JURNAL KIMIA MULAWARMAN
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ISOLASI DAN KARAKTERISASI SENYAWA TERPENOID DARI DAUN Macaranga beccariana Merr.
Full text linkIsolation and characterization of terpenoid compounds from ethyl acetate fraction of Macaranga beccariana Merr. have been done. The separation process at ethyl acetate fraction using gravity column chromatography with gradient elution method. The obtained isolates were tested for purity using thin layer chromatography with various eluents namely n-hexane, chloroform, methanol, acetone and ethyl acetate with Rf values 0; 0.75; 0.80; 0.87 and 0.97 respectively. The terpenoids which were successfully isolated were white crystals with a mass of 0.0119 grams. UV analysis produced 1 peak at l 207.03 nm. Analysis of compounds with FT-IR indicated the functional groups O-H, aliphatic C-H, aliphatic C=C, C-O and C=O. Based on the results of the UV and FT-IR spectrum, the isolate compounds were thought to contain terpenoids.Isolasi dan karakterisasi senyawa terpenoid dari fraksi etil asetat Macaranga beccariana Merr. telah dilakukan. Proses pemisahan pada fraksi etil asetat menggunakan kromatografi kolom gravitasi dengan metode elusi gradien. Isolat yang diperoleh diuji kemurniannya dengan menggunakan kromatografi lapis tipis dengan berbagai eluen yaitu n-heksana, kloroform, metanol, aseton dan etil asetat dengan nilai Rf secara berturut-turut yaitu 0; 0,75; 0,80; 0,87 dan 0,97. Senyawa terpenoid yang berhasil diisolasi berbentuk kristal putih dengan massa 0,0119 gram. Analisis dengan UV menghasilkan 1 puncak pada l 207,03 nm. Analisis senyawa dengan FT-IR mengindikasikan gugus fungsi -OH, C-H alifatik, C=C alifatik, C-O dan C=O. Berdasarkan dari hasil spektrum UV dan FT-IR maka senyawa isolat diduga mengandung senyawa terpenoid
KUMARIN TERISOPRENILASI DAN ALKALOID INDOL DARI KULIT BATANG Zanthoxylum ovalifolium TUTCHER: Zanthoxylum ovalifolia
Full text linkTwo isoprenylated coumarins, imperatorin (1), isopimpinelin (2) and one indol alkaloid compound, canthine-6-one (3) were isolated from the stem bark of Zanthoxylum ovalifolium Tutcher. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Imperatorin (1) showed high activity toward DPPH radical and isopimpinelin (2) and chantine-6-one (3) has moderate activity.Antioksida
INKORPORASI VITAMIN E PFAD PADA CAMPURAN GALAKTOMANAN KOLANG-KALING (Arenga pinnata) DAN GUM ACASIA
Full text linkIncorporation of vitamin E from palm fatty acid distillate (PFAD) into matrix of mixed gum acacia and galactomannan from Arenga pinnata (kolang-kaling) (GAP) has been studied. Galactomannan extracted from Arenga pinnata was 4.7%. Incorporations were conducted using using 7 gram gum acacia (GA), 1.3 gram vitamin E from PFAD and GAP varied from 0.1 – 0.4 gram in 100 ml total volume. The thickness of the film occurred in the range of 0.600 – 0.780 mm. In the increment of GAP amount the viscosity and stability of film was increased. The best film obtained which most compatible and has viscosity similar with standard of ISO 9001 – 2008 and ISO 22000 – 2005 was from formula 3 contained 0.2 gram GAP. The oncentration of vitamin E determined using gas chromatography was 75.4501%. The composition of vitamin E was tocotrienol 74.41% and tocopherol 25.59%
Identifikasi Potensi Jeruk Purut Sebagai Demulsifier Untuk Memisahkan Air Dari Emulsi Minyak di Lapangan Minyak Riau
