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Secure and Tamper-Proof Blockchain-Enabled Cybercrime Reporting and Evidence Management System
No full textWith cybercrime constantly increasing, a more legitimate and secure digital evidence collection filing tool with an audit trail and immutability is necessary. However, central reporting/evidence tools are still vulnerable to hacking, exclusionary to any accessibility controls, and devoid of Chain of Custody requirements to prevent De Minimus reductions of legal admissibility. The Blockchain-Enabled Cybercrime Reporting and Evidence Collection System proposed is AES-256-GCM encryption and RSA signature and SHA-256 hash suited with, distributed stor- age via IPFS and Avalanche Fuji smart contracts to create the next level of legitimate digital evidence collections. AI detection of malicious intent is possible with the LSTM-BERT Hybrid Model trained to differentiate semantic intent and sentiment detection based. Ultimately, latency and cost assessed are low, in line with other studies and acceptable based on Avalanche Fuji blockchain operating standards. Improvements to in- tegrity are relative based on the more inquiries based on operability and Chain of Custody, the better. Therefore, this system functions as a foun- dation for more realistic implementation of a public reporting tool and forensic evidence collection tool that can be legally defensible
Intelligent Traffic Signal Optimization for Automated Emergency Vehicles Using Machine Learning
No full textEffective management of traffic for emergency vehicles continues to pose a significant challenge in contemporary urban environments. Delays in emergency responses can result in dire outcomes, such as loss of life and damage to property. Conventional traffic light systems function on predetermined cycles and do not adjust dynamically to the requirements of emergencies. This paper introduces an intelligent model for traffic signal optimization that utilizes machine learning techniques to give precedence to automated emergency vehicles. The system evaluates real-time traffic data, forecasts vehicle movement, and creates adaptive green corridors specifically for emergency vehicles. Simulation outcomes indicate a reduction in response times and minimal interference with overall traffic flow
La gasdermin D, un facteur d’amplification de la réponse inflammatoire par le virus de la grippe
No full textLe télocyte testiculaire
No full textLe télocyte est une cellule interstitielle qui a été longtemps négligée, mais elle fait aujourd’hui l’objet de nombreuses recherches dans plusieurs organes. Cette cellule présente une morphologie qui varie en fonction du nombre de télopodes, de longues prolongations cellulaires, au nombre de deux à cinq par cellule. Cette morphologie lui permettrait d’accomplir une variété de rôles, dont certains restent à confirmer. Sa présence dans le testicule suggère un rôle dans la régulation des fonctions endocrines et exocrines particulières à cet organe. Cet article fait la synthèse des connaissances actuelles sur cette cellule si particulière et sur ses rôles potentiels dans le testicule
L’axe IL-23 entretient un microenvironnement tumoral immunosuppressif en activant et en stabilisant des lymphocytes T régulateurs effecteurs
No full textL’unité d’enseignement « Immun pathologie » qui propose les brèves présentées dans ce numéro est suivie par des étudiants de divers parcours du Master Biologie-Santé de l’université de Montpellier. Ce Master rassemble des étudiants issus du domaine des sciences et technologies et du domaine de la santé. On y étudie les bases physiopathologiques des maladies immunologiques, les cibles thérapeutiques et les mécanismes d’échappement des microorganismes et des tumeurs. Les articles présentés sont choisis par les étudiants, selon leur domaine de prédilection, sous l’encadrement de Thierry Vincent et de Marie-Alix Poul
Comment tu t’appelles ?
