Publikationer från Uppsala Universitet
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Mening och engagemang : En jämförande analys av multimodalitet i läromedel för studieväg 1 kurs A
No full textVariability in footpoint mapping of bursty bulk flows using Tsyganenko models : impact on swarm conjunctions
No full textMagnetospheric-ionospheric coupling studies often rely on multi-spacecraft conjunctions, which require accurate magnetic field mapping tools. For example, linking measurements from the magnetotail with those in the ionosphere involves determining when the orbital magnetic footpoint of THEMIS or Magnetospheric Multiscale (MMS) intersects with the footpoint of Swarm. The Tsyganenko models are commonly used for tracing magnetic field lines. In this study, we aim to analyze how the footpoint locations are impacted by the input parameters of these models, including solar wind conditions, geomagnetic activity, and the location in the magnetotail. A dataset of 2394 bursty bulk flows (BBFs) detected by MMS was mapped to Earth’s ionosphere with six different Tsyganenko models. Approximately 90% of the ionospheric footpoints are concentrated within 70° ± 5° magnetic latitude (MLAT) and ±3 h of magnetic local time (MLT) around midnight, with a pronounced peak in the pre-midnight sector. The MLT position showed a difference of approximately ±1 h MLT across the models. Footpoint locations were linked to the dawn-dusk position of the BBFs, with differences between models associated with variations in the interplanetary magnetic field clock angle. The MLAT values exhibited similar differences of approximately ±4° around the mean value, with a systematic shift toward lower latitudes in the T89 model. This position is also influenced by the input parameters of the model representing the dynamics of Earth’s magnetosphere, where stronger magnetospheric activity typically corresponds to lower latitudes. The uncertainty on the BBF footpoint location impacts the number of conjunctions with Swarm. Generally, Swarm B exhibited more conjunctions than Swarm A or C in the Northern Hemisphere. However, when considering only Swarm-BBF conjunctions where the distance between footpoints computed with T89 and TA15n is smaller than the size of the BBF footprint, the number of conjunctions is reduced to less than half of the total
Graph Databases for Group Decision Making in Industry : A Comprehensive Literature Review
No full textVirtual manufacturing, simulation, and optimization provide a wealth of knowledge about the possibilities of future production systems to support decision makers. However, this knowledge usually remains with a handful of domain experts, is hard to share even within the same team and cannot be easily used to support further optimization activities. At the same time, simulations can benefit from the incorporation of linked data from real factories once a process is running, to improve the accuracy of the simulation and hence the accuracy of optimization results. Graph databases provide a possible approach to storing and managing this form of interrelated heterogeneous data, with powerful querying capabilities that can identify important or interesting patterns that might otherwise remain hidden. This paper provides a structured literature review of the current directions of research within this broad but interconnected set of topics, with a special focus on how graphs can support finding knowledge within Virtual Factories, used by larger teams for industrial planning and optimization. Papers have been selected from a wide number of research databases and reviewed from the perspectives of the industries they focus on, the technologies they focus on and the approach they have taken. We conclude that current research focuses on one or two aspects of this problem but does not address all at once, despite the potential benefits of the combination
Is the composition of the solar atmosphere unusual, and if so, why? : Possible interpretations
No full textThe ongoing discussion about the atomic chemical composition of the Sun is commented on. The main focus in this review is on the deviation of the solar composition from that of most other solar-type stars in that its ratio of volatiles (like the elements C, N, O, S, P and Zn) to the refractories (most metals, like Ba, Ca, Ti, Y, Al, Sc and Zr) tends to be higher in the Sun by 10 to 20%. What does this tell about the formation and evolution of the Solar System? Scenarios in terms of galactic evolution, formation of the pre-solar nebula, of the evolution of the protoplanetary disk, of the engulfing of planets, and of other processes within the Solar System are considered, as well as the evolution of binary stars with similarly different chemical composition. Finally, implications, if any, on the habitability of the Solar System will be commented on
Imagining with the Body : Speculative Designs for Women's Embodied Empowerment in Feminist Self-Defense
No full textFeminist self-defense combines physical self-defense with mental strength exercises through role-playing scenarios. It aims to challenge limiting beliefs about women's abilities to respond to interpersonal violence. We present the experiences from feminist self-defense classes in Sweden and the results of a set of speculative designs that combined contribute to imagine how technology could play a role in experiencing these holistic practices. The goal is to illustrate the potential of embodied interaction design to empower beginner feminist self-defense practitioners. To do so, the study was conducted via two methods: semi-structured interviews with students and teachers, and a participatory speculative design workshop with novice practitioners. The speculative concepts demonstrate how design can support the practice of feminist self-defense. Through this study we contribute to the corpus of embodied design interventions, in this case combining design for bodily movements with feminist consciousness raising in relation to the topic of gender-based violence
Effects of Stress Coping Styles and Social Defeat on Zebrafish Behaviour and Brain Transcriptomics
