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Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
Get PDFScreening for domestic abuse and its relationship with demographic variables among elderly individuals referred to primary health care centers of Shiraz in 2018
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Optimizing the parameters of amoxicillin removal in a photocatalysis/ozonation process using Box–Behnken response surface methodology
Get PDFConcerns about environmental pollution from antibiotics such as amoxicillin have received
increasing attention. These compounds should be eliminated from discharged effluents to avoid
their possible negative effects on humans and animals, as well as on the environment. Recently,
advanced oxidation techniques have been used to remove antibiotics. This work aims to study the
removal of amoxicillin using a photocatalysis/ozonation process for treating pharmaceutical wastewater loaded with this type of refractory pollutants. The removal process was carried out using
different pH values (3–11), catalyst dosages (250–750 mg/L), and reaction times (30–90 min), at an
ozonation rate of 200 mg/h. Statistical analysis indicated that a quadratic model was suitable for
modeling amoxicillin degradation by the photocatalytic process and that all studied parameters
had statistically significant critical levels. Under optimum conditions (pH 11, a catalyst dose of
500 mg/L, and a reaction time of 90 min), the amoxicillin degradation efficiency of the photocatalytic
process was 78.7%. The results of the photocatalysis/ozonation process indicated that after 90 min
of ozone injection, an amoxicillin degradation efficiency of 98.7% was obtained. Therefore, it was
concluded that the combined ozonation process and photocatalytic process could be used to remove
amoxicillin effectively
In vitro inhibitory effect of recombinant human calprotectin on nalm6 leukemia cell line
Get PDFBackground & purpose: In evaluating new drugs for the treatment of various types of cancer,
investigations have been made to discover a variety of anti-tumor compounds with less side
effects on normal cells. Investigations have shown that the heterodimers S100A8 and S100A9
inhibit the enzyme casein kinase 2 and then prevent the activation of the E7 oncoprotein.
Therefore, the aim of this study was to evaluate the effect of calprotectin as an antitumor
compound on the Nalm6 (B cell precursor leukemia cell line).
Materials & methods: Transformation of genes encoding S100A8 and S100A9 human,
designed in the pQE32 plasmid, was performed by the thermal shock method into E. coli M15
bacteria. After bacterial growth in LB medium, the expression of two S100A8 and S100A9
subunits, the solubility of the protein by SDS-PAGE method was determined. Finally, the
S100A8 / A9 complex was equally placed in the microtube. In the next step, the cytotoxic
effects of calprotectin produced on the Nalm6 cell line were evaluated using the wst1 test.
Then, the apoptosis in these cells was measured using flow cytometry methods with AnnexinV coloration.
Results: In the current study, the results showed that the cytotoxic effects of Calprotectin are
time and concentration- dependent. Therefore, it can reduce the tumor expression and had a
beneficial effect by induced apoptosis in Nalm6 cell line.
Conclusion: Calprotectin has an anti-tumor effect on the Nalm6 cell line by increasing
apoptosis
نقش کیفیت ادراک شده، اعتماد و وفاداری بر ساخت ارزش ویژه برند مبتنی بر بیماران: مدل سازی برای بیمارستان های عمومی(چکیده طرح تحقیقاتی)
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