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No full textLe lactate, longtemps relégué au rang de simple déchet métabolique, est désormais reconnu comme un métabolite central du métabolisme énergétique, un substrat recyclable et un médiateur de signalisation cellulaire. Produit majoritairement par les fibres musculaires glycolytiques, le lactate permet de régénérer le NAD+ cytosolique indispensable à la poursuite de la glycolyse lors des exercices de haute intensité. Son export via les transporteurs lactate/proton MCT4, ainsi que son utilisation par d’autres tissus, notamment les fibres musculaires oxydatives grâce aux transporteurs MCT1, soulignent son rôle essentiel en tant qu’intermédiaire métabolique, loin de l’idée d’un simple déchet. De plus, son cotransport avec le proton à travers la membrane sarcolemmale contribue à la régulation du pH intracellulaire. Par ailleurs, le lactate est impliqué dans la régulation des adaptations du métabolisme énergétique oxydatif, en permettant l’activation du cofacteur de la biogenèse mitochondriale PGC-1α et la modulation de l’expression de marqueurs mitochondriaux. Parallèlement, en se liant au récepteur couplé aux protéines G GPR81, le lactate pourrait moduler des voies de signalisation clés telles qu’ERK1/2 et Akt-mTOR, impliquées dans l’hypertrophie musculaire, la sensibilité à l’insuline et la régulation lipidique. Il relierait ainsi ses fonctions métaboliques à des processus adaptatifs majeurs induits par l’exercice physique. Ce rôle fonctionnel reste toutefois à être pleinement élucidé
Retraction Notice: Traffic Light Detection for Information Systems and Telecommunications using CNN
No full textWe take a zero tolerance to any situation where fraudulent research is published in our journals. As a result, this article has been retracted by the Publisher because it is suspected to be a nonsensical computer-generated publication with a number of tortured phrases and irrelevant references.
Additional measures have been implemented to prevent these issues from reoccurring.
EDP Sciences is extremely grateful to anonymous whistleblowers and the Problematic Paper Screene
Costs of retrofitting public building in tropical climate: Improving the energy use intensity
No full textIndonesia is committed to advancing sustainability through regenerative design, motivated by the triple planetary crisis and accelerated urbanization, which have resulted in cities becoming major hubs of energy consumption and emissions. The Government's Green Building Code, the 2023-2028 roadmap, and revised SNI standards identify energy efficiency (EE) not only as a compliance requirement but also as a strategic approach to regeneration. This study evaluates budget to retrofit an existing building's Energy Use Intensity (EUI), as well as the factors that affect this outcome. Using secondary data of the Istiqlal Mosque, as a case study, as the largest mosque in Southeast Asia and an iconic government-affiliated public building, the research explores to address the costs of retrofitting. The mosque's recent retrofit achieved a 23% EUI reduction, with retrofit costs and significant influencing factors to be determined by the study's conclusion. Government aims to cut energy use by 25% for public buildings. The findings show the cost for retrofitting is reasonable for reducing the EUI in Public Building, however, the challenge is the putting and allocating the budget envelop adequately. Limitations include reliance on secondary data and combined building-landscape interventions
Upgrading of slum riverbank settlements area through land consolidation approaches in Pontianak City
No full textHousing and settlement development plays an important role in creating a livable environment and reducing the emergence of slums in urban areas, which are often caused by inadequate city planning. This study focuses on handling slums on riverbanks through Land Consolidation approach in Bansir Laut Village, Pontianak City, West Kalimantan. The main problem in providing housing is land availability, where land has varying characteristics and development support capacity according to the location of the land and its surrounding environment. With multidisciplinary science, the proposed solution is not only related to human factors, but also physical factors (buildings and environment) and non-physical factors, such as economy, culture, social, and ecology in urban areas. The method is qualitative through regulatory analysis and design considerations as well as determining design criteria and concepts through community participation. The results of the study indicate that community participation and collaboration between stakeholders are the key factors in the Land Consolidation program. The results of this study are expected to provide insights and sustainable strategic solutions to improve environmental quality and solve the problem of slum settlements on riverbanks in Indonesia
Development and evaluation of biodegradable seedling tubes from beeswax and macadamia nut composites
No full textThis study investigates the development of biodegradable seedling tubes using macadamia nutshell powder as a filler and beeswax as a natural binder, to provide a sustainable alternative to conventional polyethene tubes. A total of twenty-four experimental runs were conducted following a Design of Experiments framework to evaluate the effects of beeswax–to–macadamia ratios (90:10, 70:30, and 50:50 wt %), soil pH, temperature, and moisture content on biodegradability over a 28-day soil burial test. Elemental composition was determined by X-ray fluorescence analysis, while statistical significance was assessed using analysis of variance. Results showed that biodegradation rates ranged from 28.2% to 58.3%, with the beeswax ratio exerting the most significant influence (p < 0.05) on degradation behaviour, followed by temperature and soil moisture. Tubes with higher beeswax content exhibited greater structural stability and water resistance but lower biodegradability. Conversely, lower beeswax ratios favoured faster microbial decomposition. Elemental analysis revealed appreciable levels of SiO2, Al2O3, and Fe2O3, which contribute to mechanical stability and may facilitate micronutrient enrichment during decomposition. The findings confirm the technical feasibility of producing biodegradable, plantable seedling tubes from locally available agro-wastes. The composite formulation offers an environmentally sound, low-cost alternative to plastic seedling containers while supporting circular-economy principles and promoting sustainable nursery management practices in Malawi and similar contexts
Mathematical modelling of the contribution of senescent fibroblasts to basement membrane digestion during carcinoma invasion
