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"You're Going to Go into Some Really Dark, Dark Places in Your Mind." Loss and Disillusionment of Being Shunned From the Jehovah's Witnesses Community and Its Impact
No full textCorporate Criminal Liability and Complicity in Crimes Against Humanity: Case Note on Recent French Jurisprudential Developments
No full textThis article provides insight into corporate criminal liability as construed in French criminal law. It discusses specifically the history and contingency of the development of corporate criminal liability in French law and its legacy considering the decision of the Cour de cassation in the Lafarge cases. These landmark decisions are the first of their kind rendered by a supreme court anywhere in the world. They acknowledge that corporations, and no longer only directors of companies or corporations, may be found guilty of aiding and abetting terrorism if they have funded known terrorist organisations for business purposes. The decisions also clarify the limited circumstances where interest groups may be founded to bring private prosecutions to this effect. Given the foregoing, this paper outlines in detail the decisions of the Cour de cassation in Lafarge, analyses and contextualises their significance, and offers a long view that considers possible international developments
The evidence on educational methods for political engagement. In Who’s Afraid of Political Education? (pp. 147-162). Policy Press.
No full textSutton Women’s Safety Survey 2023: A report on how safety is perceived by women in the London Borough of Sutton
No full textIntroduction to: Roundtable discussion, 'From the shores of silence: conversations in feminist practical theology'
No full textExpression of antenatal symptoms of common mental disorders in The Gambia and the UK: a cross-sectional comparison study
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Mapeando o desenvolvimento musical em alunos com as necessidades mais complexas: o projeto sounds of intent
No full textKIR-HLA interactions extend human CD8+ T cell lifespan in vivo
No full textBACKGROUND. There is increasing evidence, in transgenic mice and in vitro, that inhibitory killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses. Furthermore, we have previously shown that iKIRs are an important determinant of T cell-mediated control of chronic virus infection and that these results are consistent with an increase in CD8+ T cell lifespan due to iKIR-ligand interactions. Here we test this prediction and investigate whether iKIRs affect T cell lifespan in humans in vivo.METHODS. We used stable isotope labelling with deuterated water to quantify memory CD8+ T cell survival in healthy individuals and patients with chronic viral infections.RESULTS. We showed that an individual’s iKIR-ligand genotype is a significant determinant of CD8+ T cell lifespan: in individuals with two iKIR-ligand gene pairs, memory CD8+ T cells survived on average for 125 days, in individuals with four iKIR-ligand gene pairs then memory CD8+ T cell lifespan was doubled to 250 days. Additionally, we showed that this survival advantage is independent of iKIR expression by the T cell of interest and further that iKIR-ligand genotype altered CD8+ and CD4+ T cell immune aging phenotype.CONCLUSIONS. Together these data reveal an unexpectedly large impact of iKIR genotype on T cell survival