Publikationer från Uppsala Universitet
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Hushåll, stad och rätt : En vänbok till Dag Lindström
No full textHushåll, stad och rätt är en vänbok till Dag Lindström, professor i historia vid Historiska institutionen, Uppsala universitet. Denna bok rymmer sexton artiklar inom de tre temana Hus och hushåll, Stad och Rätt och de är skrivna av kollegor och vänner från såväl Uppsala universitet som danska, engelska, finska och andra svenska universitet. Hus och hushåll, Stad och Rätt spänner över de forskningsfrågor och fält som karaktäriserat Dag Lindströms långa och gedigna historikergärning, vars ämnen sträcker sig från rätts-, social- och institutionshistoria, till urbanisering och urbanism, och hus och hushåll i ett tidsspann från senmedeltiden till industrialiseringens dagar.Hushåll, stad och rätt is a Festschrift to Dag Lindström, professor of history at the Department of History, Uppsala University. This book contains sixteen articles within the three themes House and Household, City and Law and they are written by colleagues and friends from Uppsala University as well as Danish, English, Finnish and other Swedish universities. The book spans the research questions and fields that have characterized Dag Lindström's long and solid historical work, whose topics range from legal, social and institutional history, to urbanization and urbanism, and houses and households in a time span from the late Middle Ages to the days of industrialization
Promise vs. Practice : Employer Branding, Culture, and the Internal-External Talent Experience in Swedish Big Four PSFs
No full textProfessional service firms depend on attracting and keeping skilled talent, but most studies analyze either the external employer brand or the internal culture, rarely both. This thesis addresses that gap by studying Sweden’s Big 4 firms, including and comparing both perspectives, extending on previous research. Guided by a theoretical foundation of Schein’s model of culture, Schneider’s ASA framework, and Rousseau’s Psychological Contract Theory, the authors used a mixed-methods design, surveying 68 final‑year master’s students and interviewing 13 early‑career employees at the Big 4. Results show that both groups value the chance for professional development and the collaborative, school‑class-like community, however, poor work‑life balance, rigid hierarchies, and slow, unfulfilled moves between roles contrast with the employer brand, breaching the psychological contract, weakening trust, and leading employees to attrite from the firms. To reconcile these differences between external and internal sides, transparency about workload, clearer career paths, and stronger, firm‑wide community practices should be central. In reconciling the gap, Big 4 firms can make use of their strengths and own their weaknesses, leveraging their brand into a more authentic, believable reason both to join and to stay, mitigating the risk of unnecessary turnover and helping them in the contest for knowledge‑based talent
ID3 and BMP Induced Apoptosis in Multiple Myeloma
No full textMultiple Myeloma is a haematological cancer that affects the plasma cells. There is currently no known cure for multiple myeloma however research has shown that bone morphogenic protein (BMP) can induce apoptosis and growth arrest in multiple myeloma. BMP induced apoptosis downregulates the protein and mRNA expression of c-MYC, a protein transcribed from a proto-oncogene aiding cancer cell proliferation and upregulates the expression of inhibitor of DNA-binding gene 3 (ID3), an indirect transcription factor. ID3 is known to interact with a different transcription factor (TCF), TCF3. The hypothesis was that TCF3 is responsible for stimulating c-MYC transcription in multiple myeloma. When BMP induces apoptosis in multiple myeloma the upregulated ID3 binds TCF3, preventing TCF3 from stimulating c-MYC transcription. Prior to the study, a CRISPR/Cas9 knockout of ID3 was performed on the human multiple myeloma cell line INA-6 resulting in, Wild type (WT), Non-targeting control (NTC), and 4 ID3 ko clones. To verify the hypothesis the clones were compared and analysed with different cell viability assays and Western blot to determine protein expression after treatment with BMP9. The cell viability assays showed the INA-6 ID3 knockout clones had up to 20% higher cell viability when treated with BMP9 than the NTC, supporting the hypothesis. The Western blot results where inconclusive regarding c-MYC expression, and demonstrated ID3 banding in all clones, indicating an incomplete ID3 knockout. In conclusion ID3 was shown to be a relevant molecule in BMP induced apoptosis. However, ID3s impact on c-MYC concentration could not be confirmed
The Competitive Edge : How Finance Professionals Perceive and Manage Stress
No full textThe study explored how professionals perceive and manage stress within the organizational culture in the Swedish finance sector. Through semi-structured interviews with eight finance professionals, the research unveiled key themes through an inductive approach, shaping stress experiences and coping strategies. The findings paint a picture of the demanding and inherently competitive nature of the sector, which promotes a high-pressure environment that was not necessarily perceived as negative. Clear goals and frequent feedback reduced the feelings of stress, even if the person operated in an otherwise intense environment. Additionally, theory emerged from the data, such as the psychological factors: silence, anxiety, and uncertainty. Together, these factors became integral components of the organizational culture, potentially exacerbating stress, but were shown in the study to be mitigated in several ways by the respondents. Career sustainability is also discussed as emerging from the data, given the long-term nature of professional careers. Methods that were used to manage stress were, for example, clear work-life boundaries, time to recover, daring to speak up about concerns, utilizing the anxiety from stress for energy, and ultimately changing positions. Understanding these dynamics offers valuable insights for organizations, worker well-being, and further research
