Althea Medical Journal
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Spirometric Values of Patients with Chronic Obstructive Pulmonary Disease in Dr. Hasan Sadikin General Hospital Bandung
Get PDFBackground: Chronic obstructive pulmonary disease (COPD) is a frequently underdiagnosed disease. Definitive COPD has been diagnosed using spirometry to evaluate pulmonary function. This study aimed to explore the spirometric values of COPD patients to aid in the diagnosis of COPD.Methods: A descriptive study was conducted in Dr. Hasan Sadikin General Hospital Bandung from October to November 2015. Data on patients diagnosed with COPD, aged 40 to 60 years old, were collected during the year 2014 prior to ethical clearance. Spirometry values consisted of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio were taken from the medical records.Results: Sixty-eight COPD patients, consisting of 48 males and 20 females, were included of with most were classified as moderate COPD. The FEV1 was 49.72±17.79, whereas the FVC was 55.90 (range 22.80–96.03), and the FEV1/FVC ratio was 0.70±0.12. Most patients were classified into moderate COPD who had FEV1 between 50 and 80% of normal as GOLD 2 standard.Conclusions: Even though patients seem to have no symptoms, spirometric values may show a silent insufficient lung function affecting patients’ daily life
Risk Factors of Dementia in Elderly of Bandung City, Indonesia: A Community-Dwelling Study
Get PDFBackground: Multiple organ degenerative processes are parts of a normal biological process in aging. One of the geriatric syndromes is cognitive disorders that range from a mild cognitive impairment to dementia. The aim of this study was to analyze factors contributing to the occurrence of dementia in the elderly.Methods: A cross-sectional analytical study was conducted using secondary data on 306 elderly people who visited the Integrated Health Post (Pos Pembinaan Terpadu, Posbindu) from June to August 2016 in Bandung City, Indonesia. Nine variables were included in this study: age, gender, education level, marital status, occupation, living arrangements, social participation, comorbidity, and dementia. The dementia status was measured by the Mini-Mental State Examination and Mini Cog Assessment instruments. Data were then analyzed statistically using Chi-Square, Fisher Exact, and Kolmogorov-Smirnov tests, as well as using the multivariate logistic regression.Results: Around 35.3% (95%CI=30%–40.6%) of respondents had dementia. There were relationships between dementia and age (p=0.035), level of education (p=0.000), and social participation (p=0.001). Social participation was the most dominant risk factor of dementia (OR=2.703;95%CI=1.491-4.902).Conclusions: Age, education level, and social participation are risk factors that contribute to dementia. The elderly who has less than two times per week of social participation has a 2.7 times higher risk for having dementia compared to the elderly who has more than two times per week of social participation
Six-Minutes Walk Test Characteristics in Geriatric Outpatient Clinic at Dr. Hasan Sadikin General Hospital Bandung
Get PDFBackground: The six-minute walk test (6MWT) is a safe, easy to perform, and inexpensive test to evaluate the functional and exercise capacity in the elderly. The purpose of this study was to describe the 6MWT distance achieved among elderly patients.Methods: This descriptive study was conducted from January to November 2014 using medical records in the geriatric outpatient clinic of the Department of Internal Medicine at Dr. Hasan Sadikin General Hospital from 2012 to 2014. The main variable was the distance achieved by the 6MWT, compared based on age, sex, and body mass index.Results: The average distance of the 6MWT in 122 elderly was 237.56 m. The highest results were in the youngest age group of 60–69 year old with an average distance of 243.87 m. A male elderly patients had an average distance of 245.26 m, and the elderly with high body mass index had 248.57 m.Conclusions: The distance achieved among the elderly during the 6MWT is relatively short. Increased physical activity such as walking is recommended for the elderly
Larvicidal Activity of Citrus aurantifolia Decoction against Aedes aegypti Larvae
