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Il Giudice costituzionale “assolve” il legislatore retrospettivo che cancella le “iniquità” del passato...e assesta un nuovo colpo al legittimo affidamento
No full textSoffermandosi su alcune recenti pronunce della Corte costituzionale, l’Autrice focalizza la sua indagine sui limiti costituzionali della legislazione ad effetti retroattivi e sulla tutela del legittimo affidamento, il quale, nonostante sia stato da tempo elevato ad “autonomo referente costituzionale”, incontra un’applicazione tutt’altro che ferma. Nella giurisprudenza costituzionale più recente si registra, in particolare, una problematica apertura su fronte dei “legittimi” scopi che il legislatore potrebbe perseguire attraverso la normativa retroattiva, determinando un ulteriore significativo colpo alla tenuta della sicurezza dei rapporti giuridici. Registrato l’abbandono, da parte della Corte, di ogni residuo tentativo di ricostruire la retroattività come un disvalore in sé, l’Autrice rileva problematicamente la promozione, tra gli obiettivi della legislazione ad effetti retroattivi idonei a giustificare il sacrificio del legittimo affidamento, la modifica dell’assetto di rapporti già definiti da precedenti leggi non rispondenti a criteri di “equità”.Analyzing some recent rulings of the Constitutional Court, the Author focuses on the constitutional limits of legislation with retroactive effects and the protection of legitimate expectation, which meets anything but a strong application, despite it has been considered an “autonomous constitutional referent” for a long time.
In the most recent constitutional jurisprudence, there is a problematic opening on the front of the “legitimate purposes” that the legislator might pursue through retroactive legislation. The result is a further hard blow to the legal certainty. Noting the abandonment by the Court of any last-ditch effort to evaluate retroactivity as a disvalue in itself, the author problematically takes into account the modification of the relationships considered against “equity” among the objectives of legislation with retroactive effects suitable for justifying the sacrifice of legitimate expectations
Cosa rende un territorio capace di attrarre imprese e persone?
No full textCos’è davvero l’attrattività di un territorio?
E perché è così centrale per imprese, competenze e sviluppo locale? In questo episodio di Parliamone Chiaro, le nostre Paola Mattavelli e Paola Landriani dialogano con la professoressa Maria Prezioso (Università di Roma Tor Vergata), esperta di geografia economica e pianificazione, per capire cosa significa rendere un territorio competitivo senza rinunciare a identità, sostenibilità e coesione. Scopriremo perché infrastrutture e incentivi non bastano, e perché la coesione sociale è una vera infrastruttura.
E soprattutto, perché l’attrattività non nasce per caso, ma da scelte strategiche, condivise e lungimiranti
Padre Facchinetti, il cardinale Salotti e il patronato francescano sull’Italia. Due protagonisti a confronto
No full textDue illustri ecclesiastici, tra i più ricercati del loro tempo per l’arte oratoria, si collocano agli estremi cronologici del processo di promozione in chiave nazionalistica del culto di Francesco d’Assisi durante il ventennio fascista: padre Vittorino Facchinetti, forse l’uomo più in vista dell’Ordine dei Minori, celebre per la sua attività di radiopredicatore e dal 1936 vicario apostolico della Tripolitania , e il cardinale Carlo Salotti, prolifico agiografo e personaggio chiave della Congregazione dei Riti della prima metà del Novecento, dove giunse a ricoprire il ruolo apicale di Prefetto . Se il francescano fu, insieme al sindaco e poi podestà di Assisi Arnaldo Fortini, il protagonista indiscusso delle celebrazioni del VII centenario del 1926 , il cardinale ebbe un ruolo determinante nella promulgazione del breve Licet commissa con cui Pio XII il 18 giugno del 1939 proclamò Francesco d’Assisi e Caterina da Siena patroni primari d’Italia.
