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Role of the RANK/RANKL/OPG and Wnt/β-Catenin Systems in CKD Bone and Cardiovascular Disorders
Get PDFThe authors wish to thank Instituto de Salud Carlos III (ISCIII; PI17/00715, PI19/00532,
PI20/00753), the ISCIII Retic REDinREN (RD06/0016/1013, RD12/0021/0023, RD16/0009/0017
and RD16/0009/0018), Fondo Europeo de Desarrollo Regional (FEDER), Plan Estatal de I+D+I
2013-2016, Plan de Ciencia, Tecnología e Innovación 2013-2017 y 2018-2022 del Principado de
Asturias (GRUPIN14-028, IDI-2018-000152), Fundación Renal Iñigo Álvarez de Toledo (FRIAT),
and University of Oviedo. N.C.L. has been supported by FINBA-GRUPIN14-028 and IDI-2018-
000152, L.M.A. by FINBA-ISCIII (PI17/00384), S.F.V. was supported by FINBA-ISCIII
(PI17/00715), and S.P. by FINBA-IDI-2018-000152.In the course of chronic kidney disease (CKD), alterations in the bone-vascular axis
augment the risk of bone loss, fractures, vascular and soft tissue calcification, left
ventricular hypertrophy, renal and myocardial fibrosis, which markedly increase
morbidity and mortality rates.
A major challenge to improve skeletal and cardiovascular outcomes in CKD patients
requires a better understanding of the increasing complex interactions among the main
modulators of the bone-vascular axis. Serum Parathyroid hormone (PTH), phosphorus
(P), calcium (Ca), fibroblast growth factor 23 (FGF23), calcidiol, calcitriol and Klotho
are involved in this axis interact with RANK/RANKL/OPG system and the Wnt/β-
catenin pathway.
The RANK/RANKL/OPG system controls bone remodelling by inducing osteoblast
synthesis of RANKL and downregulating OPG production and it is also is implicated in
vascular calcification. The complexity of this system has recently increased due the
discovery of LGR4, a novel RANKL receptor involved in bone formation, but possibly
also in vascular calcification.
The Wnt/β-catenin pathway plays a key role in bone formation, when this pathway is
activated bone is formed, when it is inhibited, bone formation is stopped. In the
progression of CKD, a downregulation of the Wnt/β-catenin pathway has been
described which occurs mainly through the not coincident elevations of sclerostin,
Dickkopf1 (Dkk1) and the secreted Frizzled Related Proteins (sFRPs).
This review analyses the interactions of PTH, P, Ca, FGF23, calcidiol, calcitriol and
Klotho with the RANKL/RANKL/OPG system and the Wnt/β-catenin, pathway and their
implications in bone and cardiovascular disorders in CK
Molecularly imprinted polymer-based electrochemical sensors for environmental analysis
Get PDFThe ever-increasing presence of contaminants in environmental waters is an alarming issue, not only because of their harmful effects in the environment but also because of their risk to human health. Pharmaceuticals and pesticides, among other compounds of daily use, such as personal care products or plasticisers, are being released into water bodies. This release mainly occurs through wastewater since the treatments applied in many wastewater treatment plants are not able to completely remove these substances. Therefore, the analysis of these contaminants is essential but this is difficult due to the great variety of contaminating substances. Facing this analytical challenge, electrochemical sensing based on molecularly imprinted polymers (MIPs) has become an interesting field for environmental monitoring. Benefiting from their superior chemical and physical stability, low-cost production, high selectivity and rapid response, MIPs combined with miniaturized electrochemical transducers offer the possibility to detect target analytes in-situ. In most reports, the construction of these sensors include nanomaterials to improve their analytical characteristics, especially their sensitivity. Moreover, these sensors have been successfully applied in real water samples without the need of laborious pre-treatment steps. This review provides a general overview of electrochemical MIP-based sensors that have been reported for the detection of pharmaceuticals, pesticides, heavy metals and other contaminants in water samples in the past decade. Special attention is given to the construction of the sensors, including different functional monomers, sensing platforms and materials employed to achieve the best sensitivity. Additionally, several parameters, such as the limit of detection, the linear concentration range and the type of water samples that were analysed are compiled
Desarrollo de wearables inteligentes y personalizados mediante tecnologías de electrónica impresa (WINTEI)
Get PDFProyecto financiado dentro de la Convocatoria del Programa Asturias de ayudas a Centros Tecnológicos en el Principado de Asturias durante el periodo 2018-2020 de la Consejería de Empleo, Industria y Turismo, Nº de expediente IDI/2018/0006
La presencia del repertorio de música contemporánea para flauta travesera en los Conservatorios Profesionales del norte de España.
