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Identification of Diseases caused by non-Synonymous Single Nucleotide Polymorphism using Machine Learning Algorithms
No full textLetting Beings Be:Review of: Gary Steiner, What We Owe to Nonhuman Animals: The Historical Pretensions of Reason and The Ideal of Felt Kinship. Routledge Human–Animal Studies Series. London: Routledge, 2024. x + 269 pp. £36.99 (pb), £135.00 (hb).
No full textImmuno-moodulin is Differentially Expressed in T Cells and Plasma in Obsessive-Compulsive Disorder Patients
No full textImmuno-moodulin (Imood), a recently discovered protein expressed in T cells, is associated with anxiety-like behavior in mice. However, its mechanism of action in modulating neuroimmune interactions remains unclear. To investigate this problem, we characterized Imood in human blood and immune cells using neutralizing monoclonal antibodies, revealing its nature as an intrinsically disordered protein (IDP) with unique expression patterns. Our findings indicate that Imood is predominantly expressed intracellularly in peripheral blood mononuclear cells (PBMCs), particularly T lymphocytes, but is absent in polymorphonuclear cells. Upon T-cell activation, Imood exhibits distinct mobilization patterns with increased surface expression. Bioinformatics analysis identified a strong propensity for oligomerization and liquid-liquid phase separation. We also found that T cells from patients with Obsessive-Compulsive-Disorder (OCD) displayed significantly elevated surface Imood expression compared to healthy controls, as well as an altered level of Imood polymerization in the plasma. Taken together, these results elucidate the expression patterns and structural properties of Imood in human immune cells, which open new avenues for OCD diagnostics, and prompt further study for understanding the aetiology of OCD and related disorders
Exploring the impact of green human resource management on firm sustainable performance: roles of green supply chain management and firm size
No full textAn Interdisciplinary Analysis of the lifeworld changes experienced by people whose HIV narratives are published on the Terrence Higgins Trust website
Get PDFTourists, Service Staff, and Food Waste: Examining the Factors that Contribute to Tourists’ Overordering Behavior at Luxury Restaurants
Get PDF© 2024, Cognizant Communication Corporation. This is the final published version of the article (version of record) uploaded in accordance with the publisher’s self- archiving policy. It first appeared online via Cognizant Communication Corporation at the link
Robots and reshoring: a comparative study of automation, trade, and employment in Europe
No full textThis paper constitutes a comparative assessment of the impact of robots on local labor markets across eight European countries. Doing so, we find that robots generally reduce employment in the manufacturing sector, while their impacts on total employment are more ambiguous. Though local markets experienced significant employment losses in Italy, Norway, and the United Kingdom, we find no statistically significant impact of robots on employment in Germany, Sweden, Denmark, Finland, and Spain. Job losses were seemingly offset by employment gains in other sectors of the economy. We explore two mechanisms that might explain these patterns: differences in investment in complementary job-creating technologies and robot-induced reshoring. Our analysis provides some support for both mechanisms in elucidating the differential impacts of robots on jobs across space