Il saggio pone a confronto le due figure e il diverso atteggiamento tenuto nei confronti del Regime
Fluoride selective nanostructural optodes – Introducing nanofibers based sensing analytical devices nFADs
No full textAn alternative for paper-based analytical devices is proposed – a nanofibers mat, a porous structure prepared from plasticized lipophilic polymer containing fluoride selective corolla ionophore and ion-exchanger. This structure is applied as a receptor allowing camera assisted readout of optical signal related to change of fluoride anions concentration in a sample due to the presence of Si-corrole ionophore. A linear relation of color intensity of the probe in red or green channel on logarithm of analyte concentration in the sample within the range from 10−6 to 10−1 M was obtained. Advantageously analytical signal is obtained within short time and due to applied modification of nanofibers mat, addition of a pH buffer to the sample is not necessary. Herein proposed system – nanofiber based analytical device, nFAD, is analogous to a paper micropads system
Nectin-4-Targeting Radiotracers: Novel Theranostic Agents for Precision Oncology in Cancer
Full text linkNectin cell adhesion molecule 4 (Nectin-4) is specifically overexpressed in most cancers of epithelial origin but downregulated in normal tissue, representing an ideal target for positron emission tomography imaging. The development of positron emission tomography imaging probes targeting Nectin-4 has gained significant attention in recent years, especially after the approval in December 2019 by the US Food and Drug Administration of enfortumab vedotin-an antibody drug conjugate targeting Nectin-4-in patients with locally advanced or metastatic bladder cancer. This article aims to comprehensively review original research articles discussing preclinical development or early translational clinical applications of radiolabeled probes targeting Nectin-4. The main radioactive compounds investigated belong to two classes, antibody-based radiopharmaceuticals and peptide-drug conjugates, in particular novel bicyclic peptides. While monoclonal antibody-based probes have demonstrated theranostic potential in preclinical studies, their clinical application has been hindered by their slow pharmacokinetic properties. However, peptide-based positron emission tomography/computed tomography tracers offer several advantages, such as ease of handling in synthesis, a more favorable biodistribution, and lower immunogenicity and have been tested in preliminary clinical experiences
Use of an Off the Shelf Inner Branch Thoraco-abdominal Endograft for the Treatment of Juxtarenal and Pararenal Aortic Aneurysms
Full text linkObjective: To investigate outcomes of an off the shelf pre-loaded inner branched endograft (E-nside) for the treatment of juxtarenal and pararenal abdominal aortic aneurysms (JP-AAAs). Methods: Data from a multicentre registry (INBREED), including patients treated with the E-nside endograft, were collected and analysed prospectively. Patients treated for JP-AAA were included. Pre-operative clinical and anatomical characteristics, procedural data, and 30 day and one year outcomes were recorded. Endpoints were technical success, 30 day death, major adverse events (MAEs), and one year freedom from target vessel instability. Results: Of 185 consecutively treated patients, 47 (25.4%) had a JP-AAA (juxtarenal n = 10, 21%; pararenal n = 37, 79%) and were included in the study; 183 target vessels were incorporated through an inner branch. Procedural setting was emergency or urgent in 18 patients (38%) owing to a contained aortic rupture (n = 2, 4%), symptomatic aneurysm (n = 4, 9%), or aneurysm > 70 mm (n = 12, 26%). The mean length of aortic coverage above the coeliac trunk was 116 ± 7 mm. Technical success was 100% and 30 day mortality rate 4% (n = 2 urgent cases). The 30 day cumulative MAE rate was 26% (n = 12): two stroke (4%); and seven spinal cord ischaemia (15%), with six in an elective setting (21%) and one in an urgent setting (6%), and five leading to permanent paraplegia or paraparesis (10%). Freedom from target vessel instability was 99% after 30 days and 97 ± 3% after one year. Conclusion: Use of an off the shelf inner branched device for treating JP-AAA was feasible in urgent and elective settings, with high technical success and satisfactory target vessel stability at one year. In the treatment of JP-AAA, stroke and spinal cord ischaemia may be associated with arm access and the increased aortic coverage that the design brings
Cross-section measurements for the production of a W-boson in association with high-transverse-momentum jets in pp collisions at root s = 13 TeV with the ATLAS detector
Full text linkA set of measurements for the production of a W-boson in association with high-transverse-momentum jets is presented using 140 fb−1 of proton–proton collision data at a centre-of-mass energy of root s = 13 TeV collected by the ATLAS detector at the LHC. The measurements are performed in final states in which the W-boson decays into an electron or muon plus a neutrino and is produced in association with jets with pT > 30 GeV, where the leading jet has
pT > 500 GeV. The angular separation between the lepton and the closest jet with pT > 100 GeV is measured and used
to define a collinear phase space, wherein measurements of kinematic properties of the W-boson and the associated jet are performed. The collinear phase space is populated by dijet events radiating a W-boson and events with a W-boson produced in association with several jets and it serves as an excellent data sample to probe higher-order theoretical predictions. Measured differential distributions are compared with predictions from state-of-the-art next-to-leading order multi-leg merged Monte Carlo event generators and a fixed-order calculation of the W +1-jet process computed at nextto-next-to-leading order in the strong coupling constant
Direct Oral Anticoagulant Use in Older Adults with Atrial Fibrillation: Challenges and Solutions
No full textAF is the most common arrhythmia in clinical practice, with a large preponderance in the older (>75 years) adult population. Stroke is the most feared complication of AF, with huge corresponding morbidity and mortality. Anticoagulation is the mainstay for stroke prevention in AF, but is commonly underutilised in clinical practice due to the fear of intracerebral bleeding. Bleeding is the primary concern in older patients with conventional vitamin K antagonist use. Direct oral anticoagulants (DOACs) have been used for a decade in clinical practice and have been found to reduce major bleeds. The advantages of DOAC use in older patients include obviating the need for intermittent international normalised ratio monitoring, fewer drug interactions and reduction in intracerebral haemorrhage. The disadvantages of DOAC use include older patients having to take multiple doses per day and a lack of a universal antidote, as opposed to vitamin K antagonists. However, a lack of head-to-head trials among DOACs and specific randomised controlled trials in older patients preclude a definite conclusion regarding the ideal DOAC that should be used in the older population. Factor XI inhibition is an emerging approach for oral anticoagulation that holds promise for dissociating thrombosis from haemostasis. This provides an additional avenue for reducing bleeding in the older adult population