1,721,819 research outputs found
Begonnen mit Zug.-Nr.: N 8500 : Abgeschl. mit Zug.-Nr.: N 11058
No full textBEGONNEN MIT ZUG.-NR.: N 8500 : ABGESCHL. MIT ZUG.-NR.: N 11058
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In vitro activities of the novel cephalosporin LB 11058 against multidrug-resistant staphylococci and streptococci
No full textLB 11058 is a novel parenteral cephalosporin with a C-3 pyrimidinyl-substituted vinyl sulfide group and a C-7 2-amino-5-chloro-1,3-thiazole group. This study evaluated the in vitro activity and spectrum of LB 11058 against 1,245 recent clinical isolates, including a subset of gram-positive strains with specific resistant phenotypes. LB 11058 was very active against Streptococcus pneumoniae. the novel cephalosporin was 8- to 16-fold more potent than ceftriaxone, cefepime, or amoxicillin-clavulanate against both penicillin-intermediate and -resistant S. pneumoniae. LB 11058 was also very active against both beta-hemolytic streptococci (MIC at which 90% of isolates were inhibited [MIC90], less than or equal to0.008 mug/ml) and viridans group streptococci (MIC90, 0.03 to 0.5 mug/ml), including penicillin-resistant strains. Among oxacillin-susceptible Staphylococcus aureus, LB 11058 MIC results varied from 0.06 to 0.25 mug/ml (MIC50, 0.12 mug/ml), while among oxacillin-resistant strains LB 11058 MICs varied from 0.25 to 1 mug/ml (MIC50, 1 mug/ml). Coagulase-negative staphylococci showed an LB 11058 susceptibility pattern similar to that of S. aureus, with all isolates being inhibited at less than or equal to1 mug/ml. LB 11058 also showed reasonable in vitro activity against Enterococcus faecalis, including vancomycin-resistant strains (MIC50, 1 mug/ml), and Bacillus spp. (MIC50, 0.25 mug/ml); however, it was less active against Enterococcus faecium (MIC50, >64 mug/ml) and Corynebacterium spp. (MIC50, 32 mug/ml). Against gram-negative pathogens, LB 11058 showed activity against Haemophilus influenzae (MIC90, 0.25 to 0.5 mug/ml) and Moraxella catarrhalis (MIC90, 0.25 mug/ml), with MICs not influenced by beta-lactamase production. in conclusion, LB 11058 demonstrated a broad antibacterial spectrum and was highly active against gram-positive bacteria, particularly against multidrug-resistant staphylococci and streptococci.JONES Grp JMI Labs, N Liberty, IA 52317 USAUniversidade Federal de São Paulo, São Paulo, BrazilTufts Univ, Sch Med, Boston, MA 02111 USAUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of Scienc
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Relatório de pesquisa
No full textDisponível online em: http://repositorio.ipea.gov.br/handle/11058/7690A pesquisa que deu origem a este relatório foi coordenada e conduzida pela Diretoria de Estudos e Políticas do Estado, das Instituições e da Democracia (Diest)Equipe técnica: Edison Benedito da Silva Filho, Eduardo Costa Pinto, Lício da Costa Raimundo, Rodrigo SabbatiniEste relatório visa compreender como o planejamento governamental, com a coordenação da regulação e dos incentivos, pode contribuir para ampliar quantitativa e qualitativamente o nível de inversões produtivas na sociedade e consequentemente o desenvolvimento econômico; e analisar, a partir deste referencial, o caso do setor elétrico brasileiro, destacando como as diferentes formas de regulação do setor e de atuação de Estado nos anos 1990 e 2000 geraram diferentes resultados em termos de investimento no setor, pois as mudanças regulatórias de 2004 e a retomada do planejamento estratégico coordenado pelo governo foram elementos fundamentais para a retomada do investimento no setor
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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