Qazvin University of Medical Sciences

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    10283 research outputs found

    Subtype distribution of Blastocystis sp. isolated from humans in Iran: a systematic review and meta-analysis

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    Aim: This systematic review and meta-analysis evaluated the subtyped Blastocystis sp. isolated from humans in Iran. Background: Blastocystis sp. is an anaerobic intestinal protozoan that infects humans as well as domestic and wild animals, i.e. mammals, amphibians, reptiles, and arthropods. Methods: A comprehensive search for papers published before April 2022 was undertaken utilizing English and Persian databases. The following MeSH keywords were used in the electronic search: (Blastocystis sp.) AND (molecular OR subtype) AND (prevalence OR epidemiology) AND Iran. The quality of the included studies was evaluated. Thereafter, a random-effects meta-analysis was conducted to estimate the pooled prevalence and odds ratios regarding the included studies. Results: A total of 32 studies comprised of five case-control studies and 27 cross-sectional studies met the eligibility criteria. The overall pooled prevalence of subtyped Blastocystis sp. in Iran was estimated to be 10% (95% confidence interval: 6 to 15%). Eight subtypes of Blastocystis sp. (ST1- ST7 and ST9) were identified in our study, of which ST3 was the most common subtype (0.04); 0.02-0.07). The difference in subtypes between two case and control groups in reported studies was not significant, but the odds ratio of infection by ST3 (0.98; 95% CI, 0.30 to 3.20) was higher in cases. Conclusion: The current systematic review showed that with the exception of ST8 and ST12, all human Blastocystis sp. subtypes reported in the world are found in different parts of Iran

    Haemophilus, Bordetella, Brucella

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    Association of 2184A/G polymorphism in the RAGE gene with nephropathy in type 2 diabetes mellitus patients

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    Aaims: The study was designed to evaluate the association of 2184A/G polymorphism in the RAGE gene with diabetic nephropathy in Qazvin populaton. Methods: In this study, there were three groups of subjects which includes diabetic nephropathy patients(116 people), diabetic patients(122 people) and healthy group (118 people). TETRA-ARMS-PCR technique was used to genotyped. Biochemical parameters among the study groups analysis was evaluated. Statistical analysis was carried out using standard statistical methods. Results: This study showed that genotypic differences among study groups are less than the significant level, so there is a significant relationship between the 2184A/G polymorphism of RAGE gene and diabetic nephropathy. Conclusion: Significant differences were found in genotype frequencies of the 2184A/G polymorphism between the three groups. Allele analysis showed that allele G of 2184A/G polymorphism was associated with diabetic nephropathy. Key words: diabetes mellitus, diabetic nephropathy, polymorphism, RAGE

    بررسي ارتباط ميزان كم شنوايي با شدت سرگيجه در مبتلایان به بیماری منيير درسال 1399 تا 1400

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    مقدمه : بيماري منيير (MD) ازجمله بيماري‌هاي گوش داخلي است که با دوره‌های مکرر سرگیجه خود به خود، کاهش شنوایی حسی عصبی، وزوز گوش، و احساس پری در گوش مشخص می‌شود. سرگیجه ناتوان کننده‌ترین علامت در بین علائم اصلی بیماری است. اپیزودهای غیرقابل پیش بینی سرگیجه و احتمال کاهش شنوایی دائمی می‌تواند از سخت‌ترین مشکلات بیماری منیر باشد. از این رو هدف از این مطالعه بررسي ارتباط ميزان كم شنوايي با شدت سرگيجه در مبتلایان به بیماری منيير بود. روش: طی این پژوهش مقطعی 212 نفر بیمار مبتلا به منییر مراجعه کننده به درمانگاه گوش و حلق و بینی بیمارستان قدس قزوین مورد بررسی قرار گرفتند. این افراد با استفاده از معیار تشخیصی (AAO-HNS) تحت شرح حال گیری و ادیومتری (PTA, SRT, SDS) قرار گرفتند. اطلاعات به دست آمده با استفاده از نرم‌افزار SPSS 21 مورد تجزیه و تحلیل قرار گرفت. يافته ها: براساس نتایج این مطالعه دامنه تغییرات سنی بیماران 14 تا 84 سال با میانگین (47.55±12.93سال) بود. دربیماران مبتلا به منییر بیشترین درگیری در گوش چپ و فرکانس‌های پایین‌تر از 2500 (7/82 درصد) با سابقه ابتلا به بیماری 1 الی 3 سال بود. این بیماران قبل از درمان (12-2) 5 بار در ماه علائم سرگیجه، وزوزگوش را تجربه کردند ( بازه ی تعداد حملات از یکبار در ماه تا سه بار در روز متغیر بود )که باعث کاهش کیفیت زندگی در آن‌ها شده بود. شدت حملات سرگیجه قبل از درمان در بیماران به طور متوسط 7.75±2.06 بود . بررسی پارامترهای ادیومتری نیز نشان دهنده کاهش شنوایی خفیف در 49.1 درصد بیماران و کاهش شنوایی متوسط در 17 درصد آنها بود که ارتباط معناداری با شدت سرگیجه نداشت. نتیجه‌گیری: نتایج این مطالعه نشان داد که بین شدت سرگیجه و میزان کم شنوایی ارتباط معناداری وجود ندارد. واژگان كليدي: بیماری منییر، شنوایی سنجی ، شدت سرگیجه ، کم شنوای

