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انعكاسات البيئة العالمية للتعليم على مسارات التعليم في الجزائر
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Within the framework of utilizing international expertise in the field of education, the Algerian Ministry of National Education and UNESCO signed a support protocol for the reform of the Algerian educational system in Paris in 2003. This protocol, which aimed to enhance the quality of compulsory education, support the organization of student flow, integrate information technology, support pedagogical training for teachers, and support the review of educational programs, served as the foundation for this study. The main research question of this study is: What are the manifestations of the global environment of education on educational pathways in primary and secondary education in Algeria? To answer this question, the study relied on two sub-questions: What are the manifestations of the global environment of education on pedagogical pathways in primary and secondary education in Algeria? What are the manifestations of the global environment of education on socio-educational pathways in primary and secondary education in Algeria?
The first sub-question was answered through the use of four indicators: internal effectiveness, integration of information technology, quality of training qualifications for teachers, and teaching skills in relation to competencies. The second sub-question was answered through the use of one indicator: the concept of citizenship in the educational frameworks of civic education and history.
The aim of this study is to evaluate education in its compulsory stage in Algeria in light of the aforementioned indicators, as well as to diagnose the reality of the chosen educational strategies by those responsible for the educational system, and to determine their effectiveness, through the opinions of teachers and educational leaders.
To achieve these objectives, the descriptive method was used. The sample for this study consisted of 385 teachers in the compulsory education stage, distributed between the primary and secondary levels as follows: 145 primary school teachers and 240 secondary school teachers, as well as seven educational leaders from secondary schools. The study relied on educational indicators and questionnaires as the main data collection tools, and interviews were used as a complementary tool to explain and clarify the data from the questionnaires.
Each question in the study was verified using a specific tool, in conjunction with a special selection process for the sample that takes into account the privacy of each question. The study was conducted during the 2015/2016 academic year and took approximately three months, from October to December 2015, for a sample of educational institutions in the primary and secondary stages in the geographical region of the city of Biskra.
The results of the study showed the following:
1.Compulsory education suffers from a significant lack of internal effectiveness.
2.The implementation of the project to integrate information technology in education is characterized by failure and inability.
3.The training qualifications for teachers suffer from a lack and inadequacy, due to theoretical training programs.
4.The skills of teachers in relation to competencies, in light of Algeria's international commitments in the field of education, reveal a lack of ability and inadequacy in practicing these competencies within the educational institutions.
5.Values and principles related to loyalty to the nation and belonging to the homeland are present in the educational frameworks and content, which is linked to the concept of belonging in the Algerian context, despite the efforts to acquire more depth and reality in relation to global citizenship values such as openness to others, achieving shared life, establishing democracy and freedom, and eliminating all forms of discrimination in order to achieve active and productive participation within and outside the school
Contribution to the Modeling of Biomolecules and Their Interactions: Inhibition of Enzymes Involved in Cancer Diseases by a New Class of Derivatives.
Get PDFThis dissertation presents the results of two research studies aimed at improving our understanding of breast cancer treatment drugs and potential targets. The first study used PLS regression to create QSAR models for 54 analogs of 2-phenyl-1H-indole, known for their antiproliferative activity on MDA MB231 and MCF-7 cancer cell lines. The dataset was split into training and testing datasets 10,000 times, with 75% of the molecules used for training and the rest for external validation. The best models were selected based on the highest probability of occurrence according to the Bayesian information criterion. As a result, the PLS regression equation derived explains 6.79% and 63% of the variability in anticancer activity around its mean for model 1(MDA MB231), and model 2 (MCF-7), respectively. The leave-one-out cross-validation R2CV, the bootstrapping correlation coefficients R2boots, and the predicted R2pred indicated a high predictive power for