59571 research outputs found
Sort by
Synthesis, characterization and fluorescence spectral studies of poly (diphenylamine-aminophenol) copolymers using a reactive surfactant
No full text38-42Poly (para-diphenylamine-co-ortho-aminophenol) copolymers have been synthesized through oxidative polymerization
with sodium dodecylsulphate as the emulsifying agent. The synthesized copolymer has been characterized using UV-Visible
spectroscopy, FT-IR, XRD, SEM and TG-DTA and DSC. The UV-Vis shows the peak at 273 nm due to the π →π*
transition which is related to the extent of conjugation between the adjacent phenylene rings in the polymeric chain. A broad
peak that shows in the area of 3850 cm−1 is due to hydrogen-bonded –OH and –NH 2 groups. Two main peaks between
1564 and 1484 cm−1 refer to the ring stretching vibrations of the quinoid and benzenoid rings, respectively. The XRD studies
confirm the polymer has semicrystalline nature. The SEM analysis of the copolymer exhibits cluster like arrangement on the
rough surfaces and wide dispersion, without any regularity in shape. The TGA illustrate there exists three stages of weight
loss. The polymer is found to be thermally stable till 518°C with the residual mass of 0.48%. The fluorescence spectroscopy
data shows that synchronous scanning for both excitation and emission peaks at 399 nm
Antiproliferative and apoptotic effects of Lamium purpureum L. extract on prostate cancer cells
No full text142-148The use of herbal agents in cancer treatment is an important concept. It is thought that the Lamiaceae family may have anticancer effects due to its polyphenol metabolites. The anticancer effect of the Lamium genus belonging to this family has been examined in some studies. However, there are few studies on the Lamium purpureum (purple dead-nettle) species. In this study, the Lamium purpureum extract/fractions were prepared in different solvents, and their effects on proliferation and apoptosis in the LNCaP prostate cancer cell line were examined in vitro. This was investigated using the CCK-8 test, JC-1 mitochondrial membrane potential assay, caspase 3/7 enzymatic activity test, and caspase-7 protein level by Western blot. It has been determined that Lamium purpureum ethanol extract suppresses cell proliferation with increasing concentration and may induce apoptosis via caspase-7. It is the first study to investigate the anticancer effect of Lamium purpureum on LNCaP cells
Synthesis of novel pyrido[2,3-d]pyrimidine derivatives with pharmacological properties
No full text137-147In search for new anti-microbial and anti-mycobacterial agents with novel mechanism of action and enhanced biological
profile, a combinatorial library of Schiff bases (7a-e), 2,3-disubstituted-4-thiazolidinone (8a-e) and 2,3-disubstituted-5-
methyl-4-thiazolidinone (9a-e) derivatives have been synthesized as new pharmacophores under standard Vilsmeier-Haack
reaction conditions. The structures of all the newly synthesised compounds have been confirmed from their FT-IR, 1H and
13C NMR, mass spectral as well as elemental analysis data. All the newly synthesized compounds have been screened for
non-automated in vitro antimicrobial and anti-mycobacterial activity against selected pathogens. Some of the newly
synthesized compounds exhibit excellent antimicrobial activity and found to be the most proficient members of the series
compared to standard drugs and hold promise as future drugs
Morpho-molecular screening of chickpea (Cicer arietinum L.) genotypes for resistance to Botrytis grey mould disease
No full text381-390The evaluation and identification of disease resistance to Botrytis grey mould (BGM) in chickpea (Cicer arietinum L.) is a critical step in the advancement of integrated disease control strategies. The current study was conducted to evaluate and identify chickpea genotypes for resistance to BGM disease in natural epiphytotic conditions. A set of 225 experimental chickpea genotypes were planted in 9 blocks during 2017-18, 135 genotypes were planted in 9 blocks during 2018-19, and 100 genotypes were planted in 4 blocks during 2018-19, including 5 checks viz., PG 3 and PG 5 (Moderately resistant),
H 208 and DCP 92-3 (Susceptible), and GL10006 (Resistant). The field experiment was conducted using an augmented block design-II. The results of field screening against BGM disease revealed that 17 chickpea genotypes were found with disease score 3 (resistant) out of 225 during rabi, 2017-18, 13 genotypes were found with disease score 3 (resistant) during rabi, 2018-19, and 11 genotypes were found with disease score 3 (resistant) during rabi, 2019-20. The 20 best genotypes were chosen from the screened genotypes based on disease score and seed yield per plant for molecular marker validation. The summary of molecular data revealed PG 17-9 (130 bp), PG 17-119 (130 bp), and PG 17-145 (130 bp) as resistant; PG 17-120 and PG 17-121 moderately resistant; and the remaining genotypes as susceptible. The field disease score data matched the genotype banding pattern by markers TR29 and TA144. TR29 and TA144 have polymorphism information content (PIC) values more than 0.5, indicating that they can be deployed for molecular tagging of Botrytis grey mould resistance genes in chickpe
Designing a Free Open-Source Software based Digital Library for Medical Imaging
No full text61-70This study explores the integration of the DICOM standard into DSpace, an open-source repository system, to develop a
medical image repository that supports the storage, query, and retrieval of DICOM objects. The research identifies the need
for a system that can handle specialized medical imaging files (dcm) and provides a solution by extending DSpace's
capabilities to recognize and manage these files, ensuring access to medical professionals and radiologists. The study also
addresses the customization of metadata elements to conform with DICOM standards, enhancing the quality and consistency
of image appearance and facilitating the search and retrieval of medical images through developed metadata patches
Intracellular reactive oxygen species scavenging potential of Benincasa hispida Cogn. confection
No full text16-22Unchecked levels of Reactive Oxygen Species (ROS) are known contributors in numerous health issues like metabolic disorders, neurological disorders and cancers. A traditional herbal preparation, Benincasa hispida Confection (BHC) is hypothesized to balance the levels ROS because of the presence of inherent antioxidative phytocomponents. However, the specific mechanisms underlying BHC purported ROS scavenging effects at cellular level have remained unexplored. We prepared BHC, and profiled its antioxidative molecules through HPLC analysis. Preparation method included B. hispida pulp base mixed with sugar candy and various medicinal herbs as key ingredients to enhance its taste and palatability. The ability to scavenge intracellular ROS was investigated using 2',7'-dichlorofluorescin-diacetate (DCF-DA) assay after ensuring the cell viability upon treatment with the extract of BHC. BHC was rich in previously known antioxidant molecules and was able to quench intracellular ROS. B. hispida also contributed to its ROS quenching abilities along with other ingredients. This study provides valuable insights into the therapeutic utility of BHC and advocates that consumption of BHC might protect the individuals from the ROS mediated oxidative stress and associated diseases