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EVALUATION OF FORENSIC CASES ADMITTED TO THE HOSPITAL IN AMASYA
No full textObjective: In this study, it was aimed to determine the demographic characteristics of the forensic cases who applied to Amasya University Sabuncuoğlu Şerefeddin Training and Research Hospital, to reveal the types of cases and to observe the changes in the cases according to the years. It will be examined whether it causes any problems in terms of criminal and compensation law. Methods: Forensic cases who applied to the Amasya University Sabuncuoğlu Şerefeddin Training and Research Hospital between 01.01.2018 and 31.12.2022 were examined. 53314 forensic case entries were evaluated. Results: In the 5-year analysis, 53314 cases were evaluated and the mean age was found to be 33.7. 76.2% of the cases were male (n=40618) and 23.8% were female (n=12696). Among all cases, occupational accidents were determined as 6.8%, traffic accidents as 9.7%, and other cases as 83.5%. Conclusion: In our study, it's noteworthy that occupational accident cases are higher than what is reported in the literature. In order to mitigate preventable health issues like occupational accidents, it is essential to organize necessary training sessions and implement precautionary measures. In the context of criminal and compensation law, it is recognized that individuals might experience loss of rights if the types of cases are not accurately identified. To prevent this situation, maintaining records accurately and comprehensively is of paramount importance
Views of Girls' Parents on Swimming Competitions
No full textIn this study, it is aimed to examine the views of girls' parents toward swimming competitions. For this purpose, phenomenology design, which is a type of qualitative research method, was used in the study. The universe of the study consists of the parents of the athletes who are interested in swimming in Amasya, and the sample group is within the scope of seven parents. The sample group in the study was determined by the criterion sampling method. The criterion in the study is the condition of parents being interested in swimming sports of their children. A semi -structured interview form consisting of 11 questions was prepared by the researchers as a data -collection tool. In line with the permissions obtained, face-to-face interviews were conducted with the parents on the specified day and time, and the interviews were audio recorded in order not to cause data loss. The audio recordings obtained were transcribed, transferred to the Nvivo program and analyzed by content analysis method. As a result of the analysis of the data obtained, it was determined that swimming contributes to children's socialization, fitness, self-confidence, and skill development, and that they direct their children to this sports branch because of factors such as fun, being safe in water, weight control, body development, and overcoming fears. In addition, it is determined that the clothes should be covered for the majority of the parents, and this is important for them in mixed competitions. On the other hand, it is determined that the children do not want to choose this branch of sports as a profession due to the fact that the income is not clear and it is not seen as a guaranteed profession. In addition to all these, regarding the swimming sport of the parents, it has been determined that children have concerns such as the danger of choking, injury, cramps, and swallowing water
Investigation of mathematical thinking processes of gifted students in different environments: GeoGebra’s potential
