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Patent foramen ovale closure versus drug therapy in patients over 60 years and a follow-up of 5 years
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Design of Delamination- and Impact-Resistant Fibre Reinforced Composites based on Customized 3D Multilayer Fabrics [DATASET]
No full textThis record provides an overview of the data from the dissertation “Design of Delamination- and Impact-Resistant Fibre Reinforced Composites based on Customized 3D Multilayer Fabrics" by Philipp Maria Huber, RWTH Aachen University, date of oral examination 31.10.2024. A total of twelve 3D-woven CFRP and one laminated reference were developed, manufactured and extensively tested. The data is provided according to the FAIR principle under the listed records. The data is intended for further use, e.g. for modelling or calculations and to facilitate the development of 3D-woven FRP. A suitable licence is attached to each individual file. The naming of the files corresponds to the nomenclature used in the dissertation. All data sets are named with the test method and the sample designation. The produced fabrics, composites, provided data and contributing students are listed in the attached PDF. The respective datasets can be accessed via the related database entries
Characterization of high Zr/Ce ratio Ba(Zr,Ce,Y)O3−δ proton conductors: investigating the impact of Y on the properties of materials
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Geological and mining factors influencing further use of abandoned coal mines – A multi-disciplinary workflow towards sustainable underground storage
No full textDemonstrating Data-to-Knowledge Pipelines for Connecting Production Sites in the World Wide Lab: Source Code
No full textThe source code (zipped git repository) created as part of the publication Demonstrating Data-to-Knowledge Pipelines for Connecting Production Sites in the World Wide Lab
Characterization of the gut-liver axis using fluorescence-based hybrid imaging techniques
No full textFluorescence imaging can longitudinally monitor the biodistribution of fluorophore-labeled drugs, nanoparticles, and antibodies. In this context, fluorescent dyes in biomedical imaging and the accuracy of tracking and characterizing biological processes in the body were investigated. While the interaction of dye labels with transporters is known, its impact on biodistribution was hardly studied. This study compared tumor cell uptake and biodistribution of four near-infrared fluorescent dyes and dye-labeled nanocarriers in A431 tumor-bearing mice. Hydrophobicity of the dyes influenced tumor cell uptake and elimination of free dyes, while dye labeling significantly influenced tumor accumulation and biodistribution of nanocarriers. This study highlights the need for low-interference dyes and further investigation of dye labels to achieve the most unbiased results possible. In our evaluation, AF750 and IRDye750 best qualified for labeling hydrophilic nanocarriers. Therefore, in the following study immunoglobulins were labeled with AF750, which aimed at improving technically the accuracy of optical imaging. CT in fluorescence imaging provides anatomical information for generating scattering and absorption maps aiding fluorescence tomography (FLT) reconstruction. However, its limited soft tissue contrast could lead to inaccurate FLT reconstruction and quantification. Therefore, a hybrid imaging approach using MRI was established and compared to the state-of-the-art (CT-FLT). The study found comparable dye quantification for Cy7 inserts and organs containing fluorescent immunoglobulins for FLT reconstructions aided by CT, MRI or CT-MRI, with or without extending scattering maps. MRI enabled the visualization of specific organs and improved segmentation, allowing more accurate fluorescence signal assignments. The novel trimodal CT-MRI-FLT whole-body imaging approach facilitated more nuanced pharmacokinetic analyses with the option for tissue characterization. In conclusion, this research investigated and optimized both the selection of dyes for biodistribution analyses and the anatomical modality for whole-body FLT in a preclinical setting