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Blood disorders
No full textBlood disorders refer to conditions that affect the development of blood cells. The most common types of blood disorders include anemia, leukemia, and thrombocytopenia. Treatment for blood disorders depends on the type of blood disorder and may include medications, blood transfusions, and bone marrow transplants. © 2023 by Nova Science Publishers, Inc. All rights reserved
Bilinear multipliers theory on some function spaces
No full textIn this work, we define the bilinear multipliers of the spaces with fractional wavelet transform and consider the basic properties of these bilinear multipliers. Moreover, we give construction examples of bilinear multipliers. © 2023, MTJPAM Turkey. All rights reserved
Association of ACE ID, MTHFR C677T, and MIF-173GC variants with the clinical course of COVID-19 patients
No full textThe course of coronavirus disease-2019 (COVID-19) differs from person to person. The relationship between the genetic variations of the host and the course of COVID-19 has been a matter of interest. In this study, we investigated whether Angiotensin-Converting Enzyme (ACE) ID, Methylenetetrahydrofolate Reductase (MTHFR) C677T, and Macrophage Migration Inhibitory Factor (MIF)-173GC variants are risk factors for the clinical course of COVID-19 disease in Turkish patients. One hundred COVID-19 patients were included in the study. The diagnosis of COVID-19 was made using Reverse Transcription Polymerase Chain Reaction (RT-PCR) and Chest Computed Tomography (CT). The patients were evaluated in 3 groups: intensive care, service, and outpatient treatment. ACE ID, MTHFR C677T, and MIF-173GC variants were genotyped by PCR-Restriction Fragment Length Polymorphism (RFLP) methods. When the genotype distribution between the groups was examined, it was found that the frequency of the ACE DD genotype and the D allele was higher in the intensive care group compared to the hospitalized and outpatient groups. MTHFR C677T CT genotype T allele and MIF-173GC, CC genotype C allele were more prevalent in the intensive care group compared to other groups. Patients with PCR-positive results had a higher MTHFR C677T C/C genotype and C allele. In CT-positive patients, the MTHFR C677T CT genotype and the MIF-173GC, G allele were more common. It is predicted that genetic predisposition may contribute to COVID-19 morbidity and mortality. Our results show that ACE ID, MTHFR C677T, and MIF-173GC variants affect the course of COVID-19 disease in the Turkish population.Amasya University, Scientific Research Projects Fund [FMB-BAP 20-0482]This study was supported by Amasya University, Scientific Research Projects Fund (FMB-BAP 20-0482)
Gebelerin Cinsel Distres Düzeyleri ve Etkileyen Faktörlerin Belirlenmesi
No full textBackground: Although sexual problems are common during pregnancy, the rates of sexual distress are not known clearly. Objective: The research was carried out to determine the sexual distress levels of pregnant women and the affecting factors. Methods: Analytical cross-sectional research was conducted with 459 pregnant women in the Pregnancy Education Class of the Midwifery Department, Faculty of Health Sciences, located in a medical center between 01 March-31 May 2021. The data were collected with “The Female Sexual Distress Scale-Revised (FSDS-R)”. Descriptive statistics, Mann Whitney-U test and Kruskal- Wallis test were used in the analysis of the data. Results: The mean age of the pregnant women was 28.68±5.552. It was determined that the median FSDS-R scores of the pregnant women were 7.0 (2.0-16.0) and according to the mean FSDS-R scores, 34.6% of the pregnant women experienced sexual distress. A statistically significant difference was found between the age, education level, trimester, some views of the pregnant women about sexuality and the median scores of FSDS-R of the pregnant women (p<.05). Conclusion: In the study, it was determined that sexual distress levels were higher in pregnant women who were under 30 years of age, had a secondary education level, and were in the first trimester of pregnancy. In addition, sexual distress levels were found to be higher in pregnant women who thought that “sexual intercourse during pregnancy may harm the baby”, “sexual intercourse during pregnancy is a source of stress for women” and “sexual intercourse during pregnancy may cause miscarriage”. © 2023, Dokuz Eylul University. All rights reserved
A SINGLE-CENTER, CROSS-SECTIONAL PREVALENCE STUDY OF CERVICAL DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS
