Qazvin University of Medical Sciences
Qazvin University of Medical Sciences RepositoryNot a member yet
10283 research outputs found
Sort by
Co-occurrence of upper respiratory tract disorders with gastrointestinal infections of helicobacter pylori in patients: a systematic review and meta-analysis
Get PDFBackground: Helicobacter pylori infection and respiratory tract infection at the same
time cause pathogenicity increase and death. The aim of this study was to evaluate the
co-occurrence of upper respiratory tract disorders and gastrointestinal infections of H.
pylori.
Methods: The present study was conducted as a systematic review and meta-analysis,
from August 2019 to Agusut 2020, at Qazvin University of Medical Sciences. Articles
in the international databases (April 2001-December 2018) on the coexistence of upper
respiratory tract disorders with H. pylori gastrointestinal infections were examined. The
random effect model with a 95% confidence level was used to analyze the data.
Results: The highest prevalence of respiratory disorders co-occurrence associated with
adenoid tissue (33%), nasal polyps (100%), chronic rhinosinusitis (71%) and
gastrointestinal infections of H. pylori was reported in 2006 in Turkey, 2011 in Poland and
2015 in Egypt .Concurrent prevalence of the disease, according to the type of upper
respiratory tract disorders in all studies, the estimated effect size according to the random
model was 53% in chronic rhinosinusitis, 63% in nasal polyps, 62% in adenoid tissue and
60% in total, which was significant (P=0/000). The prevalence of co-occurrence of upper
respiratory tract disorders with gastrointestinal infections of H. pylori in patients was
estimated to be 61% at the age of more than 27 years and 60% at the age of fewer than 27
years. Pooled estimation of the concurrent prevalence of infection (in total) was estimated
to be 60% and was significant among the studies (P=0/000).
Conclusion: The concurrent prevalence of upper respiratory tract disorders with
gastrointestinal infections of H. pylori was observed to be almost equal and significant
in elderly and young patients. Due to the fact that the simultaneous occurrence of two
types of infections and diseases in people is very dangerous, screening of patients with
each of these infections is necessary to identify the other infection and prescribe
appropriate drugs
ارزشیابی وضعیت انجام کار به روش RULA در یکی از صنایع خودرو- نیرو محرکه با هدف طراحی موثر سیستم کمک حرکتی اگزواسکلتال (فایل ارائه ژورنال کلاب)
Get PDFEnfuvirtide, an HIV-1 fusion inhibitor peptide, can act as a potent SARS-CoV-2 fusion inhibitor: an in silico drug repurposing study
Get PDFRegarding the urgency of therapeutic measures for coronavirus disease 2019 (COVID-19) pandemic,
the use of available drugs with FDA approval is preferred because of the less time and cost required
for their development. In silico drug repurposing is an accurate way to speed up the screening of the
existing FDA-approved drugs to find a therapeutic option for COVID-19. The similarity in SARS-CoV-2
and HIV-1 fusion mechanism to host cells can be a key point for Inhibit SARS-CoV-2 entry into host
cells by HIV fusion inhibitors. Accordingly, in this study, an HIV-1 fusion inhibitor called Enfuvirtide
(Enf) was selected. The affinity and essential residues involving in the Enf binding to the S2 protein of
SARS-CoV-2, HIV-1 gp41 protein and angiotensin-converting enzyme 2 (ACE-2) as a negative control,
was evaluated using molecular docking. Eventually, Enf-S2 and Enf-gp41 protein complexes were simulated by molecular dynamics (MD) in terms of binding affinity and stability. Based on the most important criteria such as docking score, cluster size, energy and dissociation constant, the strongest
interaction was observed between Enf with the S2 protein. In addition, MD results confirmed that EnfS2 protein interaction was remarkably stable and caused the S2 protein residues to undergo the fewest fluctuations. In conclusion, it can be stated that Enf can act as a strong SARS-CoV-2 fusion inhibitor
and demonstrates the potential to enter the clinical trial phase of COVID-19.