both models. This study was accompanied by molecular docking/dynamics simulations, revealing that ligands L39, L40, and L48 fit into the pocket of estrogen-α receptor (PDB:1A52), while ligand L47 showed affinity with progesterone receptor (PDB:1A28). This affinity was confirmed by high negative score values and the establishment of several non-covalent interactions with the active site residues of both receptors. Furthermore, drug-likeness and ADME prediction analyses showed favorable absorption and oral bioavailability characteristics for ligands L39 and L48, suggesting their potential as precursor compounds for breast cancer drug development. The second study aims to identify the binding mechanism of Glutaminase C (GAC) as a potential target for triple-negative breast cancer (TNBC). Molecular docking was employed to explore the interaction of 26 Withangulatin A (WA) derivatives with the allosteric site of GAC. The molecular docking/dynamics simulation results revealed that compounds A5, A8, A13, and A18 show high affinity toward the allosteric pocket of the GAC (PDB:3UO9), as confirmed by the high negative score values. These compounds interact with the most important residues and suggest a similar binding mechanism to the native compound (BPTES) and the clinical trial drug (CB-839). The combination of MEP analysis and molecular docking/dynamics studies confirms the favorable reactive sites of these compounds. Finally, pharmacokinetics prediction showed that A8 and A13 present the best ADMET profile among the selected compounds
أثر المخططات المعرفية اللاتكيفية على إدراك الضغط النفسي لدى عينة من الراشدين: الجلد كمتغير وسيط ومعدل
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هدفت الدراسة إلى التعرف على اثر مجالات المخططات المعرفية اللاتكيفية على مستوى ادراك الضغط النفسي حيث قدرة الجلد كوسيط بينهما وفي حالة كونه متغير معدل لدى عينة من الراشدين. شملت الدراسة على عينة من 168 فردا، وتراوحت أعمارهم بين 20 إلى 60 سنة ( متوسط = 35.65، انحراف معياري = 12.37، الإناث %58,97). استعمل مقياس المخططات المعرفية المبكرة جيفري يونغ (2006) وسلم ادراك الضغط النفسي كوهن و آخرون (1983) واختبار الجلد كونور دفيدسون (CD-RISC) المختصر. بينت النتائج تقارب مستوبات تاثير مجالات المخططات المعرفية اللاتكيفية وفروعها، وكذلك جود علاقة ارتباط طردية دالة احصائيا بين كل من مجالات المخططات المعرفية اللاتكيفية وادراك الضغط النفسي، بينما توجد علاقة ارتباط عكسية دالة احصائيا بين كل من مجالات المخططات المعرفية اللاتكيفية والجلد وكذلك بين الجلد وادراك الضغط النفسي. كما بينت نتائج نموذج تحليل المسار للعلاقات بين المخططات المعرفية اللاتكيفية وادراك الضغط النفسي والجلد كوسيط بينهما أنه يوجد تأثير غير مباشر. وكذلك في نموذج الجلد كمتغير معدل وجود اثر غير مباشر دال احصائيا للمخططات المعرفية اللاتكيفية على ادراك الضغط النفسي. ولا توجد فروق تعزى لمتغير الجنس وحسب فئات العمر والمستوى التعليمي والمستوى المعيشي في كل من المخططات المعرفية اللاتكيفية وادراك الضغط النفسي و الجلد. توصلت الدراسة إلى أن مجالات المخططات المعرفية اللاتكيفية تنبئ بمستوى ادراك الضغط النفسي وان مستوى التأثير المرتفع لمجالات المخططات المعرفية اللاتكيفية يدل على مستوى ادراك الضغط النفسي المرتفع أيضا. وفي وجود الجلد كوسيط أو معدل فإن ذلك يؤدي إلى انخفاض مستوى ادراك الضغط النفسي.
الكلمات المفاتيح: ، المخططات المعرفية اللاتكيفية المبكرة؛ ادراك الضغط النفسي؛ الجلد.
ABSTRACT :
The study aimed to identify the effect of the areas of maladaptive cognitive schemas on the level of perceived stress and resilience capacity as a mediator between them, and in the case that it is a moderator variable in a sample of adults. among a sample of adults. The study included a sample of 168 individuals, whose ages ranged from 20 to 60 years (mean = 35.80, standard deviation = 12.23, female 58.97%). The Jeffrey Young Early Cognitive Schemas Scale (2006), Stress Perception Scale (Cohen et al., 1983), and Connor Davidson Abbreviated Skin Test (CD-RISC) were used. The results showed convergence in the levels of influence of the areas of maladaptive cognitive schemas, as well as the existence of a positive correlation statistically significant between each of the areas of maladaptive cognitive schemas and the perceived stress, while there is negative correlation statistically significant between each of the areas of maladaptive cognitive schemas and the resilience, as well as between the resilience and perceived stress. Results of path analysis model of the relationships between maladaptive cognitive schemas and perceived stress and resilience as mediator between them showed that there is an indirect effect. Also, the model of resilience as a moderator showed a statistically significant indirect effect of maladaptive cognitive schemas on perceived stress. However, there are no differences due to the variables of gender, age groups, educational level and economic level in maladaptive cognitive schemas, perceived stress, and resilience. The study clarified that high level maladaptive cognitive schemas predict the high level of perceived stress as well, while; in the presence of the resilience as a mediator or as moderator, this leads to a lower level of perceived stress
Synthèse et caractérisations d’un nouveau matériau de type MZrTiO3 ; Pb(0,95-x) La0.03 Sm0.02 Bix (Zr0.3, Ti0.7)y O3.
