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Some results associated with hyperbolic Tangent function
No full textIn this paper, we examine some properties of analytic functions associated with hyperbolic Tangent functions. That is, the behaviour of the hyperbolic Tangent function inside and at the boundary of the unit disk has been examined. The sharpness some of these results is also proved. Furthermore, an example for our results is considered
Evaluation of systemic immune-inflammation index, systemic inflammatory response index and hematologic inflammatory parameters in generalized anxiety disorder: a controlled study
No full textAims: The current study aimed to examine the values of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) in generalized anxiety disorder (GAD). Methods: In this retrospective study, 147 GAD patients who did not receive treatment and 154 healthy controls with similar characteristics to the patient group were included. NLR, PLR, MLR, SII, and SIRI values calculated from the complete blood count values of the GAD group were compared with age- and sex-matched healthy controls. Results: Neutrophil, lymphocyte, monocyte, platelet counts and NLR, MLR, SII, and SIRI values were significantly higher in the GAD group compared to healthy controls (p<0.001, p=0.001, p<0.001, p<0.001, p<0.001, p=0.003, p<0.001, p<0.001, respectively). The logistic regression analysis revealed that SII and SIRI were identified as significant variables associated with receiving a diagnosis of GAD. Conclusion: Inflammatory markers such as NLR, MLR, SII, and SIRI are thought to play an important role in the evaluation of inflammatory activity in GAD. However, larger and more comprehensive studies are needed
Synthesis, crystal structure, spectroscopy and quantum chemical investigations of hexahydroquinoline molecule
No full textThe synthesis and crystal structure of benzyl 4-([1,1'-biphenyl]-4-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate are described. Single crystal X-ray diffraction of title molecule was used to investigate the crystal structure. The most stable optimised structure was identified using the B3LYP/6-31 + G(d) method. IR, 1H-NMR and elemental analysis of the title compound were performed. Besides, frontier molecular orbitals, molecular electrostatic potential, and thermodynamic properties were investigated by theoretically. In order to explore the nonlinear optical properties were performed theoretically. Hirshfeld analysis was also performed to determine the interactions of the molecule. [GRAPHICS]Scientific Research Unit of Hacettepe University [THD 2017-13452]; NSF [1205608]; NSF-MRI programme [CHE0619278]This study was supported by the Scientific Research Unit of Hacettepe University (Project no: THD 2017-13452). RJB is grateful for NSF award 1205608 for partial funding of this research, to Howard University Nanoscience Facility to access to liquid nitrogen, and the NSF-MRI programme (grant number CHE0619278) for funds to purchase the X-ray diffractometer
Investigation of mental endurance levels with mental training skills of women footballers
No full textBu çalışmanın amacı, Türkiye'deki kadın futbolcuların, zihinsel antrenman becerileri ve zihinsel dayanıklılık düzeylerini yaş, futbol geçmişi, kulüp ligi, millilik durumu ve millilik kategorisi değişkenleri açısından incelemektir. Çalışmaya 2022-2023 sezonunda kadınlar futbol liglerinde yer alan ve çalışmaya gönüllü olarak katılan 205 kadın futbolcu oluşturmaktadır. Çalışmada veriler, kişisel bilgi formu, Yarayan ve İlhan (2018) tarafından Türkçe uyarlaması yapılan Sporda Zihinsel Antrenman Envanteri (SZAE) ve Türkçe uyarlaması Altıntaş ve Koruç (2016) tarafından yapılan Sporda Zihinsel Dayanıklılık Envanteri (SZDE) kullanılarak toplanmıştır. Verilerin analizinde tanımlayıcı istatistikler, normal dağılım gösteren veriler için bağımsız gruplarda t-testi, tek yönlü varyans analizi, normal dağılım göstermeyen veriler için ise Kruskall Wallis analizi kullanılmıştır. Gruplar arası farkın kaynağını belirlemek amacıyla LSD Post Hoc analizi yapılmıştır. Analiz sonuçlarına göre, kadın futbolcuların sporda zihinsel antrenman düzeyleri ile yaş, futbol geçmişi, kulüp ligi, millilik durumu ve millilik kategorisi değişkenleri arasında istatistiksel olarak anlamlı fark yoktur (p>0,05). SZDE düzeyleri ile ilgili sonuçlara bakıldığında ise futbolcuların SZDE toplam puan ortalamaları ile yaş, futbol geçmişi, milli olma durumu ve millilik kategorisi değişkenleri arasında anlamlı bir fark vardır (p0.05). When we look at the results of SZDE levels, there is a significant difference between the SZDE total score averages of the football players and the age, football history, nationality and national category variables (p<0.05). In addition, between the confidence dimension age and national status variables from the SZDE sub-dimensions of the football players; It was determined that there was a statistically significant difference between the control dimension and the age, football history, club league, nationality and national category variables (p<0.05). According to the results, it can be said that female football players in the 23-year-old and over age group have a higher level of confidence and control than those in the lower age categories; 2nd league athletes have lower control level than super and 1st league athletes; national athletes have a higher level of confidence and control than non-national athletes. According to the national team category variable, the SZDE total score average and control levels of the players in the A national team are higher than the players in the U17 national team. Finally, it has been determined that the SZDE total score averages and control levels of women football players with a football history of 5 years or more are higher than the groups with below 5 years
