19683 research outputs found
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Integrated health systems for children in out-of-home care – Phase 2 – 2023/2024
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Computational assessment of the radical scavenging activity of cleomiscosin
No full textCoumarinolignans such as cleomiscosin A (CMA), cleomiscosin B (CMB), and cleomiscosin C (CMC) are secondary metabolites that were isolated from diverse plant species. Cleomiscosins (CMs) have numerous interesting biological activities, including noteworthy cytotoxicity of cancer cell lines along with hepatoprotective and assumed antioxidant activities. In this present study, the antioxidant properties of three cleomiscosins were investigated with a focus on the structure-activity relationship using thermodynamic and kinetic calculations with the M06-2X/6-311++G(d,p) method. The results show that CMs, including CMA, CMB, and CMC, are weak antioxidants in apolar environments, with koverall of 7.52 × 102 to 6.28 × 104 M−1 s−1 for the HOO˙ radical scavenging reaction in the gas phase and 3.47 × 102 to 6.44 × 104 M−1 s−1 in pentyl ethanoate. Remarkably, the difference in the fusion of phenylpropanoid structure with coumarin via two ortho-hydroxyl groups (CMA and CMB) does not cause any noticeable effect on their antioxidant activity, while the presence of a methoxy substitute on the aromatic ring of phenylpropanoid units (CMC) increases the reaction rate to about 61 to 84 times faster than that of CMA. In contrast, the studied CMs exhibit a good antioxidant capacity in polar environments, with a koverall range from 4.03 × 107 to 8.66 × 107 M−1 s−1, 102-103 times faster than that of Trolox, equal to that of ascorbic acid and resveratrol. The angular fusion of the phenylpropanoid and coumarin structures, as well as the methoxy substitution on the aromatic ring of the phenylpropanoid unit of the studied CMs, do not have any considerable effect on their antioxidant activity under the studied conditions
Reliability of cervicocephalic sense of force
No full textAbstract: Cervicocephalic proprioception (CCP) is an important assessment item for people with a range of clinical conditions, where reduced CCP is associated with neck pain and imbalance. Reliability has been established for a range of positional and movements tests, but there is limited data regarding sense of force, particularly across three planes of movement. The current test–retest study assessed reliability when evaluating sense of force in healthy adults (8 males, 6 females, mean age 31.50 years [SD 10.14]) over two sessions, 4–7 days apart. A force matching protocol was used to evaluate reliability of absolute error (AE), constant error (CE), and variable error (VE) for 10 % and 25 % maximal voluntary contraction (MVC) target forces for flexion, extension, lateral flexion, and rotation. Participants were strapped to a chair to limit trunk movement and data was captured using a compressive force transducer fixed to an adjustable wall mount. Six trials were performed for each contraction-type, totaling 72 submaximal MVCs per session. ICC estimates for AE (0.15–0.77), CE (0.01–0.85), and VE (0.00–0.83) were varied and confidence intervals were mostly wide. Considering lower limits of confidence intervals, CE had best reliability values generally, but more specifically the most reliable contraction type and movement was 25 % MVC flexion (ICC 0.85, confidence interval 0.54–0.95). This study found that reliability for sense of force testing was dependent upon contraction, type of error, and target force utilized. Further reliability analysis should be performed when applying this test to measure validity outcomes in clinical populations.</p
Research Landscape on Hidden Workers in Aging Populations: Bibliometric Review
No full textIn this study, we employ ‘hidden workers’ as a key concept to integrate the three vulnerable subgroups of aging workers: underemployed, unemployed, and discouraged workers. (1) Background: The challenges faced by underemployed, unemployed, and discouraged workers in the older population are complex. It would be beneficial to visualize the intellectual landscape of these three distinct groups in aging populations to understand which aspects have been highlighted by various disciplines and where gaps exist. (2) Method: Through a scientometric analysis of more than 50 years of research, this study identified the size, scope, and structure of knowledge on hidden workers in an aging population using 2831 articles collected from the Web of Science database in January 2024. (3) Results: Indeed, the multidisciplinary nature of hidden workers goes beyond welfare and labor economics and involves issues such as health, occupational science, behavior change, policy interventions, and circles around the keyword of unemployment. Keyword co-occurrence and co-citation analysis confirm that the spectrum of research on hidden workers is being carried out distinctly within distinct disciplines across the broader aging research horizon. (4) Conclusions: The relatively scattered and uneven intellectual, conceptual, and social landscape of research on hidden workers in aging populations evidently falls short of providing concerted policy recommendations for the population group. This study provides a conceptual understanding of hidden workers in different research clusters and identifies gaps and opportunities for future research
