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A dietitian-led coeliac clinic improves gluten free diet adherence and reduces unnecessary duodenal biopsies
No full textPerinatal, obstetric and parental risk factors for asthma in the offspring throughout childhood: a longitudinal cohort study
Get PDF© 2023, Walter de Gruyter GmbH, Berlin/Boston. The attached document (embargoed until 19/06/2024) is an author produced version of a paper published in Journal of Perintal Medicine uploaded in accordance with the publisher’s self-archiving policy. The final published version (version of record) is available online at the link. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it. Objectives Asthma is a common chronic and burdensome disease which typically begins in childhood. The aim of this study was to assess perinatal and obstetric factors which may increase the risk of developing asthma in the offspring. Methods Data from five consecutive waves (n=7,073 children, from birth to 15 years old) from a nationally-representative birth cohort of people born in the United Kingdom between 2000 and 2002, the Millennium Cohort Study (MCS), were used. The Kaplan–Meier survival curve was used to graphically display the risk of developing asthma from early childhood to adolescence. The Z-based Wald test was used to prove significant covariate loading. Results Cox regression analyzing the influence of covariates on asthma development risk showed a significant likelihood ratio test, χ2(18)=899.30, p<0.01. A parent with asthma (OR=2.02, p<0.01), a younger maternal age at delivery (OR=0.98, p<0.05), and the use of assisted reproductive technology (OR=1.43, p<0.05) were associated with an increased risk of developing asthma in the offspring. Conclusions Perinatal factors (a younger maternal age, assisted reproductive technology) and a parental factor (a parent with asthma) increased the risk for developing asthma in the offspring
Distributed RMI-DBG model: Scalable iterative de Bruijn graph algorithm for short read genome assembly problem
Get PDF© 2023, Pergamon Press, Inc. The attached document (embargoed until 22/06/2025) is an author produced version of a paper published in Expert Systems with Applications: An International Journal uploaded in accordance with the publisher’s self-archiving policy. The final published version (version of record) is available online at the link. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it. Genome assembly is the computational process of merging short parts of DNA into larger sequences called contigs. Rapid growth of high-throughput genome sequencing technologies and production of large amount of data have led to the genome assembly paradigms shift from shared memory to distributed memory systems in the recent years. Among the existing assembly algorithms, the iterative de Bruijn Graph is a leading approach for assembling short reads. This approach by exploring the advantages of all k between kmin to kmax, generates high quality assembly. However, the assembly operations are decelerated especially in the larger data sets. RMI-DBG is an agile iterative de Bruijn Graph algorithm that has the computational efficiency of de Bruijn Graph methods and the flexibility of overlap-based algorithms. In this paper, we suggest a distributed iterative DBG model based on RMI-DBG, named DRMI-DBG. The proposed idea is to address the problem of parallelizing the de Bruijn Graph construction and processing on distributed memory systems at each iteration of the algorithm. DRMI-DBG is a scalable iterative DBG framework over a Hadoop cluster by applying the power of Spark (a batch processing engine) and Giraph (a distributed big graph processing system). Experiments on a variety of real data sets show that DRMI-DBG accelerates the performance of RMI-DBG algorithm and IDBA-UD assembler up to 4.8 times with comparable or better results in the quality of the assembly. For more evaluation, performance of the proposed model is compared to ScalaDBG, as the state-of-the-art distributed assembler based on the multiple k-values strategy
Visuo-spatial imagery in dreams of congenitally and early blind: a systematic review
No full textBackground: The presence of visual imagery in dreams of congenitally blind people has long been a matter of substantial controversy. We set to systematically review body of published work on the presence and nature of oneiric visuo-spatial impressions in congenitally and early blind subjects across different areas of research, from experimental psychology, functional neuroimaging, sensory substitution, and sleep research. Methods: Relevant studies were identified using the following databases: EMBASE, MEDLINE and PsychINFO. Results: Studies using diverse imaging techniques and sensory substitution devices broadly suggest that the “blind” occipital cortex may be able to integrate non-visual sensory inputs, and thus possibly also generate visuo-spatial impressions. Visual impressions have also been reported by blind subjects who had near-death or out-of-body experiences. Conclusion: Deciphering the mechanistic nature of these visual impression could open new possibility in utilization of neuroplasticity and its potential role for treatment of neurodisability
Variability in variability: Does variation in morphological and physiological traits differ between men and women?
No full textImpact of COVID-19 initial lockdown on the mental health and lifestyle changes of children in Turkey during the school closure: Impact of COVID-19 lockdown on child mental health.
No full textCreating Synergies between International Law and the Rights of Nature
No full textAgainst the backdrop of failing environmental governance, rights of nature (RoN) are increasingly lauded as the paradigm shift needed to transform law’s approach to nature. RoN have been increasingly proclaimed domestically but remain mostly absent from international law. As examined in this article, this is notably due to some profound incompatibilities between international law and RoN, including the fact that most international treaties approach nature as resource to be owned, exploited or protected for the sake of humans. However, despite this dominant approach to nature, some areas of international law, notably under the leadership of Indigenous peoples, are starting to acknowledge a more relational approach to nature, putting forward concepts of care, kinship and representation of nature in international law. Building on these developments, this article offers a reflection on potential synergies between RoN and international law, specifically by changing the latter’s approach to nature. It argues that some of the RoN concepts concerning duty of care, institutional representation of nature’s voice, and ecocentricism could serve as a platform to re-interpret some of the anthropocentric principles of international law, creating some potential synergies between RoN and international law. <br/
