1,733,741 research outputs found
Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRAS<sup>G12C</sup> Inhibitor ARS-2102
No full textA scaleup route for a first-generation covalent KRASG12C inhibitor ARS-2102 was devised, featuring an “early
cross-coupling”
strategy to construct the tetra-substituted atropisomeric biaryl scaffold.
An iterative diastereomeric recrystallization enabled an effective
chiral resolution of key intermediate 24. A global deprotection
followed by chemoselective functionalization afforded ARS-2102 in
excellent yield and diastereomeric enrichment. This chromatography-free
sequence was successfully executed on kilogram scale
Illinois Central (IC) 2102
No full textA photograph print showing the Illinois Central (IC) 2102 (Lima), 2-8-2, Freeport, IL
Block Card 2102 Fairfax Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Bungalow Style | Dwelling | 2102 Fairfax Road (Toledo, Ohio) | Dauer Gardens Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 2102 Fairfax Road (Toledo, Ohio
Draft genome sequence of Bacillus endophyticus 2102
No full textBacillus endophyticus 2102 is an endospore-forming, plant growth-promoting rhizobacterium isolated from a hypersaline pond in South Korea. Here we present the draft sequence of B. endophyticus 2102, which is of interest because of its potential use in the industrial production of algaecides and bioplastics and for the treatment of industrial textile effluents.open
- …
