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The significance of bicuspid aortic valve after surgery for acute type A aortic dissection.
No full textTo access publisher's full text version of this article click on the hyperlink belowObjective: Decision-making concerning the extent of the repair of acute type A aortic dissection (ATAAD) includes functional and anatomical assessment of the aortic valve. We hypothesized that bicuspid aortic valve (BAV) does not impact outcome after surgery for ATAAD. We therefore evaluated the outcome after ATAAD surgery in relation to the presence of BAV, acute aortic regurgitation (AR), and surgical approach, using the Nordic Consortium for Acute Type A Aortic Dissection database.
Methods: Eight participating Nordic centers collected data from 1122 patients undergoing ATAAD surgery during the years 2005 to 2014. Early complications, reoperations and survival were compared between patients with BAV and tricuspid aortic valves (TAV) before and after propensity score matching for sex, age, AR, organ malperfusion, hemodynamic instability, and site of the tear. Mean follow-up (range) for patients with TAV and BAV was 3.1 years (0-10.4 years) and 3.2 years (0-9.0 years), respectively.
Results: Altogether, 65 (5.8%) of the patients had BAV. Root replacement was more frequently performed in the BAV as compared with the TAV group (60% vs 23%, P < .001). Survival, however, did not differ significantly between patients with BAV or TAV, either before (P = .230) or after propensity score-matching (P = .812). Even so, in cohort as a whole, patients presenting with AR had less favorable survival.
Conclusions: Early and mid-term survival did not differ significantly between patients with BAV and TAV.Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital
Mats Kleberg Foundation, Stockholm, Swede
Haploinsufficiency of KMT2D is sufficient to cause Kabuki syndrome and is compatible with life.
Get PDFTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadWe present the first patient described with haploinsufficency of KMT2D leading to Kabuki syndrome. Deletion of KMT2D has been thought to be lethal, but here we describe a patient with KMT2D deletion and classical Kabuki syndrome phenotype.Icelandic Research Fund
Louma G. Foundation
Wellcome Trus
Measuring health and its economic significance
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Prescribing physical activity after labour, for women diagnosed with gestational diabetes mellitus
No full textTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadTILGANGUR
Algengi meðgöngusykursýki fer hratt vaxandi og tæplega 19% kvenna
sem fæddu á Landspítala á árinu 2018 höfðu þessa greiningu. Þær
konur sem fá meðgöngusykursýki eru í aukinni hættu að fá hana
aftur á síðari meðgöngum og einnig í aukinni áhættu á að þróa sykursýki tegund 2 síðar á ævinni. Ofþyngd og hreyfingarleysi eru sterkir
áhættuþættir. Hreyfiseðill er meðferðarúrræði sem stendur til boða á
öllum heilbrigðisstofnunum. Markmið rannsóknarinnar var að kanna
áhrif meðferðar með hreyfiseðli eftir fæðingu hjá konum sem höfðu
meðgöngusykursýki, á virkni þeirra, líðan og þætti sem tengjast efnaskiptavillu.
EFNIVIÐUR OG AÐFERÐIR
Konur sem fæddu börn frá 1. janúar 2016 til 30. júní 2017, voru í
mæðravernd hjá Heilsugæslu höfuðborgarsvæðisins og greindust
með meðgöngusykursýki var boðin þátttaka. Þátttakendum var skipt
tilviljanakennt í tvo hópa þar sem annar hópurinn fékk meðferð með
hreyfiseðli í 5 mánuði en viðmiðunarhópurinn hefðbundna meðferð.
Mælingar á blóðgildum, hæð, þyngd, virkni og líðan voru gerðar þremur mánuðum og 8 mánuðum eftir fæðingu.
NIÐURSTÖÐUR
Áttatíu og fjórar konur tóku þátt, 45 í íhlutunarhópi og 39 í viðmiðunarhópi. Virkni jókst marktækt í íhlutunarhópi en ekki urðu marktækar
breytingar á blóðmælingum. Viss áhrif en ekki marktæk mældust á
þyngd, líkamsþyngdarstuðli og lífsgæðum. Þær konur sem voru með
barn sitt á brjósti voru með marktækt lægra insúlín en þær konur sem
ekki voru með barn sitt á brjósti. Sterkari fylgni var á milli þyngdar og
insúlíns en á milli fastandi blóðsykurs og insúlíns.
ÁLYKTUN
Meðferð með hreyfiseðli eftir fæðingu jók marktækt virkni kvenna sem
höfðu meðgöngusykursýki. Brjóstagjöf hefur mögulega áhrif til lækkunar insúlíns
Lipoprotein(a) and risk of cardiovascular disease
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Gold nanoisland substrates for SERS characterization of cultured cells.
Get PDFTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadWe demonstrate a simple approach for fabricating cell-compatible SERS substrates, using repeated gold deposition and thermal annealing. The substrates exhibit SERS enhancement up to six orders of magnitude and high uniformity. We have carried out Raman imaging of fixed mesenchymal stromal cells cultured directly on the substrates. Results of viability assays confirm that the substrates are highly biocompatible and Raman imaging confirms that cell attachment to the substrates is sufficient to realize significant SERS enhancement of cellular components. Using the SERS substrates as an in vitro sensing platform allowed us to identify multiple characteristic molecular fingerprints of the cells, providing a promising avenue towards non-invasive chemical characterization of biological samples.Icelandic Centre for Research
Haskoli Islands
European Research Council (ERC
“This was the most difficult role I have taken on”: lived experiences of close family members as caregivers of a loved one with alzheimer and their experiences of the service provided
No full textTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadBakgrunnur: alzheimer-sjúkdómur er form heilabilunar. fylgikvillar sjúkdómsins eru persónuleikabreytingar sem versna jafnt og
þétt og kalla á stöðugt aukna þörf fyrir umönnun. aðstandendur eru
helstu umönnunaraðilar um leið og þeir takast á við þungbæra sorg
sem hefur áhrif á andlega og líkamlega heilsu þeirra.
