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Asymmetric biocatalytic synthesis of fluorinated pyridines through transesterification or transamination. Computational insights into the reactivity of transaminases.
No full textThe synthesis of a family of pyridines bearing a fluorinated substituent on the aromatic ring has been carried out through two independent and highly stereoselective chemoenzymatic strategies. Short chemical synthetic routes toward fluorinated racemic amines and prochiral ketones have been developed, which served as substrates to explore the suitability of lipases and transaminases in asymmetric biotransformations. The lipase-catalyzed kinetic resolution
via acylation of racemic amines proceeded smoothly giving conversions close to 50% and excellent
enantioselectivities. Alternatively, the biotransamination of the corresponding prochiral ketones was investigated giving access to both optically pure amine enantiomers using transaminases with complementary selectivity. High to quantitative conversion
values were achieved, which allowed the isolation of the amines in moderate to high yields (40–88%). A deeper understanding of the latter process was enabled by performing theoretical calculations on thermodynamic and mechanistic aspects. Calculations showed that the biotransamination reactions are highly favoured by the presence of fluorine atoms and the pyridine ring
Unusual flexibility of mesophase pitch-derived carbon materials: An approach to the synthesis of graphene
No full textStructural flexibility in a petroleum pitch-derived carbon material has been indirectly evaluated using X-ray diffraction (XRD), immersion calorimetry and inelastic neutron scattering (INS) measurements. Exposure of the carbon material to an organic solvent (e.g., n-nonane) gives rise to a large internal rearrangement, associated with a drastic re-ordering of the graphitic microdomains. These structural changes are also associated with a high flexibility of the internal porous network, as observed by inelastic neutron scattering measurements. The internal rearrangement and the structural flexibility could be responsible for the excellent performance of this kind of activated carbons in a wide variety of adsorption processes. Last but not least, the structural characteristics of these carbon materials composed of graphitic microdomains has been used to synthesize graphene “egg-like” flakes following a simple procedure based on exfoliation with organic solvents.UK Science and Technology Facilities Council for the provision of beam time on the TOSCA spectrometer (Project RB1410624) and financial support from the European Commission under the 7th Framework Programme through the “Research Infrastructures” action of the “Capacities” Programme (NMI3-II Grant number 283883). J.S.A. acknowledge financial support from MINECO Projects: MAT2013-45008-p and CONCERT Project – NASEMS (PCIN-2013-057) and from Generalitat Valenciana (PROMETEO2009/002). Financial support from Principado de Asturias-PCTI (Severo Ochoa pre-doctoral grant of A.M. Pérez-Mas
El juego y los medios de comunicación. II Jornada de Juego Responsable del Principado de Asturias
No full textPrograma de la II Jornada de Juego Responsable del Principado de Asturias centrado en el impacto del juego patológico, publicidad y jóvenes
Las medidas de incorporación vinculadas al salarios social básico en Asturias. Situación, evolución y perspectivas
No full textEn este documento se desarrolla el estudio Las medidas de incorporación social vinculadas al Salario Social Básico: situación, evolución y perspectivas en el Principado de Asturias, encargado de forma conjunta por las Direcciones Generales de Gestión de Prestaciones y Recursos y de Planificación, Ordenación e Innovación Social de la Consejería de Servicios y Derechos Sociales del Principado de Asturias
Turbulence structure around an asymmetric high-lift airfoil for different incidence angles
Get PDFAn exhaustive investigation of the structure of the turbulence around an asymmetric FX 63-137 wind turbine airfoil is carried out in this paper. Reliable hot-wire velocity measurements, made at the Xixon Aeroacoustic Wind Tunnel, are presented with the aim of analyzing the turbulent flow features. The probe was placed at two different positions along the streamwise direction, one over the airfoil and the other at the wake, both on the suction and pressure side. These measurements were performed in order to capture the evolution of the flow and its behavior at the wake. The experimental data were collected at a Reynolds number of 350000 for several incidence angles to explore their influence in the turbulence characteristics. The data processing from the dual hot-wire, capable of measuring two velocity components, allowed to achieve half set of the Reynolds stresses, the turbulence intensity and the degree of anisotropy. The boundary layer and wake size were estimated from the Reynolds stress components. In addition, the production term of the turbulence kinetic energy budget is calculated to visualize the unsteadiness energy inside the boundary layer. As a result of these analyses, it was observed that the transversal fluctuations were higher than the longitudinal ones. Besides, an alternative description of the turbulence structure is obtained when a frequency analysis of the motion is provided, disclosing a clear change in the spectra tendencies in the wake and boundary layer regions. This analysis, combined with the degree of anisotropy analysis, was helpful to define a transition zone between the clearly distinguishable instability zone and the free-stream zone. Finally, the integral length scale of turbulence was estimated from the area under the autocorrelation function of the velocity fluctuations. The combination of the results of this work have provided a wide description of the turbulent behavior of the flow around the airfoil and present a clearer physical picture of the phenomena.Gobierno del Principado de Asturias, beca predoctoral Severo Ochoa BP1306
La intervención breve en la prevención del consumo de alcohol en menores: ampliando el marco competencial enfermero en el contexto educativo.
