Qazvin University of Medical Sciences
Qazvin University of Medical Sciences RepositoryNot a member yet
10283 research outputs found
Sort by
Weight-related stigma and psychological distress: A systematic review and meta-analysis
Get PDFBackground & aims
Individuals who are overweight or who have obesity are likely to perceive or experience unfriendly treatment (i.e., weight-related perceived stigma) from different sources such as work colleagues because of the stigma towards excess weight. People who are overweight may accept such stigma and devalue themselves (i.e., weight-related self-stigma).
Methods
A systematic review and meta-analysis was conducted to examine the relationship between weight stigma (including weight-related self-stigma and weight-related perceived stigma) and psychological distress (including depression and anxiety) using random-effects meta-analyses. Utilizing five academic databases (PubMed, Scopus, WOS, Embase and ProQuest) and keywords related to weight stigma and psychological distress, empirical studies focusing on the association between weight stigma and psychological distress were selected. The timeline for the searched papers was from the inception of each database to the end of August 2019.
Results
Eligible studies (N = 30; 25 on weight-related self-stigma and eight on weight-related perceived stigma) were analyzed with a total of 9345 participants experiencing weight-related self-stigma, and 15,496 experiencing weight-related perceived stigma. The pooled associations were moderate between weight-related self-stigma and psychological distress (corrected Fisher's Z = 0.40 for depression; 0.36 for anxiety) and between perceived stigma and depression (Fisher's Z = 0.44).
Conclusions
Results of the meta-analysis demonstrated that weight stigma is associated with psychological distress. The comprehensive search of the literature and rigorous methodology employed are the two major strengths in the present study. Because self-stigma and perceived stigma are different concepts, their associations with psychological distress should not be merged together
Stability of SARS-CoV-2 in Different Environments and the Effect of Disinfectants on its Survival
Get PDFIn December 2019, the prevalence of a pneumonia with unknown cause was reported in China which
was later named Coronavirus Disease 2019 (COVID-19) caused by a virus called SARS-CoV-2. One of
the most important ways of COVID-19 transmission is contaminated surfaces. In this review study, we
investigated the stability of SARS-CoV-2 in air and on surfaces and the methods of preventing its spread
Reported in studies conducted from 2003 to April 2020 which were searched in PubMed, Scopus, Embace,
and Google Scholar databases using keywords including Coronavirus, COVID-19, SARS-CoV-2, disinfection,
transmission and surfaces. Out of 118 articles identified in the initial search, 73 were remained
after screening their titles and abstracts. By applying inclusion and exclusion criteria, 51 articles were
finally selected for review. The novel coronavirus epidemic in humans is more widespread than previous
coronaviruses, indicating the high infectivity and environmental stability of the virus. The SARS-CoV-2
can stay active for up to 28 days at low temperatures (4°C). Currently, due to the lack of effective treatment
and vaccines, the best ways to deal with this disease is to avoid contamination, use disinfectants,
and prevent its spread by protective measures
Wnt network: A brief review of pathways and multifunctional components
Get PDFThe Wnt signaling pathway appears to activate intracellular signaling transduction in embryonic development, cell migration, hematopoiesis, and
several diseases. Wnt signaling is basically recognized as a canonical beta-catenindependent signaling pathway. However, in recent years, generally three
Wnt-mediated pathways have been investigated, which operate independently of beta-catenin and include calcium/calmodulin-dependent kinase II and
protein kinase C, planar cell polarity, and a third one recruits hetrotrimeric GTP-binding proteins to stimulate phospholipase C and phosphodiesterase. We
provide an overview of the noncanonical Wnt signaling pathway and then will focus on canonical Wnt signaling components, Wnt ligands, agonists, and
antagonist. This review will also discuss beta-catenin, both cytoplasmic and nuclear mechanisms, through signaling transduction, and, as a consequence, we
have briefly highlighted potential implications of Wnt/beta-catenin in some cancers
بررسی مداخله آموزشی تغذیه محور بر اساس الگو رويكرد فرايند عمل بهداشتي (HAPA ) بر پیامدهای بارداری مادران باردار تحت پوشش برنامه حمایتی(فایل دفاع نهایی)
Get PDFروان¬سنجی مقیاس گفتمان جنسی زوجین در زنان متأهل سنین باروری مراجعه کننده به مراکز سلامت شهر قزوین
Get PDFبررسی استانداردهای بین المللی گردشگری پزشکی: مرور جامع وضعیت بیمارستانهای ایران (چکیده طرح تحقیقاتی)
Get PDFMethylation status of interleukin-6 gene promoter in patients with Behçet's disease
Get PDFBackground: IL-6 mRNA expression is significantly high in many autoimmune diseases such as Behc¸ et’s
disease; this is often related with more aggressive phenotypes. Nevertheless, the essential molecular
process for its high expression has not been completely realized. The aim of this study was undertaken
to estimate the gene copy number variation and promoter methylation to IL-6’s high expression.
Methods: This study was performed on 51 patients and 61 healthy controls. Initially, DNA and RNA
were extracted from all specimens. Promoter methylation levels of IL-6 were evaluated by MeDIPqPCR technique. Also, IL-6 gene expression was measured by Real-time PCR. After that, we evaluated
the relationship between gene expression and methylation, as well as their relationship with clinical
specification.
Results: As we expected, the expression level of IL-6 gene increased significantly in the patient group
compared to the healthy subjects. Also, the relative promoter methylation level of the IL-6 mRNA was
significantly lower in patient group compared to healthy group (p < 0.001).
Discussion: We disclosed that the promoter hypomethylation may be considered as one of the main
defects for IL-6 mRNA high expression in patients with Behc¸ et’s disease
