1,908,120 research outputs found
IlluminierteUrkunden 1471-99-99_Wien
No full textEine ausführliche Beschreibung des Schandbriefs bei 1471-05-12 (?
IlluminierteUrkunden 1471-05-12_Wien
No full textSchmähbrief mit Schandbild des Richard Puller von Hohenburg gegen seinen Schwiegervater Hans Konrad Bock, Patrizier zu Strassburg.Anlassfall war, dass sich Puller von seinem Schwiegervater in finanziellen Dingen hintergangen und betrogen fühlte. Nachdem er vergeblich versucht hatte, an das von ihm geforderte Geld zu gelangen, ging er dazu über, die Ehre seines Schwiegervaters durch infamierende Zeichnungen, die er in der Umgebung plakatierte, anzugreifen.Richard Puller von Hohenburg liess das Schandbild 1471 in mehreren Ausfertigungen im Umkreis der Städte Ensisheim und Straßburg anschlagen. (HHStA
Resistance gene expression determines the in vitro chemosensitivity of non-small cell lung cancer (NSCLC)
No full textBackground
NSCLC exhibits considerable heterogeneity in its sensitivity to chemotherapy and similar heterogeneity is noted in vitro in a variety of model systems. This study has tested the hypothesis that the molecular basis of the observed in vitro chemosensitivity of NSCLC lies within the known resistance mechanisms inherent to these patients' tumors.
Methods
The chemosensitivity of a series of 49 NSCLC tumors was assessed using the ATP-based tumor chemosensitivity assay (ATP-TCA) and compared with quantitative expression of resistance genes measured by RT-PCR in a Taqman Array™ following extraction of RNA from formalin-fixed paraffin-embedded (FFPE) tissue.
Results
There was considerable heterogeneity between tumors within the ATP-TCA, and while this showed no direct correlation with individual gene expression, there was strong correlation of multi-gene signatures for many of the single agents and combinations tested. For instance, docetaxel activity showed some dependence on the expression of drug pumps, while cisplatin activity showed some dependence on DNA repair enzyme expression. Activity of both drugs was influenced more strongly still by the expression of anti- and pro-apoptotic genes by the tumor for both docetaxel and cisplatin. The doublet combinations of cisplatin with gemcitabine and cisplatin with docetaxel showed gene expression signatures incorporating resistance mechanisms for both agents.
Conclusion
Genes predicted to be involved in known mechanisms drug sensitivity and resistance correlate well with in vitro chemosensitivity and may allow the definition of predictive signatures to guide individualized chemotherapy in lung cancer
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Bristol 1471: Particulars of Account of Richard Walwyn and Nicholas Warynges, customers, 29 March 1471 to 29 September 1471
No full textDigitised Customs Account records relating to the Port of Bristol, March 1471 - Sept 1471 Transcription and translation, on an EXCEL spreadsheet, of the Exchequer ‘particular’ Customers' account for Bristol for 29 March - 29 September 1471, based on TNA, E122/19/8. The spreadsheet is accompanied by a 2,700 word introduction (pdf), which discusses the oddities of the account and the extent to which the dynastic conflicts of the 'Wars of the Roses' impacted on the record keeping and the administration of the customs system in Bristol. The introduction includes a general explanation of the transcription process and the editorial conventions adopted
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
How do adolescents talk about self-harm: a qualitative study of disclosure in an ethnically diverse urban population in England
No full textThe electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2458/13/572.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Memòria Digital de Catalunya
No full textEl text havia estat erròniament atribuït a Mehmed II, sultà dels turcs, 1432-1481, però en realitat n'és l'autor Laudivio, de Vezzano. Segons ISTC: "Falsely attributed to Mahomet II by the author, Laudivius Zacchia (F. Babinger, Laudivius Zacchia, der Erdichter der 'Epistolae Magni Turci', Bayerische Akademie der Wissenschaften, Phil.-hist. Klasse, Sitzungsberichte, Heft 13, 1960) (CIBN)" i "Add: Antonius Beccadelli, Panormita: De Hermaphrodito"Tít. i menció de responsabilitat obtinguts de l'epígraf del f. sign. [a]1. A la fi del text (f. sign. [c]6) hi ha la menció: Epistolae magni Turci finiunt, a Laudino equite Hierosolimitano editae, seguida de: De Hermaphrodita per D. Panormitanum CarmenPeu d'impr. obtingut dels repertoris. A la fi de la taula (f. sign. [c]8): G. F. T.Signatures: [a]8, [b]6, [c]8Espai en blanc, amb testimoni, per a la 1a caplletr
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