18397 research outputs found
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Model-based engineering approach for heat transfer analysis and simulation of double diaphragm preforming of carbon fibre reinforcements
No full textThis research focuses on improving how carbon fibre materials are heated and shaped during aircraft manufacturing. By studying how heat moves through layers of fabric and silicone, and creating a computer model that simulates the process, the study helps manufacturers predict temperature and heat loss more accurately. The results show how different heating methods affect material quality. This work can lead to better production methods that use less energy, reduce waste, and ensure stronger, more reliable parts for industries like aerospace and transport.</p
Investigating the Role of Sphingosine-1-Phosphate Lyase (SPL) Inhibition in Inflammatory Demyelination Using an Experimental Model of Multiple Sclerosis
No full textMultiple Sclerosis (MS) is a debilitating neurological condition driven by immune-mediated damage to myelin, the protective sheath around nerve fibres. While current therapies focus on modulating the immune system to reduce relapses, they fall short in halting the progressive disability ultimately underpinned by myelin loss. Leveraging a high-throughput drug screening approach, this research identified a strategy that suppresses inflammation and protects myelin and myelin-forming cells via regulating the metabolism of sphingosine-1-phosphate (S1P), a bioactive lipid in the brain. The results of this research could pave the way for a new class of MS therapies to not only prevent disease progression but also restore function.</p
Enabling older adults’ confidence in technology use in residential care settings
No full textThis research investigates confidence of older adults using technology. The aim was to understand how to support older adults in building and sustaining confidence, enabling them to benefit from technology in everyday lives. Guided by Participatory Action Research, this research conducted fieldwork in three different residential aged care settings. Findings show that positive experiences and pre-existing interests are key to building confidence, as demonstrated through indicators. A Confidence in Technology Use Framework was developed, providing theoretical guidance to researchers on observing and evaluating older adults' confidence in technology use, and offering practical guidance to technology support services for older adults.</p
Chapter 3: Coalitions and partnerships for advanced recycling in Australia
No full textNo description supplied</p
Deformation of metallic plates under hailstorm impact
No full textSevere hailstorms may cause substantial damage in urban areas, leading to high costs for repairing or replacing windows, vehicles and building claddings. The severity of the impact depends on various factors, including the mass, the velocity and the strength of the hail ice. This research investigates the factors that influence the severity of hail ice impacts and explores the potential to predict the deformation of a metallic plate subjected to such impacts, offering insights for further studies on hail ice impact phenomena.</p
The Impact of Early Life Exposure to Intimate Partner Violence on Children’s Social Functioning: Pathways of Risk and Protection
No full textThis thesis by publication highlighted the long-term impacts of children’s early life exposure to intimate partner violence on their social development, including peer relationships, social skills, peer victimisation and bullying. Mothers’ depressive symptoms were identified as a key pathway of risk to poor social development, while emphasising the protective role of parenting engagement for the development of children’s social skills. Early childhood educators shared the vital role that they can play in supporting affected children, and the need for further training and resources to better understand and support families affected by intimate partner violence. Finally, the findings underscored the importance of recognising children’s strengths despite social challenges, and providing safe, supportive relationships to foster curiosity, learning, and healthy social development following early life trauma.</p
Understanding Young Adults' Entrepreneurial Intention: The Mediating Role of Entrepreneurial Alertness in the Perspective of Theory of Planned Behaviour
No full textThis study explores what motivates young adults to consider starting their own businesses. It examines how passion, confidence, social support, and the ability to recognize opportunities influence their decisions. The research also looks at how being alert to business opportunities helps connect personal beliefs to the intention to become an entrepreneur. The findings provide useful insights for educators and policymakers to better support young people in building an entrepreneurial mindset, which may lead to increased self-employment and innovation in society.</p
Uptake Study of Gold Nanoparticles into the Mammalian Cell Using High Order Image Correlation Spectroscopy
No full textNanotechnology has made great strides in medicine, particularly with gold nanoparticles (AuNPs) for cancer treatment and diagnostics due to their unique optical properties. Traditional therapies like chemotherapy often harm healthy cells, prompting the need for targeted methods. AuNPs, with their tunable size, biocompatibility, and surface plasmon resonance, show promise. However, understanding their behavior in cells remains incomplete. This project proposes using high-order image correlation spectroscopy (HICS) alongside dark field and confocal microscopy to accurately track AuNP aggregation and uptake in real time, offering potential improvements in cancer diagnostics, drug delivery, and therapeutic monitoring.</p
Entity Alignment in Multi-lingual, Temporal, and Probabilistic Knowledge Graphs
No full textThis Thesis focuses on dynamic knowledge graphs, specifically addressing entity alignment. In temporal scenarios, take weather forecasting as an example. Our methods can analyze historical data from knowledge graphs over time, improving prediction accuracy. In probabilistic knowledge graphs, in medical research, it deals with uncertain patient symptoms and test results. Doctors can make more informed diagnoses, potentially saving lives. By streamlining knowledge utilization, it not only boosts efficiency in these diverse fields but also enriches user experiences, ultimately bringing widespread benefits to society, from enhancing scientific research capabilities to making daily life more convenient.</p
Mechanical Properties of Rubber-Soil Mixtures with Bitumen for Sustainable Geotechnical Applications
No full textThis project builds on the growing trend of recycling tyre rubber in geotechnical applications through rubber-soil mixtures. Its main contribution is the enhancement of these mixtures by incorporating bitumen and examining its effects on their static, dynamic, and post-cyclic properties. Beside the environmental benefits, the significance of this research lies in its potential to improve the seismic performance of soil beneath foundations, while also enhancing bearing capacity and reducing settlement in the conventional rubber-soil mixtures.</p