Get PDFTrabajo fin de estudios.This article presents a study of the teaching of the contemporary music repertoire written for flute in the professional conservatories located in the north of Spain, specifically in the autonomous communities of El Principado de Asturias, Castilla y León, Cantabria, La Rioja and la Comunidad Foral de Navarra. A review of the didactic programs on the transverse flute subject has been carried out in order to research which are the orientational pieces of music framed in the period since 1936 as contemporary music. Likewise, a survey addressed to teachers has been proposed in order to know their perspective on this topic.Conservatorio Superior de Música "Eduardo Martínez Torner".El presente trabajo fin de estudios (TFE), comprende el estudio de la enseñanza del repertorio de música contemporánea escrita para flauta travesera en los conservatorios profesionales del norte de España, concretamente en las comunidades autónomas del Principado de Asturias, Castilla y León, Cantabria, La Rioja y la Comunidad Foral de Navarra. Se ha realizado una revisión de las programaciones didácticas de la asignatura de flauta travesera, para investigar acerca de cuáles son las obras orientativas enmarcadas en el período comprendido desde 1936 en adelante, como música contemporánea. De igual modo, se ha propuesto una encuesta dirigida a los profesores para conocer el estado de la cuestión desde su perspectiva como docentes
The effect of pasteurization in the expression of bovine milk microRNA
No full textThe edaphoclimatic conditions in Asturias (northwest Spain) enable the presence of milk production systems oscillating between farms based on grazing and low consumption of conserved feed and forages as well as a low density of
animals per surface, and intensive farms with confined animals, with a higher density, and higher consumption of
conserved feed and forages. Identifying milk according to its origin is a useful way to highlight the positive effects
of grazing farms on the environment, milk quality, animal welfare, and social aspects. MicroRNAs (miRNAs) are
21-25-nucleotide small RNAs that perform various functions within cells, including gene expression regulation. They can be profiled through microarray, quantitative real-time Polymerase Chain Reaction (RT-qPCR), or sequencing.
Their expressions vary according to the genetic context and external factors to the animal (feeding, handling, etc.).
Besides, these molecules are resistant to adverse physicochemical conditions, which make them potential biomarkers. In previous studies, a set of miRNAs from raw milk with differential expression according to some ingredients of the diet were determined. However, it is important to evaluate the effect of technological treatments, in milk factories,(pasteurization, fermentation, sterilization, etc.) on these miRNAs. Furthermore, taking into account the potential bioactivity of milk according to its miRNAs content, it is important to assess miRNAs milk content intended for human consumption. In the present study, we analysed the effect of pasteurization on the miRNAs determined as biomarkers.
For that purpose, the expression of nine miRNAs was analysed in the same volume of twenty tank milk samples before and after pasteurization. The expression analysis of the different biomarkers in pasteurized and non-pasteurized milk showed that the expression of most miRNAs was lower after pasteurization, although without significant differences
(P<0.05). Moreover, pasteurization of raw milk affects differently fat and cell fraction. These results suggest that
miRNAs are quite resistant to pasteurization.- L. Abou El Qassim tiene una beca predoctoral Severo Ochoa del Principado de Asturias (Bp 17 049)
- INIA RTA 2015 00058 C 06 02
- INIA RTA 2015 00061 C 02 01
- FICYT PCTI IDI 2018 00023772nd Annual Meeting of European Federation of Animal Scienc
Desarrollo de aplicaciones robóticas para la mejora de la productividad y la seguridad en la Industria 4.0 (ROBOTS 4.0)
Get PDFProyecto financiado dentro de la convocatoria de Programa Asturias de ayudas a Centros Tecnológicos en el Principado de Asturias durante el periodo 2018-2020 de la Consejería de Empleo, Industria y Turismo, nº de expediente IDI/2018/0006
Estrategias de normalización para la estimación de la expresión diferencial de microARN en la leche de vaca
No full textApoyo parcial de la subvención INIA y FEDER (RTA2014-00086-C03-02; RTA2015-0061-C02-01) y Principado de Asturias (PCTI 2018-2020, GRUPIN: IDI2018-000237). L. Abou el Qassim
es beneficiaria de la beca predoctoral Severo Ochoa (BP17-49) del Principado de AsturiasXIX Jornadas sobre Producción AnimalLos microARNs (miARNs) son pequeños ARNs no codificantes de 21-25 nucleótidos que realizan diversas funciones dentro de las células, incluida la regulación de la expresión de genes. Estudiando las variaciones de los perfiles de
miARNs en leche cruda de vaca procedente de diferentes sistemas de producción (Abouelqassim, 2017; Abouelqassim et al., 2018), en las células y la grasa de la leche (Li et al., 2016), se identificó un sistema
de normalización interno para la fase grasa de la leche, obtenida bajo sistemas de producción diferentes,usando el algoritmo GeNorm (Abouelqassim, 2017). Sin embargo, la determinación de los miARNs normalizadores en la fase de células no fue tan evidente. El objetivo de este trabajo es probar dos
diferentes técnicas de normalización, para mostrar la importancia del sistema de normalización sobre el resultado de un estudio
MEREMB.0
Get PDFMemoria del proyecto MEREMB.0 (Programa Asturias de ayudas económicas a Centros Tecnológicos y Centros de apoyo a la Innovación Tecnológica en el Principado de Asturas, 2018-2020).Development and implementation of a digitized control system for the Asturian chorizo drying process to monitor food safety / quality and improve profitability through data analysis. For this, it has been carried out:
• Development of a continuous and digitized control system of the chorizo dried process by monitoring the weighing.