Abbreviations: ACE-2: angiotensin-converting enzyme 2; Enf: Enfuvirtide; FDA: Food and Drug
Administration; HIV: human immunodeficiency virus; MD: molecular dynamics; RBD: receptor binding domai
Appropriate neck/waist circumference cut-off points for gestational diabetes prediction in Iranian pregnant women: The baseline analysis of the Qazvin maternal and neonatal metabolic study (QMNMS), Iran
Get PDFAbstract
Background: Gestational diabetes is the most common complication during pregnancy and it is essential to identify the high-risk groups for gestational diabetes mellitus (GDM) in the first trimester. A large neck circumference (NC) in the first trimester is a measure of obesity.
Objective: The present study investigated whether pregnant women's first-trimester NC and waist circumference (WC) measurements present a predictive index for GDM diagnosis.
Materials and methods: This longitudinal cohort study was conducted on 676 pregnant women aged ≥20 years. Pregnant women at 12-14th (baseline) gestational weeks underwent measurement of neck and other anthropometric indices. GDM was diagnosed with 75-g oral glucose tolerance test at 24-28th gestational week.
Results: GDM was developed in 110 (16.3%) pregnant women. The logistic regression analysis showed that baseline NC > 33.5 cm (OR: 2.037, 95% CI: 1.313-3.161; P = 0.002) and WC > 90.5 (OR: 2.299, 95% CI: 1.510-3.501; p 33.5 cm, with 68.5% sensitivity and 48.3% specificity, and for baseline WC it was >90.5.50 cm, with 57% sensitivity and 63.4% specificity.
Conclusion: Pregnant women with an NC > 33.5 cm and a WC > 90.5 cm at baseline (12-14th gestational weeks) had a higher chance of developing GDM. first-trimester NC and waist circumference (WC) measurements present a predictive index for GDM diagnosis.
Keywords: Cut-off points; Gestational diabetes mellitus; Neck circumferences
The Prevalence of Clostridium difficile and Clostridium perfringens in Minced and Ground Beef in Iran
Get PDFIn this study, due to the importance of human societies, the prevalence of Clostridium difficile and
Clostridium perfringens in minced and ground beef was investigated in Qazvin city, Iran. All samples were collected
randomly by sampling method. The number of samples taken was estimated based on statistical methods and
according to previous studies. Clostridium difficile moxalactam norfloxacin (CDMN) culture media was used to
isolate Clostridium difficile and TCS Agar and TPGY culture media was used for Clostridium perfringens. After
isolation, a PCR (Polymerase Chain Reaction) test was used to confirm the species diagnosis. According to the results,
21.26% of all samples were infected with these two bacteria. The prevalence of Clostridium perfringens (18.04%) was
significantly (p < 0.05) higher than Clostridium difficile (3.22%). Given the results and the pathogenicity of
Clostridium species, especially Clostridium difficile and Clostridium perfringens, special attention should be paid to
the methods reducing the contamination of these pathogenic bacteria in raw food
Recent Advances in Early Diagnosis of Viruses Associated with Gastroenteritis by Biosensors
Get PDFGastroenteritis, as one of the main worldwide health challenges, especially in children, leads
to 3–6 million deaths annually and causes nearly 20% of the total deaths of children aged < 5 years,
of which ~1.5 million gastroenteritis deaths occur in developing nations. Viruses are the main
causative agent (~70%) of gastroenteritis episodes and their specific and early diagnosis via laboratory
assays is very helpful for having successful antiviral therapy and reduction in infection burden.
Regarding this importance, the present literature is the first review of updated improvements in
the employing of different types of biosensors such as electrochemical, optical, and piezoelectric
for sensitive, simple, cheap, rapid, and specific diagnosis of human gastroenteritis viruses. The
Introduction section is a general discussion about the importance of viral gastroenteritis, types of
viruses that cause gastroenteritis, and reasons for the combination of conventional diagnostic tests
with biosensors for fast detection of viruses associated with gastroenteritis. Following the current
laboratory detection tests for human gastroenteritis viruses and their limitations (with subsections:
Electron Microscope (EM), Cell Culture, Immunoassay, and Molecular Techniques), structural features
and significant aspects of various biosensing methods are discussed in the Biosensor section. In
the next sections, basic information on viruses causing gastroenteritis and recent developments for
fabrication and testing of different biosensors for each virus detection are covered, and the prospect
of future developments in designing different biosensing platforms for gastroenteritis virus detection
is discussed in the Conclusion and Future Directions section as well
