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Polymerization Isomerism in [MFe(CO)4n]n- (M = Cu, Ag, Au; N = 3, 4) Molecular Clusters Supported by Metallophilic Interactions
No full textGoal Programming Models for Managerial Strategic Decision Making
No full textThe Goal Programming (GP) model is an important Multiple Objective
Programming (MOP) technique that has been widely utilized for strategic decision
making in presence of competing and conflicting objectives. The GP model
aggregates multiple objectives and allows obtaining satisfying solutions where the
deviations between achievement and the aspirations levels of the attributes are to be
minimized. The GP model is easy to understand and to apply: it is based on
mathematical programming techniques and can be easily solved using software
packages such as LINGO, MATLAB, and AMPL. The GP describes the spectrum
of the Decision Maker’s preferences through a user-friendly and learning
decision-making process. This chapter aims to present the state-of-the-art of GP
models and highlight its applications to strategic decision making in portfolio
investments, marketing decisions and media campaign
Frequentist and Bayesian small-sample confidence intervals for Gini’s gamma index in a Gaussian bivariate copula
No full textIn this paper we consider frequentist and Bayesian likelihood-based small-sample procedures to compute confidence intervals for Gini’s gamma index in the bivariate Gaussian copula model. We furthermore discuss how the method
straightforwardly extends to any measure of concordance which is available in closed form, and to any type of copula for which the considered measure of concordance has a closed-form expression
Oltre la muraglia, verso l’oceano. Guangzhou, un polo strategico tra Cina ed Europa (1514-1842)
No full textOver the centuries, Guangzhou (Canton) grew as one of the Chinese
mainland and maritime terminus of the Silk Routes. During the early modern
period, it was a key international seaport of Imperial China for trade,
diplomacy and cultural relations with Western Europe. This paper focuses on
the political and economic strategies adopted to make Guangzhou the pivot
of the “one door” policy under the rule of Ming and Qing dynasties, aiming
to collect and control all Western maritime exchanges exclusively in the area
A guide to PIN1 function and mutations across cancers
No full textPIN1 is a member of a family of peptidylprolyl isomerases that bind phosphoproteins and catalyze the rapid cis–trans isomerization of proline peptidyl bonds, resulting in an alteration of protein structure, function, and stability. PIN1 is overexpressed in human cancers, suggesting it promotes tumorigenesis, but depending on the cellular context, it also acts as a tumor suppressor. Here, we review the role of PIN1 in cancer and the regulation of PIN1 expression, and catalog the single nucleotide polymorphisms, and mutations in PIN1 gene associated with cancer. In addition, we provide a 3D model of the protein to localize the mutated residues