Full text linkEmulsion stability is an indicator that needs to be controlled to prevent the degradation of petroleum quality. Emulsion breakdown is one of the mechanisms to separate the water phase from oil. It is transformed into a chemical compound that is expected to function as emulsion blocking or commonly known as a demulsifier. An organic demulsifier is one of the right ideas in preventing environmental pollution without diminishing its main function as an emulsion breaker. The bottle test method is one of the most commonly used methods in demulsification tests. Testing using this method is done by inserting the prepared emulsion into the bottle, then it will be placed into a waterbath under certain temperature conditions for several hours. This test will be done by looking at the demulsification that occurs every 30 minutes. From the testing of temperature, concentration, and effectiveness of the formulated formula, an optimal condition is obtained based on the highest demulsification efficiency. Based on the research, optimal condition of organic demulsifier formula is (3ml, 80˚C) with 7 ml demulsification efficiency. The results obtained from organic material formulations have not been able to increase the effectiveness of emulsion-breaking processes compared to commercial demulsifiers and basecase conditions (20 ml).Stabilitas emulsi merupakan indikator yang perlu dikontrol guna mencegah penurunan kualitas minyak bumi. Pemecahan emulsi ialah salah satu mekanisme yang dilakukan guna memisahkan fasa air dari minyak. Hal ini ditransformasikan menjadi senyawa kimia yang diharapkan dapat berfungsi sebagai emulsion blocking atau lazim dikenal dengan demulsifier. Demulsifier organik adalah salah satu gagasan yang tepat dalam mencegah pencemaran lingkungan tanpa mengurangi fungsi utamanya sebagai pemecah emulsi. Metode bottle test merupakan salah satu metode yang paling sering digunakan dalam uji demulsifikasi. Pengujian menggunakan metode ini dilakukan dengan memasukkan emulsi yang telah dipreparasi ke dalam botol, kemudian akan diletakkan ke dalam waterbath dengan kondisi temperatur tertentu selama beberapa jam. Pengujian ini akan dilakukan dengan melihat demulsifikasi yang terjadi setiap 30 menit. Dari pengujian temperatur, konsentrasi, serta efektivitas dari formula yang diformulasikan didapatkan kondisi optimal berdasarkan efisiensi demulsifikasi tertinggi. Berdasarkan penelitian yang dilakukan, kondisi optimal dari formula demulsifier organik adalah (3ml,80˚C) dengan perolehan efisiensi demulsifikasi sebesar 7 ml. Hasil yang diperoleh dari formulasi bahan organik belum mampu meningkatan efektivitas proses pemecahan emulsi dibandingkan dengan demulsifier komersil dan kondisi basecase (sebesar 20ml)
ANALISIS SIFAT TERMAL DAN UJI KELARUTAN DARI KARET ALAM SIKLIS DAN KARET ALAM CAIR SIKLIS
Full text linkAbstract. The research has done analysis of thermal properties and solubility test of Cyclic Natural Rubber (CNR) and Cyclic Liquid Natural Rubber (CLNR). Cyclic Liquid Natural Rubber (CLNR) is a cyclical natural rubber which has decreased molecular weight. Synthesis of Cyclic Liquid Natural Rubber (CLNR) do by oxidative degradation after cyclic. Oxidative degradation after cyclic using Cyclic Natural Rubber (CNR) and phenylhydrazine reagent with flow rate 2 LMin-1 of oxygen atmosphere during 24 hours. Thermal analysis of Cyclic Natural Rubber (CNR) and Cyclic Liquid Natural Rubber (CLNR) by Differential Scanning Calorimetry (DSC),the glass transition temperature (Tg) of Cyclic Natural Rubber (CNR) and Cyclic Liquid Natural Rubber (CLNR) are 102,82 o C and 103,67 o C, the crystal transition temperature (Tc) of Cyclic Natural Rubber (CNR) and Cyclic Liquid Natural Rubber (CLNR) are 362,45 o C and 330,29 o C and the melting transition temperature ( Tm) of Cyclic Natural Rubber (CNR) and Cyclic Liquid Natural Rubber (CLNR) are 509,24 o C and 440,00 o C. Solubility test by dilute Cyclic Natural Rubber (CNR) and Cyclic Liquid Natural Rubber (CLNR) in some solvent with different properties and polarity index. Solubility test shows the results Cyclic Natural Rubber (CNR) and Cyclic Liquid Natural Rubber (CLNR) has polarity index around 2,4 – 4,4 and 2,4 and 4,4.
