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Intra-breath respiratory mechanics of prematurity-associated lung disease phenotypes in school-aged children
Get PDFBackground: Intra-breath oscillometry potentially offers detailed information regarding airway function, with increasing magnitude of difference between resistance and reactance at end-expiration to end-inspiration potentially associated with obstructive airway disease, but less is known about specific respiratory mechanics in preterm-born children using this methodology. We investigated whether different spirometry phenotypes of prematurity-associated lung disease (PLD) have specific intra-breath oscillometry features.; Methods: 167 school-aged (7-12 years) children, 14 with prematurity-associated obstructive lung disease (POLD; forced expiratory volume in 1 s (FEV1) <lower limit of normal (LLN), FEV1/forced vital capacity (FVC) <LLN), 11 with prematurity-associated preserved ratio impaired spirometry (pPRISm; FEV1 <LLN, FEV1/FVC ≥LLN), 90 preterm controls (FEV1 ≥LLN) and 52 term controls, performed intra-breath oscillometry at baseline, following maximal cardiopulmonary exercise testing and following post-exercise bronchodilation.; Results: Children with POLD showed greater resistance and more negative reactance throughout the respiratory cycle, including at zero-flow states of end-expiration and end-inspiration. The difference between end-expiration and end-inspiration did not show differences between groups until corrected for tidal volume, whereby children with POLD and pPRISm both demonstrated approximately two-fold greater difference compared to both preterm and term controls for resistance (2.24 and 2.22 versus 1.28 and 1.11 hPa·s·L-1, respectively), and in particular a greater magnitude of difference for reactance for children with POLD versus preterm and term controls only (-1.58 versus -0.26 and 0.03 hPa·s·L-1, respectively).; Conclusions: Intra-breath respiratory mechanics for preterm-born children with an obstructive lung phenotype have greater impedance throughout the respiratory cycle, features different to those observed in children with other wheeze phenotypes including preschool wheeze and asthma. Copyright ©The authors 2025
Overall Survival of Hungarian Cancer Patients Diagnosed Between 2011 and 2019, Based on the Health Insurance Fund Database
Get PDFA hasi aorta aneurysma szűrés létjogosultságának kérdése a hazai alapellátásban [Addressing the feasibility of abdominal aortic aneurysm screening in Hungarian primary care]
Get PDFHealth as a value in the context of smoking and alcohol consumption among university students
Get PDFAngst vor der Säkularisierung unter den Reformierten der Batschka und des Banats zwischen 1781 und 1791
Get PDFHabsburg Emperor Joseph II's Patent of Toleration and the Act of 26 June 1791 put an end to the oppression of Protestants in the Kingdom of Hungary. As a result, the Calvinist and Lutheran churches began to develop: the organisation of new parishes and the building of churches received a great impetus. From 1781, censorship did not prohibit the printing of Protestant books, so Calvinists and Lutherans became very optimistic about the future. However, the unbridled golden age was overshadowed by the Enlightenment's criticism of religion and the centralising measures of the absolutist state. The Enlightenment was highly critical of traditional religiosity, while the state restricted the autonomy of church administration in many ways. It was only after 1781 that the regions of Bacska and Banat, in the south of the Kingdom of Hungary, became missionary destinations for the Calvinist Church, as it became possible to organise parishes in these areas. This was done by recruiting Hungarian and German-speaking settlers at a time when the Calvinist Church was experiencing one of its greatest crises: a double episcopal election took place in 1791, with a struggle between secular and ecclesiastical powers in the background. The Calvinists living in Banat and Bacska were also involved in this dispute, which is not recorded in church history. This article examines how the Enlightenment's critique of religion influenced the life of Calvinist congregations, and what the interference of secular power in church life meant in practice. In other words, this article seeks to identify the processes of secularisation that took place in Bacska and Banat between 1781 and 1791
