Publikationer från Uppsala Universitet
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Evaluating early mobilisation in critically ill COVID-19 patients : Secondary analysis from the ESICM UNITE-COVID-II multicentre observational study
No full textBackground: Early mobilisation (EM) within the first 72 h of ICU admission is essential for preventing ICU-acquired weakness; however, mobilisation rates remained low among mechanically ventilated (MV) COVID-19 patients during the pandemic waves. This study aimed to characterise the association between EM and 60-day outcomes. Methods: A multicentre observational study conducted by the European Society of Intensive Care Medicine (ESICM) examined mobilisation strategies during the second COVID-19 wave (UNITE-COVIDed2021). All patients with confirmed SARS-COV-2 infection who were in the ICU on the peak day between 1st January and 1st June 2021 were included. The analysis expanded on the UNITE-COVIDed2020 study, comparing the first and second COVID-19 waves using a combined dataset. Results: Data from 2053 patients during the second wave across 103 ICUs in 35 countries were analysed and compared with 4190 patients from the first wave. EM was achieved in 801 (39%) vs. 1114 (27%), p < 0.001, respectively. In the combined cohort, MV on admission significantly reduced the likelihood of EM (OR 0.29, 95% CI: 0.25-0.33, p = 0.001). While EM did not improve ICU or hospital length of stay, it was associated with reduced 60-day mortality (OR 0.74, 95% CI: 0.64-0.86, p = 0.001) and transfer rates to other care facilities (OR 0.74, 95% CI: 0.59-0.94, p = 0.001). Conclusion: EM is feasible and beneficial for critically ill COVID-19 patients. It was associated with reduced mortality and lower transfer rates to other care facilities, which underscores the critical role of EM in enhancing patient recovery during a pandemic
Trust in the Digital Vault : A Study on Key Factors for Continuous Trust in Banking Apps
No full textThis study investigates which factors have the greatest impact on users’ continuous trust in mobile banking applications. The study is based on a framework that integrates three established models of trust in digital banking and includes six factors: perceived value, confirmation of expectations, perceived security risk, perceived usability, organizational reputation, and customer support. The data consists of 68 survey responses analyzed using reliability analysis, exploratory factor analysis, as well as regression- and correlation analysis. The results show that perceived value, confirmation of expectations, perceived security risk, and perceived usability are the factors with the strongest influence on continuous trust. Organizational reputation and customer support showed weaker associations and were not significant in all analyses. The study contributes with a combined model where the four most central factors have been identified, providing a more focused understanding of what drives trust in everyday use of banking apps. The results have both theoretical importance for research on digital trust and practical relevance for developers and decision-makers in the banking sector. They specifically highlight the importance of creating services that are functional, understandable, and perceived as valuable in users’ daily lives
"You can put your brain into them" : An interveiw study about tween boys' reading and the literary dissemination method Lesersørvis
No full textThis master’s thesis presents a qualitative interview study with Swedish boys aged 9 to 11 that focuses on their reading preferences and especially in relation to the literary dissemination method Lesersørvis. Semistructured interviews were carried out with the librarian who introduced the Lesersørvis method to Swedish libraries, 2 children’s librarians and 38 boys aged 9 to 11. The interviews with the boys were inspired by and partly modelled after a phenomenological approach to interviewing. The interview answers were analysed thematically. In terms of layout the study starts with an interview with 2 children’s librarians and the answers from this interview serve as the basis for the formulation of further interview questions aimed at the boys. The results show that the 2 children’s librarians find it difficult to reach tween boys and that they believe that greater knowledge of the Lesersørvis method in relation to boys’ reading preferences could aid them in this difficult work. The interviews with the boys show that many read 5 to 15 minutes a day and prefer genres such as humour, nonfiction, action and fantasy. A recurring motivation for the preferences of many of the boys less accustomed to reading is the ability to understand the book at hand. Simultaneously other boys express a desire for challenging literature and a desire to learn. It is also worth noting that many of the boys are interested in video games and in the light of previous research on boys, literacy, digitality and video games, it seems like children’s librarians working with literary dissemination have a lot to gain by tapping into this interest in different ways. Furthermore, it also appears to be very important to approach the Lesersørvis method with a critical awareness of the risks and limitations associated with generalisations based on gender. This is a two years master’s thesis in Library and Information Science
The modern family housing : An investigation of housing ideals in the early 1930s in the Social Democratic Women's Associations magazine Morgonbris and two government investigations
No full textGoverning Backup Power Systems : Challenges of Responsibility, Coordination and Resilience in Sweden’s Crisis Preparedness
No full textIn an increasingly electrified and volatile world, backup power systems play a crucial yet underexplored role in ensuring the resilience of critical societal functions. This thesis examines how Sweden’s backup power sector is organized and governed in practice, based on interviews with actors across municipalities, agencies, and industry. By applying the theoretical lens of institutional logics, the thesis identifies how state, market, and professional logics shape actor behavior and contribute to tensions between cost-efficiency, resilience, and sustainability. The findings demonstrate that while backup power is vital for crisis preparedness, its development is hindered by unclear mandates, constrained procurement frameworks, and limited knowledge diffusion. The study shows that technical solutions alone are not enough; without coordinated governance and clearer institutional support, backup power remains a vulnerable link in Sweden’s preparedness system
Neuroinflammatory signatures in degenerative Ascending Aortic Aneurysm