Scoping review of literature relevant to the efficacy of warning labels on aerosols
No full textThis scoping review addresses the overarching question: What does the academic literature suggest regarding the efficacy of warning labels (WLs) on product packaging for aerosol sprays subject to volatile substance misuse (VSM)? It is inspired by a specific concern to identify the potential impact of WLs in deterring misuse by young people, as well as the design elements of such labelling that research suggests is likely to be most effective.</p
The effectiveness of a short course to improve coaches’ knowledge on considerations for female athletes
No full textThis study aimed to assess the effectiveness of an online short course in improving the knowledge and confidence of coaching and support staff when working with female athletes. A mixed-methods survey design was used, where participants completed surveys pre-, post-, and 6 months following an 8-week online course. Qualitative responses were analysed inductively using thematic analysis based on two pre-identified themes. Of the 92 participants who completed both pre- and post-course surveys, 72% (n = 66) were female and 67% (n = 62) were from team sports. Perceived knowledge and confidence improved following the course (p </p
Comparison of standard goal attainment scaling (GAS) and the GAS-light method for evaluation of goal attainment during neurorehabilitation of the upper limb
No full textBackground: Goal attainment scaling (GAS) is now widely used as a person-centered measure of outcome from rehabilitation and has demonstrated validity in diverse populations with sensitivity to change. However, as originally described, it is time-consuming for use in busy clinical settings. The "GAS-light" is a simplified version designed for application in routine clinical practice. Although increasingly taken up by clinicians, published evidence of the validity of GAS-light method is currently lacking. Objective: To evaluate the validity and sensitivity of the GAS-light rating method as a measure of goal attainment in clinical neurorehabilitation practice. To examine its agreement with the standard GAS rating (as originally described by the developers) as the gold standard and to assess its clinical utility and acceptability. Methods design: A direct, head-to-head comparison of the 2 GAS rating methods in a cohort of adults undergoing upper limb motor rehabilitation programs across a range of rehabilitation settings, including hospital, community outpatient, and spasticity clinic services. Study population: 60 patients (n=54 poststroke) set a total of 136 goals (range 1-4 per patient). In this comparative study, patients acted as their own controls. Measures: The 2 rating methods were applied independently and in parallel from a single goal-setting discussion. Goal attainment was measured on the original 5-point GAS using a predetermined follow-up guide and the GAS-light with its 6-point verbal rating scale. The evaluation included concurrent validity (intraclass correlation coefficients and agreement between the 2 ratings) and sensitivity to change using the standardized response mean (SRM). Thirteen clinicians and 52 participants completed surveys of clinical utility and patient acceptance, respectively. Results: Individual absolute agreement of 2-way mixed-effects intraclass correlation between the tools indicated good agreement (ICC(A,1)=0.88, 95% CI: 0.80, 0.93), and small systematic bias (-1.72 (95% CI: -3.04, -0.41). Both tools measured similar levels of change over time (GAS SRM=1.79; GAS-light SRM=1.62). Clinicians perceived GAS-light had stronger clinical utility, being quicker and easier to administer, score, and understand. Patients perceived GAS-light as acceptable, comfortable, worthwhile, and helpful. Conclusions: GAS-light is reliable and sensitive to change, with better clinical utility than the standard GAS. Either tool may be used to assess goal attainment in clinical upper limb neurorehabilitation
A chain mediation model on organizational support and turnover intention among healthcare workers in Guangdong province, China
