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Oportunidades del nuevo modelo productivo asturiano habilitado por la investigación en computación y arquitecturas avanzadas
Get PDFEl proyecto ALCATRAZ tiene como objetivo general la investigación en la resolución de problemas
prácticos de una alta complejidad, que estén estrechamente ligados al tejido industrial regional
asociados al propio modelo productivo a través del estudio de cómo de viable y eficiente sea la
aplicación de distintas técnicas de computación cuántica en contraposición de técnicas clásicas.
En la siguiente figura se presenta de forma visual un resumen de dicho planteamiento.The ALCATRAZ project aims at conducting research to solve practical problems of high complexity that are closely linked to the regional industrial fabric associated with the productive model itself, through the study of the viability and efficiency of applying different quantum computing techniques as opposed to classical techniques. The following figure visually summarizes this approach
Estudio del Concierto para flauta y orquesta de cuerdas de André Jolivet
No full textEste trabajo estudia desde varias perspectivas el Concierto para flauta y orquesta de
cuerdas (1949) de André Jolivet, artista y compositor francés del siglo XX. Para ello,
contextualiza la vida y obra del autor, su biografía, desarrollo personal y artístico y los
orígenes de su estilo compositivo. A continuación, analiza el concierto en el texto y sobre
la partitura, ahondando en sus elementos estilísticos, formales, armónicos, melódicos,
rítmicos y motívicos, y relacionándolos con el contexto previo. Finalmente, se estudia la
difusión de este concierto desde su publicación, comprobando su historial de
programación en las orquestas profesionales españolas y su presencia en la discografía
mundial.This project studies the flute concerto for string orchestra (1949) by André Jolivet, a
French artist and composer of the 20th century, from various perspectives. To do so, it
contextualizes the author's life and work, his biography, personal and artistic
development, and the origins of his compositional style. Next, it analyzes the concerto in
the text and over the score, delving into its stylistic, formal, harmonic, melodic, rhythmic,
and motivic elements, and relating them to the previous context. Finally, the diffusion of
this concerto since its publication is studied, checking its programming history in Spanish
professional orchestras and its presence in the world discography
DNA metabarcoding analysis of three material types to reveal Joro spider (Trichonephila clavata) trophic interactions and web capture
Get PDFVitamin D Receptor From VSMCs Regulates Vascular Calcification During CKD: A Potential Role for miR-145a
Get PDFBACKGROUND: Vascular calcification (VC) is a highly prevalent complication of chronic kidney disease (CKD) and is associated
with the higher morbidity-mortality of patients with CKD. VDR (vitamin D receptor) has been proposed to play a role in the
osteoblastic differentiation of vascular smooth muscle cells (VSMCs), but the involvement of vitamin D in VC associated to
CKD is controversial. Our aim was to determine the role of local vitamin D signaling in VSMCs during CKD-induced VC.
METHODS: We used epigastric arteries from CKD-affected patients and individuals with normal renal function, alongside an
experimental model of CKD-induced VC in mice with conditional deletion of VDR in VSMC. In vitro, experiments in VSMC
with or without VDR incubated in calcification media were also used.
RESULTS: CKD-affected patients and mice with CKD showed an increase in VC, together with increased arterial expression of VDR
compared with controls with normal renal function. Conditional gene silencing of VDR in VSMCs led to a significant decrease
of VC in the mouse model of CKD, despite similar levels of renal impairment and serum calcium and phosphate levels. This was
accompanied by lower arterial expression of OPN (osteopontin) and lamin A and higher expression of SOST (sclerostin). Furthermore,
CKD-affected mice showed a reduction of miR-145a expression in calcified arteries, which was significantly recovered in animals
with deletion of VDR in VSMC. In vitro, the absence of VDR prevented VC, inhibited the increase of OPN, and reestablished the
expression of miR-145a. Forced expression of miR-145a in vitro in VDRwt VSMCs blunted VC and decreased OPN levels.
CONCLUSIONS: Our study provides evidence proving that inhibition of local VDR signaling in VSMCs could prevent VC in CKD
and indicates a possible role for miR-145a in this process.
