MTA-SZTE Research Group on Artificial Intelligence
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A Comprehensive Overview on Chemotherapy-Induced Cardiotoxicity: Insights into the Underlying Inflammatory and Oxidative Mechanisms
Get PDFThe Microbiological Background of Medication-Related Osteonecrosis of the Jaw (MRONJ): Clinical Evidence Based on Traditional Culture and Molecular Biological Detection Methods
Get PDFHeterogeneous water distribution in between peridotite xenoliths from Kaapvaal Craton kimberlites: Constraints on diamond barren nature of kimberlites
Get PDFImpact of different soil solutions on the stability and photocatalytic activity of commercial zinc oxide nanoparticles
Get PDFRegardless of changes of ZnO NPs after interaction with the soil solutions, it remains active
The analysis of utterances with imperative forms in Hungarian health-related fake news
Get PDFThis paper aims to contribute to the linguistic detecting of disinformation by providing a corpus-based form-to-function study of Hungarian health-related fake news. It starts from the hypothesis that there is a difference between fake and real news regarding the use of directives as a potential tool of exerting pressure on readers. The most direct and strongest strategy of performing directives in Hungarian is the use of a verb with an imperative suffix. However, the same suffix can also appear without any directive function in subjunctive structures. In order to determine which function utterances containing verbs with an imperative ending have, a manual pragmatic annotation was carried out in our MedCollect corpus. Three major groups of utterances were distinguished: (i) utterances with directive function, (ii) utterances with discourse function, and (iii) utterances without any directive or discourse function. The results support our hypothesis that fake news contains a significantly higher number of directives performed using this direct strategy due to a higher motivation of placing pressure on readers
Ápolás és sztereotípia – Hallgatók tapasztalatai a nemek közötti megkülönböztetésről [Nursing and Stereotyping – Students’ Experiences of Gender Discrimination]
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IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning
Get PDFAlthough many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of acute myocardial ischemia/reperfusion injury (IRI), their clinical translation to patient benefit has been largely disappointing. A major factor is the lack of rigor and reproducibility in the preclinical studies. To address this, we have established the IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) small animal multisite acute myocardial infarction (AMI) network, with centralized randomization and blinded core laboratory IS analysis, and have validated the network using ischemic preconditioning (IPC). Eight sites from the COST Innovators Grant (IG16225) network participated in the IMPACT AMI study. Mice and rats were randomly allocated into Sham, Control, or IPC groups. The IRI group underwent 45 min (mice) or 30 min (rats) of left coronary artery occlusion followed by 24 h reperfusion. IPC comprised three cycles of 5 min occlusion/reperfusion before IRI. IS was determined by a blinded core lab. The majority of site showed significant cardioprotection with IPC. In pooled mouse data, IPC (N = 42) reduced IS/AAR by 35% compared to control (N = 48) (30 ± 16% versus 46 ± 13%; p < 0.005), and in rat data, IPC (N = 36) reduced IS/AAR by 29% when compared to control (N = 39) (32 ± 19% versus 45 ± 14%; p < 0.01). The IMPACT multisite mouse and rat AMI networks, with centralized randomization and blinded core IS analysis, were established to improve the reproducibility of cardioprotective interventions in preclinical studies and to facilitate the translation of these therapies for patient benefit
