22282 research outputs found
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The evolution of cooperation and diversity in public good producing organisms
No full textIn a population of altruists, all individuals thrive. But altruists are exploited by cheating individuals which do not perform altruistic acts but still benefit from those. In these conditions cooperation cannot easily evolve. This issue is resolved by kin recognition: altruists recognise each other through the use of a conspicuous tag. These altruists do well until cheaters acquire the signalling tag and disrupt the cooperation. But altruists using a different tag can then invade the population, followed by new cheaters. This mechanism can lead to a diversity of tags coexisting in the population. However it has not yet been applied in realistic biological systems. In this thesis, I formulated mathematical and simulation models to investigate the effect of diversity on the evolutionary dynamics in systems where different altruists compete with cheaters. In particular, I focused on organisms producing public goods, i.e. goods that can profit to the whole population. I considered two biological systems models: gynodioecious populations of plants, where hermaphrodites produce pollen that can be used by female-only individuals, and bacteria producing an iron-chelating molecule, called siderophore, that can be exploited by both producers and non-producers. I found that diversity in gynodioecious plants is dependent on population structure. In particular, I found that the maximal level of diversity occurs when the population structure does not favour altruists or cheaters. Next, I found a number of important results in siderophore-producing bacteria. By considering a detailed ecological model, I derived Hamilton's rule in a metapopulation and found that the level of cooperation in a population depends on the length of interaction between strains. Finally, I discovered a novel evolutionary mechanism generating and maintaining diversity and showed that it results from non-equilibrium mechanisms. These findings explain why cheaters appear readily in experiments but are rare in natural populations. My results demonstrate the importance of integrating ecological details in order to understand the mechanisms leading to cooperation and diversity, and will provide a basis and framework for future studies on the emergence and maintenance of diversity
E-BASS25 - eBooks Survey
Get PDFPresentation given at the E-BASS25 End of Project Briefing on the survey of 30 UK institutions about eBooks
Talking to publishers about consortial PDA: a report by JISC Collections for E-BASS25
Get PDFThis report compiles the responses from e-book suppliers to questions on patron-driven models of e-book acquisition (PDA) for consortia. These questions were put to them in a series of telephone interviews conducted by JISC Collections staff in January 2013 as part of the E-BASS 25 project. All responses are unattributed at the request of some of the participants. The report concludes with a series of recommendations for institutions considering using PDA as a consortium, derived from the responses received
Effectiveness and cost-effectiveness of a novel, group self-management course for adults with chronic musculoskeletal pain: study protocol for a multicentre, randomised controlled trial (COPERS)
No full textIntroduction: Chronic musculoskeletal pain is a common condition that often responds poorly to treatment. Self-management courses have been advocated as a non-drug pain management technique, although evidence for their effectiveness is equivocal. We designed and piloted a self-management course based on evidence for effectiveness for specific course components and characteristics. Methods/analysis: COPERS (coping with persistent pain, effectiveness research into self-management) is a pragmatic randomised controlled trial testing the effectiveness and cost-effectiveness of an intensive, group, cognitive behavioural-based, theoretically informed and manualised self-management course for chronic pain patients against a control of best usual care: a pain education booklet and a relaxation CD. The course lasts for 15 h, spread over 3 days, with a –2 h follow-up session 2 weeks later. We aim to recruit 685 participants with chronic musculoskeletal pain from primary, intermediate and secondary care services in two UK regions. The study is powered to show a standardised mean difference of 0.3 in the primary outcome, pain-related disability. Secondary outcomes include generic health-related quality of life, healthcare utilisation, pain self-efficacy, coping, depression, anxiety and social engagement. Outcomes are measured at 6 and 12 months postrandomisation. Pain self-efficacy is measured at 3 months to assess whether change mediates clinical effect. Ethics/dissemination: Ethics approval was given by Cambridgeshire Ethics 11/EE/046. This trial will provide robust data on the effectiveness and cost-effectiveness of an evidence-based, group self-management programme for chronic musculoskeletal pain. The published outcomes will help to inform future policy and practice around such self-management courses, both nationally and internationally. Trial registration: ISRCTN24426731
Accounting and the absence of a business economics tradition in the United Kingdom