    بررسی ارتباط RDW با بقای دو ساله و پنج ساله پس از جراحی در مبتلایان به سرطان پستان

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    چکيده مقدمه: سرطان پستان، شایع ترین سرطان زنان است. با توجه به شیوع بالای سرطان پستان و اهمیت درمان صحیح و تعیین پروگنوز و پیش آگهی در بیماران مبتلا بر آن شدیم تا اثر پیشگویی کنندگی پارامترهای تستی حاصله از شمارش کامل سلول های خونی در پیش بینی بقای بیماران و بقای دو ساله و 5 ساله پس از جراحی در بیماران مبتلا به سرطان پستان را بررسی نماییم. روش کار: در این مطالعه مشاهده ای که به صورت یک بررسی تحلیلی انجام شد، پرونده تعداد 144 نفر از افراد مبتلا به سرطان پستان که در بیمارستانهای شهر قزوین از سال 1395 بستری شده بودند، به صورت در دسترس انتخاب شد و مورد بررسی قرار گرفت . يافته¬ها: میانگین سن بیماران 3/11 ± 9/53 سال و در دامنه سنی 40 تا 75 سال بودند. میزان بقای 2 و 5 ساله بیماران بر حسب RDW نرمال 85 و 59درصد گزارش شد. ارتباط بین بقا و RDW بر حسب سن، HER2 ، لومینال ، نوع بدخیمی معنادار بود نتيجه‌گيري: میزان بقاء 2 و 5 ساله سرطان پستان در زنان ایرانی در حد مطلوب می باشد و با افزایش سال های سپری شده از زمان تشخیص، میزان بقاء کاهش می یابد. اندازه گیری RDW به طور سریال می تواند پزشک را در پیگیری و روند درمان بیماری های مزمن یاری کند زیرا افزایش آن یک زنگ خطر در پیشرفت بیماری و رابطه مستقیم با مرگ و میر دارد کلمات کليدي: RDW ، بقا ، سرطان پستا

    Assessment of gastric caused by Helicobacter pylori and pathologic elements correlation with -511 IL1-β and -308 TNF-α polymorphisms in gastritis patients

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    Helicobacter pylori (H.pylori) is the main reason for gastric disorders including gastric lymphoma, ulcer disease, gastric carcinoma (GC), and chronic atrophic gastritis. H.pylori has two more significant virulence factors named cagA and vacA. Some host cytokines polymorphisms (Interleukin (IL-1) and tumor necrosis factor (TNF-α)) may contribute to H. pylori-related diseases. In the present study, we investigated the association of H. pylori gastritis and its pathogenic genes as well as the association of IL-1β and TNF-α polymorphisms in patients with gastritis. We collected gastric biopsy samples from patients with gastritis. After extracting DNA from biopsy specimens infected with H. pylori, cagA + and vacA + were detected by the polymerase chain reaction (PCR). To genotyping TNF-α polymorphism at position − 308 and IL-1β polymorphism at position − 511, PCR-based restriction fragment length polymorphism analysis was performed. Our study indicated that IL-1β-511 polymorphism, unlike TNF-α-308 polymorphism (P = 0.030), did not show a significant relationship between patients infected with H. pylori (p = 0.219). Also, our results indicated that alleles C and T of polymorphism of IL-1β-511 and alleles G of TNFα-308 were not significantly correlated with cagA status among patients infected with H. pylori (p = 0.793, p = 0.674, p = 0.179, respectively) unlike allele A of TNFα − 308 (p = 0.016

    Association between COVID-19 preventive behavioral changes and anxiety in Karachi, Pakistan: A cross-sectional pilot study

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    Background: COVID-19 has turned into emergent psychological impacts across cohorts with devastating consequences related to preventive measures. Health organizations recommended some preventive measures (e.g., wearing masks, frequent handwashing, etc.) to overcome the COVID-19 pandemic. However, performing these behaviors may increase anxiety among populations. Thus, the present study aimed to investigate the role of behavioral changes to prevent COVID-19 infection and anxiety during the COVID-19 pandemic in Pakistan. Subjects and methods: The present cross-sectional study was conducted for 10 days during July 2020 among the general public of Karachi after the imposition of lockdown amid the COVID-19 pandemic, with a sample size of 331 participants. The questionnaire consisted of three parts i.e., (i) socio-demographics, (ii) perception and preventive behaviors towards COVID-19, and (iii) anxiety-related questions using the Urdu Generalized Anxiety Disorder (GAD-7). The data was analyzed using logistic regression to investigate the association between behavior change and anxiety. Results: Almost half of the participants (i.e., 48.9%) reported being anxious. Although most of the participants were compliant with preventive behavioral changes in their daily lives but no associations between preventive behaviors and anxiety were found. There were significant associations between anxiety and some of the sociodemographic variables (i.e., gender: females were more anxious; age group and marital status single participants were more anxious). Conclusion: Based on the present findings, it is clearly evident that Pakistani people are suffering psychiatric problems during the COVID-19 pandemic. Hence, appropriate initiatives should be adopted as soon as possible. Besides, COVID-19 related preventive behavioral measures are highly recommended to practice without putting anything back for psychological fears

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