GRAPHIC ABSTRACT: A graphic abstract is available for this article.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure
Get PDFAbstract: Drugs providing antihypertensive and protective cardiovascular actions are of clinical interest in controlling cardiovascular events and slowing the progression of kidney disease. We studied the effect of a hybrid compound, GGN1231 (derived from losartan in which a powerful antioxidant was attached), on the prevention of cardiovascular damage, cardiac hypertrophy, and fibrosis in a rat model of severe chronic renal failure (CRF). CRF by a 7/8 nephrectomy was carried out in maleWistar rats fed with a diet rich in phosphorous (0.9%) and normal calcium (0.6%) for a period of 12 weeks until sacrifice. In week 8, rats were randomized in five groups receiving different drugs including dihydrocaffeic acid as antioxidant (Aox), losartan (Los), dihydrocaffeic acid+losartan (Aox+Los) and GGN1231 as follows: Group 1 (CRF+vehicle group), Group 2 (CRF+Aox group), Group 3 (CRF+Los group), Group 4 (CRF+Aox+Los group), and Group 5 (CRF+GGN1231 group). Group 5, the CRF+GGN1231 group, displayed reduced proteinuria, aortic TNF- , blood pressure, LV
wall thickness, diameter of the cardiomyocytes, ATR1, cardiac TNF- and fibrosis, cardiac collagen
I, and TGF- 1 expression. A non-significant 20% reduction in the mortality was also observed.
This study showed the possible advantages of GGN1231, which could help in the management of
cardiovascular and inflammatory processes. Further research is needed to confirm and even expand
the positive aspects of this compound.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
Asociación de la gamma glutamil transferasa con la presencia y progresión de calcificaciones aórticas abdominales y con cambios en densidad mineral ósea
Get PDFIntroduction and objective: abdominal aortic calcification (AAC) is a predictor of cardiovascular events. This study aimed to assess the association of gamma glutamyl transferase (GGT) in the presence and progression of AAC, as well as changes to bone mineral density (BMD) in the lumbar spine and femoral neck. Materials and methods: a total of 326 men and women over 50 years of age were selected for this study. They completed a questionnaire, underwent two lateral dorso-lumbar spine X-rays, and BMD measurements. The same tests and 1 analytical assessment were repeated after 4 years. Results: the presence and progression of AAC (new occurrences or increased severity) were lower in GGT quartile 1 (Q1) compared with the other quartiles (40 % vs 58 %; p = 0.021; 24 % vs 44 %; p = 0.022). Compared with Q1, the confound-ers-adjusted logistic regression analysis showed that Q2 and Q4 were associated with more presence of AAC [odds ratio (OR), 2.53; 95 % confidence interval (95 % CI), 1.22-5.25 and OR, 3.04; 95 % CI, 1.36-6.77]. Additionally, Q2, Q3, and Q4 were associated with more AAC progression [OR, 2.24; 95 % CI, 1.07-4.67; OR, 2.35; 95 % CI, 1.09-5.07; and OR, 3.47; 95 % CI, 1.56-7.70]. The gender-stratified multivariate analysis revealed that in both men and women, the Q4 of GGT was associated with AAC progression [OR, 3.27; 95 % CI, 1.14-9.36, and OR, 3.26; 95 % CI, 1.03-10.29, respectively], and women alone, with greater lumbar BMD losses. There were no effects regarding the prevalence of AAC. Conclusions: elevated GGT levels could serve as an indicator of the presence and progression of AAC in individuals older than 50 years. When analyzed separately by gender, higher GGT levels were associated with AAC progression, which acted as a prognostic marker for cardiovascular disease.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA
Participación ciudadana: guía de diseño, ejecución e incorporación de procesos de participación ciudadana a la administración y sector público del Principado de Asturias
Get PDFGuía elaborada por la Universidad de Oviedo en colaboración con la Dirección General de de Gobernanza Pública, Transparencia, Participación Ciudadana y Agenda 2030.Esta guía pretende ofrecer una herramienta práctica con el objetivo de facilitar el desarrollo de procesos de participación ciudadana promovidos desde la Administración delPrincipado de Asturias y su sector público, en todas sus fases.
La guía toma como punto de partida tanto el marco conceptual de referencia, en el que se explicita el papel de la participación en la nueva gobernanza pública, como el marco legal en el que debe incardinarse, teniendo en cuenta también la Estrategia de Gobernanza Pública de la Comunidad Autónoma, que se encuentra en fase de tramitación.
