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Evaluation of The Effect of Abscissa Part on Seismic Response of Historical Masonry Church
No full textChurch buildings, which are the worship buildings of the Christian faith, were built in different plan typologies in different regions. There are many church structures built in Anatolia during the Ottoman Period. During the population exchange period in 1924, Muslims settled in the settlement areas instead of the non-Muslim community in Anatolia. In this period, church buildings were converted into mosque structures due to the change in the religious belief of the people. These structures, which are used by cultures belonging to and which are components of urban identity, have gained a place in the memory of the citizens. For this reason, it is necessary to ensure sustainability by protecting it. Churches have been destroyed either completely or locally due to earthquakes that have occurred over time. In this study, it is aimed to examine the earthquake behavior of the structure used as the Maden Mosque in Amasya. The effects and causes of this structural element on the dynamic behavior of the church, whose apse was destroyed, were investigated and reinforcement suggestions were presented accordingly. The 3D finite element model of the church has been developed, and structural responses were investigated under linear and nonlinear dynamic loads. As a result of the analyses, it has been determined that the most critical parts of the structure are the nave and wall at the west facade
Detection of COVID-19 Incidentally in 68Ga-PSMA PET/CT for Restaging of Prostate Cancer
No full textBackground: A series of pneumonia cases with clinical presentations of viral pneumonia secondary to new coronavirus and subsequent global transmission arose in Wuhan, Hubei, China, in December 2019. Several cases of coronavirus disease 2019 (COVID-19) have been described incidentally in positron emission tomography-computed tomography (PET/CT) with F-18-fluorodeoxyglucose (FDG) as a result of the pandemic. Herein, we describe the findings of a patient with unknown COVID-19 in PET/CT with the other radiopharmaceutical, Ga-68-labeled prostate-specific membrane antigen (Ga-68-PSMA). Case Report: A 69-year-old man had previously undergone radical prostatectomy for adenocarcinoma. Ga-68-PSMA PET/CT imaging was performed due to biochemical recurrence. Ga-68-PSMA uptake in the prostate bed suggestive of local recurrence was detected in PET/CT images. Also, bilateral ground-glass opacities with slightly increased Ga-68-PSMA uptake were seen in the lungs, suspected of COVID-19. A reverse transcription-polymerase chain reaction test has confirmed the infection. Conclusion: Even in asymptomatic patients, nuclear medicine departments must be aware of the possibility of COVID-19, take appropriate post-exposure procedures, and protect employees and other patients
Cervicovaginal coronavirus disease 2019 (COVID-19) positivity: A pilot study
No full textSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can potentially infect female reproductive organs. In this study, we investigated the presence of SARS- CoV-2 in cervicovaginal fluid. This study included 31 female patients aged 18–65 years. The presence of SARS-CoV-2 RNA was investigated by RT?PCR in two separate cervicovaginal swab samples collected from patients 14 days apart. Viral RNA was extracted using Bio-Speedy ®vNAT® Viral Nucleic Acid Buffer (vNAT) solution, and SARS-CoV-2 RNA was analyzed using Bio-Speedy SARS-CoV-2 RT?qPCR kits in a Bio-Rad CFX96 TouchTM device. First and second cervical swab samples were collected 14 days apart. The SARS-CoV-2 RNA result was negative in all 53 cervicovaginal swab samples collected. Negative SARS-CoV-2 RNA results in cervicovaginal swab sam- ples indicate that coronavirus disease 2019 (COVID-19) is not sexually transmitted. However, the number of studies on this subject and the sample size examined are still insufficient for reaching this conclusion
The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia
No full textOBJECTIVE: Fibromyalgia (FM) is a clinical syndrome characterized by prominent physical and psychological impairment and widespread pain on both sides of the body, above and below the waist, and along the axial skeleton. It often causes sleep difficulties, memory impairment, mood changes, irritable bowel syndrome, and fatigue. Our study aimed to investigate the relationship between FM and prolidase (peptidase D) and histone H3 protein levels by comparing a patient group with a healthy control group. PATIENTS AND METHODS: In total, 176 people were examined in our study, 88 of whom were healthy and 88 of whom had FM. Serum level was measured by ELISA. Then the results were analyzed using SPSS. All p < 0.05 were considered statistically significant. RESULTS: A significant increase in the levels of prolidase was observed in the patient group compared with the control group (6.28-4.68, p <0.001). Histone H3 protein values were not significantly different between the patient and control groups (p=0.184). The ROC analysis indicated that prolidase was statistically significant in disease prediction (p<0.001, AUC: 0.795 (0.697-0.893), while histone H3 protein was statistically insignificant in predicting disease. CONCLUSIONS: The results of the study show that prolidase activity may play a role in diagnosing FM. In addition, since no study like ours has been performed before, it can bring a new perspective to the literature. © 2022 Verduci Editore s.r.l. All rights reserved
İnsan Kaynakları Yönetiminde Dijitalleşme: Bibliyometrik Bir İnceleme
No full textDijitalleşmeyle birlikte iş dünyasında dijital iş modelleri, dijital stratejiler, dijital kültür ve dijital insan kaynağı gibi kavramlar gündeme gelmeye başlamıştır. İnsan Kaynakları Yönetimi’nin (İKY) dijital dönüşümü de hem örgütsel hem de bireysel boyutta son yılların dikkat çeken araştırma alanlarından biri olmuştur. İKY alanında dijital dönüşüm genel olarak operasyonel ve rutin İK süreçlerinin dijital teknolojilerle entegre edilerek otomatik hale gelmesini ifade eder. Böylece İKY verilere dayalı kararlar alabilen, objektif, şeffaf ve verimli bir işletme fonsksiyonuna dönüşür. Bu çalışmada 2012-2021 tarihleri arasında Web of Science Core Collection veri tabanından elde edilen ve İKY’de dijitalleşmenin ve dijital teknolojilerin kullanımını konu edinen uluslararası araştırma ve inceleme makaleleri bibliyometrik analizlerle incelenmiş ve sınıflandırılmıştır. İKY alanında dijitalleşmeyi ve dijital dönüşümü konu edinen toplamda 406 makale verisinden hareketle yayınların yıllara göre dağılımı, tek yazarlı ve çok yazarlı yayın sayısı, yayınlara yapılan atıf sayıları, en üretken yazarlar, ülkeler ve dergiler gibi bilgiler ortaya çıkarılmıştır. Ayrıca, VOSviewer yazılımı ile veriler arası ilişkilerin grafiklerle görselleştirmenin yanı sıra veri kümelerindeki ağ yapıları da ortaya çıkarılmıştır. Makale ortak atıf analizlerinden yararlanılarak elde edilen sınıflandırmaya göre üç temel araştırma alanı elde edilmiştir: “İK Analitiği”, “E-İKY Yaklaşımı” ve “Endüstri 4.0, Akıllı İK Uygulamaları ve Performans İlişkisi”. Bu çalışma, İKY alanındaki dijitalleşme girişimlerini araştırma ve bu alandaki akışı anlamaya yönelik ilk araştırma girişimlerinden olması bakımından önem arz etmektedir
The Frequency of Synchronous Parathyroid Adenomas and Papillary Thyroid Carcinomas: Clinicopathological Evaluation
No full textObjective: We aimed to evaluate the frequency and clinicopathological features of papillary thyroid carcinomas synchronized with parathyroid adenoma and to compare theparathyroid adenoma with papillary thyroid carcinoma andparathyroid adenoma without papillary thyroid carcinoma groups. Methods: The study included 287 parathyroid adenoma cases that had concomitant thyroid surgery. Age, gender, parathyroid adenoma characteristics, diagnosis for thyroid materials, and clinicopathological prognostic parameters for papillary thyroid carcinomas were recorded from the pathology reports. Results: Synchronous parathyroid adenoma and thyroid malignancy rate was 27.2%, and papillary