Mapping the competence situation in the swedish nuclear power sector
No full textSweden has not built new nuclear power in the last 40 years, which has led to uncertainty regarding the current competence situation within the sector. As the Swedish government has set a target to expand the nuclear power, this study aims to map the competence situation and thus assess whether the competence required is sufficient for new construction and continued operation. The study is based on interviews with nine actors from both the private and the public sector. These interviews were analyzed in relation to a theoretical framework that divided the concept of competence into psychomotoric-, cognitive-, affective- and social factors as well as tacit knowledge. The respondents described a lack of competence in all areas alongside potential solutions to acquire some of these. Multiple respondents shared the view that the ability to lead large infrastructural projects as well as extensive knowledge of the facility is something Sweden is lacking due to the previous decommissioning. This knowledge is described as tacit and connected to experience, something which makes it hard to acquire. Labor immigration was discussed as a potential solution to cover this experience based competence gap, however it was described as challenging due to the regulations surrounding nuclear power, such as security clearances. The conclusion is that the competence situation for continued operation is adequate. However, the lack of the tacit, experience based knowledge was identified as the most challenging if Sweden aims to expand its nuclear capacity, rather than cognitive- or psychomotoric competencies.Sverige har inte byggt ny kärnkraft på över 40 år, vilket har bidragit till en osäkerhet kring det aktuella kompetensläget inom sektorn.. Då Sveriges regering idag har ett utsatt mål att utöka kärnkraften syftar detta arbete till att kartlägga kompetensläget och således bedöma huruvida den kompetens som krävs för nybyggnation samt drift finns tillgänglig. Arbetet bygger på intervjuer med nio aktörer från privat- och offentlig sektor. Dessa intervjuer analyserades i relation till ett teoretiskt ramverk som delade upp kompetensbegreppet i psykomotoriska-, kognitiva-, affektiva- och sociala faktorer samt tyst kunskap. Respondenterna beskrev en avsaknad av kompetens inom samtliga områden samt potentiella lösningar för att anskaffa vissa av dessa. Flera respondenter delade uppfattningen att förmågan att leda storskaliga infrastrukturprojekt samt djup anläggningskännedom är något Sverige saknar till följd av de senaste årens avveckling. Denna kunskap beskrivs som tyst och erfarenhetsbaserad, något som gör den svår att anskaffa. Arbetskraftsinvandring diskuterades som en potentiell strategi för att täcka detta erfarenhetsbaserade kompetensgap, men beskrevs samtidigt som utmanande på grund av olika regelverk kopplade till kärnkraft, såsom krav på säkerhetsklassningar. Slutsatsen är att kompetensläget för fortsatt drift är adekvat. Däremot är avsaknaden av den tysta, erfarenhetsbaserade kunskapen det mest utmanande om Sveriges ska bygga ny kärnkraft, snarare än de kognitiva- eller psykomotoriska kompetenserna
Leaning With, or Against the Wind? : A Quantitative Study of Earnings Management under Macroeconomic Uncertainty
No full textFirms operate in an unstable environment, where unforeseen events frequently create uncertainty about the future. The uncertain environment can affect firm behaviour in various ways. This study aims to examine whether a relationship exists between macroeconomic uncertainty and earnings management. Based on our theoretical framework and previous empirical findings, we hypothesized that earnings management engagement would be positively related to macroeconomic uncertainty. Using a quantitative approach, panel data from Swedish listed firms (2014-2023) was analysed. Earnings management was measured by discretionary accruals (Modified Jones Model), and macroeconomic uncertainty by the logarithmic annual mean of the Swedish EPU-index. A fixed effects regression with robust standard errors was employed. The results indicated a slight positive, but not statistically significant relationship between the two variables. The hypothesis was therefore not accepted, and the study concludes that there is no significant relationship between macroeconomic uncertainty and Swedish firms’ earnings management during this period. The results imply that Swedish firms do not adjust their financial reporting behaviour in response to fluctuating macroeconomic uncertainty, which could suggest a certain level of stability and reliability in financial reporting practices among Swedish firms
Drivers and obstacles for eco-innovation and its implications for achieving sustainability goals : A case study of a Swedish construction consultancy firm
