage response) which are exacerbated in the luteal phase of the ovulatory cycle. BRCA1/2 luteal versus follicular phases are involved in endoplasmic reticulum stress, migration, MAPKK. Whereas decreased differentially expressed genes are involved with G2/M checkpoint, DNA replication and ER-associated degradation pathway. Post-ovulatory phase of the ovarian cycle drives inflammation, differentiation and DNA damage-repair in FTE cells. Furthermore, GSEA analysis of the luteal and follicular phases showed positive enrichment of the inflammatory response pathway and negative enrichment of oxidative phosphorylation in the luteal phase. Conclusions: Our results highlight distinct pathways related to repair and inflammation for the BRCA1 mutation carriers and luteal phase of the fimbria. These results are consistent with previous examination of the fallopian tube and provide insight into targetable genes associated with the development of HGSC. Citation Format: Ramlogan Sowamber, Iru Paudel, Alex Sanchez, Alexandra Diaz, Patricia Shaw, Matthew Schlumbrecht, Sophia George. BRCAness in HGSC cancer initiation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 2155
[Conclavi de Pontefici Romani] (Ms. 2155-2158)
No full textManuscritos número 2155-2158 de la Biblioteca Histórica de la USAL4 v. (1 h.+464 f.+1 h. ; 382 f.+2 h. ; 1 h.+414 f.+2 h. ; 1 h.+ 347 f.+1 h.) : papel ; 290x200 mmLetra itálica de varias manos. - Cortes doradosContiene : Vol. I (Ms. 2155): Nicolás V-Clemente VII --- Vol. II (Ms. 2156): Pablo III-Sixto V --- Vol. III (Ms. 2157): Urbano VII-León XI --- Vol. IV (Ms. 2158): Pablo V-Urbano VII
H.E.S.S. Monitoring of PKS 2155-304 in 2015 and 2016
Get PDFPKS 2155-304 is one of the brightest blazar located in Southern Hemisphere, monitored with H.E.S.S. since the first light of the experiment. Here we report multiwavelength monitoring observations collected during the period of 2015–2016 with H.E.S.S., Fermi-LAT, Swift-XRT, Swift-UVOT, and ATOM. Two years of multiwavelength data with very good temporal coverage allowed to characterize broadband emission observed from the region of PKS 2155-304 and study potential multifrequency correlations. During the period of monitoring, PKS 2155-304 revealed complex multiwavelength variability with two outbursts characterized by completely different multiband properties. The 2015 activity of the blazar is characterized by a flare observed at all wavelengths studied. The broadband emission observed during the outburst is well correlated without any time lags. Contrary to 2015, in 2016, only orphan outburst in the optical and ultraviolet wavelengths was observed. Such an orphan activity is reported for the first time for the blazar PKS 2155-304
Block Card 2155 Perth Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Modern Colonial Style | 2155 Perth Street (Toledo, Ohio) | apartment houses | Evansdale Addition (Toledo, Ohio) | Colony Area (Toledo, Ohio
Infectious salmon anaemia virus (ISAV) ringtest: validation of the ISAV diagnositic process using virus-spiked fish tissues and ISAV TaqMan® real-time RT-PCR
No full textFourteen laboratories validated their procedure for detection of infectious salmon anaemia virus (ISAV) in fish tissues using TaqMan® real-time RT-PCR targeting ISAV RNA segment 8. The participants included 12 laboratories from South America, one from Asia and one from Europe. The OIE Reference Laboratory for ISA at the Atlantic Veterinary College in Canada served as the standard. All laboratories received a panel of 36 blind-coded samples representing six different ISAV preparations in homogenized fish liver or L-15 medium, each in six replicates. A clearly positive control ISAV of known titer was also included. From the results obtained, the 14 laboratories that submitted results reported no false positives. False negatives were mostly observed in the ISAV-spiked fish liver homogenate samples. The lowest virus titer to be detected in the fish liver homogenate was 101 TCID50/ml, but the virus titer that could be detected accurately by most laboratories was 103 TCID50/ml in L-15 medium. Within those laboratories that accurately detected presence of virus in a sample, there was great variation in the Ct values making it impossible to recommend a single cut-off Ct value. A significant factor influencing the Ct values obtained and therefore the diagnostic sensitivity might be the thermocycler software used. The repeatability of the test within each laboratory was high, but the reproducibility between laboratories was low. Presumably this could be improved if all the laboratories used the same RNA extraction method since the starting quality and the quantity of the RNA template is the main determinant of the quality of results once reagents have been optimized. The low reproducibility of the test between laboratories is also suggestive of the need to standardize the threshold fluorescence line of the thermocycler software and to use properly trained personnel to perform the test.Accession Number: 20113281818. Publication Type: Journal Article. Language: English. Number of References: 23 ref. Subject Subsets: Veterinary Science; Veterinary ScienceSource type: Electronic(1)http://search.ebscohost.com/login.aspx?direct=true&db=lah&AN=20113281818&site=ehost-live; http://www.omicsonline.org/2155-9546/2155-9546-2-110.ph
- …