No full textSenescent cells have been recognized to play major roles in tumor progression and are nowadays included in the hallmarks of cancer. Our work aims to develop a mathematical model capable of capturing a pro-invasion effect of senescent fibroblasts located in the conjunctive tissue. We focus in the present article on the first moments of the invasion cascade. Considering a localized epithelial tumor, we model the digestion of the collagen fibers of the basement membrane by the proteolytic enzyme MMP-2. The activation of MMP-2 is modelled in detail, as MT1-MMPs bound to the surface of tumor cells interact with proMMPs and TIMPs, proteins enriched in the secretome of senescent Cancer-Associated Fibroblasts, along with its inhibition by TIMPs. Using numerical simulations of the model, calibrated via an extensive literature search, reproducing biologically relevant scenarios, we test the model’s suitability to investigate the effect on basement membrane digestion of fibroblasts presenting a senescence-associated secretory phenotype. Via model reduction, steady state and global sensitivity analyses, we identify the most influential parameters in view of their calibration with empirical data. We conclude the paper discussing mathematical and interdisciplinary perspectives
Study of artificial recharge of Turonian aquifer (Tadla Bassin-Phosphate Plateau-Downstream Tassaout)
No full textThe Turonian aquifer of the Tadla basin-Phosphate Plateau-Tassaout downstream, is currently experiencing a significant decrease in its hydraulic capacities, due to the combination of intensive exploitation and the shortage of beneficial precipitation. To remedy this problem, we proposed various possible scenarios for artificially recharging the aquifer, namely: Exploitation of dams, The use of wastewater treatment plants, The creation of infiltration thresholds along wadis upstream of the aquifer; based on hydrological/hydrogeological, geological, and climatological studies, in order to better adapt the development scenarios to the aquifer under study and its functioning. As for the volume of water needed for recharge depends on the objective of artificial recharge: either maintain the piezometric level of the previous year, or raise the piezometric level to a given level. The methodology adopted would constitute a working and exploitation methodology that could be transposed to other aquifers with similar characteristics
Pakan-SIP adoption as a featured ruminant-rations product of TEFA Feed Mill Polije on trends in body weight and physiological responses of local crossbred sheep
No full textThis research examined the impact of Pakan-SIP adoption on body weight trends and physiological characteristics of local crossbred sheep compared to conventional feeding based on native grass. Nine heads of local crossbred sheep were randomly allocated in a Completely Randomized Design (CRD) with 3 dietary treatment levels, each in triplicate. It was 100% native grass (T0), 50% native grass and 50% Pakan-SIP (T1), and 100% Pakan-SIP (T2). The sheep, aged ±12 months old with initial body weight of ±28.97 kg/head. They were adapted to individual pens, simultaneously offered native grass and Pakan-SIP, and provided ad libitum drinking water during several weeks. Thereafter, body weight and physiological responses were monitored over a month. Results showed an upward trend in body weight for sheep fed Pakan-SIP with average of 6.37 kg/head/month without any deleterious effects on rectal temperature, heart rate, and respiratory rate. These findings suggest that Pakan-SIP can serve a superior feed for fattening local crossbred sheep, supporting growth performance without compromising physiological stability or affecting animal welfare
Integrated management of urban valleys in Fez in the face of flooding: Toward a sustainable environmental and territorial assessment
No full textYou should leave 8 mm of space above the abstract and 10 mm after the abstract. The heading Abstract should be typed in bold 9-point Arial. The body of the Faced with the growing frequency and intensity of urban flooding, particularly in Moroccan cities undergoing rapid and poorly planned urbanization, valley management is a strategic issue that is both environmental and territorial in nature. As a territory exposed to complex dynamics, the Fez metropolitan area provides an ideal case study for developing an integrated model for urban valley management, aimed at reducing flood risk and enhancing the ecological value of river environments. The approach adopted is based on an integrated analysis of hydrogeomorphological dynamics, land use patterns, and socio-environmental vulnerability indicators.
Modeling hydraulic hazards, analyzing hydrogeomorphological features, and assessing the ecological functions of valleys have helped identify sustainable development solutions such as riverbed restoration, the creation of buffer zones, and the integration of green infrastructure. The results highlight the need for collaborative territorial governance and prior environmental assessment to guide development proposals. The objective is to contribute to international debates on integrated water resource management and urban resilience by proposing operational recommendations for sustainable land-use planning based on the ecological and functional potential of valleys
Profiling of untargeted compounds from the ethanolic extract of green melinjo (
No full textMelinjo (
Gnetum gnemon) is one of the plants that is quite well known in Indonesia. The seeds of melinjo fruits are commonly processed as chips named as emping melinjo, while the fruit peel and leaves are consumed as vegetables. Extracts from melinjo peels have been reported to exhibit antioxidant activity and are utilized as ingredients in functional beverages. In addition, melinjo peel extracts have also been reported to have potential antihyperuricemic effects. The compounds suspected to contribute to antioxidant and antihyperuricemic activities belong to the phenolic compound group. Other compounds with potential antioxidant and antihyperuricemic properties from melinjo peel have not yet been identified. Therefore, this study aimed to explore the untargeted metabolite content in green melinjo peel. Ethanol extracts of green melinjo peel were analyzed using LC-HRMS. This analysis provides qualitative information for structural or molecular formula identification as well as quantitative data for each compound. The untargeted metabolites identified in retention time the ethanol extract of green melinjo peel were classified into 10 groups: amino acids-peptides, choline, vitamin, piperidines, phorbin, purines, phenolics, polyols, lipids, and alkaloid. The four dominant untargeted metabolites were choline (428.00 ppm), 2-hydroxy-2-butenedioicacid (213.20 ppm), phenylalanine (189.60 ppm), and Tempol_H (184.00 ppm)