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Examination of non-conventional dysplasias adjacent to colorectal adenocarcinoma in patients with IBD
Get PDFObjectiveRecently, several non-conventional variants of IBD-associated dysplasia have been described; however, their prevalence in Central-Eastern Europe is unknown. We aimed to perform a retrospective pilot study by re-evaluating several IBD-associated adenocarcinoma cases to survey the incidence of adjacent non-conventional dysplasia and validate that recent North American findings may apply to a European population.MethodsRetrospectively, 28 randomly chosen cases of IBD-associated adenocarcinomas diagnosed between 2010 and 2022 were re-evaluated. The patient’s sex, age (at the diagnosis of IBD and neoplasia), type of IBD, type of specimen [biopsy (n = 8)/surgical specimen (n = 20)], histological type, grade, localisation, stage, disease-free (DFS) and overall survival (OS) were obtained. Statistical analyses were carried out by using Mann-Whitney (continuous variables), Fisher’s exact (categorical variables), Kaplan-Meier (DFS/OS curves), and logrank test (survival curves).ResultsExclusively, conventional dysplasia was observed in 11, and non-conventional dysplasia in 8 patients. Combined conventional and non-conventional dysplasia was detected in 9 patients. Non-conventional dysplasia showing a combination of multiple subtypes was noted in 10 cases. Altogether, 25 non-conventional dysplastic foci were identified, which were diagnosed as hypermucinous (n = 9), goblet cell-deficient (n = 6), serrated not otherwise specified (NOS) (n = 6), and traditional serrated adenoma-like (n = 4). The majority of non-conventional dysplasias were associated with ulcerative colitis (n = 12). Mucinous adenocarcinoma was exclusively associated with non-conventional dysplasia, while medullary carcinoma was only with conventional dysplasias (p = 0.014 and 0.041).ConclusionBased on our results, non-conventional dysplasia is common (60%) adjacent to IBD-associated adenocarcinomas in a Central-Eastern European population and may be detected in biopsies. As multiple recent publications reported evidence of a worse prognosis and more common flat morphology compared to conventional dysplasias, their recognition is of great importance, and stricter follow-up with random biopsy samples may be considered.</sec
Scale Treatment Planning Using Broaching Method in a Vapor-Dominated Geothermal Well X at Kamojang Geothermal Field
Get PDFSelf-appointed and Self-taught? Professional Characteristics and Challenges of LSP Teachers in Hungary
Get PDFDespite the growing international recognition of Languages for Specific Purposes (LSP), the role and needs of LSP teachers in Hungary remain underexplored. Based on a survey of Hungarian higher education LSP teachers, this study examines their professional characteristics and challenges. The findings reveal that many LSP teachers transition from general language teaching without formal training in their students’ disciplines or LSP-specific methodologies. LSP teaching poses unique challenges, including the significant time required to develop curricula and teaching materials. Beyond preparation, teachers often engage in extensive self-directed learning to acquire specialised content knowledge needed to meet diverse and evolving demands. The study underscores the importance of institutional support, advocating for legal frameworks that recognise that teaching LSP differs from teaching languages for general purposes. The results suggest that it would be crucial to create formal training opportunities, foster collaboration between content specialists and LSP teachers, implement mentorship programmes, and reduce the workload of LSP teachers. This research advocates for establishing LSP teaching as a distinct profession within the Hungarian educational landscape, laying the foundations for future research and contributing to the greater recognition of LSP teaching in national and international contexts
Nursing student volunteerism for marginalized populations: Predictive analysis of influencing factors
No full textEllátási és ápolási mutatók vizsgálata thrombolysisen átesett ischaemiás stroke betegek körében : pilot study [Analysis of Nursing Care Indicators Among Ischaemic Stroke Patients Underwent Thrombectomy – a Pilot Study]
