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Hubungan Tingkat Stres dengan Sindrom Pramenstruasi pada Mahasiswi Fakultas Kedokteran Angkatan 2021 Universitas Tarumanagara
Full text linkPremenstrual syndrome (PMS) is physical and non-physical symptoms experienced by women of the reproductive age two to fourteen days before menstruation. One of the factors can cause PMS is stress. Objective: To determined the correlation between stress and premenstrual syndrome among year 2021 Faculty of Medicine students at University of Tarumanagara. Methods: This research was an observational analytic study with a cross-sectional research design. The stress variable was measured using the Depression Anxiety Stress Scales-21 (DASS-21) questionnaire and the premenstrual syndrome variable was measured based on prospective questionnaire by the American College of Obstetricians and Gynecologists (ACOG). The number of respondents obtained was 138 and the chi-square test was analyzed as a hypothesis test. Results: There were 56 (62,2%) respondents classified as having stress and experienced PMS, while 15 (31,3%) respondents not having stress experienced PMS. The 34 (37,8%) respondents were classified as being stressed but not experiencing PMS, and 33 (68,8%) respondents were not stressed and not experiencing PMS. The affective and somatic symptoms most often experienced irritability (77,54%) and joint or muscle pain (49,28%). There was a significant relationship between stress and premenstrual syndrome with p-value = 0,001 (p-value <0,05). Conclusion: There is a statistically significant relationship between stress and PMS (p<0,05). Affective symptoms were felt more than the somatic ones.Keywords: DASS-21, diagnostic criteria of PMS, premenstrual syndrome, stres
Hubungan Infeksi Soil-Transmitted Helminths (STH) dengan Angka Kejadian Tuberculosis (TB) pada Balita Stunting di Kecamatan Rambipuji
Full text linkInfection is one of the factors associated with stunting. The relationship between stunting and infection can have reciprocal effects. Stunting can increase the risk of infection. Conversely, infections such as Soil-Transmitted Helminths (STH) and Mycobacterium tuberculosis (M. tuberculosis) can also increase the risk of stunting. Objective: To analyzed the correlation between STH infection and the incidence of tuberculosis (TB) in stunting toddlers. Methods: The subjects of this study were 108 stunting toddlers obtained from a simple random sampling method. It was conducted from May 2023 to March 2024 in several villages within the Rambipuji District of Jember Regency, including Gugut, Rambigundam, Pecoro, and Kaliwining. The statistical analysis used in this study was the contingency coefficient test. Results: Findings revealed that the occurrence of STH infection with TB in stunting toddlers was 0%. Conclusion: There is no statistically significant relationship between STH infection and the incidence of TB in stunting toddlers in the Rambipuji District, Jember Regency.Keywords: soil-transmitted helminths, tuberculosis, stuntin
Hubungan Indeks Massa Tubuh dan HDL dengan Laju Filtrasi Glomerulus pada Pasien Hipertensi di Klinik Media Farma Samarinda
Full text linkChronic Kidney Disease (CKD) is an irreversible, catastrophic condition. CKD is most commonly caused by hypertension, it is important to explore risk factors in hypertensive patients associated with Glomerular Filtration Rate (GFR) as an indicator of kidney function. Objective: To determined the relationship between risk factors, namely Body Mass Index (BMI) and High Density Lipoprotein (HDL), and how these factors influence GFR in hypertensive patients. Methods: This analytical observational study, using a cross-sectional approach, used 100 medical records from hypertensive prolanis patients at Media Farma Clinic, Samarinda, from January to December 2021. Statistical analysis was conducted using the Spearman correlation test, with p < 0.05 considered a significant correlation. Results: There were 40 male and 60 female patients. Among them, 51 patients had controlled blood pressure, while 49 had uncontrolled blood pressure. The median systolic blood pressure was 136.5 mmHg, and the mean diastolic blood pressure was 82.83 mmHg. The median age of the patients was 54.50 years. The median BMI was 27.23 kg/m², the median HDL was 41.5 mg/dL, and the median GFR was 73 ml/min/1.73 m². The relationship between BMI and GFR in hypertensive patients showed p = 0.034; r = 0.212. The relationship between HDL and GFR in hypertensive patients showed p = 0.020; r = 0.232. Conclusion: Both BMI and HDL have a significant positive correlation with GFR in hypertensive patients.