No full textDuring this study an early-stage calculation tool for climate impact and cost was developed to optimise the opaque building envelope’s climate footprint and the cost for these optimisations. The study investigates the drivers for sustainability efforts inside the studied construction consultancy firm and important considerations for implementations. Furthermore, the customer's perception of a company’s sustainability efforts was studied. This was studied with semi-structured interviews with consultants with different disciplines as well as studying an existing customer survey. The study showed that regulations, economic opportunities and the climate impact that the construction industry has are the main drivers within the company. It was also found that important factors for implementation are sufficient training, a clear context surrounding a new tool and ease of use. Lastly, it was found that consultants have a clear understanding that customers appreciate and strive for sustainability efforts and want to work with organisations that value sustainability. It was concluded that even though the construction industry is largely driven by market pull, mainly because of regulations from large governing bodies, an early calculation tool like the one developed during this research is more the result of a technology push made by the researched company to streamline operations and offer their customer effective solutions
The Plausible and the Possible : Metadata, meaning, and the fan-made real in Formula 1 RPF
No full textThis thesis investigates how participatory storytelling practices functions as a site of canon negotiation within digital fandoms, focusing on Real Person Fiction (RPF) in the Formula 1 fandom. The purpose of this study is to explore how fans collaboratively construct meaning through metadata functions such as tags, author’s notes, and comment threads on the platform Archive of Our Own (AO3). The central research question asks: How does worldbuilding and canon negotiation unfold in Formula 1 RPF through metadata elements on the platform Archive of Our Own? To address this question, the study adopts a qualitative case study approach, applying Lindgren Leavenworth’s method of paratextual navigation to analyse the long-form fanfiction Icarus by WinterLantern. Theoretically, the study bridges concepts from transmedia storytelling, fan studies, and media epistemology. It applies Couldry and Hepp’s (2017) framework of communicative figurations and deep mediatization alongside Bronwen Thomas’ (2014) concept of consensual plausibility, as well as transmedia storytelling based on Jenkins (2006) theory. Findings suggest that AO3’s metadata performs a dual function as both navigational infrastructure and epistemic guide. These features enable readers and writers to negotiate ethical boundaries and collaboratively define narrative plausibility. The study concludes that Formula 1 RPF operates as a dynamic space of mediated worldbuilding and interpretive labour. Methodologically, the thesis combines paratextual analysis with a digital ethnographic orientation, drawing on long-term contextual familiarity to interpret participatory practices from within the field. This research contributes to broader understandings of fanfiction as a cultural practice and offers insights into the epistemic dimensions of transmedia fandoms
Risk Evaluation of Host Cell Proteins in E. coli-Based Production of Affibody Molecules
No full textAffibody® molecules are therapeutic proteins used for various purposes, including usage in biotech tools, treating neurodegenerative diseases, inflammation disorders and in oncology. In production of therapeutic drugs using Affibody® molecules, Escherichia coli (E. coli) is commonly used as host for expression. During the production, impurities such as host cell proteins (HCPs) can be introduced. These HCPs are undesirable in therapeutic drugs as they may affect product stability and efficacy by triggering immunogenic responses in patients or degradation of Affibody® molecules due to enzymatic activity. In this study, common HCPs with known risks were identified through a literature study. A simulation of Affibody’s purification step of ion exchange chromatography (IEX) was performed to predict which HCPs are likely to co-purify with the Affibody® molecule. Additionally, each HCP from the complete E. coli genome were assigned with an immunogenicity risk score, based on the prediction tool DeepImmuno-CNN. In total, 15 common HCPs in E. coli were identified, of which 10 were associated with a risk of triggering immune response according to the literature study. In the data-driven risk assessment, simulation of IEX was performed using Chromatography Analysis and Design Toolkit (CADET). The performed simulation using CADET was successful, suggesting that it is a powerful tool for prediction of which HCPs will co-elute with Affibody® molecules. Immunogenicity scores from the DeepImmuno-CNN predicition revealed that HCPs associated with an immunogenic potential from the literature study tend to have high immunogenicity scores
Search for e+e-→KS0KS0hc
No full textUsing e+e- collision data at 13 center-of-mass energies ranging from 4.600 to 4.951 GeV collected with the BESIII detector, we conduct the first search for the e+e- -> KS0KS0hc process and investigate the resonance structures in the cross section line shape. No significant signal is observed, and the upper limits of the Born cross sections at each center-of-mass energy are presented. The ratio sigma e+e--> KS0KS0hc sigma e+e--> KS0KS0J/psi is determined to be 0.15 +/- 0.22. This result indicates that if vector states exist in this energy region, their decay into hc is significantly suppressed compared to decays into J/psi.For complete list of authors see http://dx.doi.org/10.1007/JHEP05(2025)144</p