No full textMathematical thinking is a higher-order thinking style specific to mathematics that allows the solving of problems. In this context, it is inevitable to consider mathematical thinking in determining giftedness specific to mathematics. How superior mathematical thinking should be measured and the potential of different environments to elicit this mathematical thinking are a matter of debate. In this study, it was investigated how mathematical thinking in gifted students differed between using a paper and a pencil and using dynamic geometry software. Three gifted students’ solutions for given tasks in the paper-and-pencil and GeoGebra environments were compared within the scope of sub-dimensions (specializing, generalizing, conjecturing, and proving) of mathematical thinking. As a result of this study, the work undertaken by the students in the specializing step were seen to be similar in both the P&P and GeoGebra environments. On the other hand, it can be said that GeoGebra had the potential to reveal high-level work at the generalizing step. Different environments seemed to be important in revealing the ability to make assumptions. And it was seen that higher-order thinking skills for proof can be revealed with GeoGebra
Investigation of transactional distance and self-regulation in three types of interaction in online learning environments
No full textBu araştırmanın amacı, çevrimiçi öğrenme ortamlarında ders alan öğrencilerin transaksiyonel uzaklık algıları ve üç etkileşim türünde öz düzenleme becerileri arasındaki ilişkinin incelenmesidir. İlişkisel tarama modeli kullanılmıştır. Çalışma grubunu, Türkiye'de uzaktan eğitim ile ders veren 49 üniversiteden 374 öğrenci (241 Kadın, 133 Erkek) oluşturmaktadır. Transaksiyonel Uzaklık Ölçeği ve Üç Etkileşim Türünde Çevrimiçi Öz Düzenleme Ölçeği kullanılmıştır. Transaksiyonel Uzaklık Ölçeği, 38 madde ve diyalog, yapı esnekliği, içerik organizasyonu, kontrol ve özerklik olmak üzere 5 boyuttan oluşmaktadır. Üç Etkileşim Türünde Çevrimiçi Öz Düzenleme Ölçeği, 30 madde ve Öğrenci-İçerik, Öğrenci-Öğretmen ve Öğrenci-Öğrenci olmak üzere 3 boyuttan oluşmaktadır. Bağımsız örneklem t testi, tek faktörlü varyans analizi, iki faktörlü varyans analizi, Pearson korelasyon ve çoklu regresyon analizleri kullanılmıştır. Sonuçlar incelendiğinde, öğrencilerin transaksiyonel uzaklık algılarının ve üç etkileşim türünde öz düzenleme becerilerinin ortalamanın üzerinde olduğu görülmektedir. Öğrencilerin transaksiyonel uzaklık algıları ve üç etkileşim türünde öz düzenleme becerilerine cinsiyet açısından, aralarında anlamlı bir fark olmadığı gözlemlenmiştir. Transaksiyonel uzaklık algılarına kendilerine ait bilgisayar olup olmaması açısından, genel itibariyle bir fark gözlenmemekte fakat Kontrol alt faktöründe kendine ait bilgisayarı olan öğrenciler lehine anlamlı bir fark gözlemlenmiştir. Öz düzenleme becerilerine kendilerine ait bilgisayar olup olmaması açısından, hem genel olarak hem de alt faktörler bazında kendine ait bilgisayarı olan öğrenciler lehine anlamlı bir farkın olduğu gözlemlenmiştir. Öğrencilerin transaksiyonel uzaklık algıları ve üç etkileşim türünde öz düzenleme becerileri yaş açısından da incelenmiş olup, anlamlı bir fark gözlemlendiği ortaya çıkmıştır. Bu fark 30-35 yaş aralığı lehine gözlemlenmektedir. Transaksiyonel uzaklık ve üç etkileşim türünde öz düzenleme becerilerinin internet kullanma sıklığı açısından, anlamlı bir farklılık ortaya koymamıştır. Bununla birlikte, transaksiyonel uzaklık algıları ve üç etkileşim türünde öz düzenleme becerilerinin yaş ve internet kullanma sıklıkları bakımından farklılık gösterip göstermediği analiz edilmiş istatistiki olarak farklılık görülmediği gözlemlenmiştir. Araştırma sonucunda, öğrencilerin transaksiyonel uzaklık algıları ve üç etkileşim türünde öz düzenleme becerileri arasında yüksek düzeyde pozitif ve anlamlı bir ilişki olduğu tespit edilmiştir. Öğrencilerin üç etkileşim türünde öz düzenleme becerisi transaksiyonel uzaklık ve alt faktörlerden kontrol alt faktörünü yordamaktadır. Çıkan bu sonuçlar çerçevesinde araştırma sonuçları alan yazın kapsamında detaylı bir şekilde tartışılmış ve gelecek araştırmalara yönelik önerilerde bulunulmuştur. Anahtar Kelimeler : Uzaktan Eğitim, Acil Uzaktan Öğretim, Üç Etkileşim Türünde Öz Düzenleme, Transaksiyonel UzaklıkThe aim of this research is to examine the relationship between the perceptions of transactional distance and self-regulation skills in three interaction types of students taking courses in