Get PDFLes PZT sont des matériaux largement utilisés dans diverses applications, mais rarement
dans une formulation chimique simple. Ils sont souvent modifiés par l’introduction d’éléments
de substitution (dopants) dans les sites-A ou les sites-B, de leur structure pérovskite ABO3. Le
rôle des dopants est généralement l’amélioration des propriétés de ces matériaux en vue de leur
adaptation à des applications bien spécifiques.
Dans la présente étude, nous avons choisi une composition de PZT (non dopé et dopé)
située dans la zone morphotropique (Zr : Ti = 30:70) et pour étudier l'effet de dopage, nous
avons choisi pour la même composition le Bi comme élément additif au site "A" de Pb0.95-x
La0.03 Sm0.02 Bix(Zr 0.3Ti 0.7)yO3 avec x% =0, 2, 4, 6, 8, 10 %, abrégé PLSBZT.
Dans ce travail, les échantillons polycristallins de Pb0.95-x La0.03 Sm0.02 Bix (Zr 0.3Ti 0.7)yO3
(x=0, 0.02, 0.04, 0.08, 0.1) ont été préparés par une technique de réaction à l'état solide à haute
température. Les techniques SEM et DRX ont été utilisées pour examiner la cristallisation de
la céramique. Nous avons vu les résultats d’étude structurale et morphologique des différents
nouveaux matériaux à base de PZT. Ces échantillons, dopés au site A de la pérovskite par Bi3+
avec le rapport Zr/ Ti (30/70), ont été synthétisés, en utilisant la méthode d’addition
géométrique par DRX et aussi le MEB. Les résultats de DRX montrent que la structure de phase
des échantillons est tétragonale.
Les mesures des propriétés diélectriques ont été effectuées après métallisation des deux faces
des échantillons céramiques (à la température optimale) par la pâte d'argent. L'évolution en
fonction de la température a été effectuée entre 100 K et 900 K à différentes fréquences (1
kHz,1000 kHz). Cette étude a révélé que :
• Toutes les céramiques PLSBZT présentent un comportement normal des matériaux
diélectriques, la valeur de εr max est jugée la plus élevée pour la composition non
dopée (εr max =9984.3502 à Tc = 720K). Pour les compositions dopées, ε max est
attribuée à x=0.08 (εr max= 7332,11265 à Tc=798K).
• On peut donc dire que le dopage avec le Bi sur le PLSZT abaisse les propriétés
diélectriques et électriques, mais une fois le système est dopé, ces paramètres
s'améliorent légèrement avec l'augmentation de la teneur de Bi.
MOTS-CLÉS : PZT – Pérovskite – PLSBZT- Tétragonal - Bi - dopants – DRX – SEM -
Propriétés diélectrique
مؤشرات الاجهاد مابعد الصدمة لدى الممرض المتعافي من كوفيد-19- INDICATEURS DE STRESS POST-TRAUMATIQUE CHEZ UNE INFIRMIÉRE GUÉRI DU COVID-19-
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Cette étude intitulé les indicateurs du PTSD chez l'infirmière guéri du covid -19- , a poue but d'identifier des indicateurs du PTSD chez ces cas. Pour réaliser cette étude nous avons adopté la méthode clinique étude de cas. Utilisant l'interview clinique et le test de Davidson. Appliqué sur trois cas d'infirmiers travaillant dans le service de covid -19- . Etude effectué dans la wilaya de Skikda. Des ayant déjà été atteint par l'épidémie et s'en était remis.
