1,745,446 research outputs found
Preclinical pharmacokinetics, CYP phenotyping, and tissue distribution study of novel anti-breast cancer candidate S-011-1559
No full textS-011-1559 is a tyrosine-derived novel benzoxazine CDRI molecule targeted to the oestrogen-related receptor (ER-α/β) modulator in breast cancer. To explore the pharmacokinetics of S-011-1559, a selective and sensitive bioanalytical method using LC-MS/MS was established and validated in different biological matrices of female rats.Blood-to-plasma ratio and plasma protein binding (PPB) of S-011-1559 were found to be 97% in both rats and humans, respectively. The human serum albumin (HSA) and alpha-1-acid glycoprotein (AAG) binding was found in the range of > 68 to 45% and >14% respectively. Half-life and intrinsic clearance by microsomal stability study were found to be 28.83 min and 0.05 mL/min/mg in rats, 78.35 min and 0.036 mL/min/mg in humans, respectively. The IC50 value of S-011-1559 against CYP isoforms was revealed to moderately inhibit CYP2D6 by a reversible non-competitive mechanism.Tissue distribution of S-011-1559 on single intravenous injection at 2 mg/kg was found in the order of C lungs > C mammary gland > C spleen > C heart > C kidney > C liver > C brain.The data from the present study provides crucial information about S-011-1559 for further development as a novel potential drug candidate in modulating ER-α/β receptors of lung and breast neoplasia. S-011-1559 is a tyrosine-derived novel benzoxazine CDRI molecule targeted to the oestrogen-related receptor (ER-α/β) modulator in breast cancer. To explore the pharmacokinetics of S-011-1559, a selective and sensitive bioanalytical method using LC-MS/MS was established and validated in different biological matrices of female rats. Blood-to-plasma ratio and plasma protein binding (PPB) of S-011-1559 were found to be 97% in both rats and humans, respectively. The human serum albumin (HSA) and alpha-1-acid glycoprotein (AAG) binding was found in the range of > 68 to 45% and >14% respectively. Half-life and intrinsic clearance by microsomal stability study were found to be 28.83 min and 0.05 mL/min/mg in rats, 78.35 min and 0.036 mL/min/mg in humans, respectively. The IC50 value of S-011-1559 against CYP isoforms was revealed to moderately inhibit CYP2D6 by a reversible non-competitive mechanism. Tissue distribution of S-011-1559 on single intravenous injection at 2 mg/kg was found in the order of C lungs > C mammary gland > C spleen > C heart > C kidney > C liver > C brain. The data from the present study provides crucial information about S-011-1559 for further development as a novel potential drug candidate in modulating ER-α/β receptors of lung and breast neoplasia.</p
Анатомы - лечащие врачи папства (обзор литературы)
No full textСтаття присвячена анатомам, які були особистими лікарями Пап Римських у різний час:
М. Р. Коломбо (1515-1559), Г. Б. Канано (1515-1579), Г. C. Аранзі (1530-1589), К. Варолій (1543-
1575), А. Чезальпіно (1525-1603), М. Мальпігі (1628-1694), Дж. M. Ланцізі (1654-1720) та
Дж. Флайяні (1739-1808). Подається інформація про їх внесок у розвиток медицини та короткі
біографічні данні.
При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/31507Статья посвящена анатомам, которые были лечащими врачами Пап Римских в разные годы:
М. Р. Коломбо (1515-1559), Г. Б. Канано (1515-1579), Г. C. Аранзи (1530-1589), К. Варолий (1543-
1575), А. Чезальпино (1525-1603), М. Мальпиги (1628-1694), Дж. M. Ланцизи (1654-1720) и
Дж. Флайяни (1739-1808). Рассказывается об их вкладе в развитие медицины и короткие
биографические данные.
При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/31507Article is about anatomists, who were papal physicians: M.R. Colombo (c.1515-1559),
G.B. Canano (1515-1579), G.C. Aranzi (1530-1589), C. Varolio (1543-1575), A. Cesalpino (1525-
1603), M. Malpighi (1628-1694), G.M. Lancisi (1654-1720) and G. Flaiani (1739-1808). Their
contribution into anatomy and brief biographical information are given.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3150
1559, agost 23. Venda
No full textBartomeu Esquerda, orfebrer de Barcelona, i el seu fill Joan venen a Bartomeu Rabassa, agricultor de Sant Mateu de Bages, el mas de Mas Soler amb les seves terres, situat a Sant Mateu de Bages, pel preu de 33 lliures (23 d'agost de 1559). El document va seguit de l'àpoca de rebut (12 de setembre de 1559
Die Casseler Schützen von 1559 bis 1865
No full textDIE CASSELER SCHÜTZEN VON 1559 BIS 1865
Die Casseler Schützen von 1559 bis 1865 ( - )
Title page ( - )
[Hauptteil.] ( -
Renaissances, 1453-1559
No full textDans les Cahiers de recherches médiévales et humanistes, Marino Lambiase propose une relecture critique de l'ouvrage de Philippe Hamon, Les Renaissances, 1453-1559, Paris, Belin, 2009. Marino Lambiase, « Philippe Hamon, Les Renaissances 1453-1559 », Cahiers de recherches médiévales et humanistes [En ligne], 2009, mis en ligne le 08 mai 2010, consulté le 19 avril 2015. URL : http://crm.revues.org/11869 Le compte rendu est disponible en pdf : crm-11869-philippe-hamon-les-renaissances-1453-155
[Kalender für 1559]
No full textDie Kopfleiste des Kalenders enthält einen Holzschnitt, der eine Ansicht des Bodensees zeigt. Gemäss Vischer würde darunter rechts ein Aderlassmann zu sehen sein und der linke Rand würde von je zwei Fischen geziert werden[anonym]Es handelt sich um die Kopfleiste eines Kalenders auf das Jahr 1559 (zahlreiche weitere Fragmente des Kalenders befinden sich in der Schachtel mit der Signatur "Kalender Schweiz 1559 III,1")Angaben zum Drucker und zur Datierung gemäss VischerDas Vorschaubild zeigt die Kopfleiste des Kalender
Renaissances, 1453-1559
No full textDans les Cahiers de recherches médiévales et humanistes, Marino Lambiase propose une relecture critique de l'ouvrage de Philippe Hamon, Les Renaissances, 1453-1559, Paris, Belin, 2009. Marino Lambiase, « Philippe Hamon, Les Renaissances 1453-1559 », Cahiers de recherches médiévales et humanistes [En ligne], 2009, mis en ligne le 08 mai 2010, consulté le 19 avril 2015. URL : http://crm.revues.org/11869 Le compte rendu est disponible en pdf : crm-11869-philippe-hamon-les-renaissances-1453-155
- …