online learning environments. Relational screening model was used. The study group consists of 374 students (241 Female, 133 Male) from 49 universities in Turkey that offer distance education courses. Transactional Distance Scale and Online Self-Regulation Scale for Three Interaction Types were used. The Transactional Distance Scale consists of 38 items and 5 dimensions: dialogue, structure flexibility, content organization, control and autonomy. The Three Types of Interaction Online Self-Regulation Scale consists of 30 items and 3 dimensions: Student-Content, Student-Teacher and Student-Student. Independent sample t-test, one-factor analysis of variance, two-factor analysis of variance, Pearson correlation and multiple regression analyzes were used. When the results are examined, it is seen that the students' perception of transactional distance and self-regulation skills in three interaction types are above the average. It was observed that there was no significant difference between students' perceptions of transactional distance and self-regulation skills in three interaction types in terms of gender. There is no difference in transactional distance perceptions in terms of whether they have their own computer or not, but a significant difference was observed in the Control sub-factor in favor of students who have their own computer. It has been observed that there is a significant difference in favor of students who have their own computer in terms of self-regulation skills, both in general and on the basis of sub-factors. Transactional distance perceptions of students and self-regulation skills in three interaction types were also examined in terms of age, and it was found that a significant difference was observed. This difference is observed in favor of the 30-35 age range. Transactional distance and self-regulation skills in the three interaction types did not reveal a significant difference in terms of internet use frequency. However, it was analyzed whether the perceptions of transactional distance and self-regulation skills in the three interaction types differ in terms of age and frequency of internet use, and it was observed that there was no statistical difference. As a result of the research, it was determined that there was a high level of positive and significant relationship between students' perception of transactional distance and self-regulation skills in three interaction types. Self-regulation skills of students in three interaction types predict transactional distance and control sub-factor from sub-factors. Within the framework of these results, the results of the research were discussed in detail within the scope of the literature and suggestions were made for future research. Keywords : Distance Learning, Emergency Remote Teaching, Self Regulation In Three Types of Interaction, Transactional Distanc
Comparison of the production values of a photovoltaic power plant with the results of simulation software: The example of a solar power plant in the municipality of Erbaa
No full textBu çalışmada Tokat ili Erbaa ilçesinde kurulu olan Erbaa Belediyesi 990 kWp Güneş Enerji Santrali'nin bir yıllık enerji üretim verileri elde edilmiştir. Güneş enerji santrallerinin fizibilite çalışmalarında kullanılan PV*SOL ve PVsyst yazılımlarının deneme sürümleri kullanılarak santralin tasarımı ve benzetimi gerçekleştirilmiştir. Benzetimlerde santralin meteorolojik parametreleri meteonorm veri tabanından elde edilmiştir. Benzetimlerde kullanılan modüller ve eviriciler santralde kullanılan modüllerin ve eviricilerin marka ve modelinde seçilmiştir. Albedo, modül eğim açısı, azimut açısı parametrelerinin verileri ile kablolara ve uyumsuzluklara bağlı kayıplara ait veriler gerçeğe uygun olarak girilmiştir. Tüm parametrelerin her iki benzetim yazılımında da sabit tutulması koşulu ile eğimli yüzeylere düşen toplam ışınımın hesaplanmasında kullanılan Hay-Davies ve Perez modelleri ile ikişer tane olmak üzere toplam dört benzetim gerçekleştirilmiştir. Benzetim sonuçları gerçek üretim verileri ile grafikler ve şekiller