1,768,593 research outputs found
Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
Graduale – TÜR, Mscr 1078
No full textIncipit & explicit: (r) me faciam vos fie[ri] piscatores hominum /.../ secuti sunt dominu[m] Gloria pa* Communio; textus: (v) Dilexit andream dominus in odo[rem]Proprium sanctorum. (r) Vigilia Andreae: [Int. Dominus secus mare Galilaeae vidit]; V. At illi relictis retibus et; Gr. Nimis honorati*; Off. Gloria et honore*; Comm. [...]; (v) Andreae: All. Alleluia dilexit Andream dominus inKÖIDE: Kaanteks ühekordne pärgamentfragment, mille külge olid õmmeldud käsikirja ploki paberpoognad; fragment konserveerimistööde käigus sisuplokist lahutatud, sirutatud ja puhastatud (Tulvi Turo, Ennistuskoda Kanut, 2012, EK-2011-307 L-52)PROVENIENTS: Mscr 1078 on saabunud Tartu Ülikooli Raamatukokku 1922. a Harald v. Samsoni kogust; kuulunud tõenäoliselt juristile Reinhold Johann Ludwig Samson von Himmelstiernile (1778–1858); käsikiri on sisu järgi otsustades Vana-Liivimaa päritoluFragmendi recto poolel köidetud käsikirja pealkiri uusaegse käekirjaga: Chronica Der Heremeister / Item / Die Lyffländisze Ridder RechteRubr.Quadr.Textuali
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Whitehead, Kristy (SC 1078)
Get PDFFinding aid only for Manuscripts Small Collection 1078. Paper written by Kristy Whitehead for an English class at Western Kentucky University, Bowling Green, Kentucky, describing a storm that occurred on 16 April 1998
Alvin 1078 Dive 1078 5 December 1980, St Croix
No full textAlvin 1078 Dive 1078 5 December 1980, St CroixThe runtime for this video is 1h 20m 49s.Alvin dive 1078 took place on December 05, 1980 during voyage LU-107. The Chief Scientist was F. Grassle in the operating area of DOS#3. The purposewas described as 'BIOLOGY' and the sponsor as 'NSF-ONR'.The items in this collection are embargoed in the system in keeping with copyright requirements. However, they are available to users upon request. Please contact the MBLWHOI Library to access the items at [email protected] of this material was supported by a Recordings at Risk grant from the Council on Library and Information Resources (CLIR). The grant program is made possible by funding from The Andrew W. Mellon Foundation. CLIR is an independent, nonprofit organization that forges strategies to enhance research, teaching, and learning environments in collaboration with libraries, cultural institutions, and communities of higher learning. To learn more, visit www.clir.org and follow CLIR on Facebook and Twitter.2200-01-0
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Psychosocial and health variables (n = 1078).
No full textPsychosocial and health variables (n = 1078).</p
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