No full textIntroduction: In this study, we aimed to investigate the prevalence and characteristics of cervical diffuse idiopathic skeletal hyperostosis using computed tomography scans of the cervical vertebra.Materials and Methods: This study was performed using the Picture Archiving and Communication System of our hospital. Computed tomography images of 1744 patients were included in this study. The patients were divided into age groups by decade. The characteristics of the cervical osteophytes and intervertebral bridging were recorded. Cervical diffuse idiopathic skeletal hyperostosis was diagnosed based on the criteria described by Resnick and Niwayama.Results: The mean age of the study group was 48 years. The prevalence rate of cervical diffuse idiopathic skeletal hyperostosis was 6.3% (6.4% in males and 6.2% in females). The difference between genders was not statistically significant (p=0.908). The prevalence rates significantly increased as age increased. The prevalence rate of cervical osteophytes was 36.5% (33.9% in males and 40.6% in females). The most frequently affected level was C5-6 (16.9%), and the vertebra was C6 (30.6%). Osteophytes were localised in the midline with a rate of 75.5% and was most frequently found in the 70-79 age group (81.2%).Conclusion:In our study, we detected the prevalence rates of cervical diffuse idiopathic skeletal hyperostosis and cervical osteophytes, which were 6.3% and 36.5%, respectively. In comparison, the most frequently affected vertebra and intervertebral levels were, respectively, C6 (30.6%) and C5-6 (16.9%), and cervical osteophytes was most often formed in the midline (75.5%)
2017-2022 YILLARI ARASINDA TÜRKİYE’DE MATEMATİK EĞİTİMİNDE GÖRSELLEŞTİRME İLE İLGİLİ YAPILAN ÇALIŞMALARIN İÇERİK ANALİZİ
No full textYapılan çalışmada, 2017-2022 yılları arasında Türkiye’de matematik eğitimi kapsamında görselleştirmeye yönelik yapılan çalışmaların güncellik boyutunu tespit etmek amacıyla içerik analizi yapılarak çalışmalar incelenmiştir. Çalışmada araştırma yöntemi olarak nitel araştırma yönteminden doküman incelemesi kullanılmıştır. Veriler, literatür taraması yapılarak doküman şeklinde toplanmış, çözümlemesinde ise içerik analiz yöntemi kullanılmıştır. Bu çalışmada görselleştirmeye dair yapılan çalışmaların yayınlanma yılı, araştırma yapılan grupları, araştırma yöntemleri, verilerin nasıl toplandığı, veri analizleri, çalışmayı gerçekleştiren akademisyenlerin unvanları ve çalışmaların yayınlandığı enstitülerine ait elde edilen veriler frekans ve yüzde hesaplamalarıyla grafik ve tablolar hazırlanarak bulgulara ulaşılmıştır. Matematik eğitimi alanında görselleştirmeye yönelik çalışmaların bir dönem artıp bir dönem azalan şeklinde normal olmayan bir akış gösterdiği görülmektedir. Çalışma gruplarına bakıldığında en çok öğretmen adayı ve ortaokul gruplarıyla, en az okul öncesi dönem öğretmenlerinde yapıldığı görülmektedir. Araştırma yöntemi olarak en fazla nitel araştırmaların, en az karma yöntemin tercih edildiği görülmektedir. Kullanılan araştırma yöntemlerinde nitel çalışmalardan en fazla durum çalışması yapıldığı, nicel çalışmalardan en fazla deneysel araştırma yönteminin yapıldığı görülmektedir. Veri toplama aracı olarak nicel çalışmalarda en sık ölçeklerin, nitel çalışmalarda ise en fazla görüşme tekniğinin kullanıldığı belirlenmiştir. Çalışmaların analizinde nicel çalışmalarda en fazla t-testi ve nitel çalışmalarda en fazla içerik analizi kullanıldığı görülmektedir. Yapılan çalışmalardan yola çıkarak uzamsal beceriler üzerinde çok fazla durulduğu görülmektedir. Çalışmayı gerçekleştiren akademisyen unvanı olarak en fazla Profesör Doktor unvanlı kişiler olduğu görülmektedir. Yüksek lisans ve doktora tezlerinin yayınladığı enstitülerde ise en fazla Fen Bilimleri Enstitüsü olduğu görülmektedir. Sonuç olarak görselleştirme ile ilgili yapılan öğretimin, öğrencilerin akademik başarılarına pozitif yönde bir etkisi olacağı ve bu tür çalışmaların sayıca artmasının daha iyi bir öğrenme sürecinin geliştirilmesine fayda sağlayacaktır. Soyut olan matematik kavramların somutlaştırılmasında, derslerde daha fazla görselleştirme yaklaşımına yer verilmesi ve görselleştirme ile ilgili araştırmaların yapılması önerilmektedir
Linking emotional solidarity with residents' support for religious tourism development: an empirical research from a cultural heritage context