kullanılarak karşılaştırılmıştır. Aylık benzetim sonuçlarının PV*SOL yazılımında gerçek verilere daha yakın olduğu, yıllık benzetim sonuçlarının ise PVsyst yazılımında kullanılan Perez eğimli yüzeyler üzerine düşen toplam ışınım modeli ile geçekleştirilen benzetimin gerçek verilere daha yakın olduğu sonucuna ulaşılmıştır.In this study, annual energy production data of the Erbaa Municipality 990 kWp Solar Power Plant, which is located in Erbaa district of Tokat province, were obtained. The design and simulation of the power plant was carried out by using the trial versions of PV*SOL and PVsyst softwares used in the feasibility studies of solar power plants. In the simulations, the meteorological parameters of the power plant were obtained from the meteonorm database. The modules and inverters used in the simulations were selected according to the brand and the model of the modules and the inverters used in the power plant. The data of albedo, module tilt angle, azimuth angle parameters and data of losses due to cables and mismatches were entered in accordance with reality. A total of four simulations, two each, were performed using the Hay-Davies and Perez models used to calculate the total irradiance on a tilted surface, provided that all parameters are kept constant in both simulation software. The simulation results were compared with the real production data by using graphs and figures. It has been concluded that the monthly simulation results are closer to the actual data in the PV*SOL software, while the annual simulation results are closer to the actual data of the simulation implemented by the total radiation model falling on Perez inclined surfaces used in the PVsyst software
Solubility of the discontinuous Sturm-Liouville problem
No full textBu tezde, süreksizlik noktasına sahip dolayısıyla iki aralıklı ve süreksizlik noktasında ayrıca geçiş şartları bulunduran bir Sturm-Liouville problemi Sobolev uzaylarında incelenecektir. Bu probleme uygun diferansiyel operatör kurulacak daha sonra bu diferansiyel operatörün Fredholm operatörü olma özelliği incelenecek ayrıca incelenen operatörün izomorfizm olma şartları araştırılacaktır.In this thesis, a two interval Sturm-Liouville problem, which has a discontinuity point and also has transition conditions at the discontinuity point, will be examined in Sobolev spaces. A differential operator suitable fort his problem will be established, the feature of this diferential operator as a Fredholm operator will be examined, and the conditions for isomorphism of the examined operator will be investigated
Determination of dyspnea, social support and quality of life in individuals with COPD
No full textBu çalışma, KOAH'lı bireylerin dispne, sosyal destek, yaşam kalitesi düzeylerini ve sosyal destek ile yaşam kalitesi arasındaki ilişkiyi belirlemek amacıyla yapılmıştır. Tanımlayıcı ve ilişki arayıcı tipteki bu çalışma, 31 Mayıs 2021-15 Mart 2022 tarihleri arasında bir eğitim ve araştırma hastanesinin göğüs hastalıkları ve göğüs cerrahisi yerleşkesinde tedavi gören, 181 KOAH'lı bireyle yürütülmüştür. Çalışmada veriler, Hasta Tanıtım Formu, KOAH Değerlendirme Testi (CAT), Modifiye Borg Skalası (MBS), Çok Boyutlu Algılanan Sosyal Destek Ölçeği (ÇBASDÖ) ve St. George Solunum Anketi (SGRQ) kullanılarak toplanmıştır. Post Hoc Power analiz sonucuna göre çalışmanın gücü %99 olarak belirlenmiştir. İstatistiksel anlamlılık düzeyi olarak p<0,05 kabul edilmiştir. KOAH'lı bireylerin %82,9'unun erkek, %69,1'inin evli ve yaş ortalamasının 67,86±9,14 olduğu saptanmıştır. Bireylerin %63,0'ının sigarayı bıraktığı, %24,9'unun pasif içici olduğu, %76,8'inin KOAH'tan başka kronik hastalığının olduğu ve %40,3'ünün ailesinde de KOAH hastası olduğu saptanmıştır. Bireylerin %92,8'inin dispne için inhaler ilaç kullandığı, %35,4'ünün kontrollere düzenli gittiği, %91,2'sinin hastalığı süresince yakın çevresinden yardım aldığı, %90,6'sının üzüldüğünde veya mutlu olduğunda kendisini destekleyen birisinin olduğu saptanmıştır. Ayrıca bireylerin %79,6'sı hastalığının yaşamını yüksek düzeyde olumsuz