Get PDFBackground: Infected female Aedes mosquito is the primary vector of virus transmission for dengue hemorrhagic fever (DHF). Natural phytochemical larvicide is becoming a complementary way for vector control management. The citrus plant extract has natural chemical reactions against mosquito larvae. This study aimed to identify the larvicidal activity of Citrus aurantifolia leaves decoction against larvae of Aedes aegypti as an effort to discover natural phytochemical repellant.Methods: This was an analytic experimental study using twenty-five Aedes aegypti larvae. The larvae were placed in translucent cups containing different concentrations of C. aurantifolia leaves decoction. The cups were filled with Abate as positive controls and water as negative controls. The experiment was repeated for three consecutive days, and the mortality of larvae was monitored for 48 hours as described in the World Health Organization (WHO) guidelines for laboratory and field testing for mosquito larvicides (WHOPES).Results: C.aurantifolia decoction significantly decreased the number of larvae. The highest mortality was shown in 30% concentration with a total of 224 dead larvae. Probit analysis showed LC50 was 38.5% and 6.6% at 24 and 48 hours, respectively. The highest rate of killing the larvae was taken at LC60 with 91.6% for 24 hours and LC65 64.4% for the 48 hours; thus LC90 could not be determined. The significance of the decoction concentration was analyzed by one way ANOVA preceded with Post-hoc test (p-values 0.000).Conclusions: Decoction of C.aurantifolia leaves has proved to have larvicidal activity against larvae of Aedes aegypti and could be used as phytochemical larvicides in controlling vector of DHF
The Bacterial Vaginosis among Pregnant Women in Jatinangor
Get PDFBackground: Bacterial vaginosis (BV) is polymicrobial that causes superficial vaginitis due to a shift in vaginal flora. In pregnant women, BV can result in a significant risk of some serious consequences. The objective of this study was to identify the BV prevalence and to explore the characteristics and personal hygiene practices among pregnant women.Methods: This study was conducted in Desa Cipacing, Jatinangor, using the cross-sectional descriptive method, including pregnant women. The BV was detected by Gram-stained vaginal smears using Nugent Score. Furthermore, other microorganisms such as trichomoniasis and candidiasis were detected by direct microscopic observation. The questionnaire was distributed, consisting of details of personal hygiene practices.Results: In total, 17.9% of 52 pregnant women included were diagnosed with BV and 14.3% with mixed infection. Pregnant women with BV were predominantly aged younger than 25 years (61.1%), nullipara (50%) and in a second-trimester pregnancy (50%).Conclusions: Bacterial vaginosis (BV) is common among young pregnant women, predominantly in their first pregnancy. It is related to personal hygiene practices, indicating the need for targeted interventions of healthcare education among these young pregnant women to reduce the BV prevalence
Propolis of Trigona spp. Protects Mucosa from Aspirin-Induced Gastric Mucosal Damage in Rats
Get PDFBackground: Helicobacter pylori and non-steroid anti-inflammatory drugs are the major causes of peptic ulcer in the world. Indonesian native stingless bee species, Trigona spp., produces propolis that might be effective to protect mucosal damage. The aim of the study was to determine the protective effect of Trigona spp. propolis on aspirin-induced gastric mucosal damage in rats.Methods: This experimental study was conducted from September–November 2013 at Animal Laboratory of Department of Pharmacology and Therapy Faculty of Medicine Universitas Padjadjaran. Healthy male Wistar rats (n=24) aged 2–3 months old and weighed 200–250 grams were randomly divided into three groups. The first group was control negative, the second group was given 100 mg/kg body weight of aspirin, and the third group was given 200 mg/kg body weight of Trigona spp. propolis, one hour before administration of 100 mg/kg body weight of aspirin. After two weeks of treatment, rats were sacrificed by laparotomy to obtain gastric tissues, followed by processing for the paraffin section for histopathological analysis. The grade of gastric mucosal damage was determined under a light microscope. Data were then compared between groups using the Mann-Whitney test.Results: Oral administration of aspirin-induced gastric mucosal damage ranging from grade 0 to grade IV; whereas administration of propolis showed a reduction of gastric mucosal damage’s grade when compared to the aspirin group (p<0.05).Conclusions: Trigona spp. propolis has a protective effect on aspirin-induced gastric mucosal damage. Further study is encouraged to study an optimal dose of aspirin after propolis administration.
