33380 research outputs found

    High-resolution computational plasticity at the micron scale

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    The persistent demand for green, strong and ductile advanced high strength steels, with a reduced climate footprint, calls for novel and improved multi-phase microstructures. The development of these new steels requires an in-depth understanding of the governing plasticity mechanisms at the micron scale. In order to address this challenge, novel numerical-experimental methods are called for that account for the discreteness, statistics and the intrinsic role of interfaces. This lecture sheds light on recent and innovative developments unravelling metal plasticity at the micron scal

    Experimental and numerical investigations on bending behavior of fixed open-web steel beams

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    The effects of opening parameters on the bending behavior of fixed open-web steel beams under static loading were experimentally investigated using six specimens of different opening length-to-height ratios, area ratios, and distributions. The experimentally obtained failure modes, bearing capacities, and load-displacement curves of the specimens were compared with those extracted from numerical simulations performed via Abaqus finite element analysis software. The results revealed the following: (i) The typical failure mode of the fixed open-web steel beams was plastic failure at the opening corners in the shear-bending sections, with compressive corners experiencing flexion and tensile corners experiencing tearing. (ii) For a given opening area ratio and opening height-to-beam height ratios, decreasing the opening length and increasing the number of openings significantly increased the bearing capacity of the open-web beam (by more than one-fold) when the openings were appropriately configured, compared with beams with a small number of large openings. (iii) Increasing the opening height and length had similar effects on the bending behavior of the open-web beam

    The Implications of Selective Serotonin Reuptake Inhibitors Towards Adolescent Depression

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    The current scientific understanding of adolescent depression is incomplete, requiring further research and attention. This review of Selective Serotonin Reuptake Inhibitors (SSRIs) in the context of adolescent depression seeks to inform adolescents about the mechanisms in which SSRIs affect the body, common side effects associated with this class of antidepressants, and the efficacy rates of SSRIs in their population group. This review also underscores the gaps in research regarding both adolescent depression and adolescent antidepressant usage. When considering the use of prescription drugs, especially ones that have large implications towards neurological function, it is essential to understand all facets of the medication. This review provides adolescents and their families with direct information that will inform their thinking about SSRI use. This review considers academic and popular sources in collating evidence for the impact and efficacy of SSRIs on adolescents. Through careful analysis of the consequences and benefits associated with SSRI usage, this review provides a comprehensive scientific overview of SSRIs. To inform adolescents and their families, this review will first offer a mechanistic overview of the SSRI drug class, next evaluate evidence for the neurological effects of SSRIs on the adolescent brain, and then highlight clinical testing of two specific SSRIs, Fluoxetine and Escitalopram. Both the implications of SSRIs on adolescent brain development and their possible short-term and long-term negative side effects are considered in this review. Most importantly, this review draws attention to the multitude of unknowns surrounding SSRI usage in adolescents and urges researchers to continue evaluating the implications of early antidepressant usage. With an adolescent centered viewpoint and a focus on extensivity, this report provides adolescents and their families with the resources to make personalized decisions about SSRI exposure

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