etkilediğini bildirmiştir. Bireylerin CAT puan ortalaması 30,58±7,15; MBS puan ortalaması 7,56±2,14; ÇBASDÖ puan ortalamaları toplam 50,92±18,56 ve alt boyutları sırasıyla, Aile 12,03±7,77; Özel Bir İnsan 22,39±6,05; Arkadaş 16,50±6,68'dir. SGRQ puan ortalamaları toplam 75,93±13,25 ve alt boyutları sırasıyla, Semptom 77,31±16,10; His 66,29±16,95; Aktivite 92,07±12,02'dir. CAT ile SGRQ toplam puan ortalaması arasında anlamlı, pozitif yönlü ve yüksek düzey ilişki (r=0,749; p<0,0001), MBS ile SGRQ toplam puan ortalaması arasında anlamlı, pozitif yönlü ve orta düzey ilişki olduğu saptanmıştır (r=0,661; p<0,0001). ÇBASDÖ ile SGRQ toplam puan ortalamaları arasında anlamlı, negatif yönlü ve orta düzey ilişki olduğu saptanmıştır (r=-0,421; p<0,0001). Bireylerin sağlık durumunun kötü, dispne şiddetinin çok ciddi, algıladıkları sosyal desteğin orta düzeyde ve yaşam kalitesi düzeyleri düşük bulunmuştur. Sağlık durumu, dispne şiddeti ve algılanan sosyal destek yaşam kalitesi düzeyi ile ilişkilidir, KOAH'lı bireylerde bu durumların değerlendirilmesi, tedavi ve bakıma entegre edilmesi önerilmektedir.This study was conducted to determine the dyspnea, social support, quality of life levels of individuals with COPD and the relationship between social support and quality of life. This descriptive and relationship-seeking study was conducted with 181 individuals with COPD who were treated at the pulmonology and thoracic surgery campus of a training and research hospital between May 31, 2021 and March 15, 2022. In the study, data were collected using Patient Identification Form, COPD Assessment Test (CAT), Modified Borg Scale (MBS), Multidimensional Perceived Social Support Scale (MPSSS) and St. George's Respiratory Questionnaire (SGRQ). According to the results of Post Hoc Power analysis, the strength of the study was determined as 99%. The statistical significance level was accepted as p<0,05. It was determined that 82,9% of the individuals with COPD were male, 69,1% were married and the average age was 67,86±9,14 years. It was estimated that 63,0% of the individuals quit smoking, 24,9% were passive smokers, 76,8% had a chronic disease other than COPD and 40,3% had COPD in their family. It was determined that 92,8% of the individuals used drugs inhalers for dyspnea, 35,4% went to the controls regularly, 91,2% received help from their immediate surroundings during their illness, and 90,6% had someone who supported them in their sad or happy times. In addition, 79,6% of individuals reported that the disease had a high level of negative impact on their lives. The average CAT score of individuals is 30,58±7,15; MBS average score is 7,56±2,14; the average scores of the MPSSS are 50,92±18,56 in total and the sub-dimensions are Family 12,03±7,77; A Special Person 22,39±6,05; A friend 16,50±6,68, respectively. SGRQ score averages are 75,93±13,25 in total and sub-dimensions are Symptom 77,31±16,10; Sense 66,29±16,95; Activity 92,07±12,02, respectively. It was appointed a significant, positive and high-level relationship between CAT and SGRQ total average scores (r=0,749; p<0,0001) and a significant, positive and mid-level relationship between MBS and SGRQ average scores (r=0,661; p<0,0001). It was found that there was a significant, negative and mid-level relationship between the average scores of MPSSS and SGRQ (r=-0,421; p<0,0001). It was revealed that the health status of the individuals was poor, the dyspnea severity was very serious, the social support they perceived was at a moderate level and the quality of life levels were low. Health status, dyspnea severity and perceived social support are associated with the level of quality of life, and it is recommended that these conditions be evaluated and integrated into treatment and care in individuals with COPD
Factors associated with HIV-positive status awareness among adults with long term HIV infection in four countries in the East and Southern Africa region: A multilevel approach