Keywords: BMI, HDL, hypertension, GF
Dosis Radiasi Pekerja dan Pasien Pada Prosedur Intervensi Di RSUP Dr. M. Djamil, Padang
No full textAplikasi radiasi di bidang medik merupakan penyumbang terbesar dari paparan radiasi yang diterima oleh populasi dunia. Tujuan: Mengetahui tingkat dosis radiasi yang diterima pekerja dan pasien pada saat dilakukan tindakan intervensi yang dilakukan di Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil, Padang. Metode: Penelitian dilakukan pada bulan Februari sampai Maret 2018 dengan mengukur dosis pekerja menggunakan dosimeter termoluminesensi (TLD) dalam bentuk chip, dan merekam kerma dan KAP (kerma-area product) pasien yang ditampilkan pada layar monitor pesawat sinar-X. Hasil: Perawat yang terlibat dalam tindakan PAC menerima dosis efektif, dosis tiroid dan dosis ovarium tertinggi sebesar masing-masing 0,1043 mSv, 0,1141 mSv dan 0,1040 mSv, sementara dosis lensa mata tertinggi sebesar 0,3020 mSV diterima perawat dalam tindakan pemasangan pacu jantung, dan dosis ekstremitas jari tertinggi sebesar 0,3964 mSv diterima dokter yang melakukan tindakan angio dan PTCA elektif. Untuk pasien, kerma tertinggi sebesar 3053 mGy dan KAP tertinggi sebesar 16443 cGy cm2 diterima oleh pasien yang menjalani tindakan PAC diikuti PTCA. Simpulan: Dosis radiasi tertinggi yang diterima pekerja radiasi menyiratkan bahwa tidak hanya dokter namun perawat juga dapat menerima dosis radiasi tertinggi, sedangkan pasien diduga menerima risiko efek deterministik dan efek stokastik terbesar saat menjalani tindakan PAC diikuti PTCA.Kata kunci: dosis pasien, dosis pekerja, tindakan intervensi, paparan medikÂ
Hubungan Morfologi Plak pada Stenosis Arteri Karotis Ekstrakranial dengan Kejadian Stroke Iskemik
Full text linkStenosis arteri ekstrakranial bermanifestasi dalam berbagai kondisi, mulai dari asimptomatik hingga stroke iskemik. Salah satu modalitas diagnostik untuk mengevaluasi gambaran stenosis tersebut adalah carotid duplex. Terdapatnya plak pada stenosis arteri ekstrakranial mempengaruhi kejadian stroke iskemik. Namun masih belum jelas hubungan antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik. Tujuan: Menentukan hubungan morfologi plak pada stenosis arteri karotis ekstrakranial dengan kejadian stroke iskemik. Metode: Penelitian ini merupakan studi analitik dengan desain cross sectional yang dilakukan pada 20 orang sampel pada bulan Januari hingga September 2018 di RSUP Dr M Djamil, Padang. Kriteria inklusi adalah pasien yang telah didiagnosis stenosis arteri ekstrakranial dengan plak dari pemeriksaan carotid duplex dan kriteria eksklusi adalah pasien yang tidak datang kontrol atau tidak bisa dihubungi. Hubungan antar variable diuji dengan uji Chi-square. Hasil dianggap bermakna secara statistik jika nilai p<0,05. Hasil: Sebanyak 12 orang (60%) sampel adalah perempuan dan 8 orang (40%) adalah laki-laki. Median umur sampel adalah 56 tahun (37-71 tahun). Morfologi plak berupa plak nonulcerated sebanyak 11 orang (55%) dan plak ulcerated sebanyak 9 orang (45%). Kejadian stroke iskemik ditemukan sebanyak 9 orang (45%) dan tidak stroke sebanyak 11 orang (55%). Terdapat hubungan antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik (p = 0,02); RR = 5. Simpulan: Terdapat hubungan bermakna antara morfologi plak pada stenosis arteri ekstrakranial dengan kejadian stroke iskemik.Kata Kunci: morfologi plak, stenosis arteri ekstrakranial, stroke iskemi
Efek Intervensi Perilaku Terhadap Manajemen Diri Penderita Diabetes Melitus Tipe 2: Sistematik Review