No full textAscending Aortic Aneurysm (AscAA) is an asymptomatic disease defined by a restricted dilation in the ascending aorta. Progression of the pathological condition can result in symptomatic and fatal rupture or dissection. The degenerative type of AscAA is associated with aging and a tricuspid aortic valve (TAV). The aim of this study is to characterize the innervation and expression of neuroinflammatory markers in the ascending aorta and investigate their potential association with degenerative ascending aortic aneurysm (AscAA), in the human TAV condition. Immunostaining of aortic tissue from TAV patients with non-dilated or dilated ascending aorta was made, using the antibodies Neuron-specific class III b-tubulin (TUJ1), Tyrosine hydroxylase (TH), Calcitonin gene-related peptide (CGRP) and CD68. The results showed no significant difference of CD68 expression between non-dilated and dilated aortas and the antigens were not located around neurovascular bundles. Non-dilated aortas expressed TUJ1 and TH, whereas dilated aortas only expressed TUJ1. The CGRP expression differed between the patient groups where it was mainly located in the adventitia in dilated aortas and in the lower media in non-dilated aortas. Visual data showed no colocalization between CGRP and TUJ1, but quantitative analysis of the immunofluorescence data did. The main conclusions of this study are that sympathetic denervation may play a role in AscAA and there could be signs of sensory dysregulation during the progression. Further studies need to be made to confirm whether CGRP really is expressed by other cell types in addition to neurons, to be able to fully determine if CGRP impact regarding AscAA pathology
Att integrera kontinuerlig förbättring i AI-drivna startups: En fallstudie av Willow.co
No full textThis thesis explores how continuous improvement is implemented within Willow.co, a fast-paced AI-driven startup, and investigates how current challenges might be overcome to establish a more sustainable improvement culture. The study addresses the problem of fragmented improvement efforts, which are often informal, undocumented, and unevenly distributed across departments. The purpose is to develop theory-based, practical suggestions that can help embed learning routines into daily operations without compromising the company’s agility. The research draws on Lean Startup principles, the Toyota Production System, Total Quality Management, and change management theory to frame its analysis. A qualitative case study methodology was used, combining interviews, a company-wide survey, and internal document analysis to understand existing practices and surface key challenges. Findings show that while Willow.co has a strong culture of experimentation and ownership, it lacks consistent structures for measuring, reflecting, and sharing what works. Improvement efforts tend to remain localised and are rarely revisited. The study proposes lightweight routines, such as adopting the Build–Measure–Learn loop company-wide, introducing shared documentation practices, and fostering cross-team communication, to support structured learning. Additionally, it reflects on how AI agents could assist in automating feedback loops, for example by completing postmortems or generating improvement summaries, thus supporting learning in high-speed environments. The thesis concludes that sustainable improvement in startups depends not only on motivation, but on embedding small but consistent practices that make learning visible and shared
Ledares syn på förändringsarbete i omorganisationer
No full textThis study explores leaders working in international corporations and their view on reorganization. Previous research regarding leaders, change management and reorganization has formed the basis of the discussion regarding the leaders role in reorganizations. By collecting data, a qualitative method has been used in the form of semi structured interviews. Eight leaders from different international companies have been a part of this study and explained their view on how a leader should lead the reorganization. The collected empirical material from the interviews has been compared with theoretical starting points with the purpose of trying to answer questions regarding leaders strategies, handling resistance and the leaders role. The leader has an important role when it comes to change management. In case of lack of understanding why an organization needs to change the leader will have a hard time getting the employees on board and with the driving force that is required. An organization changes due to the need to be competitive and increase its efficiency and profitability. A reorganization can come with a lot of resistance that can make the work harder, something the leader continuously needs to be working on. To solve the problem with resistance and counteract a common denominator from all of the respondents and the previous research. The common denominator is the importance of communication and openness about what is going on in the change management.
Digitising Indonesian Artefacts in Europe : A Case Study of Wereldmuseum, Museum Bronbeek and the Museum of Ethnography
No full textThe purpose of this thesis is to explore the practices and approaches to the digitisation of Indonesian artefacts in three organisations, Wereldmuseum and Museum Bronbeek in the Netherlands and the Museum of Ethnography in Sweden. The study seeks to find how the digitisation of Indonesian artefacts is undertaken, particularly within the context of the museums’ colonial histories and postcolonial digital humanities. Semi-structured interviews were conducted with museum professionals, with the addition of an overview of each museum’s online database. A thematic analysis was applied to the data collected from both the interviews and the database overview. Though the colonial contexts of the museums’ Indonesian collections are not considered during their digitisation, each of the museums have ethical considerations when it comes to the digitisation and digital display of culturally sensitive objects. Dialogue with source and diasporic communities also play a prominent role in the museums’ digitisation of Indonesian objects. Great variation is found in the presentation of the collections in the databases, with the occasional inclusion of information about the objects’ colonial contexts. Despite the lack of considerations concerning colonial contexts and the possibility of including more reflections during the digitisation process of such collections, the museums still have some considerations that aid in creating postcolonial workflows that help centre Indonesian voices in these European museums