Get PDFLa adolescencia representa un periodo crítico en el inicio y experimentación de conductas de riesgo como el consumo de alcohol. Según el informe de la Encuesta Estatal sobre Uso de Drogas en enseñanzas secundarias (ESTUDES) realizado en 2015 revelan un importante aumento del consumo de alcohol, así el 78,9% de los estudiantes de entre 14 y 18 años ha probado alguna vez en la vida el alcohol, el 76,8% ha consumido en el último año y el 68,2% ha consumido alcohol en el último mes. En los últimos años, en España se ha producido un cambio en los patrones de consumo caracterizado por la ingesta de bebidas alcohólicas sólo en fin de semana, en cantidades altas y abusivas, en muchos casos con el objetivo claro de conseguir en poco tiempo la embriaguez.
Nuestro sistema sanitario ofrece unas barreras que dificultan que el adolescente tenga acceso al mismo. Por ello, y dado que la implantación de una consulta en la escuela liderada por enfermeras está presente en varias Comunidades Autónomas, se propone ampliar el rol competencial enfermero, en el abordaje de los problemas relacionados con el consumo de alcohol, para dar respuesta a un problema “oculto”, ya que sólo el 10% de los adolescentes recibe ayuda profesional. Los resultados de diferentes estudios internacionales, indican que las intervenciones breves conducidas por enfermeras son una estrategia eficaz para reducir el consumo de alcohol, se propone incluir la intervención breve en los protocolos de actuación en el contexto escolar español dirigidos por enfermeras.Adolescence represents a critical period in the beginning and experimentation of risk behaviors such as alcohol consumption. According to the report of the Statewide Survey on Drug Use in secondary education (ESTUDES) conducted in 2015, reveal a significant increase in alcohol consumption, 78.9% of students between the ages of 14 and 18 have ever tried Life alcohol, 76.8% have consumed in the last year and 68.2% have consumed alcohol in the last month. In recent years, in Spain there has been a change in patterns of consumption characterized by the consumption of alcoholic drinks only at the weekend, in high amounts and abusive, in many cases with the clear objective of achieving in a short time the drunkenness .
Our health system offers barriers that make it difficult for the adolescent to have access to it. Therefore, and since the implementation of a consultation in school led by nurses is present in several Autonomous Communities, it is proposed to expand the role of nurse competence in addressing problems related to alcohol consumption, to respond to a "hidden problem " as only 10% of adolescents with addiction problems receive professional help. The results of different international studies indicate that brief interventions conducted by nurses are an effective strategy to reduce alcohol consumption; it is proposed to include short intervention in the protocols of action in the Spanish school context led by nurses
El efecto limitado del sexismo en la agresión psicológica contra la pareja
No full textX congreso internacional de psicología jurídica y forens
De verso a proverbio: el caso de Od. 9.109
No full textOrganismo FICYT en colaboración con el Gobierno del Principado de Asturia