Keywords: CLNR, CNR, oxidative degradatio
AKTIVITAS AMILASE, PROTEASE dan LIPASE DARI MADU LEBAH Trigona sp, Apis mellifera dan Apis dorsata
Full text linkActivities of amylase, protease and lipase from honey Trigona sp, Apis mellifera and Apis dorsata, determination protein concentration and the activity protease done with Bradford method, the determination of the glucose standard and activity amylase done with 3,5-dinitro salicylic acid (DNS) method and activity lipase done with acid-base titration with coconut oil substrate. The honey from Trigona sp has value of the activity amylase and lipase respectively by 0,0136 U / mg and 0,359 U/mg, whereas honey Apis mellifera has activity of protease, amylase and lipase of each 1,22 x 10-6 U/mg; 0,944 U/mg and 0,304 U/mg and then honey Apis dorsata has amylase and lipase activity of each of 0,0645 U/mg and 0,287 U/mg
AKTIVITAS ANTIMALARIA SENYAWA FLAVANON TERISOPRENILASI DARI KULIT BATANG Erythrina fusca L.
Full text linkTwo isoprenylated flavanones namely as lonchocarpol A (1) dan lupinifolin (2) were isolated from the stem bark of Limonia accidissima L. Erythrina fusca L. Their structures were determined based on spectroscopic data such as UV, IR, MS and NMR. Compounds 1–2 were evaluated for their antimalarial against Plasmodium falciparum strain 3D7 showing their IC50 were 1.18 and 0.8 µg/ml, respectively and very high activity.
 
Isolation Of Antioxidant Compounds Of N-Hexane Extract Of Nutmeg (Myristica Fragrans Houtt) Leaves
Full text linkThe isolation of antioxidant active compounds from n-hexane extract of nutmeg leaves (Myristica fragrans Houtt) with dipphenylpicrylhydrazyl (DPPH) has been carried out. n-Hexane extract of nutmeg leaves (0.35%) was obtained by partitioning of methanol extract (535.7 g) using n-hexane solvent. Isolation of active compound of n-hexane extract with gravitational column chromatography gradient elution of n-hexane : ethyl acetate with ratio (9 : 1) – (7 : 3) obtained 7 mixed fraction of MFHD1 - MFHD 7. MFHD 2 fraction further isolated obtained MFHD 2.1. The nutmeg n-hexane extracts and their fractions showed strong antioxidant activity with IC50 values <100 ppm except MFHD 6 fraction showed for IC50 values of 114.95 ppm. The most potent antioxidant activity in MFHD 4 fraction with IC50 value of 0.729 ppm (compared with vitamin C value of IC50 7,875 ppm as positive control). The GC-MS analysis of the MFHA 2.1 fraction shows the presence of sitostenone and eucalyptol compounds, both of which have been reported to have been isolated from several different plants and have antioxidant activity
STUDI PENGGUNAAN KITOSAN KOMPOSIT CuO SEBAGAI ADSORBEN UNTUK MENYERAP LOGAM BESI (Fe) MANGAN (Mn) DAN SENG (Zn) PADA AIR SUNGAI BELAWAN