1-(3-Methylthiophene-2-yl)-N-(3,4,5-trimethoxyphenyl)methanimine: Synthesis, Spectroscopic Characterization, Antileishmanial Activity, and DFT and In Silico Studies
No full textAbstract: 1-(3-Methylthiophen-2-yl)-N-(3,4,5-trimethoxyphenyl)methanimine (1, MTM) was synthesized from 3-methylthiophene-2-carbaldehyde and 3,4,5-trimethoxyaniline and characterized by FTIR and 1H and 13C NMR spectra. The geometric structure of the title compound was optimized, and its electronic (FMO, NLO, MEP, NBO), spectroscopic (NMR, IR, UV), and thermodynamic properties were calculated by quantum chemicial methods. The calculated and experimental geometric parameters were compared with each other. Compound 1 was tested for leishmanicidal activity against Leishmania infantum by the broth microdilution method and was found to be efficient against Leishmania infantum promastigotes in the concentration range studied. Possible interactions responsible for the antileishmanial activity were determined by molecular docking analysis against trypanothione reductase (TRe). The docking results demonstrated high inhibition constant of the title compound and supported its antileishmanial activity. © Pleiades Publishing, Ltd. 2024.Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTA
An In Vitro Study: Assessment of Gene Expression Changes Induced by Nanoparticles Synthesized from Cladonia subulata Lichen on Colon Cell Lines
No full textFMB-BAP 23-0594Lichens are among the living organisms used for the biological synthesis of nanoparticles. Lichens are typically organisms where algae and fungi exist symbiotically. These organisms possess a wide array of biological components and are particularly rich in secondary metabolites. These characteristics give them an advantage in NPs synthesis. The use of microorganisms and plant sources in biological synthesis provides a less toxic and more environmentally friendly alternative compared to chemical methods. This study examined the effects of copper-based NPs obtained through biological synthesis from Cladonia subulata (L.) lichen on colon cancer cells from a molecular biology perspective. DLD-1 (colon cancer) and CCD18-Co (healthy colon) cell line were treated with concentrations of NPs ranging from 3.91 to 500 µg/ml for 24 hours, based on the evaluation of MTT test results, and changes in the expression levels of the CYP1A1 and BCL-2 genes involved in the cancer pathway were detected. In DLD-1 cells, a significant increase in the expression levels of the BCL-2 and CYP1A1 genes was observed following the application of Cu-NPs. This increase is believed to support the anti-cancer properties of Cu-NPs by affecting uncontrolled cell proliferation. Similarly, Cu-NPs increased the expression levels of the BCL-2 and CYP1A1 genes in CCD18-Co cells. The highest expression levels were observed at 125 µg/ml in both cell lines. These results suggest that Cu-NPs may also exhibit anti-cancer effects in healthy cells. The results support the evaluation of NPs obtained through biological synthesis as a potential strategy in cancer treatment.[EN] Amasya University Scientific Research Unit (Project No: FMB-BAP 23-0594)
THE EFFECT OF SOCIAL MEDIA USE LEVEL AND SLEEP QUALITY ON WORK PERFORMANCE AMONG UNIVERSITY EMPLOYEES
No full textIt is important to determine the level of social media addiction in the working population and to determine its relationship with sleep quality, and how both variables affect the work performance of the employees. In this study, it was aimed to determine the effects of social media addiction levels and sleep quality of employees at Amasya University on their work performance. The population of the cross-sectional study consisted of staff in all employment types at Amasya University. Sociodemographic data form, Social Media Addiction Scale-Adult Form (SMAS-AF), Pittsburgh Sleep Quality Index (PSQI), and Work Role Functioning Questionnaire (WRFQ) were applied by face-to-face survey method between August 15 and October 15, 2022. A total of 148 individuals participated in the study. The total score on the SMAS-AF was 40.0 (20-84), the PSQI total score was 6.0 (1-15) and the WRFQ total score was 92.5 (6-100). The WRFQ was found to be lower in individuals with associate degree or higher education, females, and academic staff (p=0.042; p=0.010 and p=0.008 respectively). The WRFQ total score indicated low, moderate, and negative significant correlations with the SMAS-AF and PSQI total scores (r= -0.333 and -0.344, respectively, p< 0.001). It was found that as the level of social media addiction increased and sleep quality deteriorated, work role functionality was negatively affected. A holistic approach, including behavioral problems, should be exhibited in the evaluation of work performance