No full textIntroduction: The outbreak of the Coronavirus Disease 2019 pandemic has presented significant difficulties for healthcare workers worldwide, resulting in a higher tendency to quit their jobs. This study aims to investigate the correlation between organizational support, work-family-self balance, job satisfaction, and turnover intention of healthcare professionals in China’s public hospitals. Methods: A cross-sectional survey was conducted on 5,434 health workers recruited from 15 public hospitals in Foshan municipality in China’s Guangdong province. The survey was measured by organizational support, work-family-self balance, job satisfaction, and turnover intention using a five-point Likert scale. The association between organizational support, work-family-self balance, job satisfaction, and turnover intention was investigated using Pearson correlation analysis and mediation analysis through the PROCESS macro (Model 6). Results: Organizational support indirectly affected turnover intention through three pathways: the mediating role of work-family-self balance, job satisfaction, and the chain mediating role of both work-family-self balance and job satisfaction. Conclusion: Health administrators and relevant government sectors should provide sufficient organizational support, enhance work-family-self balance and job satisfaction among healthcare workers, and consequently reduce their turnover intentions
Breastfeeding outcomes at 3 months for women with diabetes in pregnancy: Findings from the Diabetes and Antenatal Milk Expressing randomized controlled trial
No full textBackground: Women with diabetes in pregnancy have decreased exclusivity and duration of breastfeeding compared with women without diabetes, and their infants are at increased risk of hypoglycemia. Clinicians often suggest pregnant women with diabetes to express breastmilk, and studies have reported increased breastfeeding exclusivity in the early postnatal period for patients who have expressed. Little is known about longer term outcomes. We investigated whether advising low-risk women with diabetes in pregnancy to express beginning at 36 weeks of pregnancy increased exclusivity and maintenance of breastfeeding at 3 months. Methods: We conducted a multicenter, two-group, randomized controlled trial at six hospitals in Melbourne, Australia, between 2011 and 2015. Women were randomized to either standard maternity care or advised to hand express for 10 min twice daily, in addition to standard care. Women were telephoned at 12–13 weeks postpartum and asked a series of questions about feeding their baby, perceptions of their milk supply, and other health outcomes. Results: Of 631 women in the study, data for 570 (90%) were analyzed at 12–13 weeks. After adjustment, we found no evidence that women allocated to antenatal expressing were more likely to be giving only breastmilk (aRR 1.07 [95% CI 0.92–1.22]) or any breastmilk (aRR 0.99 [95% CI 0.92–1.06]) at 12–13 weeks postpartum compared with women in the standard care group. Conclusion: While the practice of antenatal expression for low-risk women with diabetes during pregnancy is promising for increasing exclusivity of breastmilk feeding in hospital, at 12–13 weeks, there was no association with breastfeeding outcomes
HIV self-testing knowledge, attitudes, and practices among Asian-born gay, bisexual, and other men who have sex with men in Australia: a qualitative study
No full textBackground: Achieving virtual elimination of HIV transmission in Australia requires a combination of high treatment rates and high testing coverage among individuals at risk of acquiring HIV. HIV self-testing (HIVST) is an additional testing approach for key populations. Objective: We aimed to examine the knowledge, attitudes, and practices of HIVST among Asian-born gay, bisexual and other men who have sex with men (GBMSM). Methods: This qualitative study used semi-structured interviews of overseas-born GBMSM of Asian background in Australia. Participants were recruited from personal networks, social media platforms, snowballing, and the Melbourne Sexual Health Centre. Twenty-five participants were purposively sampled with a range of ages and previous levels of experience with HIVST. Interview transcripts were imported into Nvivo 12 for data management. Results: The age of the participants ranged from 19 to 44 years, with a median of 30 years. Most were unaware of HIVST before the interview, and only a few had ever used one. All had limited sexual health knowledge (i.e., HIV testing, PrEP) before they arrived in Australia. Upon learning about HIVST during the interview, many expressed willingness to use HIVST, but in limited circumstances, such as traveling overseas, interim testing while taking on-demand PrEP, and point-of-sex testing. Almost all were open to distributing HIVST to their casual partners or friends, especially those they knew who engaged in high-risk sexual practice (i.e., condomless anal sex) and were not engaged in sexual healthcare. About half still preferred conventional serology testing because of regular HIV testing as part of PrEP prescription and the need for testing for other sexually transmitted infections. Conclusion: HIVST may be an acceptable additional testing approach for HIV testing among Asian-born GBMSM. Peer education and secondary distribution may help raise HIVST awareness and use