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THE EFFECT OF RETICULOCYTE HEMOGLOBIN CONTENT ON THE DIAGNOSIS OF IRON DEFICIENCY ANEMIA: A META-ANALYSIS STUDY
No full textBackground: Iron deficiency anemia (IDA) is the most common type of anemia worldwide and has many adverse effects on life quality. This meta-analysis study aims to show that reticulocyte hemoglobin content (CHr) is more effective than routinely used parameters in the diagnosis of IDA. Methods: Comprehensive and systematic research was done using international databases including PubMed, Web of Science, Cochrane Library, Science Direct, and Google Scholar, which contain all articles published on IDA until December 29, 2020. Seventeen articles were included in the meta-analysis. Results: The analyses found the Cohens deffect size (Standardized Mean Difference) values of the parameters. Accordingly, CHr is 2.84 (95\% CI 2.36 to 3.31), mean corpus volume (MCV) is 2.46 (95\% CI 1.97 to 2.95), ferritin is 2.37 (95\% CI 1.63 to 3.11), and transferrin saturation (TSAT) is 3.76 (95\% CI 2.14 to 5.38). To diagnose IDA, the sensitivity value of the CHr concentration was found as 83.5\% (95\% CI 76.1 to 89.8), specificity value to be 91.8\% (95\% CI 85.5 to 96.4), and mean cut-off value as 28.2 pg. Conclusions: The results of our study reveal the findings that CHr is a better biomarker than MCV and ferritin used in determining IDA, and its efficacy is lower than TSAT. It is very important to use it routinely for the pre-diagnosis of IDA, which is very important for public health. The groups in the study are heterogeneous but contain bias. Therefore, meta analyses of studies with less heterogeneity of CHr are needed.11-134
14-16 yaş adolesanların akdeniz diyetine uyumu ile bağırsak sağlığı arasındaki ilişkinin değerlendirilmesi
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Benign Paroxysmal Positional Vertigo: Is It Really an Otolith Disease?
No full textThe current theory in physiopathology of benign paroxysmal positional vertigo is the mechanical theory, namely the cupulolithiasis-canalolithiasis theory. Repositioning maneuvers based on this theory has now taken place in therapy. However, mechanical theory is insufficient to explain some clinical situations and cannot fully enlighten the physiopathology. Mechanical theory is based on very few histological studies. Currently, these few articles are still used for reference. Anatomically, there are uncertainties that need to be explained in this theory. In this literature review, the histological and anatomical evidence is reviewed and the value of mechanical theory in benign paroxysmal positional vertigo physiopathology has been questioned. Studies suggest that the debris in the semicircular canals is caused by degeneration due to aging and may not be responsible for the symptoms in benign paroxysmal positional vertigo. Some patients with debris in semicircular canals do not have benign paroxysmal positional vertigo symptomatology, while some patients without debris may have benign paroxysmal positional vertigo symptomatology. Experimental and histological findings suggest that vestibulopathy due to inflammation caused by neurotropic viruses may lead to benign paroxysmal positional vertigo picture. For all these reasons, in benign paroxysmal positional vertigo physiopathology, there must be other factors besides particle debris in semicircular canals.1JAN62-701
Effects of Anemia on Clinical Outcomes in Hospitalized Patients with COVID-19 Pneumonia
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Objective: We aimed to examine the role of anemia on clinical outcomes including intensive care unit (ICU) admission
and mechanical ventilation (MV) in coronavirus disease 2019 (COVID-19) patients.
Materials and methods: Totally 175 hospitalized COVID-19 patients were retrospectively included. Patients with a
hemoglobin level of <12 g/dL in women and <13 g/dL in men constituted the anemic group, while COVID-19 patients
with normal hemoglobin levels constituted the non-anemic group. A logistic regression analysis was performed to
investigate the role of anemia and serum ferritin value for prediction of ICU and MV requirement.
Results: Of patients, 46 (45.7%, 21 men) had anemia and 129 (68.2%, 88 men) had normal hemoglobin levels. The ICU
requirement and MV rates were significantly higher in anemic group compared to non-anemic group (30.4% vs. 15.5%,
respectively; p=0.028 and 23.9% vs. 10.9%, respectively; p=0.030). Median length of hospital and ICU stay was longer in
patients with anemia (10.5 days vs. 8 days, respectively; p=0.047 and 0 days vs. 0 days, respectively; p=0.027). Anemia
and ferritin were significant risk factors for ICU admission in univariate model and multivariate model [OR: 2.384 (95% CI:
1.084-5.246), p=0.031] vs. [OR: 2.738 (95% CI: 1.130-6.635), p=0.026] and [OR: 5.058 (95% CI: 1.968-12.998), p=0.001]
vs. [OR: 4.218 (95% CI: 1.521-11.697), p=0.006]. Anemia was also a risk factor for MV [OR: 2.582 (95% CI: 1.075-6.197),
p=0.034].
