509 research outputs found
sj-pdf-2-hpi-10.1177_11207000221126968 – Supplemental material for Increased dislocation rates following total hip arthroplasty in patients with ankylosing spondylitis
No full textSupplemental material, sj-pdf-2-hpi-10.1177_11207000221126968 for Increased dislocation rates following total hip arthroplasty in patients with ankylosing spondylitis by Brian C Chung, Michael Stefl, Hyunwoo Paco Kang, Raymond J Hah, Jeffrey C Wang, Lawrence D Dorr and Nathanael D Heckmann in HIP International</p
Incremental Word Learning Using Large-Margin Discriminative Training and Variance Floor Estimation
No full textAyllon Clemente I, Heckmann M, Denecke A, Wrede B, Görick C. Incremental Word Learning Using Large-Margin Discriminative Training and Variance Floor Estimation. In: Proceedings INTERSPEECH. 2010
Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
No full textBoth human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known ris
Voice recognition in aphasic and non-aphasic stroke patients
No full textLang CJG, Kneidl O, Hielscher-Fastabend M, Heckmann JG. Voice recognition in aphasic and non-aphasic stroke patients. Journal of Neurology. 2009;256(8):1303-1306
Nephridiacanthus major Golvan 1962
No full textNephridiacanthus major (Bremser, 1811) Golvan, 1962 Host: Erinaceus concolor Locality: Tonekabon (Heckmann et al. 2013) Host: Hemiechinus auritus Locality: Shahrood (Heckmann et al. 2013)Published as part of Tavakol, Sareh, Amin, Omar M., Luus-Powell, Wilmien J. & Halajian, Ali, 2015, The acanthocephalan fauna of Iran, a check list, pp. 237-258 in Zootaxa 4033 (2) on page 240, DOI: 10.11646/zootaxa.4033.2.3, http://zenodo.org/record/23377
Enantio-Complementary Synthesis of 2-Substituted Pyrrolidines and Piperidines via Transaminase-Triggered Cyclizations
No full textChiral N-heterocycles are a common motif in many active pharmaceutical ingredients; however, their synthesis often relies on the use of heavy metals. In recent years, several biocatalytic approaches have emerged to reach enantiopurity. Here, we describe the asymmetric synthesis of 2-substituted pyrrolidines and piperidines, starting from commercially available ω-chloroketones by using transaminases, which has not yet been comprehensively studied. Analytical yields of up to 90% and enantiomeric excesses of up to >99.5% for each enantiomer were achieved, which has not previously been shown for bulky substituents. This biocatalytic approach was applied to synthesize (R)-2-(p-chlorophenyl)pyrrolidine on a 300 mg scale, affording 84% isolated yield, with >99.5% ee.</p
Zinc Gluconate in the Treatment of Dysgeusia—a Randomized Clinical Trial
No full textIn the treatment of dysgeusia, the use of zinc has been frequently tried, with equivocal results. The aim of the present randomized clinical trial, which involved a sufficiently large sample, was therefore to determine the efficacy of zinc treatment. Fifty patients with idiopathic dysgeusia were carefully selected. Zinc gluconate (140 mg/day; n = 26) or placebo (lactose; n = 24) was randomly assigned to the patients. The patients on zinc improved in terms of gustatory function (p < 0.001) and rated the dysgeusia as being less severe (p < 0.05). Similarly, signs of depression in the zinc group were less severe (Beck Depression Inventory, p < 0.05; mood scale, p < 0.05). With the exception of the salivary calcium level, which was higher in the zinc patients (p < 0.05), no other significant group differences were found. In conclusion, zinc appears to improve general gustatory function and, consequently, general mood scores in dysgeusia patients
Active Damping of Railway Carbody Vibrations with Piezoelements
No full textThis paper presents a methodology for the simulation and control of smart structures with piezoceramic patches by means of multibody dynamics. A theoretical background is mentioned adapting a modal multifield approach. Then a methodology for the control design is proposed. The methodology includes the optimisation of actuator placement, which is based on modal representation of the elasticity. The methodology is applied for simulation and control synthesis of an active damping for a railway carbody. The application example illustrates the implemented process chain. This procedure provides a complex development environment for the simulation, optimisation and control design of elastic structures with smart materials
An Annular Plate Model in Arbitrary-Lagrangian-Eulerian Description for the DLR FlexibleBodies Library
No full textThe bending deformation of rotating annular plates and the associated vibration behaviour is important in engineering applications which range from automotive or railway brake systems to discs that form essential components in turbomachinery.
In order to extend the capabilities of the DLR FlexibleBodies library for such use cases, a new Modelica class has been implemented which is based on the analytical description of an annular Kirchhoff plate. In addition the so-called Arbitray Langrangian-Eulerian (ALE) representation has been adopted so that rotating and non-rotating external loads may be applied conventiently to rotating plates.
Besides these particularities the new class AnnularPlate completely corresponds to the concept of FlexibleBodies library with the two already available model classes Beam and ModalBody.
This paper gives an overview on the theoretical background of the new class AnnularPlate, explains the usage and presents application examples
Distal sensory polyneuropathy in South Africans infected with human immunodeficiency virus : a cross-sectional analysis of a community cohort
No full textIncludes bibliographical references (leaves 93-107).Introduction: Distal sensory polyneuropathy (DSP), the most common neurological complication of HIV infection, is related to either HIV or antiretroviral therapy (ART). Dideoxynucleoside reverse transcriptase inhibitors such as stavudine are widely used in resource-poor countries and often associated with neuropathy. The prevalence of DSP in developed countries range from 21% to 63%; little data is available from Africa. We aimed to estimate the prevalence of DSP in a South African community clinic-based population and to investigate associated risk factors. Methods: In a cross-sectional study, DSP status was determined in 598 HIV-infected adults using validated tools (Brief Peripheral Neuropathy Screen and a modified version of the Total Neuropathy Score) to categorize subjects. Symptomatic DSP required the presence of at least two neuropathic signs together with at least one symptom. Asymptomatic DSP required the presence of two neuropathic signs. Clinical, anthropometric, quality of life and laboratory evaluations were prospectively performed. Information about CD4 counts, antiretroviral therapy (ART) and questionnaires regarding previous tuberculosis (TB) and alcohol exposure was retrospectively collected Results: Approximately half (49%) of the study population were diagnosed with DSP (30% symptomatic DSP). In the ART-naïve group 37% had evidence of neuropathy (23% symptomatic) compared to 63% of the ART-exposed subjects (39% symptomatic). Overall, subjects with DSP were older (p<0.001) and had lower CD4 counts (p<0.001) compared to those without neuropathy. Previously treated TB infection (p<0.001) and ART use (p<0.001) showed strong associations with DSP. In multivariate analyses the odds (95% confidence interval) of developing DSP was independently associated with ART use (OR 1.7, 1.0-2.9), age (per 10 year increments) (OR 1.7, 1.4-2.2) and previously treated TB infection (OR 2.0, 1.3-3.0). Although stavudine significantly associated with DSP, the duration of exposure was similar irrespective of neuropathy status. Pain or paresthesia was reported by 69% of those with symptomatic DSP and rated as at least moderate to severe. ART-exposed subjects had a tendency towards lower pain scores compared to ART-naïves (p=0.032). Conclusions: DSP is a clinically significant problem in urban HIV-infected Africans. The findings of this study raise the possibility that with avoidance of stavudine-containing regimens in older subjects, especially those with a history of previously treated TB infection, the prevalence of DSP may be reduced
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