Effects of shilajit addition to honey bee diet on semen freezing
No full textThis study aimed to investigate the effects of adding shilajit to the diet of honey bees on semen freezing. A total of 5 groups were formed in the research, one of which was a control group (SH-0) and the other four were an experimental group (SH-1, SH-2, SH-3, SH-4). A total of 25 study colonies were used, 5 in each group. While the SH-0 group was formed without using any additives, the experimental groups were fed with the addition of shilajit (1/1 sugar/water) in different doses (5, 10, 15, 20 mg/L) to the honey bee diet. The collected semen samples were frozen in liquid nitrogen vapor and then stored in liquid nitrogen at -196°C. Then, semen samples were thawed at 37°C and evaluated to determine spermatological parameters (motility, acrosome integrity, plasma membrane integrity, spermatozoa concentration). It was also examined in terms of total oxidant and total antioxidant. Compared to the control group, it was determined that all shilajit doses significantly increased spermatological parameters such as motility, hypoosmotic swelling test (HOST), acrosome integrity (p<0.001), but did not significantly affect the spermatozoa concentration value (p >0.05). Although there is no statistical difference between the groups in terms of semen TAS (Total Antioxidant Status) and TOS (Total Oxidant Status) values, which are oxidative stress parameters, the numerical increase in TAS values in SH-2 and SH-3 groups; striking. As a result, it was determined that adding shijajit to the honey bee diet positively affected the post-thawing spermatological parameters of frozen bee semen
Apilarnil ve Kraliçe Arı Larvası Liyofilizatlarının Genotoksik ve Antigenotoksik Etkilerinin Mikronükleus Testi ile Belirlenmesi
No full textApiterapi arı ürünleri kullanılarak yapılan tamamlayıcı ve alternatif bir tedavi yöntemidir. Bu çalışmada apiterapi ürünlerinden olan liyofilize erkek arı larvası (apilarnil =APL) ve kraliçe (ana) arı larvasının (KAL) insan periferal lenfositlerinde mikronükleus (MN) testi ile genotoksik ve antigenotoksik etkilerinin belirlenmesi amaçlanmıştır. Bunun için sağlıklı bir erkek ve bir kadın donörden alınan lenfositlere APL ve KAL liyofilizatlarının 1,56; 3,13; 6,25; 12,5; 25,00; 50,00 ve 100,00 µg/mL’lik konsantrasyonları tek başına ve mitomisin-C (MMC) ile eş zamanlı olarak uygulanmıştır. Ek olarak nükleer bölünme indeksine (NBI) etkileri de değerlendirilmiştir. Sonuçta APL ve KAL liyofilizatlarının tek başına kontrole göre MN frekansını etkilemediği görülmüştür. MMC ile birlikte uygulandığında, APL (en düşük iki konsantrasyonu hariç) ve KAL (en düşük konsantrasyonu hariç) tüm konsantrasyonlarda pozitif kontrole göre MN oranını önemli ölçüde azalttığı tespit edilmiştir. Her iki apiterapi ürünü de NBİ'de değişikliğe neden olmamıştır. Elde edilen bu sonuçlar APL ve KAL liyofilizatlarının insan lenfositlerinde genotoksisiteye neden olmadığını ve MMC tarafından oluşturulan hasara karşı da antigenotoksik etkili olduğunu göstermiştir. Bu gözlemlerin diğer in vivo ve in vitro testlerle desteklenmesi önerilmektedir
Factors influencing Omani Gen Z tourists' destination choices
No full textAbstract: Research on the travel preferences of younger generations is the primary approach that tourism service providers should undertake, as they are one of the main target customers. The "post-millennials" or "Generation Z (Gen Z)" are the new generation, and they significantly influence how tourism is currently characterized by its goals and behaviours. As a result, the goal of this study is to evaluate the economic and personal aspects that affect Omani Gen Z tourists' choice of travel location. Additionally, the study will look into the sociocultural aspects that affect Omani Gen Z visitors' choices of travel destinations. Because the group being researched is heterogeneous, this study used descriptive research and implemented stratified sampling to ensure that each attribute was fairly represented. 228 participants responded to the survey that the study used to get the data. The following are the most important factors in the categories of personal, economic, social, and cultural: The location offers security and personal safety (4.35); the destination has low fees for using ATMs and currency exchange centres (4.12); the destination was recommended by social media and influencers (4.07); and traditional and Halal foods are available at the destination (4.30). By considering these factors, tour operators and tourist destinations can modify their products to better cater to Omani "Gen Z" travellers’ wants and interests and deliver a more genuine and immersive travel experience that takes into account their diverse demands and preferences