No full textBevezetésVizsgálatunk célkitűzése a thrombolysisen átesett betegek ápolásának mérőszámainak felmérése volt. Elsődleges végpontként az ápolási napok számát, a szövődmények számát és a maradandó károsodással gyógyult betegek számát határoztuk meg. Ezek alapján elemeztük az ellátás hossza és a kezelés összefüggéseit, a szövődmények kialakulásának prevalenciáját, valamint azt, hogy azok mennyiben befolyásolják a betegek későbbi életminőségét.MódszerekA vizsgálatot a Szegedi Tudományegyetem Neurológiai Klinika Stroke Osztályán végeztük, thrombolysisen átesett betegek körében, 2022 tavaszán. A vizsgálati időtartam hat hónap volt, amely alatt 113 beteg felelt meg a beválasztási kritériumoknak. Saját szerkesztésű adatgyűjtési lap került kitöltésre minden beválasztott beteg esetén. EredményekBetegeink átlagéletkora 70,6 év volt, nemi aránya kiegyenlített. Ellátási mutatók terén 161 perces átlagos időablakot, hatnapos átlagos ápolási időt mértünk. Az időablak hossza nem volt hatással az ápolási időtartamra. Vérzéses szövődmény 10%-ban fordult elő, amely közül 7 esetben agyállományi vérzés jelentkezett. A kezelés után a minta 38%-a önellátásra képes, 52%-a tartós segítséget igénylő állapotban került elbocsátásra. KövetkeztetésA fenti eredményeink rávilágítanak a megelőzés fontosságára. A maradandó károsodások, az életminőség drasztikus változása úgy kerülhető el a legeredményesebben, ha az ahhoz vezető kórkép ki sem alakul. Az agyi érkatasztrófák döntő többsége valamilyen krónikus betegség következményeként alakul ki, amelyek jellegzetesen megelőzhetők. Azon túl, hogy a meghatározott vizsgálati végpontjaink az ellátás eredményességéről adnak kulcsinformációkat, elemzésük minőségbiztosítási, ellátásmenedzsment és ápolásoktatási szempontból is fontos lehet.Vizsgálatunk célkitűzése a thrombolysisen átesett betegek ápolásának mérőszámainak felmérése volt
Projected climate suitability for Hungarian tourism in the 21st century: application of the Holiday Climate Index and modified Tourism Climate Index
Get PDFClimatic factors significantly influence travellers’ destination selection and demand for tourism products. To maintain sustainable tourism development, it is essential to monitor how tourist destinations will be affected by the projected future changes in the climate system. This study aims to reveal the future impact of climate change for tourism sector in Hungary using the Holiday Climate Index specified for urban tourism (HCI-Urban) and a modified version of Tourism Climate Index (mTCI). The paper employs an ensemble of multiple climate models (ALADIN5.2 and REMO2015) and emission scenarios (RCP4.5 and RCP8.5) to determine the future evolution of indices. Initially, the reference climatic conditions derived from the observational dataset CarpatClim-HU are presented. Then, the climate model results are validated against the observational database for both indices. Afterwards, bias-corrected model outputs are analysed for the periods 2041–2070 and 2071–2100 based on the ensemble of models and scenarios. The spatial distributions of indices are depicted on a monthly level and at a Hungarian district spatial scale. Both the observational and model results highlight that the climatic conditions are more favourable in spring and autumn compared to the summer months. It is also demonstrated that the climatic conditions in Hungary are expected to be more favourable or unchanged from autumn until spring, while there is a general worsening in summer. In terms of the future directions, larger uncertainties are found in May and September. Based on the anticipated trends, the paper pinpoints sector-specific recommendations for adapting tourism services to the altered climatic conditions
A fogászati prevenció jelenlegi helyzetének összehasonlító elemzése Szerbiában és Magyarországon
Get PDFStenting strategy and imaging use in left main percutaneous coronary intervention : insights from a 15-year registry
Get PDFLeft main (LM) percutaneous coronary intervention (PCI) remains a major interventional challenge, with outcomes influenced by various patient- and procedure-related factors.To analyze procedural characteristics and outcomes of patients who underwent LM PCI over a 15-year period in a single center.We retrospectively analyzed data from all consecutive patients who underwent LM PCI between 2006 and 2022. Procedural details, with a focus on stenting technique, were collected. Primary outcome was all-cause mortality at 1 year.In total 3494 patients were included. The majority (67%) presented with chronic coronary syndrome. Seventy-seven percent of all patients (n = 2690) underwent PCI by single stent (SS) strategy and 23% (n = 804) by double stent (DS) strategy. One-year mortality was significantly lower in SS cases compared to DS (3.5% vs. 5.1%, HR 0.64, 95% CI 0.43-0.96). Intravascular imaging was used in 17% of the cases but showed no significant difference in one-year mortality compared to angio-guided PCI (4.8% vs. 3.7%; HR 1.11, 95% CI 0.71-1.73).In real-world LM PCI practice, patients for whom a provisional single-stent strategy was feasible had better outcomes than those requiring a double-stent approach