Correlation between Hemoglobin Concentration and Cardiorespiratory Fitness in Adolescent Sportsmen
Get PDFBackground: Sport is a physical activity that increases human body oxygen demand. Hemoglobin has a major role to fulfill the oxygen demand. The body capacity to fulfill the increasing oxygen demand could be seen as cardiorespiratory fitness. Sportsmen have a high cardiorespiratory fitness due to the intensity and frequency of training. This study aimed to explore how hemoglobin concentration affects the cardiorespiratory fitness of adolescence sportsmen. Method: This study used a cross-sectional approach. The sampling started in October – November 2019. Sample of this study were 15-19 years old male badminton and basketball sportsmen at Jakarta and Bogor (n=72). Hemoglobin concentration measured with a digital hemoglobinometer which used an azide-methemoglobin method. VO2max estimated with a beep test. FITNESSGRAM® Performance Standard was used for the classification of cardiorespiratory fitness. All measurement’s ethical issues had been approved. The result of hemoglobin concentration and cardiorespiratory fitness was processed by SPSS program with Spearman and Kruskal-Wallis analysis method. Results: There was a correlation between hemoglobin concentration and cardiorespiratory fitness (p = 0.001, p < 0.05). Spearman analysis showed there was a weak correlation (r = 0.38) between hemoglobin concentration and cardiorespiratory fitness. Kruskal-Wallis analysis showed there was a meaningful mean difference in hemoglobin concentration on cardiorespiratory fitness groups (p = 0.005, p < 0.05). Conclusion: The mean of the hemoglobin concentration on the Healthy Fitness Zone (HFZ) cardiorespiratory group was higher than on the Need Improvement (NI) group and the Need Improvement within Health Risk (NI-HR) group.
Perspective of Cikahuripan Villagers on Traditional Health Service Provisions in Government Regulation No. 103 Year 2014
Get PDFBackground: Traditional health service is one of the health services that is still currently used in Indonesia, especially in rural communities. The government has been regulating these services since 2014. Despite its long existence, there is a recent increase of potential regulation violation among traditional health service providers. This study aimed to explore the perspective of the Cikahuripan Villagers on Government Regulation on traditional health services.Methods: This was a qualitative study using in-depth interviews and direct observations on traditional health services in Cikahuripan Village. Sixteen informants consisting of 8 villagers who met the inclusion criteria and another 8 informants in the triangulation negative case analysis, member checking, peer debriefing, and observation was involved.Results: There were two different perspectives in the community on traditional health service provisions in the Government Regulation. Supporters of the regulation believed that the regulation would make traditional health services more responsive and safer, which would improve service quality and health benefits as well as imposing effective sanctions. In contrast, the opposition believed that regulations were too late, would make the costs for licensing expensive, and too complicated.Conclusion: There are two different public perspectives on the regulation of traditional health services, which are supporting and opposing the regulation. It is expected that the local government create a derivative of the regulation by making adjustment to the community’s situation
Clinical Profile of Adverse Cutaneous Drug Reactions in Patients with Human Immunodeficiency Virus