No full textAntiretroviral treatment (ART) appropriately and regularly used decreases the human immunodeficiency virus (HIV) viral load in the bloodstream, preventing HIV-infected people from spreading the infection to others. Disparities in ART adoption persists in East and Southern Africa, with low HIV-positive status knowledge being the primary factor. We investigated individual and household characteristics of HIV-positive status awareness among adults with long-term HIV infection in four East and Southern African countries: Eswatini, Malawi, Tanzania, and Zimbabwe. The study analyzed data from surveys conducted in Eswatini, Malawi, Tanzania, and Zimbabwe in 2015-2016. Only individuals who tested positive for HIV through rapid tests were included in the analysis. Those who already knew they were HIV-positive were categorized as aware, while those who reported being negative, never tested, or didn't know their status were categorized as unaware. Statistical models were used to examine various factors related to HIV awareness. Pooled and country-specific odds ratios were computed. The percentage of people who knew they had HIV ranged from 58% (Tanzania and Malawi) to 87% (Eswatini). After adjusting for other variables, young persons in all countries were less likely to be aware of their HIV-positive status. Gender, marital status, education, working status, household wealth, and urbanization level of households were also associated with HIV-positive status awareness but inconsistent across countries. HIV-positive status awareness in these four East and Southern African nations remained unsatisfactory as compared to the United Nations' 95% guideline, indicating that testing and knowledge of HIV testing in this region still has a lot of potential for improvement. The observed variations among nations may be attributable to differences in HIV pandemic culture and policies. The findings of this study will assist governments determining which subpopulations to target to boost adoption of HIV testing services, as well as in designing and development of policies
Theoretical and Experimental Investigation of Gamma Shielding Properties of TiO2 and PbO Coated Glasses
No full textThis manuscript has investigated the effect of TiO2 and PbO-coated glasses on radiation absorption properties to develop alternative materials for radiation shielding. The shielding properties of glass materials coated with oxides were calculated experimentally with a gamma spectrometer with NaI(Tl) detector and theoretically with the XCOM computer program and GATE simulation program. Within this scope, the shielding properties of TiO2, Pb0, and Pb0 doped TiO2 glasses at 511, 662, 1274 keV gamma energies were calculated. The results obtained showed that 50% Pb0 contribution can increase the shielding properties of TiO2 glasses. Also, it has been observed that the experimental and theoretical results obtained are compatible with each other. © IJCESEN.Amasya University Scientific Research Projects DepartmentBilimsel Araştırma Projeleri Birimi, İstanbul Teknik Üniversitesi, BAP, (FMB-BAP-18-0315)Bilimsel Araştırma Projeleri Birimi, İstanbul Teknik Üniversitesi, BA
Investigation of the cytotoxic, genotoxic, apoptotic effects of 4-(substituted)-3,4-dihydropyrimidinone compounds on human lung cancer cell and Drosophila melanogaster
No full textBu çalışma ile, yeni sentez edilmiş 4-(Sübstitüe)-3,4-dihidropirimidinon türevlerinin (PMe, PPh ve PNO2) olası sitotoksik, genotoksik ve antikanserojenik etkinliklerinin belirlenmesi amaçlanmıştır. Bu amaçla bileşiklerin olası etkileri A549 insan akciğer kanser hücre hattı ve MRC-5 insan sağlıklı akciğer hücre hattında ve Drosophila melanogaster'de araştırılmıştır. Çalışmada bileşiklerin sitotoksik etkilerini değerlendirmek amacıyla WST-8 test yöntemi, genotoksik etkilerini değerlendirmek amacıyla ise Drosophila kanat somatik mutasyon rekombinasyon testi (SMART) kullanılmıştır. Bileşiklerin, ısı şoku protein genlerinin, antioksidan genlerinin ve apoptotik yolakta etkili olan genlerin ekspresyon seviyeleri RT-PCR yöntemiyle tespit edilmiştir. Araştırmanın sonuçlarına göre, bileşiklerin A549 akciğer kanseri