MTA-SZTE Research Group on Artificial Intelligence
SZTE Publicatio Repozitórium - SZTE - Repository of PublicationsNot a member yet
32192 research outputs found
Sort by
Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice
Get PDFBackground: Cognitive, emotional, and social impairments are pervasive across neuro-psychiatric conditions, where alterations in the tryptophan (Trp)-kynurenine pathway and its product kynurenic acid (KYNA) from kynurenine aminotransferases (KATs) have been linked to Alzheimer's disease, Parkinson's disease, depression, and post-traumatic stress disorder. In novel CRISPR/Cas9-engineered KAT II knockout (aadat −/− also known as kat2 −/−) mice, we observed despair-linked depression-like behavior with peripheral ex-citotoxicity and oxidative stress. KAT II's role and its crosstalk with serotonin, indole-pyruvate, and tyrosine-dopamine remain unclear. It is unknown whether deficits extend to cognitive, emotional, motor, and social domains or whether brain tissues mirror peripheral stress. Objectives: Delineate domain-wide behaviors, brain oxidative/excitotoxic profiles, and pathway interactions attributable to KAT II. Results: Behavior was unchanged across strains. kat2 −/− deletion remodeled Trp metabolic pathways: 3-hy-droxykynurenine increased, xanthurenic acid decreased, KYNA fell in cortex and hippo-campus but rose in striatum, quinaldic acid decreased in cerebellum and brainstem. These region-specific changes indicate metabolic stress across the brain and align with higher Academic Editors: Korrapati V. Citation: Szabó, Á.; Galla, Z.; Spekker, E.; Martos, D.; Szűcs, M.; Fejes-Szabó, A.; Fehér, Á.; Takeda, K.; Ozaki, K.; Inoue, H.; et al. Behavioral Balance in Tryptophan Turmoil: Regional Metabolic Rewiring in Kynurenine Aminotransferase II Knockout Mice. oxidative load and signs of excitotoxic pressure. Conclusions: Here, we show that KAT II deletion reshapes regional Trp metabolism and amplifies oxidative and excitotoxic imbalance. Although domain-wide behavioral measures, spanning cognition, sociability, and motor coordination, remained largely unchanged, these neurochemical alterations signify a latent emotional bias rather than overt depressive-like behavior. This work, therefore, refines prior findings by delineating KAT II-linked biochemical vulnerability as a potential substrate for stress-reactive affective dysregulation
Content Adaptation, Validation, and User Experience of the Music Island App for Chinese Elementary Music Education
Get PDFBackground/purpose. This study examined the adaptation and user experience of the Chinese version of the Hungarian music teaching software Music Island, addressing the need for localized digital tools to support elementary music education in China. The objective was to assess its user experience for both teachers and young learners within the national curriculum context.
Materials/methods. Over the course of a year, the adaptation retained core gamification elements while integrating translated text, localized audio, and culturally relevant materials. Content and face validity were evaluated by six music education experts and three elementary school teachers. Additionally, 124 elementary students participated in a one-month, one-group, posttest-only user experience study.
Results. Expert review indicated I-CVI ≥ .78 across items and modified kappa (k*) ≥ .74 after revisions, supporting clear and culturally appropriate content. Student feedback reflected high perceived ease of use and engagement. The adapted content was considered linguistically clear, pedagogically appropriate, and culturally aligned with Chinese aesthetic values, supporting its use in classroom-based music instruction. Major revisions focused on translating and localizing textual and audio components, and integrating culturally relevant materials aligned with national curriculum standards.
Conclusion. The findings support the feasibility of adapting international music software to align with local curricular goals and learner needs, offering insights into future cross-cultural educational technology development. However, the study was limited by its short-term, posttest-only design. Future research should incorporate longer and more rigorous interventions
Current ethical and legal issues of AI in healthcare with specific emphasis on patient information
Get PDF
NO/NOS system dysregulation as a key molecular mechanism in chemotherapy-induced cardiotoxicity: a review
Get PDFCardiotoxicity, as a side effect of chemotherapeutic treatments, represents a major limiting factor during anti-tumour therapies. This is usually evident by decreased cardiac function, and the cardiovascular diseases linked to chemotherapeutic agents can range from mild arrhythmias and hypertension to myocardial injuries and heart failure. One of the most important regulators of cardiovascular function is nitric oxide (NO), a small signalling molecule associated with multiple cardioprotective properties. The activity of NO producing enzymes, the nitric oxide synthases (NOSs), is tightly regulated by pathways responsible for maintaining the cardiovascular NO homeostasis. Thus, the dysregulation of the NO/NOS system could lead to severe pathologic changes in cardiomyocytes and endothelial cells. This narrative review examines the evidence on how chemotherapeutic agents affect cardiac NOS activity and NO signalling, and explores whether NO/NOS dysregulation may be considered as a relevant mechanism in the development of chemotherapy-induced cardiotoxicity