Aunque no existe un único concepto de participación ni de dimensión de la misma, esta guía recoge unas pautas, principios, instrumentos, herramientas, técnicas y recomendaciones, que faciliten la labor de diseño, ejecución e incorporación de procesos de participación ciudadana a la Administración y sector público de la Comunidad Autónoma; entendiendo por tales el conjunto de actuaciones y trámites desarrollados en este ámbito dirigidos a posibilitar la participación real y efectiva de la ciudadanía en los asuntos públicos autonómicos, ya sea de forma individualizada o colectiva, con especial atención a aquellos de carácter deliberativo. Es decir, aquellos procesos en que se involucra a la ciudadanía en la deliberación y toma de decisiones, dentro de su ámbito competencial y en el marco legal de referencia
Colloidal Synthesis of Hybrids Graphene-Mo2C with Potential Application in Water Splitting
No full textGraphene is a carbon allotrope that is formed by a single layer of carbon atoms, which are tightly bounded in a hexagonal honeycomb lattice. It was isolated for the first time by Andre K. Geim and Konstantin Novoselov of the University of Manchester in the early 2000s. From that moment, this material has gained enormous interest due to its promising properties for different applications. These include high thermal and electrical conductivities, high elasticity and flexibility, high resistance, or antibacterial effect, among other. However, graphene can be decorated with metals, organics, or other phases to improve its characteristics for certain applications, for instance in sensors or catalyzers for water splitting. As it is possible to check, one of the fields
where the hybrids graphene-metal phase (i. e. strontium titanate or molybdenum disulfide) is gaining interest is in the field of catalyzers to produce hydrogen from the water splitting. Apart from the above-mentioned combinations, one of the options that is more hopeful in the field of catalyzers for hydrogen evolution is the decoration of graphene with molybdenum (II) carbide. Different alternative methods have been proposed for the synthesis of these nanocomposites, although the common issue of the processes is the complexity of the method with the use of several stages, long processes, or complex reagents. Therefore, a novel process based on colloidal processing method is proposed to synthesize the hybrids using molybdenum chloride as precursor of the carbide
Characterization of graphite-chromium carbide composites manufactured by Spark Plasma Sintering.
Get PDFThis manuscript contains an investigation about the influence of the chromium content on the properties of novel graphite-chromium composites obtained by spark plasma sintering (SPS), with great potential application in heat dissipation. Green compacts of 40 mm in diameter were first obtained by uniaxial pressing at 60 MPa, and then the composite was sintered at 1800°C in SPS under vacuum conditions and a pressure of 30 MPa. These sintering conditions involved local liquid phase, which promoted the densification of the composite up to values close to 90%. Different chromium contents were studied, 0, 1, 2, 5, 7 and 10 vol. %, where the best properties (densification, young modulus, electrical conductivity, thermal conductivity, and flexural strength) were obtained in the case of the composite with 7 vol. % Cr: 86.22%, 52.7 GPa, 0.79 MS/m, 264 W/m·K and 38.97 MPa, respectively, measured in the in-plane direction due to the anisotropic behavior of the composite
The Role of Social Work for Emergency Medical Services (EMS): A Systematic Review
Get PDFAbstract
Introduction: Emergency Medical Services (EMS) are integrated services involving
doctors, paramedics, nurses, and social workers. This research was carried out to synthesize
the evidence concerning social work roles for EMS. The aim of this study was to synthesize
literature on the social worker’s role in EMS settings.
Methods: The study was a systematic review. Data were collected through selected
databases. The researcher used Scopus, Sociology Database, Social Science Database, and
Public Health Database related to EMS and social work settings. English papers were
selected, without restrictions on publication time, place, and year. The searched keywords
were: “Social Work ANDEmergency Medical ServicesANDAmbulance Services,” “Social
Worker AND Emergency Medical Systems AND Ambulance Services,” “Social Work
AND EMS,” “Social Worker AND EMS,” “Social Work OR Social Worker,” “Social
Work Role AND EMS,” Social Worker AND EMS,” “Emergency Medical Services OR/
AND Emergency Medical Systems.”
Results: The study synthesized the literature about the social work role in pre-EMS, during
emergency, and post-EMS. The following themes were highlighted: social workers act as
cultural liaisons, effective communicators, emergency workers, and mental health
practitioners, collaborating with other disciplines and researchers, for this study. In preemergency
stages, social workers have roles as educators, communicators, advocates, and
awareness builders. During an emergency, social workers act as search and rescue workers,
advocates, facilitators, networkers, psychosocial assessors, consultants, counselors, and
liaisons for referral activities. And in the post-emergency period, social workers have roles as
planners, liaisons, interdisciplinary collaborators, researchers, evaluators, and individuals
responsible for follow up.
Conclusion: This study synthesizes the roles of social workers inEMSsettings. It is the first
study on this topic, aiming to produce new knowledge, evidence, and an EMS practice
framework for the social worker.Instituto de Investigación Sanitaria del Principado de Asturias (ISPA