Après avoir appliqué les outils d’examen, dépouillé et interprété les données, nous avons conclu que les cas de l'étude ont montré les indicateurs du PTSD dues al' atteinte par le covid -19. Les indicateurs du trouble ont apparu a des degrés divers comme suit :
- Les indications de revivre l’expérience traumatique sont: l'imagination des souvenirs, des pensées et des rêves troublants lies à l’évènement traumatique; de ressentir des sentiments que les expériences vécues se répèteront, d’être agace par des choses et des personnes liées à l’évènement traumatique; ce qui entraine une sensation d’essoufflement, une augmentation des battements de cœur, des tremblements et une transpiration abondante.
- Les indications de l'évitement de l’expérience traumatique, tel que l'évitement des pensées, des sentiments, des situations et des choses qui vous rappellent l'évènement traumatisant ; la difficulté à profiter de la vie ou des activités quotidiennes ; le sentiment d’isolement et d’engourdissement et la difficulté à imaginer survivre longtemps pour atteindre les objectifs.
- Indicateurs d’hyperexcitabilité : les troubles du sommeil tels que la difficulté à s'endormir ou à rester endormi, des accès de tension de colère et d'irritabilité pour des raisons anodines, une distraction dans l'attention et un sentiment de motivation s'attendant toujours au pire et au bord du gouffre d’effondrement.
ABSTRACT :
This study dealt with indicators of post-traumatic stress disorder in male nurse recovering from covid-19-, and aimed to identify indicators of the PTSD. To realize this study, we chose the clinical method case formulation. it was applied on three cases of male nurses working in the covid-19- healthcare service, in Skikda city (Algeria). The cases of study had previously contracted the epidemic and recovered from it.
After applying the assessing tools and extracting and interpreting the data, we concluded that the study case has shown PTSD indicators, due to the infection with covid-19-. These indicators were provided in different degrees as follows:
- The indicators of reviving the traumatic experience are the imagination of images, memories, thoughts and disturbing dreams related to the traumatic event feeling. Brutal feelings or experiences that what happened will be repeated again; and being annoyed by things and people related to the traumatic event, which leads to breath difficulties and an increase in breathlessness. Heartbeat tremors and profuse sweating.
- The indicators of the traumatic experience avoidance: avoidance of thoughts, feelings, situations, and things that remind the traumatic event; the difficulty to enjoying daily activities, feeling isolated and numb; the difficulty to imagine surviving for a long time to achieve the life goals.
- The indicators of hyper excitability, which are sleep disturbances, such as difficulty in falling asleep or staying asleep, boots of tension, anger, emotion for trivial reasons, distraction in attention, a sense of motivation, always expecting the worst, and the brink of collapse
الإعلام الصحي ونشر التوعية الصحية لدى الشباب الجامعي الجزائري في ظل جائحة كورونا "دراسة تحليلية ومسحية لعينة من مشاهدي برنامج كوفيد- 19 لقناة الجزائرية الثالثة خلال سنة 2020"
Get PDFThis study addresses the problem of the relationship between exposure to the event health television program COVID-19 and health awareness which can occur based on exposure to this program, by revealing the manner and degree to which this health program contributes to benefiting the viewing audience from the study sample In a way that leads to achieving health awareness among them, which is the cornerstone for preventing possible infection with the Coronavirus (COVID-19) and maintaining health in general in light of this health threat.
Therefore, this study, in addition to examining the potential effects that the COVID-19 program could have on members of the sample studied (Algerian university youth), also attempts to examine the experience of this health program in dealing with the coronavirus pandemic and accompanying it on the one hand, as well as dealing with and accompanying the members of the surveyed sample on the other hand.
In our study of this phenomenon, we relied on theoretical and methodological approaches that allowed us to investigate the cognitive and behavioral structure of the media audience, based on highlighting and analyzing some elements of reception within the potential levels of influence, some of which represent how to receive the content to which the respondent is exposed to from the study sample, as well as perceive it within the cognitive level.
The study provided us with pictures of how the COVID-19 program contributed to spreading health awareness among Algerian university youth in light of the coronavirus pandemic, Which turned out to be a very limited contribution, It was limited to achieving health awareness - to some extent - within the cognitive level, and the study also gave us a perception of the program’s inability to build individuals capable of dealing with the Coronavirus crisis
Virtual screening applied in several series of bioactive heterocyclic molecules
Get PDFMalaria is one of the most widespread and fearsome parasitic disease in the world. Plasmodium falciparum is the parasite that causes the most severe type of malaria, this species transmits in the human body and attack the important organ; which is the human liver cells, will then reenter the blood stream and begin infecting the red blood cells. The major enzymes in this parasite is Plasmodium falciparum dihydrofolatereductase (PfDHFR), it is responsible for the biosynthesis of essential amino acids and nucleotide bases. The emergence of
resistance of this kind of parasite to antimalarial agents had led for several years, still represents a threat, which draws our attention for the adoption of new guidelines for the treatment of malaria cases of P. falciparum species. For this reason, in this thesis we focus light on the discovery and development of Sym-triazine derivatives, which have provided a class of antimalarial drugs highly effective against PfDHFR. In this context, it is necessary to focus on Virtual Screening computational approaches in the fields of target identification and lead discovery.