No full textL’émergence de nouvelles entités de laboratoire soulève notamment la question de leur dénomination. C’est le cas des cultures de cellules souches qui reproduisent in vitro les processus majeurs du développement de l’embryon humain. De nombreux termes ont été proposés pour désigner ces construits cellulaires, tels que modèles d’embryon ou modèles embryonnaires, embryons synthétiques ou artificiels, ou encore embryoïdes. Chacune de ces formules s’accompagne de présupposés quant à la nature et au potentiel des entités qu’elles prétendent désigner. Ce sont ces présupposés, et les enjeux éthiques qu’ils charrient, que nous analysons ici en recensant les principaux termes utilisés dans la littérature et en présentant les avantages et inconvénients de chacun
Biodiversité du microbiote intestinal et alimentation moderne
No full textL’essor de l’alimentation moderne, caractérisée par la consommation accrue de produits dits ultra-transformés, pauvres en fibres et riches en graisses saturées ainsi qu’en sucres simples, bouleverse l’écosystème du microbiote intestinal. Cette altération de la biodiversité microbienne, essentielle à la santé humaine, entraîne des modifications profondes des interactions métaboliques, immunitaires et nutritionnelles entre l’hôte et son microbiote. Une compréhension approfondie de ces relations ouvre la voie à des approches alimentaires préventives et thérapeutiques innovantes. Cette revue présente une synthèse des mécanismes par lesquels les différents composants alimentaires modernes modulent la composition et les fonctions du microbiote intestinal, et discute de leurs conséquences sur le risque de maladies chroniques
Des protéines produites par des tumeurs et formant des capsides virales sont à l’origine de troubles neurologiques
No full textFirst measurement of cross sections for the
No full textNeutron irradiation experiments are performed at the China Academy of Engineering Physics (CAEP) to determine the (n,d*) reaction cross-section of the even Z-even N 78Kr at five neutron energies (13.59 ± 0.12, 13.86 ± 0.15, 14.13 ± 0.16, 14.70 ± 0.13, and 14.94 ± 0.02 MeV) using a high-pressure spherical gas sample. In order to determine the 78Kr(n,d*)77Br reaction cross section, the influence of 78Kr(n,2n)77Kr via EC(100%) decay is subtracted. The neutron energies and their uncertainties are calculated using the Q-value equation of the 3H(d,n)4He reaction, which takes into account the solid angle of the sample. Reaction 93Nb(n,2n)92mNb is used to monitor the neutron flux. The self-absorption and cascade of rays, as well as the geometry and solid angle of the sample, are corrected. The cross-section of the 78Kr(n,d*)77Br reaction is measured and reported for the first time. The measured results are compared to the results of available empirical and systematic formulas, theoretical results obtained using TALYS-2.0 with an adjustable density of six energy levels, and evaluation database results. The reaction 78Kr(n,d*)77Br cross-section determined for the first time in this experiment is of great significance for verifying the nuclear reaction models, improving the databases, and systematics
Intra-Annual Non-Uniform Characteristics of Extreme Precipitation Process Events in China
No full textExtreme precipitation process events (EPPEs) with long durations exhibit greater hazard potential and serve as a crucial trigger for basin-wide floods. Studying the intra-annual inhomogeneous characteristics of such EPPEs is of great significance for flood disaster early warning and risk management. Based on daily precipitation data from 610 stations in China during 1960 to 2009, this study introduces two new parameters, namely the concentration degree and the concentration period of EPPEs, to characterize their temporal distribution. Using trend analysis and Morlet wavelet analysis, the study investigates the intra-annual non-uniformity of annual extreme precipitation process events in China. Results indicate that both the concentration degree and concentration period of EPPEs exhibit a spatial pattern of “low-high-low” from southeast to northwest, whereas the spatial distribution of their standard deviations shows an opposite pattern. The area-averaged series of concentration degree and concentration period in the four major regions of China (western, northern, southern, and southwestern regions) demonstrate distinct interannual variations and oscillations. The EPPEs in Northern, Southern, and Southwest China have shown a tendency toward concentration, leading to an increased risk of multiple flood disasters occurring intensively within a certain period of the year. In contrast, those in Western China have exhibited a tendency toward dispersion, with the occurrence time of annual flood disasters tending to be discretized. Except for Southern china, EPPEs in other sub-regions have shown an advancing trend—indicating an elevated flood risk during the post-flood season in Southern China and a heightened flood risk during the pre-flood season in the other regions. A significant negative correlation coefficient is found between the concentration degree of EPPEs and extreme precipitation amount, indicating that a higher concentration of EPPEs corresponds to a smaller extreme precipitation amount, particularly along the coastal areas of south China