• Development of new control systems for the drying process based on NIR (Near Infrared Spectroscopy), HSI (Hyperspectral Image) and humidity sensors.
• Integration of the systems developed into an Industry 4.0 environment for data analysis and active management of the process and food safety.Consejería de Ciencia, Innovación y Universidad (Gobierno del Principado de Asturias).Desarrollo e implementación de un sistema digitalizado de control del proceso de secado de chorizo asturiano para monitorización de la seguridad/calidad alimentaria y mejora de la rentabilidad mediante el análisis de datos. Para ello se ha realizado:
•Desarrollo de un sistema de control en continuo y digitalizado del proceso secado en chorizo mediante la monitorización de la pesada.
•Desarrollo de nuevos sistemas de control del proceso secado a partir de sensores NIR (Espectroscopia de infrarrojo cercano), HSI (Imagen hiperespectral) y sensores de humedad.
•Integración de los sistemas desarrollados a un entorno de Industria 4.0 para análisis de datos y gestión activa del proceso y seguridad alimentaria
Update in Biomolecular and Genetic Bases of Bicuspid Aortopathy
Get PDFBicuspid aortic valve (BAV) associated with aortopathy is the most common congenital heart disease in the general population. Far from being a simple harmless valve malformation, it can be a complex and heterogeneous disease and a source of chronic and acute pathology (early valvular disease, aneurysm, dissection). In the previous years, intense research has been carried out to find out and understand its mechanisms, but the pathophysiology of the disease is still not fully understood and many questions remain open. Recent studies have discovered several genetic mutations involved in the development of valvular and aortic malformations, but still cannot explain more than 5–10% of cases. Other studies have also focused on molecular alterations and cellular processes (TGF-β pathway, microRNAs, degradation of the extracellular matrix, metalloproteinases, etc.), being a field in constant search and development, looking for a therapeutic target to prevent the development of the disease. Increased knowledge about this multifaceted disorder, derived from both basic and clinical research, may influence the diagnosis, follow-up, prognosis, and therapies of affected patients in the near future. This review focuses on the latest and outstanding developments on the molecular and genetic investigations of the bicuspid aortopath
Atti LIII Convegno Internazionale della ceramica 2020. Ceramica per i complessi religiosi e i luoghi di assistenza e misericordia: committensa, produzione e consumo
No full textArtículo.Busto Zapico, M., Orejas Saco del Valle, A., & Montes López, R. (2021). La ceramica moderna delle monache Agostiniane Recollette di Gijón (Asturie, Spagna). Tra opulenza e sobrietà. En AAVV (Ed.), Atti LIII Convegno Internazionale della ceramica 2020. Ceramica per i complessi religiosi e i luoghi di assistenza e misericordia: committensa, produzione e consumo (273-284). Albisola: Centro ligure per la storia della ceramica, All'Insegna del Giglio.
Le monache Agostiniane Recollette furono il primo ordine religioso installatosi nella città di Gijón. Questa comunità giunse nel 1668 per volere della Madre María de Santo Tomé la quale si fece accompagnare da altre sette monache. Le Agostiniane occuparono temporaneamente il rifugio noto come la Casa del Forno mentre venivano portate avanti le opere di costruzione del convento del Santísimo Sacramento y Purísima Concepción, inaugurato nell'ottobre del 1684.
Realizzeremo un'analisi del repertorio ceramico utilizzato dalle Agostiniane. Queste donne si rifornirono soprattutto dai vasai locali, ma allo stesso tempo consumarono un buon numero di produzioni importate. Questi pezzi costituiscono il riflesso materiale del corredo domestico di una comunita religiosa, all'interno della quale la regola monastica e i suoi rituali segnano le tipologie di utensili necessarie.
Questo lavoro forma parte del Proyecto de intervención arqueológica en la Fábrica de Tabacos de Gijón (Proyecto Tabacalera II).Ayuntamiento de Gijón. Esta publicación es parte de la Ayuda IJC2020-046135-I financiada por MCIN/AEI /10.13039/501100011033 y por la Unión Europea NextGenerationEU/PRTR