The aim of our study was to apply this type of in silico methodology, with the aim of modelling and evaluating for screening bioactive molecules derived from Sym-triazine. Our work combined between ligand-based VS methods; we based on the QSARs methods Two-dimensional (2D-QSAR(MLR/ANN)) and a three-dimensional stereo (3DQSAR( PLS)) which contains effective biological properties. The both of methods coupled with a Virtual Screening examination, by using a technique similarity search. Subsequently, we confirm the powerful and robustness of developed QSAR models by using various statistical OECD principles for the validation; internal and external validation (for training and test set), Y-randomization, and exploit of applicability domain. And structure-based VS methods; we concretized on the molecular docking analysis to determine the best interactions of the most active compound or the reference ligand which form stable complexes with the PfDHFR enzyme. The final results of our study, these different in silico methods allowed us to identify 9 new derivatives of Sym-triazine
from both studies, show excellent inhibitory concentration activities against resistant P. falciparum bearing the
mutant enzymes, making them good candidates for further development as antimalarial drugs
التوافق النفسي لتلميذ المرحلة الابتدائية وعلاقته بالتحصيل الدراسي في ظل المقاربة بالكفاءات.
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تهتم الدراسة بمعرقة العلاقة بين التوافق النفسي للتلميذ وتحصيله الدراسي في ظل المقاربة بالكفاءات وذلك باستخدام المنهج الوصفي بشقيه الارتباطي والمقارن .
وسعيا لتحقيق أهداف الدراسة فقد تم الاستعانة بعينة قوامها 231 تلميذا وتلميذة ،وتم تطبيق مقياس التوافق النفسي للأطفال لأماني عبد المقصود بعد حساب الخصائص السيكومترية له كأداة رئيسية للدراسة بالاضافة الى المقابلة وكشوف نقاط التلاميذ عينة الدراسة لسنة 2022/2023.
- توصلت الراسة الى وجود علاقة طردية موجبة بين التوافق النفسي للتلميذ في مرحلة التعليم الابتدائي والتحصيل الدراسي في ظل بيداغوجيا المقاربة بالكفاءات ،كما أن مستوى التوافق لديهم عال ،في حين أنه توجد فروق بين الذكور والاناث في مستوى التوافق ولا توجد فروق بين الجنسين في مستوى التحصيل الدراسي،
- خرجت الدراسة بمجموعة اقتراحات أهمها تفعيل دور المعالجات البيداغوجية ،الزيارات الدورية للمؤسسات التربوية من طرف الأولياء وتوسيع العلاقة مع المؤسسة التربوية،كذلك توفير التخصص النفسي المدرسي في هيئة اخصائيين نفسانيين في الدرسة.
ABSTRACT :
يسعى الانسان منذ السنوات الأولى من عمره الى اشباع حاجاته التي تكون بداية بسيطة بيولوجية وعلائقية ولكن ماتنفك أن تتوسع هذه الإحتياجات بتوسع اهتماماته وتوسع المحيط الذي يتفاعل معه ،هذا التفاعل يتطلب منه احداث توازن مستمر بين متطلبات الذات ومتطلبات المجتمع من أجل تحقيق التوافق النفسي والراحة خصوصا بعد انتقاله الى المؤسسة التربوية بمقاربتها الجديدة التي تهتم بالكفاءات وتوظيفها في خضم وضعيات تعلمية تعليمية تتطلب من التلميذ أن يكون فاعلا ضمن جماعات تربوية وهياكل مادية وبشرية ومعرفية من أجل تحقيق التوازن الذي يصبو اليه في تلك البيئة التربوية ،ذلك التوازن الذي يظهر في هيئة ما أنجزه المتعلم والمسمى بالتحصيل الدراسي