thyroid carcinomas were 88.5% of the malignancies. Papillary thyroid carcinomas were mostly seen in female patients and in right thyroid lobe, the multifocality rate was 18.8%, the follicular variant being the most common, the majority were papillary microcarcinomas and pT1 tumors, extrathyroidal extension rate was 13%. Parathyroid adenoma with papillary thyroid carcinomaand parathyroid adenoma without papillary thyroid carcinoma groups were statistically similar in the patient and parathyroid adenoma characteristics. Intrathyroidal parathyroid adenomas and the right parathyroid gland involvement were more common in parathyroid adenoma with papillary thyroid carcinoma group, while multiple parathyroid adenomas and left parathyroid gland involvement were more common in parathyroid adenoma without papillary thyroid carcinoma group. Inferior parathyroid gland involvement was more common than the superior, and the mean parathyroid adenoma size was similar for both groups. Conclusion: Synchronous parathyroid adenoma and papillary thyroid carcinoma cases are not uncommon, and detection of papillary thyroid carcinoma may change the surgical procedure. Therefore, all parathyroid adenoma cases should be thoroughly investigated for concomitant thyroid pathologies before surgery
Sosyal Bilgiler Öğretmen Adaylarının Matematiğe Yönelik Tutum Düzeylerinin İncelenmesi
No full textAraştırmanın temel amacı sosyal bilgiler öğretmen adaylarının matematiğe yönelik tutum düzeylerinin incelenmesidir. Araştırmada nicel araştırma yöntemlerinden tarama modeli kullanılmıştır. Türkiye’deki farklı devlet üniversitelerinde öğrenim gören 398 sosyal bilgiler öğretmen adayı araştırmanın örneklemini oluşturmaktadır. Araştırmada veri toplama aracı olarak Duatepe ve Çilesiz (1999) tarafından geliştirilen “Matematik Tutum Ölçeği” kullanılmıştır. Araştırmanın verileri AMOS 21 ve Jamovi 2 paket programları ile analiz edilmiştir. Sosyal bilgiler öğretmen adaylarının matematiğe yönelik tutum düzeylerini incelemek için betimsel istatistiki bilgilerden yararlanılmış, ele alınan değişkenler arasında anlamlı farklılık olup olmadığını belirlemek için ise tek yönlü ANOVA uygulanmıştır. Araştırma sonucunda sosyal bilgiler öğretmen adaylarının matematiğe yönelik tutum düzeylerinin düşük olduğu görülmüştür. Ayrıca öğretmen adaylarının “Matematik Tutum Ölçeği”nin ilgi ve sevgi, korku ve güven ile zevk alt boyutlarından aldıkları puanların da düşük düzeyde olduğu bulgusuna ulaşılmıştır. Meslek ve önem alt boyutuna ilişkin tutum düzeylerinin ise yüksek olduğu belirlenmiştir. Araştırmada sosyal bilgiler öğretmen adaylarının matematiğe yönelik tutum düzeylerinin anne eğitim duruma göre anlamlı olarak farklılaşmadığı, ancak baba eğitim duruma göre anlamlı olarak farklılaştığı sonucuna ulaşılmıştır. Son olarak sosyal bilgiler öğretmen adaylarının matematiğe yönelik tutum düzeylerinin matematik öğretmenini sevme durumu değişkenine göre de anlamlı olarak farklılaştığı görülmüştür
Convolutional neural networks for medical image processing applications
No full textThe rise in living standards increases the expectation of people in almost every field. At the forefront is health. Over the past few centuries, there have been major developments in healthcare. Medical device technology and developments in artificial intelligence (AI) are among the most important ones. The improving technology and our ability to harness the technology effectively by means such as AI have led to unprecedented advances, resulting in early diagnosis of diseases. AI algorithms enable the fast and early evaluation of images from medical devices to maximize the benefits. While developments in the field of AI were quickly adapted to the field of health, in some cases this contributed to the formation of innovative artificial intelligence algorithms. Today, the most effective artificial intelligence method is accepted as deep learning. Convolutional neural network (CNN) architectures are deep learning algorithms used for image processing. This book contains applications of CNN methods. The content is quite extensive, including the application of different CNN methods to various medical image processing problems. Readers will be able to analyze the effects of CNN methods presented in the book in medical applications. © 2023 Şaban öztürk. All rights reserved
