19683 research outputs found
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Gendering Law, Justice and the Legal Heroine: The Representation of Female Legal Professionals in Popular Japanese Television Dramas, 2001 – Present
No full textA thesis submitted in total fulfilment of the requirements for the degree of Master of Laws by Research to the La Trobe Law School, La Trobe University, Victoria, Australia.</p
An Enigmatic Group of Natufian Basaltic Artefacts at the Dar al-Saraya Archaeological Museum in Irbid, Jordan
No full textNo description supplied </p
Staying Stronger: Victorian Aboriginal Community perspectives and responses to gambling and gambling harms
No full texthttps://www.justice.vic.gov.au/safer-communities/gambling/staying-stronger-victorian-aboriginal-community-perspectives </p
Inclusion of People with Disabilities on the Boards of Not-for-Profit Disability Service Providers
No full textNo description supplied</p
What does it look like for Australia and Southeast Asia to develop a joint agenda for maritime security
No full textMaritime security is vital for Australia and Southeast Asia, making it a shared priority issue for the region. Australia must have a coherent and coordinated response to emerging maritime security challenges.Meeting these challenges will require Australia to become a trusted maritime security partner, with maritime cooperation serving as a key pillar of engagement with the region. Australia must integrate defence, diplomacy and development to become a reliable and capable partner.</p
Australia-China relations: finding the elusive balance
No full textThe relationship with China is of critical importance to Australia. It is also increasingly complex, being influenced by economics, domestic factors and strategic forces. The authors include highly respected voices in international relations, China studies and security studies, with a strong contribution from our own institution, as well as an international perspective from counterparts in China.</p
Review of the Disability Discrimination Act 1992 Issues Paper Submission - La Trobe Law School
No full textThe La Trobe Law School welcomes this opportunity to contribute to the review of the Disability Discrimination Act 1992 (Cth) (‘DDA’). No contemporary system of laws that acknowledges disability as part of the reality of human diversity is complete without fit-forpurpose anti-discrimination legislation. We commend the government for seeking to remedy concerns about the DDA in its current form, seeking reform to promote substantive equality and challenge the systemic barriers that disadvantage people with disability. Overall, this submission argues that while the DDA has made important contributions to the recognition of disability rights in Australia, it requires significant reform to become a more effective tool for achieving substantive equality and preventing disability-based discrimination. Our recommendations are directed at creating a more inclusive, accessible, and equitable legal framework in line with both leading practices in anti-discrimination law internationally, and Australia’s obligations under the UN Convention on the Rights of Persons with Disabilities (‘CRPD’). This submission focuses on the discussion questions most relevant to the expertise of Disability, Health and Law node members at the La Trobe Law School.</p
Identifying and addressing service barriers for children and young people who displayed harmful sexual behaviour
No full textPurpose: Services for children and young people who displayed harmful sexual behaviour (HSB) and their families have remained insufficient and siloed in Australia despite growing recognition of this problem. While some research explores service providers’ perspectives on the barriers and gaps preventing young people and families from accessing and engaging with support services, there is poor understanding of service users’ perspectives. This study aims to report challenges associated with accessing services for HSB from the perspective of service users. Design/methodology/approach: Qualitative interviews with young people aged 14–17 years and their caregivers were conducted and thematically analysed to identify service access barriers. Findings: Four service access barriers were identified: (1) apprehension about seeking help (2) lack of information about services and timely support; (3) service capacity and capability and (4) care continuity. Originality/value: HSB is an under-researched area, with sparse information about service provision, access and engagement in services from a service users’ perspective. This article contributes to knowledge by demonstrating that it is critical to address service access barriers by: increasing information about services for HSB, enhancing service capacity particularly specialist services in rural and remote areas, improving workforce capacity in responding and enhancing collaborative multi-agency working. Making these adjustments should improve service users’ experiences and positively impact on service engagement.</p
Differentiation grade is highly concordant between matched primary and metastatic colorectal cancer
No full textDifferentiation grade of colorectal cancers (CRC) is histologically defined by the proportion of the tumour which retains the glandular architecture of the normal colon. Poorly differentiated CRCs display loss of glandular architecture and canonical markers of colonic differentiation and are associated with increased metastatic capacity and poorer prognosis. It is currently unclear whether poorly differentiated cells within a heterogeneous primary tumour are more likely to establish metastases and if this cellular trait is conserved in the secondary tumours, or whether metastasis is largely stochastic, with most cells in the primary tumour harboring metastatic potential. To explore this, we examined the concordance in histological grade, expression of markers of colonic differentiation, and epithelial to mesenchymal transition (EMT) in 67 matched primary and metastatic CRCs. Tumour differentiation grade was scored categorically, and expression of differentiation and EMT markers were scored as continuous variables. In matched primary-metastatic pairs, tumour grade was concordant in 88% of cases (59/67 pairs), irrespective of the site of metastasis. In tumour pairs with discordant grade (n = 8), tumour grade was higher in the metastatic lesion in 6/8 (75%) cases. Consistent with the histological concordance, expression of the key driver of colonic differentiation (CDX2); colonic lineage-specific markers (VIL1, MUC2, SYN and CHG); and the markers of epithelial-to-mesenchymal transition (E-Cadherin and Vimentin) were highly concordant between matched primary and metastatic lesions. Finally, no staining of the squamous lineage marker Cytokeratin5/6 was observed in either primary or metastatic tumours. Tumour grade assessed histologically or using expression of markers of colonic differentiation or epithelial to mesenchymal transition was largely concordant between primary and metastatic CRC. These findings complement previously reported genomic similarities between primary and metastatic lesions and demonstrate that the histological grade of a primary tumour can in most cases inform the differentiation grade of associated metastatic lesions.</p