Full text linkThe synthesis of chitosan-CuO composite and its application as an adsorbent in the removal of Fe, Mn, and Zn in Belawan river water has been conducted. Chitosan-CuO composite is synthesized by addition the Cu(NO3)2 into the solution of chitosan and NaOH 2M. This adsorbent is characterized with FT-IR and its capability to adsorb heavy metals is measured with ICP-OES. The preliminary result of Fe, Mn, and Zn level in Belawan river water are 0,3032; 0,3251; and 0,06402 mg/L, respectively, those value levels are above the PP No. 82 Tahun 2004 safety limit. The optimum contact time of adsorbent to interact is found at 30 minutes, with Fe, Mn, and Zn adsorption is 69,71; 90,53; and 92,05%, respectively. The decrease of heavy metal levels in Belawan river water is influenced by the contact time of adsorbent to the sources of heavy metal.Dalam penelitian ini telah dilakukan penurunan kadar logam dengan menggunakan Kitosan komposit CuO sebagai adsorben.Bahan penyerap ini dikarakterisasikan dengan menggunakan FT-IR. Berdasarkan hasil uji pendahuluan pada logam Fe 0,3032mg/l, Mn 0,3251 mg/l, dan Zn 0,06402 mg/l berdasarkan PP no.82 tahun 2014 logam- logam tersebut berada di atas ambang batas. Pembuatan kitosan komposit CuO dengan penambahan Cu(NO3)2 pada larutan kitosan dan larutan NaOH 2M. Analisa pada kadar logam menggunakan teknik ICP-OES.. Untuk perlakuan perendaman terbaik, yaitu 45 menit dengan daya serap Fe 69,71%, Mn 90,35% dan Zn 92,05%. lama perendaman kitosan CuO sangat mempengaruhi penurunan kadar logam berat Fe, Zn dan Mn pada air sungai Belawan daya serap
Isolasi Senyawa Kimia Stigmastan-3,5-Diena Yang Mempunyai Daya Toksik Dari Daun Ekaliptus (Eucalyptus Deglupta Blume.)
Full text linkThis study was started by extraction of Eucalyptus deglupta Blume. Using organic solvent (n-hexane, ethyl acetate, ethanol and water) followed by phytochemical screening and toxicity test using Brine Shrimp Lethality Test (BSLT) method. Isolation and identification of chemical compounds contained in the fraction were done by column chromatography and Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Phytochemical screening revealed the presence of alkaloids, flavonoids, steroids and phenolics in the extract. Toxicity test results showed that the ethyl acetate extract was potentially active with LC50 value of 617.95 ppm. The extract was continued to isolation stage and gave fraction EKEA-3.1 with LC50 value of 2759.93 ppm. Identification of chemical compounds in EKEA-3.1 with KG-MS analysis showed that EKEA-3.1 was suspected to be Stigmastan-3,5-diene.
Pada penelitian ini dilakukan ekstraksi serbuk daun ekaliptus (Eucalyptus deglupta Blume.) dengan metode maserasi menggunakan pelarut organik yaitu n-heksana, etil asetat, etanol dan air kemudian dilanjutkan dengan uji skrining fitokimia dan uji toksisitas terhadap larva udang dengan metode Brine Shrimp Lethality Test (BSLT). Isolasi menggunakan kromatografi kolom dan identifikasi senyawa kimia yang terdapat dalam fraksi menggunakan Kromatografi Gas-Spektrometri Massa (KG-MS). Hasil uji skrining fitokimia dalam ekstrak mengandung senyawa metabolit sekunder alkaloid, flavonoid, steroid dan fenolik. Hasil uji toksisitas menunjukkan bahwa ekstrak etil asetat berpotensi aktif dengan nilai LC50 sebesar 617,95 ppm. Ekstrak tersebut dilanjutkan ke tahap isolasi dan diperoleh isolat EKEA-3.1 dengan nilai LC50 sebesar 2759,93 ppm. Hasil identifikasi senyawa kimia pada isolate EKEA-3.1 dengan analisis KG-MS menunjukkan senyawa kimia yang diduga terdapat dalam ekstrak etil asetat daun ekaliptus (Eucalyptus deglupta Blume.) adalah senyawa Stigmastan-3,5-diena