No full textPurposeThe aim of this research study is to examine the role of emotional solidarity on religious tourism support. Data for the present research work were attained from various groups of residents in Amasya province/Turkiye.Design/methodology/approachThe Google form-based questionnaires were self-managed by the participants. In the context of the survey, 306 complete questionnaires were gathered. For the data analysis, partial least squares structural equation modeling (PLS-SEM) technique was used via SmartPLS 4.0 software in conjunction with SPSS version 23.FindingsThe analysis results show that the emotional solidarity dimensions such as welcoming nature and sympathetic understanding were found to be positively related with religious tourism support at different coefficient levels; however, emotional closeness was not statistically related.Originality/valueThis study adds fresh insights into the field of tourist literature and has beneficial ramifications for business development in the area of religious tourism
Relationship between maxillary sinus mucosal cyst and sinus ostium 2D area in three-dimensional volumetric paranasal CT ımages
No full textObjective: To investigate the relationship between the maxillary sinus ostium 2D area (SOA) and the development of mucosal cysts of the maxillary sinus (MMC).Methods: Thirty patients (>= 18 years) with unilateral MMC who underwent paranasal sinus CT (PNsCT) were included in this single-center retrospective study. Non-MMC sinus was used as the control group. Cyst and air volume of the maxillary sinuses, diameter, and 2-dimensional area of the ostium of the patients were calculated in the 3-dimensional volumetric analysis program. Both correlation and linear regression model analyses were performed for the relationship between MMC and SOA.Results: Thirty patients were included (mean age of 42.30 +/- 17.62 years). A total of 15/30 (50%) were male. The mean SOA in patients with MMC (8.91 +/- 1.10 mm(2)) was lower than in patients without MMC (12.94 +/- 1.35 mm(2)), which was statistically significant (p < 0.001). The mean sinus ostium diameter in patients with MMC (2.12 +/- 0.71 mm) was higher than in patients without MMC (1.91 +/- 0.82 mm), which was statistically insignificant (p = 0.295). There was a statistically significant, good level of negative linear correlation between SOA and total cyst volume (TCV) [correlation coefficient (r) = - 0.680, p < 0.001]). As a result, the regression model consisting of Age, Sinus air volume, and TCV variables is a good model and has statistically significant relations with SOA.Conclusion: In conclusion, small SOAs contribute to the development of MMC. There was a negative correlation between SOA and TCV. In addition, 2D area measurement may be a more accurate method instead of diameter measurement
Effects of some flavor enhancer food additives on expression of cancer-related genes in MCF-7 and MCF-12A cells
No full textFood additives change the appearance and taste of foods, prevent their deterioration and keep them longer; are very important chemical compounds in terms of food technology. In this study, the cytotoxicity of the monosodium glutamate, monopotassium glutamate and magnesium di-glutamate salts of L-Glutamic acid are frequently used in foods as food additives and their effects on expression of cancer related (CYP1A1 and BCL-2) genes were investigated in MCF-7 and MCF-12A cell lines. For this purpose, different concentrations of MSG (437.5-27.34 mM), MPG (218.75-13.67 mM) and MDG (109.3-6.83 mM) treated with cells for 24 hours. According to the results, IC50 values of MSG, MPG and MDG were measured as 227.17, 84.64 and 80,27 mM for MCF-7 and 156.53, 197.24 and 14,05 mM for MCF-12A respectively. The most effective concentrations were determined as a result of MTT assay and expression analysis of CYP1A1 and BCL-2 genes were performed in both cell lines by qRT-PCR. BCL-2 gene; it was expressed more than its normal function against the substances in MCF-7 cells and caused unplanned cell proliferation in these cells, while it was detected that it was expressed less than its normal function in MCF-12A cells. Similarly, the CYP1A1 gene was found to be less express than its normal function in MCF-7 cells, while it was overexpressed in MCF-12A cells to against the toxicity from these agents. As a result of this study, the data showed that these food additives may cause both cytotoxicity and genotoxicity.Amasya University Scientific Research Unit [FMB-BAP 19-0421]The authors gratefully acknowledge the financial support of this work by Amasya University Scientific Research Unit (Project No: FMB-BAP 19-0421). MCF-7 and MCF-12A cell lines were used from the Amasya University Central Research Laboratory cell line collection