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The heterogeneity among people reengaging in antiretroviral therapy highlights the need for a differentiated approach results from a crosssectional study in Johannesburg South Africa
No full textGenetic therapies for movement disorders ‑ current status
No full textMovement disorders are a group of heterogeneous neurological conditions associated with alterations of tone, posture and voluntary movement. They may either occur in isolation or as part of a multisystemic condition. More recently, the advent of next generation sequencing technologies has facilitated better understanding of the underlying causative genes and molecular pathways, thereby identifying targets for genetic therapy. In this review, we summarize the advances in genetic therapy approaches for both hyperkinetic and hypokinetic movement disorders, including Parkinson’s Disease, Huntington’s Disease and rarer monogenic conditions of childhood onset. While there have been significant advances in the field, multiple challenges remain, related to safety, toxicity, efficacy and brain biodistribution, which will need to be addressed by the next generation of genetic therapies.Research EPNS Fellowship Award.PM202
Ochre use at Olieboomspoort South Africa Insight into spetecular hematite use and collection during the Middle Stone Age
No full textDrivers of woody plant phylogenetic and taxonomic beta diversity across an urban density gradient
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Functionalized Polydopamine NAnoparticles A Promising Drug Delivery Platform fo rthe Treatment of Tuberculosis
No full textCharacterisation of bacterial symbionts of the Anopheles funestus group from KwaZuluNatal Province South Africa
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