Full text linkBehavioral intervention sangat penting dilakukan dalam manajemen diri penderita Diabetes Melitus tipe 2 sebagai intervensi dalam upaya meningkatkan status kesehatan. Manajemen diri merupakan hal penting untuk mempertahankan kontrol gula darah sehingga komplikasi pada penderita DM tipe 2 dapat dicegah. Tujuan: Mengetahui bentuk intervensi perilaku untuk mengukur outcome dari manejemen diri penderita DM tipe 2. Metode:  Electronic database dari jurnal yang telah dipublikasi melalui Google Schoolar, ProQuest, PubMed., dan ScienceDirect. Hasil review dari 8 jurnal yang telah dipilih menyatakan bahwa behavioral intervention memberi pengaruh terhadap manajemen diri penderita DM tipe 2 dalam kontrol glikemik. Instrumen penelitian yang digunakan untuk mengukur behavioral intervention pada penelitian kuantitaif yakni kuesioner, melakukan observasi perubahan perilaku, sedangkan pada penelitian kualitatif menggali informasi dengan indepth interview. Hasil: Efek behavioral intervention yang meliputi pemberian edukasi dan self efficacy dapat memfasilitasi peningkatan pengetahuan, pencegahan komplikasi dan meningkatkan kualitas hidup pasien DM tipe 2. Simpulan: efek behavioral intervention sangat efektif dalam meningkatkan manajemen diri penderita DM tipe 2, namun pelaksanaan intervensi perlu dimodifikasi agar didapatkan hasil yang lebih maksimal, salah satunya dengan pemanfaatan terknologi berbasis komunitas.Kata kunci: behavioural intervention, diabetes melitus tipe 2, manajemen dir
Korelasi Kadar Adiponektin dengan Kadar Glukosa Puasa pada Penyandang Obes
Full text linkAkumulasi lemak tubuh abnormal dan berlebih pada obesitas menyebabkan low grade inflammation sel adiposit yang berkontribusi terhadap penurunan kadar adiponektin. Adiponektin berperan dalam metabolisme glukosa, sehingga kondisi hipoadiponektinemia dapat menyebabkan gangguan metabolisme glukosa. Tujuan: menentukan korelasi kadar adiponektin dengan kadar glukosa puasa pada penyandang obes. Metode: Penelitian ini merupakan studi analitik dengan rancangan potong-lintang terhadap 25 orang penyandang obes yang bekerja di Instalasi Laboratorium Sentral RSUP Dr. M. Djamil Padang yang memenuhi kriteria inklusi dan eksklusi. Penelitian dilakukan mulai bulan September 2018 sampai September 2019. Kadar adiponektin diperiksa dengan metode Elisa two-step sandwich enzyme immunoassay dan kadar glukosa puasa diperiksa dengan metode heksokinase. Data dianalisis dengan uji korelasi Pearson, bermakna jika p<0,05. Hasil: Subjek penelitian terdiri dari laki-laki 8 orang (32,0%) dan perempuan 17 orang (68,0%). Rerata umur adalah 33,5 (6,0) tahun dengan rentang 23-52 tahun. Rerata indeks massa tubuh adalah 34,0 (3,6) kg/m2. Rerata kadar adiponektin adalah 2,8 (1,5) μg/mL dan rerata kadar glukosa puasa adalah 92,8 (11,4) mg/dL. Uji korelasi Pearson menunjukkan korelasi negatif lemah antara log-adiponektin dengan kadar glukosa puasa dan tidak bermakna secara statistik (r= -0,217, p= 0,298). Simpulan: Tidak terdapat korelasi kadar adiponektin dengan kadar glukosa puasa pada penyandang obes.Kata kunci: adiponektin, glukosa puasa, inflamasi adiposit, obesita
Korelasi Kadar Adiponektin dengan Kadar Kolesterol High Density Lipoprotein pada Penyandang Obes
Full text linkAdiponectin and HDL cholesterol have a protective cardiovascular effect. Adiponectin levels decrease in obese people. This causes ATP-binding cassette transporter A1 expression and apolipoprotein A-I synthesis in hepatocytes to decrease, resulting in impaired HDL cholesterol synthesis. Objectives: To determined the correlation between adiponectin levels with HDL cholesterol levels in obese. Methods: This was the analytic study with a cross-sectional design of 59 obese people who met inclusion and exclusion criteria at RSUP dr. M. Djamil Padang, from January to August 2019. Research subjects were grouped into two groups based on WHO Asia Pacific body mass index (BMI) classification. First-degree