No full textIndividuals with divergent personality traits corresponding to stress coping styles have been suggested to differ in behavioural and neural plasticity. We used a model of social defeat stress to assess the coping ability of wild zebrafish selectively bred for boldness/shyness. Behavioural tests were applied to assess parameters such as boldness/exploration, aggressiveness, and displacement behaviour. Gene expression changes in the brain were assessed via RNA sequencing. The main results show a strong effect of shyness and boldness phenotype on behaviour and the brain transcriptome. Fish of the shy line displayed significant behavioural differences, while the number of differentially-expressed genes remained low. In contrast, fish of the bold line exhibited a small effect on behaviour and pronounced changes in brain gene expression. This study highlights the importance of boldness phenotype and its influence on the response to social challenges at the behavioural and transcriptomic levels
Towards an Analytical Procedure Control Strategy for the Capillary Zone Electrophoresis Method for Monoclonal Antibodies : Alternatives for ε-Aminocaproic Acid and Triethylenetetramine
No full textThe ICH guideline Q14 on analytical procedure development underlines the importance of science and risk-based methods for the evaluation of the quality of medicines. Ultimately, a pharmaceutical company, the sponsor, is responsible that the analytical method is fit-for-purpose during routine use throughout its lifecycle. Part of the analytical procedure control strategy is the responsibility to assure availability of critical materials of the analytical method. For capillary zone electrophoresis (CZE) methods, the background electrolyte (BGE) composition is a key and critical material. In this study, we investigated whether key ingredients of the epsilon-aminocaproic acid (eACA) CZE (eACA-CZE) method for monoclonal antibodies can be replaced by structurally related chemicals. The complex heterogeneity patterns are compared, as well as the reportable results as the percentage main, acidic and basic peaks. Overall, the results underline the ruggedness of the eACA-CZE method and provide alternative options to eACA and triethyltetramine (TETA), in case there are quality or supply issues, thus de-risking and safeguarding release and stability studies for therapeutic mAbs
Travellers, trainees, and urban transformations : knowledge circulation in the pre-industrial Stockholm metal trades, c. 1750–1820
No full textUrban contexts and town-based groups have long been associated with creativity, innovativeness, and the dissemination of technical know-how. Studies dealing with early modern European towns have recently added important findings on this subject, examining practices of work and knowledge circulation that contributed to improvements in the spheres of craftwork and manufacturing well before the onset of industrialisation. This article builds on such research contributions, and it does so by exploring developments at the fringes of a pre-industrial European economy, namely in Stockholm, Sweden, during the period c. 1750–1820. Using a large collection of sources from the Swedish state archives, and zooming in on the important metalworking sector, it illuminates transnational itineraries as well as localised activities that made the capital into a key node in the Swedish – and indeed European – metal trades. Integrating a large number of working individuals and knowledge-making practices into the discussion, moreover, it provides a good basis for nuancing traditional assumptions of a long stagnation in the Swedish capital during the end of the early modern era.P2017_0114:1 Jan Wallanders och Tom Hedelius stiftelse samt Tore Browaldhs stiftelse / The Metal Bazaar: Knowledge-making in the Stockholm Metal Trades during the ‘Long Eighteenth Century
Attitudes and ethical beliefs of Russian psychiatrists towards the use of coercive treatment practices
No full textIn many countries little is known about the attitudes and ethical beliefs of practicing psychiatrists towards the use of coercive practices. This is true as regards Russia where coercion was used for political purposes during the Soviet period. However, substantial changes have occurred in the psychiatric system in recent decades with a focus on patients' rights and the idea of consent. This study aimed to investigate the beliefs and attitudes of Russian psychiatrists towards coercive treatment practices in situations of clinical decision making. Data were obtained from 93 (81 % of all practicing) psychiatrists in the Arkhangelsk region in northwestern Russia. The psychiatrists completed three case vignettes to obtain information regarding the use of coercive treatment practices in different clinical situations, and responded to an ethical attitudes inventory. The psychiatrists' decisions regarding coercive treatment, and the extent of information provided to the patients and their relatives were impacted by the severity and risks (violence, suicidality) associated with the patient's disorder. In most instances psychiatrists were not responsive to pressure from the patient's family or other hospital personnel. Very few gender differences in attitudes and practices were found. Psychiatrists generally reported that they encountered different situations with abusive practices primarily in the past. This study suggests that the factors associated with the use of coercive treatment practices by Russian psychiatrists may mirror those in other countries. Further research should elucidate the actual extent to which coercive practices are used in Russian psychiatry and delineate the factors associated with their actual use
Ion-assisted sputter-deposition of superconducting NbN thin films on silicon
No full textNbN is an attractive material for superconducting metallization of electronic devices due to its relatively high critical temperature of superconducting transition of 16 K. In this study, we demonstrate ion assisted reactive magnetron sputter deposition of superconducting NbN thin films directly on Si without the need for elevated deposition temperatures. The highest TC achieved is 13 K. Two key factors determining the low temperature behavior are identified. The film morphology, specifically the density, influences the room temperature electron transport and the residual resistivity ratio. The degree of microstructural disorder, described as the crystallite size or microstrain, determines the critical temperature. Partial ionization of the film forming species results in both densification and increased crystallite size with beneficial impact on the film performance