Get PDFBackground: Adverse cutaneous drug reactions (ACDRs) are common problems in patients during the treatment of various diseases. The clinical feature varies from mild manifestation such as morbilliform, urticaria, and contact dermatitis, to severe manifestation such as Stevens - Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Patients infected with the human immunodeficiency virus (HIV) have an increased risk of developing ACDRs due to immune system disruption. This study aimed to describe the clinical features of ACDRs in HIV patients and the drugs that cause ACDRs.Method: This study was a retrospective study using secondary data from medical records of HIV patients with ACDRs who visited Teratai Clinic of Dr. Hasan Sadikin General Hospital Bandung from 2014 to 2018. Total sampling was applied and results were presented in percentage.Results: There were 94 HIV patients with ACDRs out of 557 HIV patients. Adverse cutaneous drug reactions are commonly found in males aged 20-39 years old. The clinical features found were morbilliform (85.6%), SJS (8.9%), urticaria (4.4%), and erythroderma (1.1%). The most common drugs causing ACDRs were Cotrimoxazole (30%), Efavirenz (28.9%), and Nevirapine (16.7%).Conclusion: The prevalence of ACDRs in HIV patients in this study is 16.9%. The most common clinical features are morbilli form and SJS with Cotrimoxazole, Efavirenz, and Nevirapine causing most of the ACDRs
Cancer Antigen 125 Serum Level in Head and Neck Diffuse Large B-Cell Lymphoma
Get PDFBackground: Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype of the Non-Hodgkin Lymphoma (LNH). Until now, lactate dehydrogenase (LDH) is the only tumor marker to assess DLBCL progression; however, increased LDH is a relatively non-specific biomarker. Cancer antigen 125 (CA-125) serum level have been used as a tumor marker in ovarian cancer. The aim of this study was to explore the possible role of CA-125 serum level as a tumor marker in head and neck DLBCL.Methods: This was an observational descriptive study among consecutively sampled DLBCL patients. CA-125 serum level examination was carried out (ADVIA Centaur CA-125II) and described along with the clinical characteristics of DLBCL patients.Results: DLBCL was mostly observed in males (54.05%), most often in the 55-65 year age group (51.3%), with stage 1 DLBCL was the most prevalent (71.9%). The mean CA-125 serum level was 22.9 U/ml and increased in patients with advanced DLBCL.Conclusions: Increased CA-125 serum level in DLBCL, especially at advanced stages, suggests that CA-125 serum level may be of benefit as a tumor marker in the head and neck DLBCL. Further study is in need to explore the role of CA-125.1. Kementerian Kesehatan Republik Indonesia. Data dan kondisi penyakit limfoma di Indonesia. InfoDatin Pusat Data dan Informasi Kementerian Kesehatan RI. 2015 [cited 2020 March 18] Available from: https://www.kemkes.go.id/resources/download/pusdatin/infodatin/infodatin-limfoma.pdf2. Dwianingsih EK, Indrawati, Hardianti MS, Malueka RG , Iswar RR, Sutapa S, et al. Histopathological features of lymphoma in Yogyakarta, Indonesia. Asian Pac J Cancer Prev. 2016;17(9):4213–16.3. Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. Riset Kesehatan Dasar (RISKESDAS) 2013. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI; 20134. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014; 32(27):3059–67.5. Ziepert M, Hasenclever D, Kuhnt E, Glass B, Schmitz N, Pfreundschuh, et al. Standard International prognostic index remains a valid predictor of outcome for patients with aggressive CD20+B-cell lymphoma in the rituximab era. J Clin Oncol. 2010;28(14):2373-2380.6. Gutiérrez A, Martínez-Serra J, Barceló B, Sampol A, Vinas L, Gonzales G, et al. Prognostic value of serum CA125 levels in diffuse large B-cell lymphoma: potential role of a new sex and age adjusted reference value. Int J Lab Hematol. 2010; 32(6 Pt 2): 582–9.7. Dilek I, Ayakta H, Demir C, Meral C, Ozturk M. CA 125 levels in patients with Non-Hodgkin lymphoma and other hematologic malignancies. Clin Lab Haematol. 2005;27(1):51–5.8. Memar B, Aledavood A, Shahidsales S, Ahadi M, Farzadnia, Raziee HR, et al. The prognostic role of tumor marker CA-125 in B-Cell non-Hodgkin’s Lymphoma. Iran J Cancer Prev. 2015;8(1):42–6.9. Garg S, Goyal B. Evaluation of CA-125 as a prognostic marker in patients with Non-Hodgkin’s lymphoma. International Journal of Medical and Health Research. 2017;3(4):13–5.10. Paoli CJ, Bach BA, Quach D, Tsai KT, Wong B, Kallich J. Performance status of real-world oncology patients before and after first course of chemotherapy. The Journal of Community and Supportive Oncology. 2014; 12(5):163–70.11. Yadav C, Ahmad A, D’Souza B, Agarwal A, Nandini M, Prabhu KA, et al. Serum lactate dehydrogenase in Non-Hodgkin’s lymphoma: a prognostic indicator. Indian J Clin Biochem. 2016;31(2):240–2