The Accuracy of Provocative Tests on Diabetic Patients with Suspected Carpal Tunnel Syndome and Comparison with Nondiabetics
No full textObjective: Carpal tunnel syndrome in diabetic patients differ in some aspects from those in the nondiabetic population. The study was designed to evaluate the diagnostic accuracy of widely used provocative tests in the diabetic population in comparison to nondiabetic population. Materials and Methods: 87 nondiabetic and 25 diabetic hands suspicious of carpal tunnel syndrome were included in this retrospective study. The presence of carpal tunnel syndrome is confirmed by nerve conduction studies. The hands were divided into DM- and DM+ groups based on patients’ diabetes mellitus history. From patient records, results of Tinel’s, Phalen’s, Durkan’s, median nerve compression, and scratch collapse tests were obtained. Sensitivity, specificity, positive predictive value, and negative predictive values of tests are calculated for each population and then compared with each other. Results: Tinel’s test had a higher sensitivity in the diabetic population. Accuracies of Phalen’s, Durkan’s, median nerve compression, and scratch collapse tests in diabetic patients were similar to those in diabetic patients. None of the tests had a high enough sensitivity to be used alone in either group. Scratch collapse test had very high specificity in both groups but very low sensitivity. Conclusion: The studied provocative tests have comparable accuracy for carpal tunnel syndrome in diabetic patients to those in nondiabetic patients, with Tinel even having higher sensitivity. But excluding scratch collapse test, none of the tests is strong enough to achieve a diagnosis and none is sensitive enough to rule out a disease
ThinPrep sıvı bazlı sitoloji yöntemiyle hazırlanan servikal smear materyallerinin değerlendirilmesi, sito-histopatolojik korelasyon
No full textAmaç: Bu çalışma; servikal sitoloji (SS) materyallerinde kalite açısından yeterlilik oranını, değerlendirme için yetersiz olanların nedenlerini, epitelyal hücre anormalliği (EHA) saptama yüzdesini, atipik skuamöz hücreler/ skuamöz intraepitelyal lezyon (ASH/SIL) oranını belirlemeyi ve sito-histopatolojik korelasyon ile tanı doğruluğunu değerlendirmeyi amaçlamaktadır. Yöntem: Sıvı bazlı sitoloji (ThinPrep) yöntemi kullanılarak hazırlanan 1368 SS materyali çalışmaya alındı. SS alınan kadınların klinik özellikleri, sitolojik değerlendirme sonuçları, mevcut olanlarda eş zamanlı veya sonrasındaki servikal doku biyopsi tanıları kaydedildi. Sitolojik değerlendirme sonuçları Bethesda 2014 sınıflamasına göre kategorize edildi. Doku biyopsisi tanısına ulaşılan 36 olguda sito-histopatolojik korelasyon yapıldı. Bulgular: Elli bir (%3.7) SS materyali değerlendirme için yetersizdi. Skuamöz hücre azlığı en sık yetersizlik nedeni olup daha çok örneklemenin optimal şekilde yapılmamasıyla ilişkiliydi. Otuz sekiz SS örneğinde EHA mevcuttu (EHA oranı %2.9): 24 ASCUS, 1 ASC-H, 8 LSIL, 5 HSIL. ASH/SIL oranı 1.9’du. EHA’yı belirleme açısından, SS’nin doğruluk oranı, spesifitesi ve sensitivitesi sırasıyla %86, %91 ve %77 olarak bulundu. Sonuç: Tekrarlayan suboptimal veya yetersiz SS preparatlarıyla karşılaşıldığında laboratuvar aşamaları kontrol edilmeli ve gerekiyorsa, doğru örnekleme için ilgili kişilerle iletişime geçilmelidir. EHA oranı merkezlere göre farklılık gösterebilir. EHA’nın çoğunluğunu ASCUS oluşturur ve gereksiz ASCUS tanısı vermekten kaçınılmalıdır. ASH/SIL oranı ve sito-histopatolojik korelasyon güvenilir kalite kontrol yöntemlerinden olup her patolog veya merkez için belirlenmiş parametreler çerçevesinde kalite kontrol yapılmalıdır. Servikal biyopsi materyalleri değerlendirilirken mutlaka SS preparatı ile karşılaştırılarak incelenmeli, tanı uyumsuzluğu olan durumlarda rapora açıklayıcı notlar eklenmelidir