Tilgangur: Tilgangur rannsóknarinnar var að kanna reynslu nánustu
aðstandenda af umönnun ástvina með alzheimer-sjúkdóm og reynslu
þeirra af fenginni þjónustu.
Aðferð: rannsóknin var eigindleg. Viðtöl voru tekin við fjórtán einstaklinga þar sem stuðst var við hálfstaðlaðan viðtalsramma. greining á texta var gerð með innihaldsgreiningu og hann flokkaður
samkvæmt innihaldi og sameinaður í meginþema og yfir- og undirþemu sem lýstu reynslu þátttakenda í gegnum sjúkdómsferlið ásamt
reynslu þeirra af þjónustunni í ferlinu.
Niðurstöður: niðurstöður gáfu vísbendingar um að djúp sorg einkenndi allt sjúkdómsferlið. hún fylgdi öllum gjörðum og ákvörðunum aðstandenda og eftir andlát tók við nýtt sorgarferli. Erfiðast
og sárast var þegar óhjákvæmilegt var að flytja ástvin á öldrunarheimili. Þemagreining sýndi yfirþemað: erfiðleikar aðstandenda alzheimer-sjúklinga eru margvíslegir vegna breytinga á hlutverki. fimm
meginþemu mynduðu samfellu í reynsluferli aðstandenda frá greiningu til lífsloka ástvinar þeirra. hvert meginþema var byggt á
nokkrum undirþemum.
Ályktanir: niðurstöður gefa til kynna að til þess að árangur náist í
umönnun og þjónustu sem veitt er alzheimer-sjúklingum og þeirra
nánustu er nauðsynlegt að hafa innsýn í þá djúpu sorg sem fylgir
sjúkdómnum. Stuðningur og ráðgjöf til alzheimer-sjúklinga og aðstandenda þeirra þarf að vera í mun fastari skorðum en hún er í dag.
Bjóða þarf upp á úrræði sem styrkja einstaklinginn bæði andlega og
líkamlega og taka upp ákveðna stefnu í málefnum þeirra er greinast
með þennan sjúkdóm og ástvina þeirra.
Lykilorð: aðstandendur, alzheimer-sjúkdómur, álag, líðan, erfiðleikar, hjúkrunarheimili, samskipti.Background: alzheimer’s disease is a form of dementia. Complications of the disease are deterioration appearing as behavioural
changes and increased need for care. family caregivers deal with
complicated grief affecting their psychological and physical health.
Aim: The aim of the study was to examine the experiences of close
family members as caregivers of a loved one with alzheimer and
their perspectives on the service provided.
Method: a qualitative method was utilized. fourteen interviews
were conducted using a semi-structured interview-frame. The text
was analysed with the methods of content analysis and categorised
into a main theme, themes and subthemes describing participants
experiences throughout the disease process as well as their experiences of the service provided through the course of the disease.
Results: results indicated that deep grief characterised the whole
disease trajectory. relatives’ decisions and actions were shaped by
grief and after the death of their loved one a new process of grief
began. The most difficult and hurtful experience was having to
transfer the loved one to a nursing home. Thematic analysis revealed an overarching theme: family caregivers of Alzheimer patients experience various difficulties because of role changes. five
main themes formed continuity in the family experiences from
the time of diagnosis to the end of life of their loved one. Each
theme contained few sub-themes.
Conclusion: results indicate that to achieve success in the care and
service provided for individuals with alzheimer and their close
family members, insight into the overwhelming grief associated
with the disease is essential. Support needs to be far more structured than it is today. Solutions need to exist which strengthen
both psychological and physical well-being of those diagnosed
with the disease and their loved ones.
Keywords: relatives, alzheimer, distress, health, difficulties, nursing home, communications
Effective treatment with balneophototherapy and narrowband UVB monotherapy reduces skin homing Th17/Tc17 and Th22/Tc22 effector cells in peripheral blood in patients with psoriasis.
No full textTo access publisher's full text version of this article click on the hyperlink belowLandspitali University Hospital Research Fund
Icelandic Technology Development Fund
Blue Lagoon Clini
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Get PDFTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadHeart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MYOZ1, SYNPO2L), protein homoeostasis (BAG3), and cellular senescence (CDKN1A). Mendelian randomisation analysis supports causal roles for several HF risk factors, and demonstrates CAD-independent effects for atrial fibrillation, body mass index, and hypertension. These findings extend our knowledge of the pathways underlying HF and may inform new therapeutic strategies.Siemens Diagnostics
Aegerion Pharmaceuticals
Amgen
AstraZeneca
Danone Research
Hoffmann-La Roche
MSD
Pfizer
Sanofi
Synageva
BASF
Abbott Laboratories
Numares AG
Berlin-Chemie
GlaxoSmithKline
Eisai Inc
Merck & Company
AstraZeneca
Johnson & Johnson USA
Novo Nordisk
Bayer AG
Bristol-Myers Squibb
Pfizer
Boehringer Ingelheim
Bayer A
Activity calculator: a method for achieving a balanced lifestyle for people with chronic fatigue
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