No full textThe chapter explains why business economics did not emerge as a distinct discipline in the UK, and examines the extent to which accounting filled the gap left by this in UK universities
Clostridium difficile: Infection and Immunity
No full textClostridium difficile is a Gram positive pathogen of significant importance in the UK, Europe and the USA. No vaccine has been developed and current treatments are focused on hospital management and the use of antibiotics. The disease is spread in hospitals in the spore form and the role of spores in C. difficile infecton is poorly understood. In this project spores of C. difficile have been characterised. The proteins from the outermost layers of the spore were identified and the genes cloned. Three of these surface proteins have unique enzymatic properties that maybe important for symptoms of disease. The ability of C. difficile spores to adhere to intestinal cells was found to be far greater than with live cells and through this we have identified that the spore may play an important role in colonisation. The regulation of spore coat gene expression during sporulation was also examined and temporal phases of genes expression identified. A major part of this project was to develop a mucosal vaccine to C. difficile. The approach used was to clone the C-terminus of toxin A onto the surface of Bacillus subtilis spores and use these recombinant spores to immunise mice and hamsters. We found that oral delivery of these spores conferred 75% protection to C. difficile infection in a hamster model of infection. Further, parenteral immunisation of the same antigens (toxin A and B) failed to generate mucosal responses and this showed that mucosal immunisation is critical for good protection. Finally, we found that antibodies to the C-terminus of toxin A were cross reactive to the C-terminus of toxin B. This showed that mucosal delivery of just the C-terminus of toxin A is sufficient to confer protection in an animal model of infection. The outcome of this work is that we have shown the parameters for successful immunisation and vaccination against C. difficile
Multi-photon quantum interference in a multi-port integrated photonic device
No full textIncreasing the complexity of quantum photonic devices is essential for many optical information processing applications to reach a regime beyond what can be classically simulated, and integrated photonics has emerged as a leading platform for achieving this. Here, we demonstrate three-photon quantum operation of an integrated device containing three coupled interferometers, eight spatial modes and many classical and nonclassical interferences. This represents a critical advance over previous complexities and the first on-chip nonclassical interference with more than two photonic inputs. We introduce a new scheme to verify quantum behaviour, using classically characterised device elements and hierarchies of photon correlation functions. We accurately predict the device's quantum behaviour and show operation inconsistent with both classical and bi-separable quantum models. Such methods for verifying multiphoton quantum behaviour are vital for achieving increased circuit complexity. Our experiment paves the way for the next generation of integrated photonic quantum simulation and computing devices
Monoidal Computer I: Basic Computability by String Diagrams
Get PDFWe present a new model of computation, described in terms of monoidal categories. It conforms the Church-Turing Thesis, and captures the same computable functions as the standard models. It provides a succinct categorical interface to most of them, free of their diverse implementation details, using the ideas and structures that in the meantime emerged from research in semantics of computation and programming. The salient feature of the language of monoidal categories is that it is supported by a sound and complete graphical formalism, string diagrams, which provide a concrete and intuitive interface for abstract reasoning about computation. The original motivation and the ultimate goal of this effort is to provide a convenient high level programming language for a theory of computational resources, such as one-way functions, and trapdoor functions, by adopting the methods for hiding the low level implementation details that emerged from practice. In the present paper, we make the initial step towards this ambitious goal, and sketch the ideas how to reach it. These ideas will be elaborated in the three sequel papers, that are in preparation
English-language theories of financial reporting
No full textThe chapter provides a historical overview of the principal theories of financial reporting in the English language. Early attempts to generalise from practice were supplemented with applications of economic theory, as well as ideas drawn from mathematics, systems theory, organisation theory, human behaviour and other disciplines to develop theories that attempted to improve current financial reporting practice. This has culminated in the development of conceptual frameworks for financial reporting. From the late 1960s, attempts have been developed to explain and predict accounting practice, and the impact of financial reporting information on the behaviour of investors and others
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