obesity group (25.0 £ BMI <30.0 kg/m2) and second-degree obesity group (BMI ≥ 30.0kg/ m2). Adiponectin levels were examined by the enzyme-linked immunosorbent assay (ELISA) method and HDL cholesterol levels by the enzymatic colorimetric method. Data analyzed by Pearson correlation test, significant if p <0.05. Results: Research subjects 59 people (17 men, 42 women), average age 35 (8.04) years. Adiponectin levels in the first-degree obesity group were higher than second-degree obesity group, with a mean difference between groups 1.03 μg/mL (CI: 95%: 0.14 - 1.92, p = 0.02). Results showed adiponectin levels positively correlated with HDL cholesterol levels of moderate strength (r = 0.45) and statistically significant (p = <0.001). The results of the population subanalysis show relatively similar patterns. First-degree obesity population (r = 0.55; p = 0.002), second-degree obesity population (r = 0.41; p = 0.026). Conclusions: Adiponectin levels correlate with HDL cholesterol levels.Keywords: adiponectin, HDL cholesterol, obesit
Limfopenia dan Rasio Neutrofil-Limfosit pada Infeksi Severe Acute Respiratory Syndrome Coronavirus 2
Full text linkSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause cytokine storm characterized by the excessive release of pro-inflammatory cytokines, leading to lymphopenia and neutrophilia. Lymphopenia and high Neutrophil-Lymphocyte Ratio (NLR) on admission were associated with the severity of the disease. Objectives: To found out lymphopenia and high NLR in SARS-CoV-2 infection. Methods: This was a cross-sectional descriptive study on all patients infected with SARS-CoV-2 who met the inclusion and exclusion criteria at Dr. M. Djamil Hospital Padang from March until August 2020. Lymphocyte count and neutrophil count on admission were examined by flowcytometry method and NLR was calculated. Lymphopenia is a lymphocyte count of <1.5x103/mm3 and high NLR is ≥ 3.13.  Results: The study samples were 123 patients, with 58.5% women. The mean age was 47.80 (15.59) years. Lymphopenia was present in 39% of patients with mean lymphocyte count was 1.84 (0.83) x103/mm3. High NLR was present in 48% of patients with a mean NLR was 5.06 (4.87). Conclusion: Lymphopenia was present in 39% of patients infected with SARS-CoV-2 and high NLR was present in 48% of patients infected with SARS-CoV-2.Keywords:  lymphopenia, neutrophil-lymphocyte ratio, SARS-CoV-
Hubungan Albuminuria dan Laju Filtrasi Glomerulus pada Pasien Diabetes Melitus Tipe 2 yang Tidak Terkontrol
Full text linkDiabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. Patients with diabetes mellitus require optimal glycemic control. Poorly controlled diabetes mellitus is at risk for complications, such as diabetic nephropathy. Diabetic nephropathy is characterized by albuminuria and can lead to decreased Glomerular Filtration Rate (GFR). Objectives: To determined the relationship between albuminuria and GFR in a patient with poorly controlled type 2 diabetes mellitus. Methods: This research was conducted at the Pontianak Branch of Prodia Health Clinic Laboratory in March 2021, using secondary data of laboratory examination results from DM patients in the 2020 period. This research was observational analytics with a cross-sectional approach. The number of samples that comply with the research criteria was 273 people. Bivariate analysis using Spearman’s correlation test. Results: Spearman's correlation test results showed significance (p=0.001) and correlation coefficient (r=0.209). Conclusion: Albuminuria and GFR in a patient with poorly controlled type 2 diabetes mellitus are significantly and positively correlated.Keywords:  albuminuria, poorly controlled type 2 diabetes mellitus, glomerular filtration rat