Qazvin University of Medical Sciences

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    فیلم مصاحبه درمورد: تغذیه در ماه مبارک رمضان

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    فیلم‌های تهیه شده از مصاحبه سرکارخانم رازی در سیمای مرکز قزوین که در ماه مبارک رمضان سال 1399 انجام شده اس

    مدیریت کیفیت در آزمایشگاه بیوشیمی

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    قسمت اول فایل مدیریت کیفیت در آزمایشگاه بیوشیمی در قالب پاورپوین

    Effects of ear and body acupressure on labor pain and duration of labor active phase: A randomized controlled trial

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    Objectives: This study sought to compare the effects of multi-point ear and body acupressure on labor pain and the duration of labor active phase. Design: Three-armed randomized controlled trial. Setting: Kowsar Hospital, Qazvin, Iran. Intervention: Participants in the body acupressure group received acupressure on GB21, GB30, BL32, LI4, and SP6 points, each for two minutes, at cervical dilation of four, six, and eight centimeters. For participants in the ear acupressure group, adhesive auriculotherapy-specific Vaccaria seeds were attached to their auricles on the zero, genitalia, Shen Men, thalamic, and uterine 1 and 2 acupoints. The seeds were compressed every thirty minutes, each time for thirty seconds. Participants in the control group received routine care services. Main outcome measures: Labor pain intensity was assessed using a visual analogue scale at cervical dilation of four and ten centimeters. Results: While there was no significant difference between mean scores of pain among three groups, mean score of labor pain in both acupressure groups was significantly less than that in the control group (P < 0.001). However, the difference between the acupressure groups was not statistically significant (P=0.12). Moreover, the duration of labor active phase in the ear acupressure group was significantly less than those in the body acupressure and the control groups (P < 0.001). Conclusion: Ear acupressure was significantly effective in reducing labor pain and shortening labor active phase. However, body acupressure solely reduces labor pain. Therefore, ear acupressure can be used to reduce labor pain and shorten labor active phase

    Psychometric Properties of the Persian Generalized Trust Scale: Confirmatory Factor Analysis and Rasch Models and Relationship with Quality of Life, Happiness, and Depression

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    The psychometric properties of the Generalized Trust Scale (GTS) are well established. Furthermore,previousstudieshavefoundthattheGTSispositivelyassociatedwithbetter mental health and lower distress, and the literature finds that trust is good for mental health. However, current literature does not have any psychometric evidence concerning the Persian GTS. This study translated the GTS into Persian and validated its psychometric properties. After translating the GTS into Persian using robust and standardized translation procedure, 1200 Iranians (mean age=34.83 years; 583 [48.6%] males) completed the GTS, along with the Hospital Anxiety and Depression Scale (HADS), Short Form-12 (SF-12), and Oxford Happiness Questionnaire Short Form (OHQ-SF). The factor structure of Persian GTS was confirmed by a unidimensional model with a method factor (comparative fit index=0.998; Tucker-Lewis index=0.992). The unidimensional model was also supported by Rasch analysis (mean square=0.75 to 1.31). Other properties of the Persian GTS were satisfactory. More specifically, test-retest reliability was good (intraclass correlational coefficient=0.865), internal consistency was good (α=0.881), and concurrent validity was supported (standardized β=−0.086 with depression in the HADS [p=0.045];=−0.162 with anxiety in the HADS [p<0.001];= 0.077 with mental component score in the SF-12 [p=0.044]; =0.624 with OHQ-SF [p<0.001]).Thesix-itemPersianGTShas promisingpsychometricpropertiesand can be an effective measure to assess trust among Iranians

    Psychosocial variables related to weight-related self-stigma in physical activity among young adults across weight status

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    A healthy lifestyle with sufficient physical activity (PA) can contribute to weight management. Yet, many people do not maintain a healthy lifestyle. To explain PA, we propose a model that incorporates the Theory of Planned Behavior (TPB) with weight-related self-stigma. We recruited 325 young adults to complete questionnaires regarding their physical activities, weight-related self-stigma, and TPB factors. We used structural equation modeling to examine the model fit and the path invariance across weight groups. The model showed excellent model fit, but path invariance was not supported. Weight-related self-stigma significantly explained the perceived behavioral control, behavioral intention, and engagement of PA. People without overweight and people with overweight have different considerations for PA. Weight-related self-stigma is important for PA as well. To promote a healthy lifestyle, healthcare providers shou

    Investigating the Mechanism of Action of SARS-CoV-2 Virus for Drug Designing

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    Coronavirus Disease 2019 (COVID-19) is a viral pneumonia emerged in December 2019 in Wuhan, China. Its cause is a new virus from the coronavirus family scientifically named Coronavirus Acute Respiratory Syndrome 2 (SARS-CoV-2). In this review study, articles published in English until March 23, 2020 on new coronavirus infection were reviewed. These articles are obtained by searching in PubMed, Scopus and Google scholar databases using keywords "SARS-CoV-2", "COVID-19" and "Coronavirus". The latest COVID- 19 statistics and information were extracted from the websites of World Health Organization and the Centers for Disease Control and Prevention. we investigated the effect of different compounds on the key macromolecules in promoting SARS-COV-2 infection using computational methods and bioinformatics analysis that can be considered as the best targets for designing inhibitory drugs. The most important macromolecules were Angiotensin Converting Enzyme 2 (ACE2) and Transmembrane Protease Serine 2 (TMPRSS2) receptors of the host cell surface and the structural and non-structural proteins of the virus. The most important structural protein was Spike, playing an important role in binding the virus to the ACE2 receptor of the host cell and the entery of the virus genome into it, while the key non-structural proteins were 3-Chymotrypsin-like protease (3CLpro), RNA-dependent RNA polymerase (RdRp), Papainlike cysteine proteinase (PLpro), and non-structural protein 13 (nsp13) helicase which are involved in viral genome replication and the virus’ release from the host cell

    Design of a gold nanoprobe for the detection of: Pseudomonas aeruginosa elastase gene (lasB)

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    Nosocomial infections are one of the major health problems that increase mortality. Pseudomonas aeruginosa is one of the important causes of nosocomial infections. This bacterium has a gene called the lasB gene, the product of which is a zinc-dependent metalloprotease. This gene plays a central role in the pathogenesis of Pseudomonas spp. This pathogen is highly toxic and destroys tissues and also has a moderating effect on the immune system; on the other hand, it initiates the intracellular pathway of biofilm growth. Although there are methods such as molecular methods for identifying the lasB gene, due to the high cost and the need for specialized personnel, it is necessary to replace them with an appropriate method. In this study, a gold nanoparticle-based DNA diagnostic sensor sensitive to the aggregation states of gold nanoparticles was used to identify amplified and non-amplified lasB genes. The results of the experiment were evaluated both visually and spectrally. The minimum detection value of this method was 10 ng of the amplified lasB gene and 50 ng of the non-amplified lasB gene. This method is very fast, simple, easy and low cost

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