Conclusion: Requirement for therapy in ICU and MV were high among anemic COVID-19 patients. Anemia is also
associated with prolonged length of stay in hospital and ICU
8-10 yaş arası taekwondo ve cimnastik soprcularında beden algısı ve beslenme durumunun saptanması
No full textNovel methods for driver gene and anti-cancer pharmacotherapy prioritization in personalized oncology
No full textCHOLERA EPIDEMICS IN THE LATE OTTOMAN ISTANBUL, HEALTHCARE AND THE FRENCH CATHOLIC SISTERS OF CHARITY
No full textThis article is about the healthcare services provided by the Sisters of Charity (Filles de la Charite) during cholera epidemics in institutions opened and managed in nineteenth century Istanbul as part of their Eastern missions. The annuals in which reports and letters were collected and addressed to the center of the congregation in Paris, Annales de la Congregation de la Mission et des Filles de la Charite (ACM), are used as primary sources. This study aims to evaluate the pandemies of cholera within the framework of world history and Ottoman context by contributing to the existing historical geographies of cholera, in addition to the literature, which accentuates the importance of agency of women in the Ottoman context, based on original findings. The article assesses how cholera affected Istanbul and how the disease was dealth with, through the connections between the sisters and local actors. The study also shows that the Ottoman example was not only a result of Western experiences, but although it was part of a wide history of pandemics, its actors had their own unique developments shaped by imperial and local settings and events.1JAN-JUN7
A Cell Culture Chip with Transparent, Micropillar-Decorated Bottom for Live Cell Imaging and Screening of Breast Cancer Cells
No full textIn the recent years, microfabrication technologies have been widely used in cell biology, tissue engineering, and regenerative medicine studies. Today, the implementation of microfabricated devices in cancer research is frequent and advantageous because it enables the study of cancer cells in controlled microenvironments provided by the microchips. Breast cancer is one of the most common cancers in women, and the way breast cancer cells interact with their physical microenvironment is still under investigation. In this study, we developed a transparent cell culture chip (Ch-Pattern) with a micropillar-decorated bottom that makes live imaging and monitoring of the metabolic, proliferative, apoptotic, and morphological behavior of breast cancer cells possible. The reason for the use of micropatterned surfaces is because cancer cells deform and lose their shape and acto-myosin integrity on micropatterned substrates, and this allows the quantification of the changes in morphology and through that identification of the cancerous cells. In the last decade, cancer cells were studied on micropatterned substrates of varying sizes and with a variety of biomaterials. These studies were conducted using conventional cell culture plates carrying patterned films. In the present study, cell culture protocols were conducted in the clear-bottom micropatterned chip. This approach adds significantly to the current knowledge and applications by enabling low-volume and high-throughput processing of the cell behavior, especially the cell-micropattern interactions. In this study, two different breast cancer cell lines, MDA-MB-231 and MCF-7, were used. MDA-MB-231 cells are invasive and metastatic, while MCF-7 cells are not metastatic. The nuclei of these two cell types deformed to distinctly different levels on the micropatterns, had different metabolic and proliferation rates, and their cell cycles were affected. The Ch-Pattern chips developed in this study proved to have significant advantages when used in the biological analysis of live cells and highly beneficial in the study of screening breast cancer cell-substrate interactions in vitro.1JAN1
Predictive value of ectopic inner foveal layer without internal limiting membrane peeling for idiopathic epiretinal membrane surgery
No full textPurpose To investigate the clinical importance of ectopic inner foveal layer (EIFL) grading (mild to severe) in patients diagnosed with idiopathic epiretinal membrane (iERM) and had pars plana vitrectomy (PPV) with solely ERM peeling. Materials and methods Patients diagnosed with iERMs who had undergone PPV including only ERM peeling were enrolled in the study, and follow-up findings were recorded at baseline, and at 3, 6, 12 months and final examinations. EIFL was categorized into four grades, from mild to severe. Pre- and postoperative anatomical changes were measured using spectral domain optical coherence tomography (SD-OCT) imaging. The association between EIFL and other SD-OCT parameters with best-corrected visual acuity (BCVA) was assessed before and after PPV surgery. Results One-hundred thirty-eight eyes of 106 patients with mild to severe EIFL were included in the study. Higher EIFL thickness was significantly correlated with lower baseline (r = 0.575, p = 0.020) and final BCVA (r = 0.748, p = 0.001). Although EIFLs continued in advanced-stage cases (stage 3 and 4) (64 eyes {[}82\%]) at the final visit, it was observed in 8 eyes (23\%) in the early stage (stage 2) of iERMs. A strong positive correlation was found between EIFL thickness and recurrence rate of ERM (r = 0.876, p < 0.001). Recurrence of ERM was detected in 27 eyes2 (7\%) at stage 1, 3 (9\%) at stage 2, 10 (23\%) in stage 3, and 12 (33\%) in stage 4 (p < 0.001). Conclusion A negative association was found between the severity of EIFL and postoperative anatomical and visual recovery. In terms of surgical timing, early stages (stages 1 and 2) may be preferred for providing good anatomical and visual recovery and a low recurrence rate following surgery.6JUN1885-18964