hücre hattında 50 ve 100µM konsantrasyonlarında sitotoksik etkiye sahip olduğu, sağlıklı akciğer hücre hattında (MRC-5) ise sitotoksik etki göstermediği tespit edilmiştir. SMART sonucunda ise her üç DHPM türevinin de sadece çok yüksek dozlarda genotoksik etki gösterdiği fakat larvalar üzerinde önemli bir toksik etki göstermediği belirlenmiştir. Bileşiklerin A549 hücre hattında apoptotik etkileri incelendiğinde, her üç bileşiğin de BAX ve CASP3 geninin, antioksidan mekanizmayla ilgili genlerden SOD1, CAT ve GSS genlerinin ekspresyon seviyelerini artırdığı, ısı şoku protein genlerinden HSP27 gen ifadesini azalttığı gözlemlenmiştir. Bileşiklerin D. melanogaster'de in vivo şartlarda apoptotik gen ifade düzeylerine etkisi incelendiğinde; PMe bileşiğinin DEBCL geninin ekspresyon düzeyini kontrol grubuna göre artırdığı, PPh ve PNO2 bileşiğinin DEBCL geninin ekspresyon seviyesini azalttığı, tüm üç bileşiğin ise BUFFY geninin ekspresyon düzeyini artırdığı görülmüştür. DEBCL/BUFFY oranına bakıldığında her üç bileşiğin de sağlıklı D. melanogaster bireylerinde antiapoptotik etki gösterdiği belirlenmiştir. Bununla birlikte tüm bileşiklerin D. melanogaster kaspazları olan DRICE geninin ekspresyon düzeyini kontrol grubuna göre artırdığı, DRONC geninin ekspresyon düzeyini sadece PMe bileşiğinin artırıp PPh ve PNO2 bileşiğinin ise gen ekspresyon seviyesini azalttığı tespit edilmiştir. Özellikle PMe bileşiğinin D. melanogaster ısı şoku proteinleri HSP27, HSP60, HSP70 ve HSP90 genlerinin ve SOD, CAT, GR ve GST genlerinin ekspresyon düzeylerini artırdığı belirlenmiştir.This study aimed to determine the possible cytotoxic, genotoxic and anticarcinogenic activities of newly synthesized 4-(Substituted)-3,4-dihydropyrimidinone derivatives (PMe, PPh and PNO2). For this purpose, the possible effects of the compounds were investigated in the A549 human lung cancer cell line, MRC-5 human healthy lung cell line and Drosophila melanogaster. In the study, the WST-8 test method was used to evaluate the cytotoxic effects of the compounds, and the Drosophila wing somatic mutation recombination test (SMART) was used to evaluate the genotoxic effects. Expression levels of compounds, heat shock protein genes, antioxidant genes and genes effective in the apoptotic pathway were determined by RT-PCR method. According to the results of the research, it was determined that the compounds had a cytotoxic effect at 50 and 100µM concentrations on the A549 lung cancer cell line, but did not show a cytotoxic effect on the healthy lung cell line (MRC-5). As a result of SMART, it was determined that all three DHPM derivatives showed genotoxic effects only at very high doses, but did not show a significant toxic effect on the larvae. When the apoptotic effects of the compounds were examined on the A549 cell line, it was observed that all three compounds increased the expression levels of BAX and CASP3 genes, SOD1, CAT and GSS genes, which are genes related to the antioxidant mechanism, and decreased HSP27 gene expression, which is a heat shock protein gene. When the effects of compounds on apoptotic gene expression levels in D. melanogaster in vivo conditions were examined; It was observed that PMe compound increased the expression level of the DEBCL gene compared to the control group, PPh and PNO2 compound decreased the expression level of the DEBCL gene, and all three compounds increased the expression level of the BUFFY gene. Considering the DEBCL/BUFFY ratio, it was determined that all three compounds showed antiapoptotic effects in healthy D. melanogaster individuals. However, it was determined that all compounds increased the expression level of the DRICE gene, which is a D. melanogaster caspase, compared to the control group, only the PMe compound increased the expression level of the DRONC gene, and the PPh and PNO2 compounds decreased the gene expression level. In particular, it was determined that PMe compound increased the expression levels of D. melanogaster heat shock proteins HSP27, HSP60, HSP70 and HSP90 genes and SOD, CAT, GR and GST genes